Incidental Mutation 'R9797:Or13p8'
ID 734982
Institutional Source Beutler Lab
Gene Symbol Or13p8
Ensembl Gene ENSMUSG00000070821
Gene Name olfactory receptor family 13 subfamily P member 8
Synonyms MOR258-6, Olfr1340, GA_x6K02T2QD9B-18823451-18822504
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R9797 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 118582919-118584393 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 118584079 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 212 (I212L)
Ref Sequence ENSEMBL: ENSMUSP00000149563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094834] [ENSMUST00000213436] [ENSMUST00000216242] [ENSMUST00000217334]
AlphaFold Q3KPC7
Predicted Effect probably benign
Transcript: ENSMUST00000094834
AA Change: I212L

PolyPhen 2 Score 0.269 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000092430
Gene: ENSMUSG00000070821
AA Change: I212L

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 4.4e-57 PFAM
Pfam:7tm_1 44 293 1.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213436
AA Change: I212L

PolyPhen 2 Score 0.269 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000216242
AA Change: I212L

PolyPhen 2 Score 0.269 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000217334
AA Change: I212L

PolyPhen 2 Score 0.269 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr3b A G 5: 26,054,895 (GRCm39) Y403C probably benign Het
Afdn A G 17: 14,066,562 (GRCm39) I600V probably benign Het
Akr1b8 G A 6: 34,333,278 (GRCm39) E52K possibly damaging Het
Alas1 A G 9: 106,113,842 (GRCm39) S468P probably damaging Het
Atp13a5 T C 16: 29,133,491 (GRCm39) T432A probably benign Het
B3glct A T 5: 149,650,304 (GRCm39) T136S probably benign Het
Bahcc1 A T 11: 120,159,147 (GRCm39) R125* probably null Het
Brat1 A G 5: 140,704,273 (GRCm39) E842G probably damaging Het
Cacna1b A G 2: 24,508,287 (GRCm39) L1830S probably damaging Het
Cd109 A G 9: 78,579,217 (GRCm39) N620D probably benign Het
Cdhr1 T A 14: 36,803,462 (GRCm39) D538V probably damaging Het
Cfap74 G A 4: 155,514,402 (GRCm39) C546Y Het
Colq T A 14: 31,250,777 (GRCm39) R343* probably null Het
Dmxl2 T C 9: 54,358,187 (GRCm39) K330R probably benign Het
Dnah5 A G 15: 28,233,316 (GRCm39) K225R probably benign Het
Dnase1l3 C T 14: 7,984,127 (GRCm38) S95N probably damaging Het
Fyco1 C A 9: 123,626,761 (GRCm39) A1317S probably benign Het
Gm9195 G A 14: 72,687,705 (GRCm39) P1944L probably damaging Het
Gse1 T G 8: 121,215,864 (GRCm39) L4R probably damaging Het
Gstm1 T C 3: 107,925,080 (GRCm39) I4M probably benign Het
Ighv2-3 A T 12: 113,574,945 (GRCm39) I70K possibly damaging Het
Krt71 C T 15: 101,645,069 (GRCm39) R414H probably damaging Het
Mcmbp T C 7: 128,317,696 (GRCm39) E183G possibly damaging Het
Med13l T C 5: 118,880,144 (GRCm39) S1079P probably damaging Het
Megf11 A G 9: 64,545,591 (GRCm39) I125V possibly damaging Het
Mtmr4 T A 11: 87,494,962 (GRCm39) V418E probably damaging Het
Mttp T C 3: 137,814,725 (GRCm39) T517A probably damaging Het
Mx1 A G 16: 97,252,893 (GRCm39) V409A probably benign Het
Olfml1 C A 7: 107,167,069 (GRCm39) H33N probably benign Het
Or4k15b A T 14: 50,272,224 (GRCm39) V212D probably benign Het
Or5w19 A T 2: 87,698,478 (GRCm39) I48F possibly damaging Het
