Mutagenetix > Incidental Mutation

Incidental Mutation 'R1638:Nav2'

173302

Institutional Source

Beutler Lab

Gene Symbol

Nav2

Ensembl Gene

ENSMUSG00000052512

Gene Name

neuron navigator 2

Synonyms

Rainb1, Unc53H2, 5330421F07Rik, POMFIL2, HELAD1, RAINB2

MMRRC Submission

039674-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.550) question?

Stock #

R1638 (G1)

Quality Score

204

Status

Validated

Chromosome

Chromosomal Location

48608796-49259838 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 49102213 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 337 (N337S)

Ref Sequence

ENSEMBL: ENSMUSP00000139045 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064395] [ENSMUST00000183659] [ENSMUST00000184124] [ENSMUST00000184945]

AlphaFold

E9Q842

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000064383

SMART Domains

Protein: ENSMUSP00000066835
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
Blast:CH	18	79	2e-35	BLAST
PDB:2YRN\|A	18	80	3e-33	PDB
SCOP:d1dxxa1	29	81	4e-15	SMART
low complexity region	94	102	N/A	INTRINSIC
low complexity region	189	202	N/A	INTRINSIC
low complexity region	229	240	N/A	INTRINSIC
low complexity region	304	316	N/A	INTRINSIC
coiled coil region	378	408	N/A	INTRINSIC
low complexity region	472	483	N/A	INTRINSIC
low complexity region	505	517	N/A	INTRINSIC
low complexity region	532	554	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000064395
AA Change: N337S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: N337S

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000183659
AA Change: N276S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: N276S

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
CH	23	126	6.19e-16	SMART
low complexity region	141	149	N/A	INTRINSIC
low complexity region	236	249	N/A	INTRINSIC
low complexity region	276	287	N/A	INTRINSIC
low complexity region	351	363	N/A	INTRINSIC
coiled coil region	425	455	N/A	INTRINSIC
low complexity region	519	530	N/A	INTRINSIC
low complexity region	552	564	N/A	INTRINSIC
low complexity region	579	601	N/A	INTRINSIC
low complexity region	785	796	N/A	INTRINSIC
low complexity region	859	883	N/A	INTRINSIC
low complexity region	886	906	N/A	INTRINSIC
low complexity region	929	943	N/A	INTRINSIC
low complexity region	1001	1013	N/A	INTRINSIC
low complexity region	1282	1299	N/A	INTRINSIC
low complexity region	1307	1324	N/A	INTRINSIC
low complexity region	1356	1371	N/A	INTRINSIC
low complexity region	1393	1405	N/A	INTRINSIC
low complexity region	1465	1479	N/A	INTRINSIC
low complexity region	1553	1567	N/A	INTRINSIC
coiled coil region	1569	1656	N/A	INTRINSIC
low complexity region	1728	1739	N/A	INTRINSIC
coiled coil region	1780	1848	N/A	INTRINSIC
AAA	2032	2186	1.69e-5	SMART
low complexity region	2343	2369	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000184124

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184155

Predicted Effect

probably benign
Transcript: ENSMUST00000184945
AA Change: N337S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: N337S

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.0%
3x: 97.9%
10x: 94.9%
20x: 87.8%

