Incidental Mutation 'R9705:Trp53tg5'
ID 729735
Institutional Source Beutler Lab
Gene Symbol Trp53tg5
Ensembl Gene ENSMUSG00000017720
Gene Name transformation related protein 53 target 5
Synonyms 1700126L10Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R9705 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 164312221-164315644 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 164313208 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 156 (S156G)
Ref Sequence ENSEMBL: ENSMUSP00000017864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017864] [ENSMUST00000125086] [ENSMUST00000138268] [ENSMUST00000142892] [ENSMUST00000164863]
AlphaFold Q9D976
Predicted Effect probably benign
Transcript: ENSMUST00000017864
AA Change: S156G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000017864
Gene: ENSMUSG00000017720
AA Change: S156G

DomainStartEndE-ValueType
Pfam:TP53IP5 28 238 2e-97 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125086
SMART Domains Protein: ENSMUSP00000121900
Gene: ENSMUSG00000045503

DomainStartEndE-ValueType
Pfam:SYS1 5 148 9.2e-61 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138268
SMART Domains Protein: ENSMUSP00000117507
Gene: ENSMUSG00000045503

DomainStartEndE-ValueType
Pfam:SYS1 5 76 1.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142892
SMART Domains Protein: ENSMUSP00000114360
Gene: ENSMUSG00000045503

DomainStartEndE-ValueType
Pfam:SYS1 5 76 1.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164863
SMART Domains Protein: ENSMUSP00000126658
Gene: ENSMUSG00000090996

DomainStartEndE-ValueType
Pfam:SYS1 5 78 6.7e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik C T 1: 11,588,913 (GRCm39) P110L probably damaging Het
Aff1 T G 5: 103,932,276 (GRCm39) L298R possibly damaging Het
B4galt1 T C 4: 40,853,474 (GRCm39) K111R probably benign Het
Brap A G 5: 121,801,373 (GRCm39) T87A probably benign Het
C1qtnf6 T A 15: 78,411,493 (GRCm39) Q61L probably benign Het
Ccar2 C A 14: 70,380,383 (GRCm39) C399F probably damaging Het
Cdh15 C A 8: 123,591,024 (GRCm39) D424E probably damaging Het
Cemip2 G A 19: 21,784,788 (GRCm39) V424I probably damaging Het
Col4a4 G A 1: 82,465,313 (GRCm39) A954V unknown Het
Cul9 T G 17: 46,854,226 (GRCm39) T159P probably damaging Het
Cyp3a59 A G 5: 146,033,120 (GRCm39) E164G probably benign Het
Dnah11 A C 12: 118,094,770 (GRCm39) L766R probably damaging Het
Drd5 T C 5: 38,478,027 (GRCm39) V340A probably damaging Het
Ephb6 G A 6: 41,596,715 (GRCm39) E921K probably benign Het
Fam83e G A 7: 45,371,921 (GRCm39) R106K probably benign Het
Fsip2 A G 2: 82,823,634 (GRCm39) T6456A probably benign Het
H2ac1 A G 13: 24,118,728 (GRCm39) N95S probably benign Het
H2-M10.6 A G 17: 37,123,642 (GRCm39) N112S probably benign Het
Hectd4 A T 5: 121,448,744 (GRCm39) Y364F probably benign Het
Hoxc9 T A 15: 102,890,362 (GRCm39) M93K possibly damaging Het
Hsd17b4 A C 18: 50,324,791 (GRCm39) K668T probably benign Het
Inpp4b T C 8: 82,772,890 (GRCm39) V728A probably benign Het
Jph3 C T 8: 122,508,913 (GRCm39) R392W probably damaging Het
Krt79 T G 15: 101,839,196 (GRCm39) E424D probably benign Het
Mphosph10 T C 7: 64,027,031 (GRCm39) E594G possibly damaging Het
Mrm2 G A 5: 140,316,990 (GRCm39) R15W probably damaging Het
Neurl4 A T 11: 69,799,679 (GRCm39) D994V probably damaging Het
Ngef G A 1: 87,431,010 (GRCm39) P269L probably damaging Het
Odam T A 5: 88,037,228 (GRCm39) F141I probably benign Het
Or1j10 A G 2: 36,266,962 (GRCm39) Y58C probably damaging Het
Or56a3b T A 7: 104,770,841 (GRCm39) L59Q probably damaging Het
Pck1 T A 2: 173,000,170 (GRCm39) S534T possibly damaging Het
Pgm3 A G 9: 86,437,414 (GRCm39) F528L probably benign Het
Pi4ka A T 16: 17,099,815 (GRCm39) I1936N Het
Ptpn13 T C 5: 103,681,221 (GRCm39) L807S possibly damaging Het
Ramp2 T A 11: 101,137,369 (GRCm39) L31Q possibly damaging Het
Rars2 A T 4: 34,646,561 (GRCm39) K275N possibly damaging Het
Rusc2 A C 4: 43,424,936 (GRCm39) N1131T probably benign Het
Snapc1 G T 12: 74,015,150 (GRCm39) K161N probably damaging Het
Spag8 G A 4: 43,652,366 (GRCm39) H325Y possibly damaging Het
Styk1 CTCTTCATGATTTTCTT CTCTT 6: 131,278,612 (GRCm39) probably benign Het
Synpo2l C T 14: 20,710,989 (GRCm39) V773M probably damaging Het
Syt3 A G 7: 44,045,225 (GRCm39) D519G probably damaging Het
Tacc2 A G 7: 130,361,018 (GRCm39) Y459C probably damaging Het
Ubb A G 11: 62,443,375 (GRCm39) Y135C possibly damaging Het
Vmn2r90 A G 17: 17,933,039 (GRCm39) I200V possibly damaging Het
Zfp27 C A 7: 29,595,342 (GRCm39) V208F possibly damaging Het
Other mutations in Trp53tg5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02387:Trp53tg5 APN 2 164,313,376 (GRCm39) missense possibly damaging 0.75
R0538:Trp53tg5 UTSW 2 164,313,401 (GRCm39) missense probably damaging 0.98
R1348:Trp53tg5 UTSW 2 164,315,521 (GRCm39) critical splice donor site probably null
R2216:Trp53tg5 UTSW 2 164,313,226 (GRCm39) missense probably benign 0.00
R2423:Trp53tg5 UTSW 2 164,313,250 (GRCm39) nonsense probably null
R3034:Trp53tg5 UTSW 2 164,313,219 (GRCm39) missense probably benign 0.00
R5569:Trp53tg5 UTSW 2 164,313,256 (GRCm39) missense probably benign 0.00
R5842:Trp53tg5 UTSW 2 164,313,289 (GRCm39) missense possibly damaging 0.56
R6021:Trp53tg5 UTSW 2 164,313,391 (GRCm39) missense probably benign 0.00
R7206:Trp53tg5 UTSW 2 164,313,378 (GRCm39) missense probably damaging 1.00
R7366:Trp53tg5 UTSW 2 164,313,027 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- AGCTCAGAGTGATGCACAGC -3'
(R):5'- TTCCAAGAGATTAGGGTCCTTG -3'

Sequencing Primer
(F):5'- GATCTACACATGATCCGGCG -3'
(R):5'- TTAGGGTCCTTGAAATGAGACC -3'
Posted On 2022-10-06