Incidental Mutation 'R6859:Or12k7'
ID 537786
Institutional Source Beutler Lab
Gene Symbol Or12k7
Ensembl Gene ENSMUSG00000083361
Gene Name olfactory receptor family 12 subfamily K member 7
Synonyms MOR159-1, Olfr360, GA_x6K02T2NLDC-33760081-33761034
MMRRC Submission 044961-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R6859 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 36958319-36959272 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36958794 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 159 (Y159F)
Ref Sequence ENSEMBL: ENSMUSP00000149581 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120704] [ENSMUST00000216706]
AlphaFold Q8VFP3
Predicted Effect probably damaging
Transcript: ENSMUST00000120704
AA Change: Y159F

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000114121
Gene: ENSMUSG00000083361
AA Change: Y159F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 206 6e-7 PFAM
Pfam:7tm_1 41 289 5.6e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216706
AA Change: Y159F

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik T C 16: 4,669,799 (GRCm39) V788A possibly damaging Het
Abca15 A T 7: 120,002,217 (GRCm39) K1577* probably null Het
Arhgap12 T C 18: 6,111,803 (GRCm39) E187G probably damaging Het
Arhgef10 T A 8: 15,025,005 (GRCm39) Y398N probably damaging Het
Baz2b C T 2: 59,731,874 (GRCm39) V2055I probably benign Het
Btnl4 T C 17: 34,688,353 (GRCm39) D475G probably damaging Het
C1qtnf12 T A 4: 156,050,070 (GRCm39) F190Y probably damaging Het
Cacul1 A G 19: 60,522,683 (GRCm39) S284P probably damaging Het
Ccdc166 C A 15: 75,853,820 (GRCm39) V87L possibly damaging Het
Ceacam13 C T 7: 17,747,032 (GRCm39) P162S probably damaging Het
Cep250 T A 2: 155,834,446 (GRCm39) S2124T probably benign Het
Chd5 T C 4: 152,462,664 (GRCm39) S1372P probably damaging Het
Chil3 C A 3: 106,067,730 (GRCm39) R145L probably benign Het
Cyp4f40 T C 17: 32,894,923 (GRCm39) S454P probably benign Het
Defa3 T A 8: 21,778,213 (GRCm39) C66S probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Glmp C A 3: 88,235,349 (GRCm39) N260K probably benign Het
Gsap T A 5: 21,486,016 (GRCm39) L653Q probably damaging Het
Il18rap T A 1: 40,564,255 (GRCm39) Y124* probably null Het
Lao1 A C 4: 118,820,948 (GRCm39) K58T probably damaging Het
Lepr T A 4: 101,622,487 (GRCm39) probably null Het
Mrgpra3 G C 7: 47,239,781 (GRCm39) I48M probably benign Het
Nck2 T G 1: 43,593,511 (GRCm39) N239K probably benign Het
Optc A T 1: 133,825,554 (GRCm39) V324E possibly damaging Het
Or4p8 A G 2: 88,727,278 (GRCm39) I221T probably benign Het
Or51b6 G A 7: 103,555,908 (GRCm39) W84* probably null Het
Otog T C 7: 45,923,205 (GRCm39) S1027P probably damaging Het
Plbd2 A G 5: 120,641,407 (GRCm39) F84L probably benign Het
Plxnb1 T C 9: 108,935,838 (GRCm39) L110P probably damaging Het
Prnp T C 2: 131,778,708 (GRCm39) V120A possibly damaging Het
Ptprh C A 7: 4,552,370 (GRCm39) E965* probably null Het
Reln T C 5: 22,239,568 (GRCm39) T900A probably damaging Het
Stt3a A G 9: 36,646,682 (GRCm39) Y644H probably damaging Het
Sulf2 A G 2: 165,929,039 (GRCm39) Y311H probably damaging Het
Tbc1d32 A T 10: 56,056,626 (GRCm39) I438N probably damaging Het
Tbcd T C 11: 121,387,937 (GRCm39) V356A possibly damaging Het
Tecta T C 9: 42,303,425 (GRCm39) N69S probably damaging Het
Topaz1 T C 9: 122,631,023 (GRCm39) V1618A probably benign Het
Usp48 C T 4: 137,352,587 (GRCm39) T627I possibly damaging Het
Vcl T C 14: 21,037,143 (GRCm39) V247A probably damaging Het
Vmn2r59 A G 7: 41,693,277 (GRCm39) L441P probably damaging Het
Zfp869 C T 8: 70,159,175 (GRCm39) G466D probably damaging Het
Other mutations in Or12k7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02394:Or12k7 APN 2 36,958,497 (GRCm39) missense probably damaging 1.00
H8786:Or12k7 UTSW 2 36,958,341 (GRCm39) missense probably benign 0.41
R4551:Or12k7 UTSW 2 36,958,355 (GRCm39) missense probably benign 0.03
R4896:Or12k7 UTSW 2 36,958,422 (GRCm39) missense probably damaging 1.00
R5004:Or12k7 UTSW 2 36,958,422 (GRCm39) missense probably damaging 1.00
R5828:Or12k7 UTSW 2 36,959,001 (GRCm39) missense probably benign 0.00
R6173:Or12k7 UTSW 2 36,959,091 (GRCm39) missense possibly damaging 0.78
R6802:Or12k7 UTSW 2 36,958,427 (GRCm39) missense probably benign
R7171:Or12k7 UTSW 2 36,958,400 (GRCm39) missense possibly damaging 0.91
R7712:Or12k7 UTSW 2 36,958,916 (GRCm39) missense probably damaging 1.00
R7798:Or12k7 UTSW 2 36,959,186 (GRCm39) missense probably damaging 1.00
R8492:Or12k7 UTSW 2 36,958,695 (GRCm39) missense probably damaging 1.00
R8815:Or12k7 UTSW 2 36,958,429 (GRCm39) missense probably benign
R8870:Or12k7 UTSW 2 36,958,982 (GRCm39) missense probably benign
R9115:Or12k7 UTSW 2 36,959,052 (GRCm39) missense probably damaging 0.96
T0722:Or12k7 UTSW 2 36,958,449 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGGAGCATTTCCTATAATCGTTG -3'
(R):5'- GGCCATGGCAATACCTATTCG -3'

Sequencing Primer
(F):5'- GCATTTCCTATAATCGTTGCATGAC -3'
(R):5'- CATGGCAATACCTATTCGAACATAAG -3'
Posted On 2018-10-18