Or6k2 T C 1: 173,986,417 (GRCm39) I26T probably benign Het
Or6n1 T A 1: 173,917,356 (GRCm39) I250N possibly damaging Het
Parp12 C A 6: 39,067,185 (GRCm39) V536F probably damaging Het
Phf11a T C 14: 59,514,862 (GRCm39) E273G possibly damaging Het
Pramel27 A G 4: 143,579,818 (GRCm39) T468A possibly damaging Het
Psd3 A G 8: 68,210,778 (GRCm39) Y743H probably damaging Het
Rnf213 T A 11: 119,333,365 (GRCm39) I2859N Het
Sec23a A T 12: 59,052,060 (GRCm39) C88* probably null Het
Sepsecs A G 5: 52,826,239 (GRCm39) probably null Het
Slc35e3 G A 10: 117,572,016 (GRCm39) T293I probably benign Het
Slc49a3 G T 5: 108,593,403 (GRCm39) T145N probably benign Het
Smu1 A G 4: 40,739,538 (GRCm39) I424T possibly damaging Het
Spata16 T A 3: 26,968,925 (GRCm39) I435N probably damaging Het
Tasp1 A G 2: 139,838,015 (GRCm39) S156P probably benign Het
Tmem237 A C 1: 59,144,735 (GRCm39) S398A probably damaging Het
Ttc39c T A 18: 12,828,542 (GRCm39) L234Q probably damaging Het
Ubxn11 C A 4: 133,851,426 (GRCm39) T22K probably benign Het
Uts2r C A 11: 121,051,518 (GRCm39) S127R probably damaging Het
Vmn1r236 A G 17: 21,506,969 (GRCm39) D29G probably benign Het
Vmn2r87 A G 10: 130,308,138 (GRCm39) I700T probably damaging Het
Vmn2r87 T A 10: 130,312,064 (GRCm39) T517S probably benign Het
Vps13b T A 15: 35,675,022 (GRCm39) V1714E probably damaging Het
Wrn T A 8: 33,758,950 (GRCm39) I1003L probably benign Het
Ylpm1 A G 12: 85,077,109 (GRCm39) D1278G possibly damaging Het
Zfp1006 T A 8: 129,946,534 (GRCm39) H97L probably benign Het
Zfp955a A C 17: 33,461,888 (GRCm39) H81Q possibly damaging Het
Zfyve26 T C 12: 79,293,006 (GRCm39) T2048A probably damaging Het
Other mutations in Or13p8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0153:Or13p8 UTSW 4 118,583,530 (GRCm39) missense possibly damaging 0.86
R0335:Or13p8 UTSW 4 118,584,367 (GRCm39) missense probably null
R0517:Or13p8 UTSW 4 118,583,831 (GRCm39) missense probably damaging 1.00
R4463:Or13p8 UTSW 4 118,583,855 (GRCm39) missense probably benign 0.32
R6240:Or13p8 UTSW 4 118,583,668 (GRCm39) missense probably benign 0.00
R6481:Or13p8 UTSW 4 118,583,930 (GRCm39) missense probably damaging 1.00
R6930:Or13p8 UTSW 4 118,584,338 (GRCm39) missense probably damaging 1.00
R7662:Or13p8 UTSW 4 118,583,504 (GRCm39) missense probably damaging 0.99
R7681:Or13p8 UTSW 4 118,583,761 (GRCm39) missense probably benign 0.00
R7782:Or13p8 UTSW 4 118,584,106 (GRCm39) missense probably damaging 1.00
R7845:Or13p8 UTSW 4 118,584,158 (GRCm39) missense probably benign 0.00
R8498:Or13p8 UTSW 4 118,583,822 (GRCm39) missense possibly damaging 0.78
R8529:Or13p8 UTSW 4 118,583,770 (GRCm39) missense probably benign 0.18
R8990:Or13p8 UTSW 4 118,584,224 (GRCm39) missense probably benign 0.01
R9017:Or13p8 UTSW 4 118,583,565 (GRCm39) missense probably benign
R9176:Or13p8 UTSW 4 118,583,850 (GRCm39) nonsense probably null
T0970:Or13p8 UTSW 4 118,583,464 (GRCm39) missense probably benign
Z1176:Or13p8 UTSW 4 118,584,338 (GRCm39) missense probably damaging 1.00
Z1177:Or13p8 UTSW 4 118,584,261 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGAGTCAAGATGAGCCAAACCC -3'
(R):5'- CTTCAGAGCCAGGTCTCATGTAC -3'

Sequencing Primer
(F):5'- AACCCTATGCATAGCCCTGGTG -3'
(R):5'- GGTCTCATGTACATGACCATGCATG -3'
Posted On 2022-11-14