Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01300:Lrrc69'

75247

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc69

Ensembl Gene

ENSMUSG00000023151

Gene Name

leucine rich repeat containing 69

Synonyms

1700034K16Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL01300

Quality Score

Status

Chromosome

Chromosomal Location

14623620-14796060 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 14773663 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000103911 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023917] [ENSMUST00000108276]

AlphaFold

Q9D9Q0

Predicted Effect

probably benign
Transcript: ENSMUST00000023917

SMART Domains

Protein: ENSMUSP00000023917
Gene: ENSMUSG00000023151

Domain	Start	End	E-Value	Type
LRR	36	58	4.57e0	SMART
LRR	59	81	2.82e0	SMART
LRR	82	105	7.55e-1	SMART
LRR	106	128	7.79e0	SMART
LRR	129	151	1.99e0	SMART
LRR	152	174	5.72e0	SMART
LRR	175	197	3.86e0	SMART
LRR	198	220	8.24e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108276

SMART Domains

Protein: ENSMUSP00000103911
Gene: ENSMUSG00000023151

Domain	Start	End	E-Value	Type
LRR	36	58	4.57e0	SMART
LRR	59	81	2.82e0	SMART
LRR	82	105	7.55e-1	SMART
LRR	106	128	7.79e0	SMART
LRR	129	151	1.99e0	SMART
LRR	152	174	5.72e0	SMART
LRR	175	197	3.86e0	SMART
LRR	198	220	8.24e0	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Anxa8	A	G	14: 33,821,700 (GRCm39)	D300G	probably benign	Het
Cacna1g	T	C	11: 94,324,738 (GRCm39)	H1161R	probably benign	Het
Col14a1	G	A	15: 55,331,372 (GRCm39)	R1471Q	unknown	Het
Gm14496	A	T	2: 181,642,753 (GRCm39)	E808V	probably damaging	Het
Gm1968	T	C	16: 29,781,038 (GRCm39)		noncoding transcript	Het
Gzmb	G	A	14: 56,497,653 (GRCm39)	R196C	probably benign	Het
Hkdc1	A	G	10: 62,231,040 (GRCm39)		probably benign	Het
Itgal	T	A	7: 126,913,290 (GRCm39)	V629E	probably damaging	Het
Jak2	T	A	19: 29,287,083 (GRCm39)	Y1050N	probably damaging	Het
Mmd	T	C	11: 90,140,537 (GRCm39)	M1T	probably null	Het
Myh6	A	G	14: 55,200,548 (GRCm39)	V191A	possibly damaging	Het
Mynn	A	G	3: 30,667,755 (GRCm39)	N485S	probably damaging	Het
Naa30	C	T	14: 49,410,714 (GRCm39)	T214M	probably damaging	Het
Ncoa3	A	T	2: 165,910,381 (GRCm39)	T1265S	probably benign	Het
Or10al2	C	A	17: 37,983,778 (GRCm39)	T288K	probably damaging	Het
Or1j10	T	C	2: 36,267,054 (GRCm39)	S89P	probably benign	Het
Prex1	A	G	2: 166,480,327 (GRCm39)	C138R	possibly damaging	Het
Prom2	A	T	2: 127,377,009 (GRCm39)	L535H	probably benign	Het
Pros1	T	C	16: 62,734,174 (GRCm39)	F327L	possibly damaging	Het
Ros1	A	G	10: 51,977,809 (GRCm39)	M1479T	probably benign	Het
Scn9a	G	A	2: 66,318,397 (GRCm39)	Q1465*	probably null	Het
Serpinb3b	A	G	1: 107,083,573 (GRCm39)		probably benign	Het
Sipa1l3	G	A	7: 29,099,253 (GRCm39)	Q339*	probably null	Het
Slc34a2	A	C	5: 53,225,469 (GRCm39)		probably null	Het
Smc3	T	A	19: 53,630,283 (GRCm39)		probably benign	Het
Tmem30a	A	G	9: 79,682,382 (GRCm39)		probably null	Het
Trappc11	A	T	8: 47,954,903 (GRCm39)	D878E	probably benign	Het
Trrap	C	T	5: 144,741,628 (GRCm39)	T1325M	probably damaging	Het
Ttc12	A	T	9: 49,359,222 (GRCm39)		probably benign	Het
Vmn1r237	T	A	17: 21,534,337 (GRCm39)	I20N	probably damaging	Het
Vmn2r115	T	A	17: 23,578,755 (GRCm39)	S743T	probably damaging	Het
Vmn2r74	A	G	7: 85,606,414 (GRCm39)	Y311H	probably benign	Het
Vnn3	T	A	10: 23,740,263 (GRCm39)	F189I	possibly damaging	Het

Other mutations in Lrrc69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01886:Lrrc69	APN	4	14,703,984 (GRCm39)	missense	probably benign	0.01
IGL03084:Lrrc69	APN	4	14,708,631 (GRCm39)	missense	probably damaging	1.00
R0588:Lrrc69	UTSW	4	14,704,001 (GRCm39)	missense	possibly damaging	0.71
R1664:Lrrc69	UTSW	4	14,775,079 (GRCm39)	missense	probably damaging	1.00
R1956:Lrrc69	UTSW	4	14,665,986 (GRCm39)	missense	possibly damaging	0.50
R1984:Lrrc69	UTSW	4	14,708,669 (GRCm39)	missense	possibly damaging	0.93
R1985:Lrrc69	UTSW	4	14,708,669 (GRCm39)	missense	possibly damaging	0.93
R1986:Lrrc69	UTSW	4	14,708,669 (GRCm39)	missense	possibly damaging	0.93
R2229:Lrrc69	UTSW	4	14,773,694 (GRCm39)	missense	probably benign	0.00
R3691:Lrrc69	UTSW	4	14,795,980 (GRCm39)	missense	possibly damaging	0.94
R5691:Lrrc69	UTSW	4	14,769,648 (GRCm39)	missense	probably damaging	1.00
R5882:Lrrc69	UTSW	4	14,708,690 (GRCm39)	missense	probably damaging	1.00
R6113:Lrrc69	UTSW	4	14,708,673 (GRCm39)	missense	probably benign	0.00
R7228:Lrrc69	UTSW	4	14,775,027 (GRCm39)	missense	probably damaging	1.00
R7880:Lrrc69	UTSW	4	14,703,946 (GRCm39)	missense	possibly damaging	0.90
R8047:Lrrc69	UTSW	4	14,773,726 (GRCm39)	missense	probably benign	0.07
R8375:Lrrc69	UTSW	4	14,795,994 (GRCm39)	missense	probably benign	0.36
R8547:Lrrc69	UTSW	4	14,704,014 (GRCm39)	missense	probably benign	0.00
R9332:Lrrc69	UTSW	4	14,774,987 (GRCm39)	missense	probably damaging	1.00
R9484:Lrrc69	UTSW	4	14,666,012 (GRCm39)	missense	probably benign	0.22

Posted On

2013-10-07