Incidental Mutation 'IGL00161:Gsto2'
ID688
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gsto2
Ensembl Gene ENSMUSG00000025069
Gene Nameglutathione S-transferase omega 2
Synonyms4930425C18Rik, 1700020F09Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00161
Quality Score
Status
Chromosome19
Chromosomal Location47865545-47886324 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 47874967 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 94 (D94G)
Ref Sequence ENSEMBL: ENSMUSP00000119680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056159] [ENSMUST00000120645] [ENSMUST00000135016]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000026048
Predicted Effect probably damaging
Transcript: ENSMUST00000056159
AA Change: D94G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052592
Gene: ENSMUSG00000025069
AA Change: D94G

DomainStartEndE-ValueType
Pfam:GST_N 23 95 1.7e-9 PFAM
Pfam:Glutaredoxin 24 75 1.1e-7 PFAM
Pfam:GST_N_3 26 101 1.9e-21 PFAM
Pfam:GST_N_2 31 96 3.2e-14 PFAM
SCOP:d1eema1 104 242 3e-25 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000120645
AA Change: D94G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113409
Gene: ENSMUSG00000025069
AA Change: D94G

DomainStartEndE-ValueType
Pfam:GST_N 22 95 3.8e-14 PFAM
Pfam:Glutaredoxin 24 75 9e-8 PFAM
Pfam:GST_N_3 26 101 6.9e-22 PFAM
Pfam:GST_N_2 31 96 1.7e-14 PFAM
SCOP:d1eema1 104 242 3e-25 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000135016
AA Change: D94G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000119680
Gene: ENSMUSG00000025069
AA Change: D94G

DomainStartEndE-ValueType
Pfam:GST_N 23 95 3.4e-10 PFAM
Pfam:Glutaredoxin 24 75 4.4e-8 PFAM
Pfam:GST_N_3 26 101 4.2e-22 PFAM
Pfam:GST_N_2 31 96 6e-15 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700022I11Rik A T 4: 42,973,982 H1105L probably benign Het
4930467E23Rik T C 8: 19,749,483 probably benign Het
Akap13 T A 7: 75,725,971 V1932E probably damaging Het
Alg3 A G 16: 20,607,858 V211A probably damaging Het
Bsn T C 9: 108,115,110 T1148A probably benign Het
Dmbt1 G T 7: 131,109,628 D1538Y probably damaging Het
Fbxl20 C T 11: 98,090,674 G396D possibly damaging Het
Igf2r T C 17: 12,713,990 I882V probably benign Het
Ltbp1 C T 17: 75,310,152 probably benign Het
Men1 G A 19: 6,337,207 probably null Het
Nlrp1b A C 11: 71,181,181 probably benign Het
Notch3 A T 17: 32,158,114 C272* probably null Het
Olfr1230 A G 2: 89,296,455 C272R probably benign Het
Olfr943 A G 9: 39,185,092 K305E possibly damaging Het
Pard3 A G 8: 127,359,818 probably benign Het
Pcsk4 A G 10: 80,322,823 Y532H probably damaging Het
Pkd1l1 A G 11: 8,929,353 probably null Het
Prex1 A G 2: 166,638,401 Y140H probably damaging Het
Ptpdc1 C T 13: 48,587,058 R238Q possibly damaging Het
Rdx A G 9: 52,086,346 D540G probably damaging Het
Rnase10 T G 14: 51,009,781 D168E possibly damaging Het
Slc30a5 A C 13: 100,806,666 D561E probably damaging Het
Spag1 C T 15: 36,195,416 R252* probably null Het
Stox1 T C 10: 62,667,913 E121G probably damaging Het
Synm T C 7: 67,734,915 M558V probably benign Het
Tenm2 C T 11: 36,206,899 probably benign Het
Vmn1r64 T C 7: 5,883,828 T239A probably damaging Het
Other mutations in Gsto2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02561:Gsto2 APN 19 47886190 unclassified probably benign
IGL02820:Gsto2 APN 19 47874959 missense probably damaging 1.00
IGL03141:Gsto2 APN 19 47874873 missense probably damaging 1.00
R1343:Gsto2 UTSW 19 47884707 unclassified probably null
R4297:Gsto2 UTSW 19 47876496 missense possibly damaging 0.49
R4427:Gsto2 UTSW 19 47871773 missense possibly damaging 0.94
R4701:Gsto2 UTSW 19 47884656 missense probably benign 0.02
R4762:Gsto2 UTSW 19 47874873 missense probably damaging 1.00
R6765:Gsto2 UTSW 19 47871788 nonsense probably null
X0018:Gsto2 UTSW 19 47874901 missense probably benign 0.12
X0067:Gsto2 UTSW 19 47886022 missense probably benign
Posted On2011-07-12