Incidental Mutation 'R9506:Cutal'
ID 717812
Institutional Source Beutler Lab
Gene Symbol Cutal
Ensembl Gene ENSMUSG00000026870
Gene Name cutA divalent cation tolerance homolog-like
Synonyms D730039F16Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # R9506 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 34764408-34782144 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34775894 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 75 (D75G)
Ref Sequence ENSEMBL: ENSMUSP00000038452 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028228] [ENSMUST00000047447] [ENSMUST00000113068] [ENSMUST00000184164]
AlphaFold Q9D1U5
Predicted Effect probably damaging
Transcript: ENSMUST00000028228
AA Change: D75G

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000028228
Gene: ENSMUSG00000026870
AA Change: D75G

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:CutA1 53 109 2.4e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000028228
AA Change: D75G

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000144258
Gene: ENSMUSG00000026870
AA Change: D75G

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:CutA1 54 110 9e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000047447
AA Change: D75G

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000038452
Gene: ENSMUSG00000026870
AA Change: D75G

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:CutA1 54 152 6e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113068
AA Change: D75G

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000108691
Gene: ENSMUSG00000026870
AA Change: D75G

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:CutA1 53 154 1.9e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000184164
AA Change: D75G

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000144477
Gene: ENSMUSG00000026870
AA Change: D75G

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:CutA1 54 152 6e-33 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp A G 16: 56,437,773 (GRCm39) T632A unknown Het
Atp2b1 T C 10: 98,858,862 (GRCm39) S1182P probably benign Het
Best3 T A 10: 116,839,826 (GRCm39) F225I probably damaging Het
Camk1g A G 1: 193,030,363 (GRCm39) probably null Het
Cdc42bpb G A 12: 111,261,372 (GRCm39) P1656S probably benign Het
Cflar A T 1: 58,791,975 (GRCm39) Q426L Het
Chrna9 T A 5: 66,128,213 (GRCm39) D140E probably damaging Het
Cmpk2 A G 12: 26,519,850 (GRCm39) D167G probably benign Het
Csmd1 A G 8: 16,250,023 (GRCm39) L985P probably damaging Het
Dnah12 G T 14: 26,514,168 (GRCm39) V1776F probably benign Het
Dnah6 A G 6: 73,119,299 (GRCm39) V1528A probably damaging Het
Elovl1 A G 4: 118,287,912 (GRCm39) D16G probably damaging Het
Ermard T A 17: 15,281,368 (GRCm39) L593M probably damaging Het
Fstl4 A G 11: 53,024,950 (GRCm39) D274G probably benign Het
Gabrg1 C T 5: 70,939,713 (GRCm39) V140M probably damaging Het
Glrx2 C T 1: 143,622,270 (GRCm39) R89* probably null Het
Gsta3 A C 1: 21,327,586 (GRCm39) D40A possibly damaging Het
H4c3 C T 13: 23,882,264 (GRCm39) G57S probably benign Het
Hsf2 G A 10: 57,381,241 (GRCm39) probably null Het
Ifi203 A G 1: 173,751,565 (GRCm39) S833P possibly damaging Het
Ilk T C 7: 105,390,020 (GRCm39) Y132H probably benign Het
Jup G A 11: 100,267,704 (GRCm39) R540C probably damaging Het
Kdm7a T A 6: 39,126,305 (GRCm39) H560L probably benign Het
Kynu T A 2: 43,571,414 (GRCm39) N443K probably damaging Het
Mbd5 T C 2: 49,162,919 (GRCm39) S1134P probably damaging Het
Mknk2 T C 10: 80,503,918 (GRCm39) D331G probably benign Het
Mtfmt C T 9: 65,343,147 (GRCm39) R18C probably benign Het
Myo5b A G 18: 74,877,831 (GRCm39) Q1584R possibly damaging Het
Nup210 G A 6: 91,048,856 (GRCm39) P467S possibly damaging Het
Nxf1 A G 19: 8,749,508 (GRCm39) Y135C probably damaging Het
Or4a67 T C 2: 88,597,840 (GRCm39) Y273C probably damaging Het
Rab11fip3 T G 17: 26,213,250 (GRCm39) E853A probably damaging Het
Rap1gap2 A G 11: 74,305,266 (GRCm39) M313T probably damaging Het
Rims2 G A 15: 39,335,832 (GRCm39) V814I probably damaging Het
Sec16a A T 2: 26,319,384 (GRCm39) probably null Het
Slc36a3 A G 11: 55,039,457 (GRCm39) I57T probably benign Het
Slc5a9 G A 4: 111,750,439 (GRCm39) R140* probably null Het
Tas2r131 T A 6: 132,934,024 (GRCm39) T262S possibly damaging Het
Tigd3 G T 19: 5,942,860 (GRCm39) A90D probably damaging Het
Txnrd3 A G 6: 89,638,461 (GRCm39) M217V possibly damaging Het
Ube3d A G 9: 86,330,825 (GRCm39) I119T probably damaging Het
Vcp A G 4: 42,983,383 (GRCm39) V559A probably damaging Het
Vmn1r173 T A 7: 23,401,963 (GRCm39) I66N probably damaging Het
Vmn1r234 T G 17: 21,449,503 (GRCm39) I139S probably benign Het
Vmn2r105 C T 17: 20,429,404 (GRCm39) M557I probably benign Het
Wnt7b A G 15: 85,465,613 (GRCm39) S22P unknown Het
Zfp850 C A 7: 27,688,987 (GRCm39) R407L possibly damaging Het
Other mutations in Cutal
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0669:Cutal UTSW 2 34,775,878 (GRCm39) splice site probably benign
R3980:Cutal UTSW 2 34,772,325 (GRCm39) missense possibly damaging 0.46
R6649:Cutal UTSW 2 34,775,933 (GRCm39) missense probably benign 0.00
R6653:Cutal UTSW 2 34,775,933 (GRCm39) missense probably benign 0.00
R6736:Cutal UTSW 2 34,778,149 (GRCm39) missense probably benign 0.06
R8424:Cutal UTSW 2 34,777,804 (GRCm39) missense probably benign 0.01
Z1176:Cutal UTSW 2 34,772,437 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- ATGCGTCTCAGGCAGGAAAAC -3'
(R):5'- CACTGAATGTAAGTCAGCTATGAGG -3'

Sequencing Primer
(F):5'- GCCTCATTAGCATTAAACTTCGAGG -3'
(R):5'- TGTAAGTCAGCTATGAGGTGCAG -3'
Posted On 2022-07-18