Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01431:Sbp'

84129

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sbp

Ensembl Gene

ENSMUSG00000024128

Gene Name

spermine binding protein

Synonyms

p25

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL01431

Quality Score

Status

Chromosome

Chromosomal Location

23941672-23945607 bp(+) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to T at 23945348 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000138447 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024940] [ENSMUST00000181985] [ENSMUST00000182519] [ENSMUST00000182868] [ENSMUST00000183017] [ENSMUST00000183155] [ENSMUST00000183252]

AlphaFold

P15501

Predicted Effect

unknown
Transcript: ENSMUST00000024940
AA Change: D168V

SMART Domains

Protein: ENSMUSP00000024940
Gene: ENSMUSG00000024128
AA Change: D168V

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Jacalin	26	151	2.32e-15	SMART
low complexity region	161	198	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000181985
AA Change: D168V

SMART Domains

Protein: ENSMUSP00000138422
Gene: ENSMUSG00000024128
AA Change: D168V

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Jacalin	26	151	2.32e-15	SMART
low complexity region	161	198	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182519

SMART Domains

Protein: ENSMUSP00000138338
Gene: ENSMUSG00000024128

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Blast:Jacalin	26	87	3e-38	BLAST

Predicted Effect

silent
Transcript: ENSMUST00000182868

SMART Domains

Protein: ENSMUSP00000138491
Gene: ENSMUSG00000024128

Domain	Start	End	E-Value	Type
signal peptide	1	44	N/A	INTRINSIC
Jacalin	53	178	2.32e-15	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183017

Predicted Effect

unknown
Transcript: ENSMUST00000183155
AA Change: D168V

SMART Domains

Protein: ENSMUSP00000138341
Gene: ENSMUSG00000024128
AA Change: D168V

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Jacalin	26	151	2.32e-15	SMART
low complexity region	161	198	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000183252
AA Change: D168V

SMART Domains

Protein: ENSMUSP00000138219
Gene: ENSMUSG00000024128
AA Change: D168V

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Jacalin	26	151	2.32e-15	SMART
low complexity region	161	198	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430A15Rik	A	T	2: 111,225,395		probably benign	Het
Adamts7	A	G	9: 90,207,785	I897T	possibly damaging	Het
Aqp2	G	A	15: 99,579,420	V90M	possibly damaging	Het
Atf6	T	C	1: 170,853,002		probably benign	Het
Cdh3	T	C	8: 106,547,669	Y607H	probably damaging	Het
Cer1	T	A	4: 82,882,831	E198D	probably benign	Het
Dscam	A	G	16: 96,652,078		probably null	Het
Ecel1	C	T	1: 87,151,504	R484H	probably damaging	Het
Entpd7	C	A	19: 43,729,839	H575Q	probably benign	Het
F11r	T	C	1: 171,462,909	V279A	probably damaging	Het
Gm17093	T	A	14: 44,521,665		probably benign	Het
Got1	T	A	19: 43,503,049	K321*	probably null	Het
Gpn1	T	C	5: 31,507,538	V302A	probably benign	Het
Hivep1	G	T	13: 42,158,017	K1244N	probably damaging	Het
Idh3b	T	C	2: 130,281,897	T116A	possibly damaging	Het
Itgb4	C	A	11: 116,006,457		probably benign	Het
Mybl1	G	T	1: 9,672,647	L579I	probably damaging	Het
Myh14	T	A	7: 44,614,358	T1694S	probably null	Het
Mylk3	T	C	8: 85,336,401	D537G	probably damaging	Het
Myo1d	A	C	11: 80,674,839	F387V	probably damaging	Het
Nek9	T	C	12: 85,314,587	Y448C	probably benign	Het
Olfr1090	A	T	2: 86,754,164	H191Q	probably benign	Het
Paxbp1	T	C	16: 91,035,916		probably benign	Het
Retreg2	T	A	1: 75,145,105		probably null	Het
Ripply3	G	A	16: 94,328,543	C16Y	possibly damaging	Het
Robo3	G	A	9: 37,419,111		probably benign	Het
Rrm1	C	A	7: 102,457,552		probably benign	Het
Rsad2	T	A	12: 26,448,667	R269S	probably benign	Het
Schip1	A	T	3: 68,617,777	Q162L	probably damaging	Het
Senp1	T	C	15: 98,082,263	Y67C	probably damaging	Het
Slc25a25	C	T	2: 32,419,091	R233K	probably damaging	Het
Smoc1	C	A	12: 81,152,751	S220*	probably null	Het
Stab1	C	A	14: 31,148,995	R1299I	probably benign	Het
Stk17b	A	G	1: 53,765,915		probably benign	Het
Tmc7	T	G	7: 118,552,762	D312A	probably damaging	Het
Vmn1r79	T	C	7: 12,176,400	S70P	possibly damaging	Het
Zfc3h1	C	A	10: 115,423,223	T1591K	possibly damaging	Het

Other mutations in Sbp

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02035:Sbp	APN	17	23942612	missense	possibly damaging	0.73
FR4449:Sbp	UTSW	17	23945364	small insertion	probably benign
FR4737:Sbp	UTSW	17	23945382	small insertion	probably benign
FR4737:Sbp	UTSW	17	23945389	small insertion	probably benign
R0457:Sbp	UTSW	17	23945312	missense	probably benign	0.04
R1083:Sbp	UTSW	17	23942730	splice site	probably benign
R1544:Sbp	UTSW	17	23945069	missense	probably benign	0.01
R2075:Sbp	UTSW	17	23945158	splice site	probably null
R3741:Sbp	UTSW	17	23945582	utr 3 prime	probably benign
R4513:Sbp	UTSW	17	23945312	missense	probably benign	0.04
R4774:Sbp	UTSW	17	23945244	missense	probably damaging	1.00
R5338:Sbp	UTSW	17	23942422	start gained	probably benign
R5576:Sbp	UTSW	17	23945578	missense	probably benign	0.05
R7315:Sbp	UTSW	17	23945306	missense	probably benign	0.10
R7894:Sbp	UTSW	17	23942189	intron	probably benign
RF003:Sbp	UTSW	17	23945369	small insertion	probably benign
RF010:Sbp	UTSW	17	23945351	small insertion	probably benign
RF011:Sbp	UTSW	17	23945354	small insertion	probably benign
RF024:Sbp	UTSW	17	23945387	small insertion	probably benign
RF037:Sbp	UTSW	17	23945384	small insertion	probably benign
RF037:Sbp	UTSW	17	23945387	small insertion	probably benign
RF038:Sbp	UTSW	17	23945384	small insertion	probably benign
RF042:Sbp	UTSW	17	23945384	small insertion	probably benign
RF044:Sbp	UTSW	17	23945366	small insertion	probably benign
RF048:Sbp	UTSW	17	23945389	small insertion	probably benign
RF054:Sbp	UTSW	17	23945371	small insertion	probably benign
RF056:Sbp	UTSW	17	23945366	small insertion	probably benign
RF059:Sbp	UTSW	17	23945377	small insertion	probably benign
RF061:Sbp	UTSW	17	23945377	small insertion	probably benign

Posted On

2013-11-11