Validation Efficiency

99% (79/80)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	C	A	6: 121,631,571 (GRCm39)	L623M	probably benign	Het
Adamts13	A	G	2: 26,886,595 (GRCm39)	E938G	possibly damaging	Het
Agfg1	A	T	1: 82,871,259 (GRCm39)	Q497L	probably damaging	Het
Ahnak	A	G	19: 8,986,813 (GRCm39)	H2699R	probably benign	Het
Antxrl	G	T	14: 33,792,453 (GRCm39)		probably null	Het
Apol7c	A	T	15: 77,410,418 (GRCm39)	V176E	probably damaging	Het
Arid5b	T	C	10: 68,113,777 (GRCm39)	N87D	possibly damaging	Het
Atp2c1	A	T	9: 105,309,897 (GRCm39)	I560N	probably damaging	Het
Atp2c2	T	C	8: 120,482,742 (GRCm39)	F868S	possibly damaging	Het
Blnk	G	C	19: 40,926,122 (GRCm39)	F326L	probably benign	Het
Bltp1	C	T	3: 37,089,961 (GRCm39)	R4130*	probably null	Het
Ckap2	C	T	8: 22,665,812 (GRCm39)	V412I	possibly damaging	Het
Clmn	A	G	12: 104,748,281 (GRCm39)	V422A	probably benign	Het
Ctnnal1	A	G	4: 56,813,856 (GRCm39)	S638P	probably benign	Het
Cyp2j5	T	C	4: 96,524,052 (GRCm39)	S327G	probably benign	Het
Dhx38	G	A	8: 110,280,177 (GRCm39)	T871M	probably damaging	Het
Dmxl1	A	T	18: 50,023,834 (GRCm39)	K1706*	probably null	Het
Dnah11	A	G	12: 117,979,154 (GRCm39)	L2648P	possibly damaging	Het
Elf2	G	A	3: 51,215,530 (GRCm39)	T60I	probably damaging	Het
Fam120b	T	A	17: 15,622,759 (GRCm39)	C246S	possibly damaging	Het
Fcho2	G	T	13: 98,882,403 (GRCm39)	T451K	possibly damaging	Het
Fzd9	T	A	5: 135,278,602 (GRCm39)	I428F	probably damaging	Het
Galnt13	T	A	2: 54,744,667 (GRCm39)	V122E	probably damaging	Het
Gm21738	T	A	14: 19,418,908 (GRCm38)	Y8F	probably benign	Het
Gnptab	A	G	10: 88,272,029 (GRCm39)	I940V	possibly damaging	Het
Gp2	A	G	7: 119,050,721 (GRCm39)		probably null	Het
Gpr6	A	G	10: 40,946,530 (GRCm39)	S351P	probably benign	Het
Gprin1	T	C	13: 54,887,689 (GRCm39)	E195G	possibly damaging	Het
Grm8	A	T	6: 28,125,882 (GRCm39)	Y81*	probably null	Het
Gtf3c3	A	T	1: 54,444,278 (GRCm39)	N703K	probably damaging	Het
Hhipl2	G	A	1: 183,208,921 (GRCm39)	V495I	probably benign	Het
Islr	G	A	9: 58,065,502 (GRCm39)		probably benign	Het
Lrrc36	T	C	8: 106,176,273 (GRCm39)	Y216H	possibly damaging	Het
Macroh2a1	T	A	13: 56,252,722 (GRCm39)	N87Y	probably damaging	Het
Me2	A	G	18: 73,906,205 (GRCm39)	I528T	probably benign	Het
