Mutagenetix > Incidental Mutation

Incidental Mutation 'I2288:Fpr-rs3'

7881

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs3

Ensembl Gene

ENSMUSG00000060701

Gene Name

formyl peptide receptor, related sequence 3

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

I2288 (G3) of strain 633

Quality Score

Status

Validated

Chromosome

Chromosomal Location

20844108-20845139 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20844757 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 128 (L128Q)

Ref Sequence

ENSEMBL: ENSMUSP00000071179 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071189]

AlphaFold

O88537

Predicted Effect

probably damaging
Transcript: ENSMUST00000071189
AA Change: L128Q

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000071179
Gene: ENSMUSG00000060701
AA Change: L128Q

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.8e-36	PFAM

Meta Mutation Damage Score

0.4431

Coding Region Coverage

1x: 89.9%
3x: 84.8%

Validation Efficiency

71% (138/195)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam3	A	T	8: 25,174,677 (GRCm39)	I696N	probably damaging	Het
Adgra1	T	C	7: 139,432,495 (GRCm39)	I111T	probably damaging	Het
Adgrv1	A	G	13: 81,585,643 (GRCm39)	L4607P	probably damaging	Het
Alppl2	A	T	1: 87,015,898 (GRCm39)	M284K	possibly damaging	Het
Arfgef1	T	C	1: 10,243,478 (GRCm39)	K1024E	probably damaging	Het
Arid2	T	C	15: 96,267,392 (GRCm39)	V624A	possibly damaging	Het
Babam1	G	A	8: 71,850,467 (GRCm39)	R32Q	probably damaging	Het
Camk1g	C	T	1: 193,033,414 (GRCm39)		probably benign	Homo
Cfap44	C	A	16: 44,269,501 (GRCm39)	Y1168*	probably null	Het
Clasp1	A	G	1: 118,492,959 (GRCm39)	H1168R	probably benign	Het
Crkl	A	G	16: 17,301,612 (GRCm39)	T289A	probably damaging	Het
Dlec1	A	G	9: 118,972,669 (GRCm39)	D1464G	probably damaging	Het
Dmxl2	A	T	9: 54,309,077 (GRCm39)	H1891Q	probably damaging	Het
Dnah10	G	A	5: 124,807,164 (GRCm39)	A150T	probably benign	Het
Dnah8	A	G	17: 30,882,428 (GRCm39)	T667A	probably benign	Het
Fxn	C	T	19: 24,239,431 (GRCm39)		probably benign	Homo
Golgb1	A	G	16: 36,718,904 (GRCm39)	H270R	probably benign	Het
Gramd1b	T	C	9: 40,218,101 (GRCm39)	I572V	probably damaging	Het
Iqch	A	T	9: 63,408,172 (GRCm39)	I664K	probably benign	Het
Kcnn2	T	A	18: 45,808,340 (GRCm39)		probably benign	Het
Lrp1b	A	T	2: 41,012,944 (GRCm39)	I2001K	probably damaging	Het
Lrrc40	T	A	3: 157,758,426 (GRCm39)	I277K	probably damaging	Het
Myo1e	A	G	9: 70,249,379 (GRCm39)	E493G	possibly damaging	Homo
Nrcam	C	A	12: 44,611,098 (GRCm39)	H567Q	probably benign	Homo
Or52d3	T	C	7: 104,229,593 (GRCm39)	C247R	probably damaging	Het
Or5bw2	A	T	7: 6,573,818 (GRCm39)	Y276F	probably damaging	Homo
Or5w19	T	A	2: 87,698,479 (GRCm39)	I48N	probably damaging	Het
Parvg	C	A	15: 84,212,981 (GRCm39)		probably benign	Het
Ripk4	A	G	16: 97,549,345 (GRCm39)	V237A	probably benign	Het
Spam1	A	G	6: 24,796,477 (GRCm39)	I143V	probably benign	Het
Synj2	A	G	17: 6,072,542 (GRCm39)		probably benign	Het
Taar4	A	G	10: 23,836,818 (GRCm39)	T143A	probably benign	Het
Ttc12	T	A	9: 49,381,558 (GRCm39)	M138L	possibly damaging	Het
Ttll9	A	G	2: 152,814,259 (GRCm39)		probably benign	Het
Usp34	T	A	11: 23,382,473 (GRCm39)		probably benign	Homo
Utrn	A	G	10: 12,297,384 (GRCm39)	Y675H	probably damaging	Het

Other mutations in Fpr-rs3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01561:Fpr-rs3	APN	17	20,844,859 (GRCm39)	missense	probably damaging	1.00
IGL02230:Fpr-rs3	APN	17	20,844,190 (GRCm39)	missense	probably damaging	1.00
IGL02503:Fpr-rs3	APN	17	20,844,817 (GRCm39)	missense	probably damaging	1.00
IGL02809:Fpr-rs3	APN	17	20,844,225 (GRCm39)	missense	probably damaging	0.99
IGL03212:Fpr-rs3	APN	17	20,844,121 (GRCm39)	missense	probably benign	0.00
R0318:Fpr-rs3	UTSW	17	20,844,410 (GRCm39)	missense	probably benign	0.02
R0565:Fpr-rs3	UTSW	17	20,844,283 (GRCm39)	missense	probably damaging	1.00
R1005:Fpr-rs3	UTSW	17	20,844,346 (GRCm39)	missense	probably benign	0.04
R1986:Fpr-rs3	UTSW	17	20,844,103 (GRCm39)	splice site	probably null
R3941:Fpr-rs3	UTSW	17	20,845,111 (GRCm39)	missense	probably benign	0.42
R4297:Fpr-rs3	UTSW	17	20,845,008 (GRCm39)	missense	probably damaging	1.00
R4809:Fpr-rs3	UTSW	17	20,844,683 (GRCm39)	missense	probably benign	0.00
R4959:Fpr-rs3	UTSW	17	20,844,211 (GRCm39)	missense	possibly damaging	0.73
R4973:Fpr-rs3	UTSW	17	20,844,211 (GRCm39)	missense	possibly damaging	0.73
R5116:Fpr-rs3	UTSW	17	20,844,562 (GRCm39)	missense	probably benign	0.12
R5356:Fpr-rs3	UTSW	17	20,844,596 (GRCm39)	missense	probably damaging	0.98
R5394:Fpr-rs3	UTSW	17	20,844,470 (GRCm39)	missense	probably benign	0.00
R5779:Fpr-rs3	UTSW	17	20,844,488 (GRCm39)	missense	possibly damaging	0.53
R6091:Fpr-rs3	UTSW	17	20,844,532 (GRCm39)	missense	probably benign	0.30
R6389:Fpr-rs3	UTSW	17	20,844,230 (GRCm39)	missense	probably damaging	0.96
R6860:Fpr-rs3	UTSW	17	20,844,560 (GRCm39)	missense	possibly damaging	0.68
R7578:Fpr-rs3	UTSW	17	20,844,293 (GRCm39)	missense	possibly damaging	0.81
R8153:Fpr-rs3	UTSW	17	20,844,685 (GRCm39)	missense	probably damaging	1.00
R8711:Fpr-rs3	UTSW	17	20,844,554 (GRCm39)	missense	probably benign
R8768:Fpr-rs3	UTSW	17	20,844,944 (GRCm39)	missense	probably damaging	1.00
X0018:Fpr-rs3	UTSW	17	20,844,899 (GRCm39)	missense	probably benign	0.30

Posted On

2012-11-13