Incidental Mutation 'R7968:Mob1a'
ID 650460
Institutional Source Beutler Lab
Gene Symbol Mob1a
Ensembl Gene ENSMUSG00000043131
Gene Name MOB kinase activator 1A
Synonyms 4022402H07Rik, Mobkl1b, Mobk1b
MMRRC Submission 046011-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.195) question?
Stock # R7968 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 83303016-83320758 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 83315287 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 145 (M145K)
Ref Sequence ENSEMBL: ENSMUSP00000054452 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038658] [ENSMUST00000055261] [ENSMUST00000101245]
AlphaFold Q921Y0
Predicted Effect probably benign
Transcript: ENSMUST00000038658
AA Change: M69K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000039115
Gene: ENSMUSG00000043131
AA Change: M69K

DomainStartEndE-ValueType
Pfam:Mob1_phocein 29 63 1.1e-9 PFAM
Pfam:Mob1_phocein 60 129 3.9e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000055261
AA Change: M145K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000054452
Gene: ENSMUSG00000043131
AA Change: M145K

DomainStartEndE-ValueType
Pfam:Mob1_phocein 29 205 3.4e-85 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000101245
AA Change: M145K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000098802
Gene: ENSMUSG00000043131
AA Change: M145K

DomainStartEndE-ValueType
Mob1_phocein 31 204 1.26e-118 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A G 6: 91,922,441 (GRCm39) T35A Het
Adamts16 A C 13: 70,886,701 (GRCm39) S1030A probably benign Het
Adgrv1 A T 13: 81,588,344 (GRCm39) V4414E possibly damaging Het
Aff4 C T 11: 53,300,175 (GRCm39) T1026I probably damaging Het
Arfgef1 T C 1: 10,243,145 (GRCm39) Y1065C probably damaging Het
Arhgef3 G T 14: 27,108,070 (GRCm39) D192Y probably damaging Het
Arhgef3 G A 14: 27,116,062 (GRCm39) R268Q probably damaging Het
Atp6v0e T A 17: 26,913,885 (GRCm39) probably null Het
B3galt9 A G 2: 34,728,257 (GRCm39) N19D probably damaging Het
Cenpc1 A G 5: 86,181,551 (GRCm39) Y605H probably benign Het
Cftr T C 6: 18,226,048 (GRCm39) V332A probably benign Het
Csmd2 A G 4: 128,091,118 (GRCm39) H219R Het
Csnk1g3 C T 18: 54,028,726 (GRCm39) probably benign Het
Cyp4f17 T C 17: 32,743,116 (GRCm39) V263A possibly damaging Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Entrep1 G T 19: 23,962,091 (GRCm39) T304K probably damaging Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
Gstm4 A T 3: 107,951,677 (GRCm39) M35K probably damaging Het
Kcna2 A G 3: 107,012,460 (GRCm39) Y347C possibly damaging Het
Kcnh7 G A 2: 62,566,444 (GRCm39) T829M probably damaging Het
Kcnu1 T C 8: 26,400,898 (GRCm39) V682A probably benign Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Kera A G 10: 97,444,821 (GRCm39) E60G possibly damaging Het
Letm2 C T 8: 26,083,766 (GRCm39) G155D probably damaging Het
Lrfn4 G A 19: 4,663,343 (GRCm39) A397V probably benign Het
Lrp4 A G 2: 91,324,424 (GRCm39) Q1253R possibly damaging Het
Nab1 A G 1: 52,529,295 (GRCm39) C201R probably damaging Het
Nlrp9b A G 7: 19,762,493 (GRCm39) E710G probably benign Het
Oas2 A G 5: 120,876,437 (GRCm39) V502A probably benign Het
Or1e26 T C 11: 73,480,154 (GRCm39) S137G probably benign Het
Or52d3 T A 7: 104,229,595 (GRCm39) C247* probably null Het
Or52h7 A T 7: 104,213,857 (GRCm39) H143L probably benign Het
Parg A T 14: 31,936,327 (GRCm39) H494L possibly damaging Het
Phf20 T A 2: 156,135,464 (GRCm39) D600E probably benign Het
Ppef2 G A 5: 92,397,022 (GRCm39) R118C probably damaging Het
Ptprz1 T A 6: 22,959,675 (GRCm39) N57K probably damaging Het
Rrbp1 A T 2: 143,832,081 (GRCm39) S29T probably damaging Het
Sema3g C A 14: 30,942,605 (GRCm39) R69S probably damaging Het
Slc12a4 G A 8: 106,678,237 (GRCm39) R319W possibly damaging Het
Slc4a3 A G 1: 75,528,007 (GRCm39) T419A probably benign Het
Smc3 T C 19: 53,611,649 (GRCm39) probably null Het
Sntg1 C T 1: 8,535,760 (GRCm39) W288* probably null Het
Synpo2l G T 14: 20,716,870 (GRCm39) probably null Het
Tap1 A G 17: 34,413,886 (GRCm39) I634V probably damaging Het
Tmem25 A G 9: 44,706,983 (GRCm39) S278P probably benign Het
Togaram2 T C 17: 72,024,428 (GRCm39) S871P probably benign Het
Trim37 T C 11: 87,040,179 (GRCm39) V225A possibly damaging Het
Tubg1 G T 11: 101,014,854 (GRCm39) A199S probably benign Het
Other mutations in Mob1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00756:Mob1a APN 6 83,309,468 (GRCm39) missense probably damaging 1.00
IGL00838:Mob1a APN 6 83,315,313 (GRCm39) missense possibly damaging 0.94
IGL01685:Mob1a APN 6 83,309,485 (GRCm39) missense probably benign 0.00
R0612:Mob1a UTSW 6 83,311,140 (GRCm39) missense probably benign 0.31
R4870:Mob1a UTSW 6 83,317,221 (GRCm39) missense probably benign 0.01
R6682:Mob1a UTSW 6 83,311,132 (GRCm39) missense possibly damaging 0.54
R7299:Mob1a UTSW 6 83,315,431 (GRCm39) splice site probably null
R7417:Mob1a UTSW 6 83,309,492 (GRCm39) missense probably benign 0.00
R8324:Mob1a UTSW 6 83,306,956 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTGAACTGTGATCCAGCAGCC -3'
(R):5'- TCAAGGTCTAAGTCCAAGGCCC -3'

Sequencing Primer
(F):5'- GAACTGTGATCCAGCAGCCTCTATC -3'
(R):5'- GTCTAAGTCCAAGGCCCAGAGATC -3'
Posted On 2020-09-15