Mecr	A	T	4: 131,585,127 (GRCm39)	I156F	possibly damaging	Het
Megf6	A	G	4: 154,346,967 (GRCm39)		probably benign	Het
Mn1	T	A	5: 111,569,435 (GRCm39)	L1135H	probably damaging	Het
Naip5	A	G	13: 100,349,177 (GRCm39)	S1384P	probably damaging	Het
Ndn	C	T	7: 61,998,256 (GRCm39)	P34L	probably benign	Het
Neb	A	T	2: 52,139,293 (GRCm39)	H3107Q	probably benign	Het
Nebl	A	G	2: 17,381,462 (GRCm39)	V738A	possibly damaging	Het
Nsd2	G	A	5: 34,039,464 (GRCm39)	R825Q	possibly damaging	Het
Nsun2	A	G	13: 69,775,705 (GRCm39)	N383S	probably damaging	Het
Ntrk3	A	T	7: 77,897,036 (GRCm39)	M667K	probably damaging	Het
Or10a48	A	C	7: 108,424,442 (GRCm39)	C255G	probably benign	Het
Or11h6	G	A	14: 50,880,565 (GRCm39)	V276M	possibly damaging	Het
Or1e29	A	G	11: 73,667,974 (GRCm39)	Y60H	possibly damaging	Het
Or6c2	A	T	10: 129,362,488 (GRCm39)	M131L	probably benign	Het
Pex6	T	C	17: 47,033,558 (GRCm39)	V633A	probably benign	Het
Phactr1	C	T	13: 43,110,147 (GRCm39)	T95M	probably damaging	Het
Pik3r4	A	G	9: 105,564,408 (GRCm39)	D1334G	probably damaging	Het
Pkhd1l1	A	C	15: 44,460,513 (GRCm39)	I4241L	probably benign	Het
Ppwd1	T	C	13: 104,356,771 (GRCm39)	E248G	probably damaging	Het
Prepl	A	C	17: 85,379,509 (GRCm39)	M393R	probably benign	Het
Ptpn6	T	C	6: 124,698,148 (GRCm39)	S532G	probably benign	Het
Rnase11	G	T	14: 51,287,058 (GRCm39)	H165Q	possibly damaging	Het
Sf1	A	G	19: 6,422,090 (GRCm39)	N172S	possibly damaging	Het
Shprh	T	A	10: 11,032,822 (GRCm39)	D269E	probably benign	Het
Slc16a1	T	C	3: 104,556,798 (GRCm39)	I61T	possibly damaging	Het
Slc38a2	A	C	15: 96,590,417 (GRCm39)	I309S	probably damaging	Het
Sry	C	G	Y: 2,663,149 (GRCm39)	Q170H	unknown	Het
Stk3	A	C	15: 35,008,454 (GRCm39)		probably null	Het
Tg	C	A	15: 66,568,015 (GRCm39)	C1306*	probably null	Het
Tnik	A	G	3: 28,719,889 (GRCm39)	M1254V	probably damaging	Het
U2surp	T	C	9: 95,366,280 (GRCm39)	E474G	possibly damaging	Het
Vmn1r224	T	A	17: 20,639,587 (GRCm39)	F55I	probably benign	Het
Vmn1r32	A	G	6: 66,529,939 (GRCm39)	I279T	possibly damaging	Het
Zc2hc1a	A	G	3: 7,581,543 (GRCm39)	D15G	probably benign	Het
Zfp827	C	A	8: 79,802,975 (GRCm39)	P516T	possibly damaging	Het
Zfyve9	A	T	4: 108,542,104 (GRCm39)		probably null	Het

