Incidental Mutation 'R8277:Mro'
ID 638043
Institutional Source Beutler Lab
Gene Symbol Mro
Ensembl Gene ENSMUSG00000064036
Gene Name maestro
Synonyms 4930507C04Rik, 4933435E20Rik
MMRRC Submission 067700-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8277 (G1)
Quality Score 225.009
Status Validated
Chromosome 18
Chromosomal Location 73992465-74014405 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 73997132 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119239] [ENSMUST00000120033] [ENSMUST00000134847] [ENSMUST00000179472]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000119239
SMART Domains Protein: ENSMUSP00000113392
Gene: ENSMUSG00000064036

DomainStartEndE-ValueType
SCOP:d1gw5a_ 23 239 9e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120033
SMART Domains Protein: ENSMUSP00000113434
Gene: ENSMUSG00000064036

DomainStartEndE-ValueType
SCOP:d1gw5a_ 23 240 3e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000134847
Predicted Effect probably benign
Transcript: ENSMUST00000179472
SMART Domains Protein: ENSMUSP00000136775
Gene: ENSMUSG00000064036

DomainStartEndE-ValueType
SCOP:d1gw5a_ 23 240 3e-10 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal reproductive morphology and physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 C A 19: 57,204,351 (GRCm39) L13F probably benign Het
Apoe C T 7: 19,432,303 (GRCm39) probably benign Het
Arap2 A G 5: 62,771,335 (GRCm39) probably null Het
Aspm T C 1: 139,382,748 (GRCm39) S27P probably damaging Het
Atcay C A 10: 81,050,646 (GRCm39) D90Y probably damaging Het
Cd46 A T 1: 194,747,030 (GRCm39) D327E probably damaging Het
Cfh A G 1: 140,029,347 (GRCm39) W1001R probably damaging Het
Chrm2 G A 6: 36,500,211 (GRCm39) V23M probably benign Het
Col1a2 G A 6: 4,516,410 (GRCm39) G175R probably null Het
Ddx52 T C 11: 83,845,940 (GRCm39) S422P probably damaging Het
Dync2i2 A G 2: 29,923,886 (GRCm39) V213A probably benign Het
Entr1 G A 2: 26,274,778 (GRCm39) A373V probably damaging Het
Gucy2d T A 7: 98,092,682 (GRCm39) W20R probably benign Het
Hao2 A G 3: 98,787,700 (GRCm39) I243T probably damaging Het
Hmcn2 A C 2: 31,259,189 (GRCm39) T1010P probably benign Het
Iqcf1 T C 9: 106,379,077 (GRCm39) S29P probably benign Het
Kat2b T A 17: 53,948,281 (GRCm39) D350E probably benign Het
Lingo4 A G 3: 94,309,931 (GRCm39) S290G possibly damaging Het
Mmrn1 A G 6: 60,954,220 (GRCm39) T834A probably benign Het
Mrps26 T A 2: 130,406,347 (GRCm39) L160Q probably damaging Het
Myh8 T C 11: 67,183,735 (GRCm39) I788T probably benign Het
Nab2 G A 10: 127,501,168 (GRCm39) probably benign Het
Nr2c2ap C T 8: 70,585,131 (GRCm39) Q67* probably null Het
Or1p1b C T 11: 74,130,842 (GRCm39) L151F probably benign Het
Pask C T 1: 93,253,085 (GRCm39) probably null Het
Pcnx2 A T 8: 126,592,755 (GRCm39) S736R probably damaging Het
Per2 G T 1: 91,348,274 (GRCm39) D1109E probably benign Het
Plxna1 G A 6: 89,334,162 (GRCm39) H156Y probably damaging Het
Polr2a G A 11: 69,638,882 (GRCm39) R51C probably damaging Het
Rbpms2 T A 9: 65,556,695 (GRCm39) F45Y probably damaging Het
Rmdn3 T C 2: 118,976,905 (GRCm39) D276G probably damaging Het
Septin2 T A 1: 93,427,030 (GRCm39) I171K probably benign Het
Serpinb3a C A 1: 106,973,970 (GRCm39) G314C probably damaging Het
Slc35f3 T A 8: 127,115,925 (GRCm39) V284D possibly damaging Het
Snapc4 A G 2: 26,255,722 (GRCm39) V934A probably benign Het
Tctn1 A G 5: 122,402,431 (GRCm39) M1T probably null Het
Tgoln1 G A 6: 72,593,838 (GRCm39) probably benign Het
Unc5c G A 3: 141,474,373 (GRCm39) probably null Het
Vmn2r11 A T 5: 109,202,833 (GRCm39) F81L probably benign Het
Vmn2r15 A T 5: 109,440,970 (GRCm39) V296E probably benign Het
Vmn2r15 C T 5: 109,441,310 (GRCm39) D183N probably damaging Het
Zfp763 T C 17: 33,252,294 (GRCm39) probably benign Het
Other mutations in Mro
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0471:Mro UTSW 18 74,009,860 (GRCm39) missense probably benign 0.04
R1671:Mro UTSW 18 74,003,126 (GRCm39) splice site probably benign
R1720:Mro UTSW 18 74,009,806 (GRCm39) missense probably benign 0.36
R2267:Mro UTSW 18 74,006,368 (GRCm39) missense probably benign 0.19
R4691:Mro UTSW 18 74,006,397 (GRCm39) missense probably benign
R5382:Mro UTSW 18 74,009,893 (GRCm39) missense probably benign 0.00
R6178:Mro UTSW 18 74,006,295 (GRCm39) missense possibly damaging 0.62
R6427:Mro UTSW 18 74,005,104 (GRCm39) missense probably damaging 1.00
R6833:Mro UTSW 18 73,997,003 (GRCm39) start gained probably benign
R7354:Mro UTSW 18 74,006,385 (GRCm39) missense probably benign 0.00
R7686:Mro UTSW 18 74,010,510 (GRCm39) missense probably benign 0.00
R8006:Mro UTSW 18 74,010,577 (GRCm39) missense possibly damaging 0.88
R9031:Mro UTSW 18 74,009,911 (GRCm39) critical splice donor site probably null
RF016:Mro UTSW 18 74,003,035 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TCGTACTCGCGGATCCTATC -3'
(R):5'- AAATGGCTTCCAGATCAGTTGTTG -3'

Sequencing Primer
(F):5'- GCTGTCTCCAAATTCCGAGAG -3'
(R):5'- AGATCAGTTGTTGCTCTATTCCATC -3'
Posted On 2020-07-28