Incidental Mutation 'R6960:Or6c74'
ID 541713
Institutional Source Beutler Lab
Gene Symbol Or6c74
Ensembl Gene ENSMUSG00000044897
Gene Name olfactory receptor family 6 subfamily C member 74
Synonyms GA_x6K02T2PULF-11704843-11705775, Olfr821, MOR109-1
MMRRC Submission 045070-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.309) question?
Stock # R6960 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129869497-129870429 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129869972 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 159 (L159P)
Ref Sequence ENSEMBL: ENSMUSP00000149027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054364] [ENSMUST00000205181] [ENSMUST00000214177]
AlphaFold Q8VG45
Predicted Effect probably benign
Transcript: ENSMUST00000054364
AA Change: L159P

PolyPhen 2 Score 0.344 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000056626
Gene: ENSMUSG00000044897
AA Change: L159P

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 5.2e-50 PFAM
Pfam:7tm_1 39 288 3.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205181
AA Change: L159P

PolyPhen 2 Score 0.344 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000144938
Gene: ENSMUSG00000044897
AA Change: L159P

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 5.2e-50 PFAM
Pfam:7tm_1 39 288 3.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214177
AA Change: L159P

PolyPhen 2 Score 0.344 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.1841 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 T C 4: 53,072,924 (GRCm39) D1170G probably benign Het
Ak7 A T 12: 105,676,503 (GRCm39) T68S probably benign Het
Arhgap12 A T 18: 6,111,901 (GRCm39) N26K probably damaging Het
B3galt1 A T 2: 67,949,033 (GRCm39) E249D probably damaging Het
Catsper4 T A 4: 133,954,648 (GRCm39) M1L probably benign Het
Cc2d2b T C 19: 40,773,506 (GRCm39) V523A possibly damaging Het
Ccn4 C T 15: 66,791,047 (GRCm39) T283M probably benign Het
Cyp11a1 T C 9: 57,925,659 (GRCm39) F98S probably damaging Het
Cyp2d26 T C 15: 82,674,446 (GRCm39) S479G probably damaging Het
Dclre1a T G 19: 56,531,141 (GRCm39) Y735S probably damaging Het
Dio2 C T 12: 90,696,671 (GRCm39) G106R probably damaging Het
Efcab12 T C 6: 115,815,273 (GRCm39) probably benign Het
Ehhadh C A 16: 21,581,028 (GRCm39) V655L probably benign Het
Ercc2 G A 7: 19,127,615 (GRCm39) R379Q probably damaging Het
Fabp4 A G 3: 10,273,537 (GRCm39) V12A probably benign Het
Fbn1 T C 2: 125,223,980 (GRCm39) I590V probably benign Het
Grm8 C A 6: 27,981,281 (GRCm39) V210L probably damaging Het
Jakmip3 A G 7: 138,625,065 (GRCm39) D359G probably damaging Het
Lrit1 G C 14: 36,782,052 (GRCm39) V242L probably damaging Het
Ly75 A T 2: 60,136,749 (GRCm39) Y1493N probably benign Het
Lyst A G 13: 13,808,663 (GRCm39) N111S probably benign Het
Lyz2 G C 10: 117,114,607 (GRCm39) I107M possibly damaging Het
Mgat5 A T 1: 127,248,371 (GRCm39) D91V possibly damaging Het
Mical3 T A 6: 120,935,504 (GRCm39) D1674V probably damaging Het
Myom2 G A 8: 15,167,741 (GRCm39) A1109T probably null Het
Naa16 A G 14: 79,596,911 (GRCm39) Y358H possibly damaging Het
Nktr T A 9: 121,571,758 (GRCm39) H226Q probably damaging Het
Ocln T G 13: 100,635,380 (GRCm39) K503T possibly damaging Het
Olfm4 T C 14: 80,258,754 (GRCm39) L301S probably damaging Het
Or4f4b G A 2: 111,314,071 (GRCm39) V127I possibly damaging Het
Paqr4 G A 17: 23,956,697 (GRCm39) A222V probably benign Het
Pcdhb13 A G 18: 37,576,509 (GRCm39) T296A probably benign Het
Phka2 G A X: 159,316,044 (GRCm39) V230I probably damaging Het
Pigg T C 5: 108,474,707 (GRCm39) V309A probably damaging Het
Ptger4 T C 15: 5,264,196 (GRCm39) R462G probably benign Het
Ptprc C T 1: 138,006,183 (GRCm39) probably null Het
Rabggta A C 14: 55,959,299 (GRCm39) probably null Het
Rnf25 A G 1: 74,634,403 (GRCm39) S207P possibly damaging Het
Rsf1 G GACGGCGGCC 7: 97,229,116 (GRCm39) probably benign Het
Rtf1 A G 2: 119,541,559 (GRCm39) Q264R probably damaging Het
Ryr2 A G 13: 11,816,129 (GRCm39) V619A probably benign Het
Serpinb6d A G 13: 33,855,181 (GRCm39) N285S probably benign Het
Slamf6 A G 1: 171,745,320 (GRCm39) M16V probably damaging Het
Slc22a23 A G 13: 34,528,140 (GRCm39) probably null Het
Slc23a2 T C 2: 131,933,173 (GRCm39) D95G probably damaging Het
Smc3 T C 19: 53,617,802 (GRCm39) Y600H probably damaging Het
Tarbp1 G A 8: 127,155,778 (GRCm39) T1320M possibly damaging Het
Tigd4 A T 3: 84,501,423 (GRCm39) K113N probably damaging Het
Tjp1 A T 7: 64,952,763 (GRCm39) F1444I possibly damaging Het
Tstd3 A T 4: 21,767,118 (GRCm39) M1K probably null Het
Zbtb46 T C 2: 181,065,217 (GRCm39) D311G probably damaging Het
Other mutations in Or6c74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01093:Or6c74 APN 10 129,869,761 (GRCm39) missense probably benign 0.01
IGL01554:Or6c74 APN 10 129,870,052 (GRCm39) missense probably damaging 1.00
R1960:Or6c74 UTSW 10 129,870,187 (GRCm39) nonsense probably null
R1968:Or6c74 UTSW 10 129,869,602 (GRCm39) missense probably damaging 1.00
R6889:Or6c74 UTSW 10 129,870,401 (GRCm39) missense probably benign
R6894:Or6c74 UTSW 10 129,870,178 (GRCm39) missense probably damaging 1.00
R7140:Or6c74 UTSW 10 129,870,083 (GRCm39) missense possibly damaging 0.89
R7828:Or6c74 UTSW 10 129,869,756 (GRCm39) missense probably damaging 0.99
R9722:Or6c74 UTSW 10 129,869,500 (GRCm39) missense probably benign 0.01
Z1088:Or6c74 UTSW 10 129,869,657 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGCCACAGGGGATAAAACC -3'
(R):5'- TGTAGGAAAGGCTTACTAATACCAG -3'

Sequencing Primer
(F):5'- GAGTGTGCAGCTCAACTATTTTTCAC -3'
(R):5'- TACCAGTGTAACCAAGAGTGTC -3'
Posted On 2018-11-28