Incidental Mutation 'R6952:Dusp1'
ID 543305
Institutional Source Beutler Lab
Gene Symbol Dusp1
Ensembl Gene ENSMUSG00000024190
Gene Name dual specificity phosphatase 1
Synonyms Ptpn16, MKP1, erp, mkp-1, 3CH134
MMRRC Submission 045064-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6952 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 26724565-26727446 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26726577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 162 (S162G)
Ref Sequence ENSEMBL: ENSMUSP00000025025 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025025]
AlphaFold P28563
Predicted Effect probably benign
Transcript: ENSMUST00000025025
AA Change: S162G

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000025025
Gene: ENSMUSG00000024190
AA Change: S162G

DomainStartEndE-ValueType
RHOD 10 134 6.41e-16 SMART
DSPc 173 311 2.22e-69 SMART
Meta Mutation Damage Score 0.0750 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice were viable, fertile, and showed no apparent morphological defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 T G 16: 20,368,484 (GRCm39) probably null Het
Acap1 C A 11: 69,776,343 (GRCm39) V219L probably benign Het
Arpp21 G A 9: 111,955,550 (GRCm39) P530S probably damaging Het
Atp6v1b1 T C 6: 83,731,792 (GRCm39) V224A probably damaging Het
Brd3 T C 2: 27,344,371 (GRCm39) D453G probably damaging Het
Btbd10 A T 7: 112,951,150 (GRCm39) probably null Het
Ccdc148 T C 2: 58,713,657 (GRCm39) H498R probably damaging Het
Cga A T 4: 34,905,171 (GRCm39) Y65F possibly damaging Het
Chd7 A T 4: 8,856,797 (GRCm39) H136L probably damaging Het
Chit1 T C 1: 134,071,022 (GRCm39) Y34H probably damaging Het
Cimap2 C G 4: 106,467,596 (GRCm39) probably null Het
Dapk2 C G 9: 66,161,904 (GRCm39) R271G probably benign Het
Dnhd1 T G 7: 105,362,895 (GRCm39) V3819G probably damaging Het
Dsg3 A T 18: 20,658,216 (GRCm39) I276F possibly damaging Het
Entrep1 A T 19: 23,962,082 (GRCm39) M307K possibly damaging Het
Gga2 C A 7: 121,598,111 (GRCm39) A328S probably benign Het
Gpr183 A G 14: 122,191,897 (GRCm39) I208T possibly damaging Het
Haspin T C 11: 73,026,971 (GRCm39) D706G possibly damaging Het
Hdac5 T C 11: 102,095,786 (GRCm39) I338V probably benign Het
Ik C T 18: 36,886,613 (GRCm39) R362C probably damaging Het
Kdm4c T G 4: 74,275,587 (GRCm39) C754W probably damaging Het
Limk1 T A 5: 134,699,332 (GRCm39) I142F possibly damaging Het
Mccc2 T C 13: 100,104,234 (GRCm39) E305G probably benign Het
Mdm1 A G 10: 118,003,962 (GRCm39) D639G probably damaging Het
Mefv T G 16: 3,528,744 (GRCm39) T566P probably damaging Het
Mep1b G A 18: 21,221,727 (GRCm39) V226I probably benign Het
Mgmt T C 7: 136,553,064 (GRCm39) M19T probably benign Het
Mrgpra6 A T 7: 46,835,693 (GRCm39) S243T probably benign Het
Myh7 C T 14: 55,229,197 (GRCm39) R169Q probably damaging Het
Myo1b T C 1: 51,801,668 (GRCm39) I917V probably damaging Het
Or4a80 A T 2: 89,582,971 (GRCm39) M67K possibly damaging Het
Phlpp1 T C 1: 106,100,209 (GRCm39) L159P probably benign Het
Plekhh3 T C 11: 101,056,482 (GRCm39) E371G probably damaging Het
Rps6ka2 C A 17: 7,495,377 (GRCm39) D21E probably benign Het
Slc47a1 T A 11: 61,235,280 (GRCm39) M518L probably benign Het
Slitrk6 T C 14: 110,987,974 (GRCm39) T578A probably benign Het
Syne2 A T 12: 75,974,205 (GRCm39) K1133N possibly damaging Het
Taco1 T C 11: 105,963,942 (GRCm39) S234P probably benign Het
Trpv4 G A 5: 114,771,263 (GRCm39) S422F probably damaging Het
Tvp23b T A 11: 62,775,952 (GRCm39) D97E possibly damaging Het
Vmn1r37 A T 6: 66,708,523 (GRCm39) I13L probably benign Het
Vrk2 T A 11: 26,485,597 (GRCm39) K130N probably damaging Het
Wdfy4 C T 14: 32,681,923 (GRCm39) R3016Q probably damaging Het
Zfp383 T C 7: 29,614,380 (GRCm39) S212P probably benign Het
Other mutations in Dusp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01346:Dusp1 APN 17 26,725,295 (GRCm39) missense probably benign 0.05
IGL01362:Dusp1 APN 17 26,725,618 (GRCm39) missense probably benign 0.16
IGL01363:Dusp1 APN 17 26,725,264 (GRCm39) missense probably damaging 0.99
IGL02186:Dusp1 APN 17 26,726,032 (GRCm39) nonsense probably null
R0374:Dusp1 UTSW 17 26,727,143 (GRCm39) missense probably damaging 0.98
R0385:Dusp1 UTSW 17 26,726,670 (GRCm39) missense probably benign 0.00
R1344:Dusp1 UTSW 17 26,727,293 (GRCm39) missense probably benign 0.28
R1418:Dusp1 UTSW 17 26,727,293 (GRCm39) missense probably benign 0.28
R1773:Dusp1 UTSW 17 26,726,081 (GRCm39) missense probably damaging 1.00
R2269:Dusp1 UTSW 17 26,726,093 (GRCm39) missense probably damaging 1.00
R2968:Dusp1 UTSW 17 26,726,679 (GRCm39) missense probably damaging 1.00
R5253:Dusp1 UTSW 17 26,727,191 (GRCm39) missense probably benign 0.01
R7909:Dusp1 UTSW 17 26,726,586 (GRCm39) missense probably benign 0.02
R9302:Dusp1 UTSW 17 26,726,148 (GRCm39) missense probably damaging 1.00
Z1177:Dusp1 UTSW 17 26,726,169 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- AGCTCCATCCAATTGCTTCATGATG -3'
(R):5'- TCCTTGTAAACTCGCAGCCC -3'

Sequencing Primer
(F):5'- GATGGACTAAAGATCCTCGTGTCC -3'
(R):5'- AGTGGCTTGTCTCCAGGTAC -3'
Posted On 2018-11-28