Other mutations in Nav2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01097:Nav2	APN	7	49,220,942 (GRCm39)	missense	probably damaging	1.00
IGL01150:Nav2	APN	7	49,102,269 (GRCm39)	missense	probably benign	0.17
IGL01649:Nav2	APN	7	49,225,477 (GRCm39)	missense	probably damaging	1.00
IGL01662:Nav2	APN	7	49,220,957 (GRCm39)	missense	probably damaging	1.00
IGL02297:Nav2	APN	7	49,243,977 (GRCm39)	missense	probably damaging	0.98
IGL02313:Nav2	APN	7	49,208,521 (GRCm39)	missense	probably damaging	0.99
IGL02441:Nav2	APN	7	49,102,260 (GRCm39)	missense	probably damaging	1.00
IGL02472:Nav2	APN	7	49,195,789 (GRCm39)	missense	probably damaging	1.00
IGL02477:Nav2	APN	7	49,232,623 (GRCm39)	missense	probably damaging	0.99
IGL02725:Nav2	APN	7	49,214,843 (GRCm39)	missense	probably damaging	1.00
IGL02944:Nav2	APN	7	49,070,004 (GRCm39)	missense	probably damaging	0.99
IGL02953:Nav2	APN	7	49,198,171 (GRCm39)	missense	probably damaging	1.00
IGL03105:Nav2	APN	7	49,114,627 (GRCm39)	missense	probably damaging	1.00
IGL03234:Nav2	APN	7	49,111,756 (GRCm39)	missense	possibly damaging	0.94
IGL03274:Nav2	APN	7	49,011,847 (GRCm39)	missense	probably damaging	1.00
IGL03294:Nav2	APN	7	49,141,205 (GRCm39)	nonsense	probably null
R0006:Nav2	UTSW	7	49,102,978 (GRCm39)	missense	possibly damaging	0.50
R0070:Nav2	UTSW	7	49,220,462 (GRCm39)	missense	probably damaging	1.00
R0113:Nav2	UTSW	7	49,185,701 (GRCm39)	missense	probably damaging	1.00
R0306:Nav2	UTSW	7	49,195,651 (GRCm39)	missense	probably benign	0.01
R0346:Nav2	UTSW	7	49,254,333 (GRCm39)	missense	probably benign	0.11
R0539:Nav2	UTSW	7	49,111,686 (GRCm39)	missense	probably damaging	1.00
R0669:Nav2	UTSW	7	49,058,431 (GRCm39)	missense	probably damaging	1.00
R0785:Nav2	UTSW	7	49,070,081 (GRCm39)	missense	probably benign	0.06
R0970:Nav2	UTSW	7	49,233,901 (GRCm39)	missense	probably damaging	1.00
R1162:Nav2	UTSW	7	49,185,788 (GRCm39)	splice site	probably benign
R1274:Nav2	UTSW	7	49,254,178 (GRCm39)	nonsense	probably null
R1463:Nav2	UTSW	7	49,185,710 (GRCm39)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,011,952 (GRCm39)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,011,952 (GRCm39)	missense	probably damaging	1.00
R1536:Nav2	UTSW	7	49,195,682 (GRCm39)	missense	probably damaging	1.00
R1612:Nav2	UTSW	7	49,220,959 (GRCm39)	missense	probably damaging	1.00
R1731:Nav2	UTSW	7	49,197,922 (GRCm39)	missense	probably damaging	1.00
R1734:Nav2	UTSW	7	49,225,468 (GRCm39)	missense	probably damaging	1.00
R1865:Nav2	UTSW	7	49,197,943 (GRCm39)	missense	possibly damaging	0.95
R1945:Nav2	UTSW	7	49,114,620 (GRCm39)	missense	probably damaging	1.00
R1997:Nav2	UTSW	7	49,198,219 (GRCm39)	missense	probably benign	0.16
R2061:Nav2	UTSW	7	49,248,645 (GRCm39)	splice site	probably benign
R2117:Nav2	UTSW	7	49,114,328 (GRCm39)	missense	probably benign	0.00
