Incidental Mutation 'IGL01527:Olfr669'
ID89589
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr669
Ensembl Gene ENSMUSG00000073916
Gene Nameolfactory receptor 669
SynonymsMOR34-6, GA_x6K02T2PBJ9-7567376-7568329
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.132) question?
Stock #IGL01527
Quality Score
Status
Chromosome7
Chromosomal Location104934240-104940477 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 104938991 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 155 (V155E)
Ref Sequence ENSEMBL: ENSMUSP00000150928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098164] [ENSMUST00000210138] [ENSMUST00000214260]
Predicted Effect possibly damaging
Transcript: ENSMUST00000098164
AA Change: V155E

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000095767
Gene: ENSMUSG00000073916
AA Change: V155E

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 8.7e-103 PFAM
Pfam:7TM_GPCR_Srsx 37 209 1.9e-10 PFAM
Pfam:7tm_1 43 295 2.7e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000210138
AA Change: V155E

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211559
Predicted Effect possibly damaging
Transcript: ENSMUST00000214260
AA Change: V155E

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik G T 17: 35,567,833 probably null Het
Abca13 T A 11: 9,290,788 W884R possibly damaging Het
Ahi1 T C 10: 20,960,085 probably benign Het
Ankfn1 G T 11: 89,391,639 P394Q probably benign Het
AW549877 T C 15: 3,988,683 Y170C probably damaging Het
Cacnb2 T C 2: 14,984,270 I393T possibly damaging Het
Ces1a G T 8: 93,045,098 P24T probably damaging Het
Col22a1 T C 15: 71,907,031 E269G probably damaging Het
Cyp24a1 A G 2: 170,496,566 L70P probably damaging Het
Cyp8b1 T C 9: 121,914,995 K424E probably damaging Het
Dicer1 G A 12: 104,691,610 Q1902* probably null Het
Dst T A 1: 34,247,653 L544Q probably damaging Het
Esrp2 T C 8: 106,132,233 T591A probably benign Het
Gap43 C T 16: 42,292,153 E82K probably benign Het
Kif17 G A 4: 138,269,086 V125I probably benign Het
Lancl2 T C 6: 57,732,322 S370P probably damaging Het
Macf1 T C 4: 123,493,160 I203V possibly damaging Het
Mphosph9 A G 5: 124,283,624 probably benign Het
Ncapg A G 5: 45,672,384 I143V possibly damaging Het
Nr3c1 A G 18: 39,486,637 V199A probably benign Het
Obscn T A 11: 59,064,417 N3890I possibly damaging Het
Olfr130 A G 17: 38,068,095 N308S probably benign Het
Olfr92 A T 17: 37,111,809 Y58N probably damaging Het
Olfr951 A G 9: 39,393,818 H6R probably benign Het
Palmd C A 3: 116,927,188 E166* probably null Het
Pdzd2 T C 15: 12,445,664 E327G probably damaging Het
Pex13 T C 11: 23,656,111 T40A probably benign Het
Pkd2 T C 5: 104,498,884 probably benign Het
Plb1 A G 5: 32,317,123 T643A probably damaging Het
Prlr T A 15: 10,329,171 D577E probably benign Het
Slc44a3 A G 3: 121,527,128 C75R probably damaging Het
Susd6 A T 12: 80,874,319 N230I possibly damaging Het
Tbx10 A G 19: 3,998,227 R251G probably damaging Het
Ttc30a1 T C 2: 75,980,516 I408V probably benign Het
Uap1l1 A G 2: 25,363,804 probably null Het
Ugt2b5 A G 5: 87,136,209 V308A possibly damaging Het
Usp28 C A 9: 49,025,873 H147Q probably benign Het
Vmn1r203 T C 13: 22,524,277 I76T possibly damaging Het
Vmn2r104 A G 17: 20,042,896 I101T possibly damaging Het
Vmn2r17 T A 5: 109,453,140 L768H probably damaging Het
Other mutations in Olfr669
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01677:Olfr669 APN 7 104938645 missense probably benign 0.01
IGL01900:Olfr669 APN 7 104939162 missense probably damaging 1.00
IGL02270:Olfr669 APN 7 104939369 missense possibly damaging 0.95
R0482:Olfr669 UTSW 7 104938814 missense possibly damaging 0.56
R0970:Olfr669 UTSW 7 104939077 missense probably benign 0.05
R4260:Olfr669 UTSW 7 104938596 missense probably damaging 0.99
R4845:Olfr669 UTSW 7 104939363 missense possibly damaging 0.95
R4947:Olfr669 UTSW 7 104938742 missense possibly damaging 0.95
R5438:Olfr669 UTSW 7 104939137 missense probably benign 0.03
R5735:Olfr669 UTSW 7 104938759 missense probably benign 0.01
R5943:Olfr669 UTSW 7 104938643 missense possibly damaging 0.78
R6435:Olfr669 UTSW 7 104938834 missense probably damaging 0.99
R6942:Olfr669 UTSW 7 104938897 missense possibly damaging 0.56
R7061:Olfr669 UTSW 7 104938676 missense probably damaging 1.00
R7122:Olfr669 UTSW 7 104939198 missense probably damaging 0.99
R7378:Olfr669 UTSW 7 104939431 missense probably benign 0.31
R7898:Olfr669 UTSW 7 104939366 missense probably damaging 1.00
R8260:Olfr669 UTSW 7 104938672 missense probably damaging 1.00
Posted On2013-12-03