Incidental Mutation 'IGL01639:Zfp641'
ID92935
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp641
Ensembl Gene ENSMUSG00000022987
Gene Namezinc finger protein 641
Synonyms9930016F01Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01639
Quality Score
Status
Chromosome15
Chromosomal Location98285585-98296161 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 98291185 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 131 (I131T)
Ref Sequence ENSEMBL: ENSMUSP00000133212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023722] [ENSMUST00000169721]
Predicted Effect possibly damaging
Transcript: ENSMUST00000023722
AA Change: I117T

PolyPhen 2 Score 0.531 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000023722
Gene: ENSMUSG00000022987
AA Change: I117T

DomainStartEndE-ValueType
KRAB 91 142 2.16e-10 SMART
ZnF_C2H2 236 258 1.58e-3 SMART
ZnF_C2H2 264 286 1.67e-2 SMART
ZnF_C2H2 292 314 1.33e-1 SMART
ZnF_C2H2 342 364 8.94e-3 SMART
ZnF_C2H2 370 392 3.83e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000169721
AA Change: I131T

PolyPhen 2 Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000133212
Gene: ENSMUSG00000022987
AA Change: I131T

DomainStartEndE-ValueType
low complexity region 83 89 N/A INTRINSIC
KRAB 95 156 2.56e-21 SMART
ZnF_C2H2 250 272 1.58e-3 SMART
ZnF_C2H2 278 300 1.67e-2 SMART
ZnF_C2H2 306 328 1.33e-1 SMART
ZnF_C2H2 356 378 8.94e-3 SMART
ZnF_C2H2 384 406 3.83e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Calm4 T A 13: 3,838,302 V136E probably damaging Het
Cnot8 A T 11: 58,111,362 I74F probably damaging Het
Coq7 A T 7: 118,525,304 V213D probably damaging Het
Itgae A G 11: 73,119,378 T565A probably benign Het
Lgi3 A G 14: 70,533,385 I155V probably benign Het
Mbd5 A G 2: 49,272,308 N42S probably damaging Het
Mpp6 T C 6: 50,178,480 I261T probably damaging Het
Olfr166 T C 16: 19,487,164 S109P probably damaging Het
Olfr535 A G 7: 140,493,186 I183V probably benign Het
Pcnx T C 12: 81,950,320 probably null Het
Pdzd3 T A 9: 44,248,679 E381D probably benign Het
Plekhg1 A G 10: 3,956,751 E556G probably damaging Het
Rab1a T C 11: 20,223,185 probably benign Het
Rfx6 A T 10: 51,715,906 R133* probably null Het
Spata31d1c T C 13: 65,036,089 S482P probably damaging Het
Spire1 C A 18: 67,545,668 A68S possibly damaging Het
Tmc1 G A 19: 20,816,192 T535M probably damaging Het
Trip10 T A 17: 57,254,165 probably benign Het
Trp53bp1 A C 2: 121,202,692 V1711G possibly damaging Het
Ubr4 G T 4: 139,417,344 R1488L probably damaging Het
Vmn2r84 A T 10: 130,389,272 Y456* probably null Het
Zc3h7a T C 16: 11,141,708 S794G possibly damaging Het
Zeb2 C T 2: 44,997,257 S581N probably benign Het
Zfp292 G A 4: 34,809,048 P1332L probably benign Het
Other mutations in Zfp641
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03092:Zfp641 APN 15 98290516 missense probably damaging 1.00
IGL03191:Zfp641 APN 15 98288687 missense probably damaging 0.98
R0079:Zfp641 UTSW 15 98289089 missense probably benign 0.28
R0243:Zfp641 UTSW 15 98289127 missense possibly damaging 0.82
R0487:Zfp641 UTSW 15 98289179 missense probably benign
R2092:Zfp641 UTSW 15 98293712 missense probably benign
R3415:Zfp641 UTSW 15 98290540 missense probably benign 0.28
R4834:Zfp641 UTSW 15 98293704 missense probably damaging 1.00
R4851:Zfp641 UTSW 15 98288717 missense probably damaging 0.99
R5776:Zfp641 UTSW 15 98289010 missense probably damaging 1.00
R6057:Zfp641 UTSW 15 98292935 missense probably benign 0.00
R6896:Zfp641 UTSW 15 98293803 start codon destroyed probably benign 0.06
R6958:Zfp641 UTSW 15 98292951 missense possibly damaging 0.46
R6969:Zfp641 UTSW 15 98290567 missense possibly damaging 0.46
Z1177:Zfp641 UTSW 15 98288535 missense probably damaging 1.00
Posted On2013-12-09