R2174:Nav2	UTSW	7	49,102,411 (GRCm39)	missense	probably damaging	0.99
R2182:Nav2	UTSW	7	49,247,002 (GRCm39)	missense	probably benign	0.38
R2251:Nav2	UTSW	7	49,103,025 (GRCm39)	missense	probably damaging	1.00
R2283:Nav2	UTSW	7	49,141,152 (GRCm39)	missense	probably damaging	1.00
R2343:Nav2	UTSW	7	49,248,565 (GRCm39)	missense	possibly damaging	0.82
R2472:Nav2	UTSW	7	49,058,632 (GRCm39)	missense	probably benign
R2568:Nav2	UTSW	7	49,247,312 (GRCm39)	missense	probably damaging	1.00
R2656:Nav2	UTSW	7	49,195,690 (GRCm39)	missense	probably damaging	1.00
R2964:Nav2	UTSW	7	49,206,780 (GRCm39)	missense	probably damaging	1.00
R2966:Nav2	UTSW	7	49,206,780 (GRCm39)	missense	probably damaging	1.00
R3817:Nav2	UTSW	7	49,114,310 (GRCm39)	missense	probably benign	0.00
R3834:Nav2	UTSW	7	49,195,606 (GRCm39)	missense	possibly damaging	0.91
R4207:Nav2	UTSW	7	49,246,979 (GRCm39)	missense	probably damaging	1.00
R4207:Nav2	UTSW	7	49,222,046 (GRCm39)	splice site	probably null
R4411:Nav2	UTSW	7	49,047,857 (GRCm39)	missense	probably benign	0.37
R4413:Nav2	UTSW	7	49,047,857 (GRCm39)	missense	probably benign	0.37
R4440:Nav2	UTSW	7	49,225,011 (GRCm39)	splice site	probably benign
R4440:Nav2	UTSW	7	49,201,785 (GRCm39)	missense	possibly damaging	0.86
R4454:Nav2	UTSW	7	49,198,292 (GRCm39)	splice site	probably null
R4729:Nav2	UTSW	7	49,102,567 (GRCm39)	missense	probably benign	0.17
R4801:Nav2	UTSW	7	49,195,600 (GRCm39)	missense	possibly damaging	0.94
R4802:Nav2	UTSW	7	49,195,600 (GRCm39)	missense	possibly damaging	0.94
R4824:Nav2	UTSW	7	49,058,749 (GRCm39)	intron	probably benign
R4887:Nav2	UTSW	7	49,198,182 (GRCm39)	nonsense	probably null
R4908:Nav2	UTSW	7	49,254,258 (GRCm39)	missense	probably damaging	1.00
R4952:Nav2	UTSW	7	48,954,288 (GRCm39)	intron	probably benign
R4965:Nav2	UTSW	7	49,202,625 (GRCm39)	nonsense	probably null
R5169:Nav2	UTSW	7	49,198,231 (GRCm39)	nonsense	probably null
R5224:Nav2	UTSW	7	49,201,473 (GRCm39)	missense	probably benign	0.00
R5249:Nav2	UTSW	7	49,185,661 (GRCm39)	missense	probably damaging	1.00
R5285:Nav2	UTSW	7	49,197,982 (GRCm39)	missense	probably damaging	1.00
R5314:Nav2	UTSW	7	49,058,440 (GRCm39)	small deletion	probably benign
R5320:Nav2	UTSW	7	49,141,121 (GRCm39)	missense	probably benign	0.00
R5377:Nav2	UTSW	7	49,238,908 (GRCm39)	missense	probably benign	0.02
R5471:Nav2	UTSW	7	49,197,917 (GRCm39)	missense	probably damaging	1.00
R5754:Nav2	UTSW	7	49,206,794 (GRCm39)	missense	probably damaging	1.00
R5832:Nav2	UTSW	7	49,197,817 (GRCm39)	splice site	probably null
R5884:Nav2	UTSW	7	49,246,917 (GRCm39)	nonsense	probably null
R5921:Nav2	UTSW	7	48,954,324 (GRCm39)	intron	probably benign
R6180:Nav2	UTSW	7	49,107,915 (GRCm39)	missense	probably benign	0.39
R6208:Nav2	UTSW	7	49,213,851 (GRCm39)	missense	probably damaging	0.99
R6373:Nav2	UTSW	7	49,102,923 (GRCm39)	missense	probably damaging	1.00
