Incidental Mutation 'R0100:Il17b'
ID 64138
Institutional Source Beutler Lab
Gene Symbol Il17b
Ensembl Gene ENSMUSG00000024578
Gene Name interleukin 17B
Synonyms 1110006O16Rik, 1700006N07Rik, Zcyto7
MMRRC Submission 038386-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # R0100 (G1)
Quality Score 138
Status Validated
Chromosome 18
Chromosomal Location 61821006-61825609 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 61823342 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 59 (M59V)
Ref Sequence ENSEMBL: ENSMUSP00000025471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025471]
AlphaFold Q9QXT6
Predicted Effect probably benign
Transcript: ENSMUST00000025471
AA Change: M59V

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000025471
Gene: ENSMUSG00000024578
AA Change: M59V

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:IL17 96 179 1.4e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191654
Meta Mutation Damage Score 0.0600 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased susceptibility to DDS-induced colitis and Citrobacter rodentium infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn A G 4: 156,259,415 (GRCm39) C814R probably damaging Het
Bbof1 T A 12: 84,457,829 (GRCm39) D31E probably benign Het
Ccdc51 C T 9: 108,921,066 (GRCm39) Q318* probably null Het
Cpxm2 T A 7: 131,656,600 (GRCm39) H554L possibly damaging Het
Dbr1 T A 9: 99,465,722 (GRCm39) D433E probably benign Het
Ddx55 C T 5: 124,694,845 (GRCm39) T91I probably damaging Het
Dhx57 T C 17: 80,582,585 (GRCm39) D340G possibly damaging Het
Dnah1 C T 14: 30,984,109 (GRCm39) probably null Het
Dpp9 C T 17: 56,512,854 (GRCm39) G118D possibly damaging Het
Fam81a C T 9: 70,010,091 (GRCm39) probably benign Het
Fat4 A C 3: 39,034,397 (GRCm39) N2683T probably damaging Het
Fbxo47 C T 11: 97,759,432 (GRCm39) G165S probably damaging Het
Garre1 A G 7: 33,953,436 (GRCm39) I442T possibly damaging Het
Gpatch2 C A 1: 186,958,014 (GRCm39) A123E probably damaging Het
Greb1 T A 12: 16,730,225 (GRCm39) Q1734L probably benign Het
Gtf2ird2 T C 5: 134,245,857 (GRCm39) L705P probably damaging Het
H13 T A 2: 152,531,783 (GRCm39) probably null Het
Hip1 T C 5: 135,465,307 (GRCm39) D367G probably benign Het
Ift140 C T 17: 25,309,928 (GRCm39) Q1112* probably null Het
Lpin3 T C 2: 160,747,260 (GRCm39) Y829H probably damaging Het
Mocs3 C T 2: 168,073,110 (GRCm39) R186C probably damaging Het
Or10al5 T C 17: 38,063,594 (GRCm39) F283S probably benign Het
Or2bd2 C T 7: 6,443,399 (GRCm39) R167C probably damaging Het
Or4c120 T A 2: 89,001,431 (GRCm39) I42F probably benign Het
Or5be3 T C 2: 86,863,939 (GRCm39) T209A probably benign Het
Osgepl1 A G 1: 53,362,372 (GRCm39) I405V probably damaging Het
Pdcd11 T C 19: 47,091,105 (GRCm39) S360P probably benign Het
Plekhs1 A G 19: 56,466,934 (GRCm39) E255G probably damaging Het
Tex22 T A 12: 113,052,392 (GRCm39) I150N probably benign Het
Tmem106a T C 11: 101,477,084 (GRCm39) S98P probably benign Het
Tnfrsf18 A G 4: 156,112,823 (GRCm39) T170A probably benign Het
Trpc6 C T 9: 8,653,035 (GRCm39) P614S probably damaging Het
Usp28 C A 9: 48,947,232 (GRCm39) P566Q probably damaging Het
Washc5 A G 15: 59,215,947 (GRCm39) F811L possibly damaging Het
Other mutations in Il17b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0045:Il17b UTSW 18 61,823,315 (GRCm39) missense probably damaging 0.99
R0100:Il17b UTSW 18 61,823,342 (GRCm39) missense probably benign 0.09
R1375:Il17b UTSW 18 61,823,325 (GRCm39) missense probably benign
R1468:Il17b UTSW 18 61,823,483 (GRCm39) splice site probably null
R1468:Il17b UTSW 18 61,823,483 (GRCm39) splice site probably null
R1517:Il17b UTSW 18 61,823,316 (GRCm39) missense probably damaging 0.98
R2157:Il17b UTSW 18 61,823,439 (GRCm39) missense probably damaging 0.98
R7869:Il17b UTSW 18 61,825,480 (GRCm39) missense probably damaging 0.99
R9310:Il17b UTSW 18 61,825,334 (GRCm39) nonsense probably null
R9616:Il17b UTSW 18 61,825,363 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- ATGCTTGGCTCTGGCCTTTGAC -3'
(R):5'- GGCAGACATTAAGAAGGCACCCATC -3'

Sequencing Primer
(F):5'- GCTCTGGCCTTTGACCAGTAG -3'
(R):5'- cagaactaatcaaccaacccaac -3'
Posted On 2013-08-06