R6450:Nav2	UTSW	7	49,244,114 (GRCm39)	missense	probably damaging	1.00
R6522:Nav2	UTSW	7	49,247,281 (GRCm39)	missense	probably damaging	1.00
R6626:Nav2	UTSW	7	49,244,100 (GRCm39)	missense	probably damaging	1.00
R6695:Nav2	UTSW	7	49,114,652 (GRCm39)	missense	probably benign	0.04
R6705:Nav2	UTSW	7	49,201,664 (GRCm39)	missense	probably damaging	1.00
R6842:Nav2	UTSW	7	49,107,917 (GRCm39)	missense	possibly damaging	0.91
R6847:Nav2	UTSW	7	49,141,204 (GRCm39)	missense	probably benign	0.14
R7287:Nav2	UTSW	7	49,070,076 (GRCm39)	missense	probably benign	0.01
R7312:Nav2	UTSW	7	49,111,672 (GRCm39)	missense	possibly damaging	0.55
R7315:Nav2	UTSW	7	49,198,037 (GRCm39)	missense	possibly damaging	0.61
R7337:Nav2	UTSW	7	49,201,521 (GRCm39)	missense	possibly damaging	0.56
R7366:Nav2	UTSW	7	49,203,951 (GRCm39)	splice site	probably null
R7451:Nav2	UTSW	7	49,202,577 (GRCm39)	splice site	probably null
R7545:Nav2	UTSW	7	49,232,605 (GRCm39)	missense	probably damaging	1.00
R7706:Nav2	UTSW	7	49,244,067 (GRCm39)	missense	probably benign	0.35
R7730:Nav2	UTSW	7	49,222,145 (GRCm39)	missense	probably damaging	1.00
R7812:Nav2	UTSW	7	49,246,921 (GRCm39)	missense	probably benign	0.13
R8097:Nav2	UTSW	7	49,237,525 (GRCm39)	missense	probably damaging	1.00
R8110:Nav2	UTSW	7	49,201,698 (GRCm39)	nonsense	probably null
R8119:Nav2	UTSW	7	49,103,232 (GRCm39)	missense	probably damaging	0.99
R8298:Nav2	UTSW	7	49,204,009 (GRCm39)	critical splice donor site	probably null
R8306:Nav2	UTSW	7	49,195,765 (GRCm39)	missense	probably benign	0.33
R8331:Nav2	UTSW	7	49,102,371 (GRCm39)	missense	probably benign
R8402:Nav2	UTSW	7	49,103,185 (GRCm39)	missense	probably benign	0.43
R8421:Nav2	UTSW	7	49,102,269 (GRCm39)	missense	probably benign
R8478:Nav2	UTSW	7	49,111,733 (GRCm39)	missense	probably damaging	0.99
R8724:Nav2	UTSW	7	49,141,184 (GRCm39)	missense	possibly damaging	0.82
R8753:Nav2	UTSW	7	49,102,320 (GRCm39)	missense	probably benign
R8835:Nav2	UTSW	7	49,248,551 (GRCm39)	missense	possibly damaging	0.83
R8933:Nav2	UTSW	7	49,111,705 (GRCm39)	missense	probably damaging	1.00
R8957:Nav2	UTSW	7	49,220,964 (GRCm39)	missense	probably damaging	1.00
R9069:Nav2	UTSW	7	49,208,561 (GRCm39)	missense	probably damaging	0.99
R9095:Nav2	UTSW	7	49,254,293 (GRCm39)	missense	probably damaging	1.00
R9223:Nav2	UTSW	7	49,202,599 (GRCm39)	missense	probably damaging	1.00
R9261:Nav2	UTSW	7	49,246,904 (GRCm39)	missense	probably damaging	1.00
X0023:Nav2	UTSW	7	49,197,647 (GRCm39)	missense	possibly damaging	0.47
Z1177:Nav2	UTSW	7	49,243,971 (GRCm39)	missense	probably benign	0.01
Z1177:Nav2	UTSW	7	49,102,509 (GRCm39)	missense	possibly damaging	0.47

Predicted Primers

PCR Primer
(F):5'- GGGATTCTGCGTTCAATCACTTAAAGC -3'
(R):5'- GCCTCCCTTGCTGTTGAAAAGTTTG -3'

Sequencing Primer
(F):5'- ggaggacaggggagatgaac -3'
(R):5'- GAGCTTTTCCAACATGGATTTCTG -3'

Posted On

2014-04-24