Incidental Mutation 'R0138:Vmn2r58'
| ID |
189151 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r58
|
| Ensembl Gene |
ENSMUSG00000090383 |
| Gene Name |
vomeronasal 2, receptor 58 |
| Synonyms |
EG628422 |
| MMRRC Submission |
038423-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.377)
|
| Stock # |
R0138 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
7 |
| Chromosomal Location |
41486305-41522094 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 41487048 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 616
(T616S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126966
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171671]
|
| AlphaFold |
K7N6V2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171671
AA Change: T616S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: T616S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.8e-23 |
PFAM |
|
Pfam:7tm_3
|
597 |
835 |
2.9e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.8%
|
| Validation Efficiency |
97% (76/78) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
T |
A |
3: 121,899,098 (GRCm39) |
N693K |
probably damaging |
Het |
| Adgrl3 |
T |
A |
5: 81,841,454 (GRCm39) |
V845D |
probably damaging |
Het |
| Anxa8 |
T |
A |
14: 33,819,896 (GRCm39) |
F269Y |
probably benign |
Het |
| Anxa8 |
T |
A |
14: 33,819,897 (GRCm39) |
F295L |
possibly damaging |
Het |
| Aox4 |
C |
G |
1: 58,268,025 (GRCm39) |
L202V |
probably damaging |
Het |
| Ap3s2 |
A |
G |
7: 79,559,617 (GRCm39) |
V104A |
probably benign |
Het |
| Aqp3 |
G |
A |
4: 41,094,843 (GRCm39) |
|
probably benign |
Het |
| Arhgef26 |
C |
T |
3: 62,355,680 (GRCm39) |
H751Y |
probably benign |
Het |
| Asic4 |
A |
T |
1: 75,446,331 (GRCm39) |
Q291L |
possibly damaging |
Het |
| Bap1 |
T |
C |
14: 30,978,681 (GRCm39) |
Y31H |
probably damaging |
Het |
| Brf1 |
A |
T |
12: 112,924,759 (GRCm39) |
V655D |
probably damaging |
Het |
| Cebpz |
A |
G |
17: 79,238,820 (GRCm39) |
S663P |
probably benign |
Het |
| Ces2h |
A |
G |
8: 105,744,693 (GRCm39) |
D357G |
probably benign |
Het |
| Cfap36 |
T |
C |
11: 29,194,073 (GRCm39) |
T90A |
probably benign |
Het |
| Ciita |
A |
T |
16: 10,330,134 (GRCm39) |
D803V |
probably damaging |
Het |
| Clnk |
C |
A |
5: 38,931,951 (GRCm39) |
|
probably benign |
Het |
| Cyp46a1 |
A |
G |
12: 108,317,470 (GRCm39) |
N158S |
probably damaging |
Het |
| Cyp4f13 |
A |
G |
17: 33,160,080 (GRCm39) |
I98T |
possibly damaging |
Het |
| Def8 |
G |
A |
8: 124,183,234 (GRCm39) |
A278T |
probably damaging |
Het |
| Dll3 |
T |
A |
7: 28,000,746 (GRCm39) |
D103V |
possibly damaging |
Het |
| Dnai1 |
T |
A |
4: 41,629,814 (GRCm39) |
M446K |
possibly damaging |
Het |
| Dppa4 |
A |
T |
16: 48,111,425 (GRCm39) |
T85S |
probably benign |
Het |
| Eif4g1 |
A |
T |
16: 20,494,095 (GRCm39) |
H57L |
probably damaging |
Het |
| Fmnl3 |
G |
C |
15: 99,220,619 (GRCm39) |
|
probably benign |
Het |
| Fn1 |
T |
A |
1: 71,663,269 (GRCm39) |
Q1073L |
possibly damaging |
Het |
| Foxp4 |
T |
C |
17: 48,180,104 (GRCm39) |
D599G |
unknown |
Het |
| Frrs1 |
T |
C |
3: 116,675,456 (GRCm39) |
V128A |
possibly damaging |
Het |
| Gcfc2 |
G |
A |
6: 81,926,935 (GRCm39) |
D608N |
probably damaging |
Het |
| Gm1043 |
T |
C |
5: 37,350,317 (GRCm39) |
|
probably benign |
Het |
| Gm5148 |
T |
C |
3: 37,768,926 (GRCm39) |
E98G |
probably benign |
Het |
| Gpr141 |
T |
C |
13: 19,936,428 (GRCm39) |
I116V |
probably benign |
Het |
| Hic1 |
T |
C |
11: 75,058,169 (GRCm39) |
N240S |
probably damaging |
Het |
| Hpx |
G |
A |
7: 105,241,445 (GRCm39) |
T322I |
probably damaging |
Het |
| Hs3st4 |
A |
T |
7: 123,996,416 (GRCm39) |
M361L |
probably benign |
Het |
| Ifrd1 |
A |
G |
12: 40,257,129 (GRCm39) |
|
probably benign |
Het |
| Ino80 |
G |
A |
2: 119,213,441 (GRCm39) |
R1249C |
probably damaging |
Het |
| Klk1b21 |
T |
A |
7: 43,755,319 (GRCm39) |
C173S |
probably damaging |
Het |
| Krt25 |
A |
T |
11: 99,213,524 (GRCm39) |
V65E |
probably benign |
Het |
| Lrrc15 |
A |
T |
16: 30,092,267 (GRCm39) |
D357E |
possibly damaging |
Het |
| Lrrd1 |
T |
A |
5: 3,901,345 (GRCm39) |
V550E |
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,334,540 (GRCm39) |
Y1490H |
probably damaging |
Het |
| Macrod1 |
A |
G |
19: 7,174,281 (GRCm39) |
|
probably benign |
Het |
| Mcm5 |
T |
A |
8: 75,847,508 (GRCm39) |
V435D |
probably damaging |
Het |
| Mctp1 |
C |
T |
13: 76,975,831 (GRCm39) |
R478C |
probably damaging |
Het |
| Med10 |
T |
C |
13: 69,959,817 (GRCm39) |
|
probably benign |
Het |
| Mrpl4 |
T |
C |
9: 20,919,888 (GRCm39) |
Y280H |
probably benign |
Het |
| Msrb3 |
T |
C |
10: 120,687,892 (GRCm39) |
E61G |
probably damaging |
Het |
| Myo1c |
T |
C |
11: 75,551,827 (GRCm39) |
Y337H |
possibly damaging |
Het |
| Myo7b |
T |
A |
18: 32,143,204 (GRCm39) |
T165S |
probably damaging |
Het |
| Myrfl |
T |
A |
10: 116,685,138 (GRCm39) |
R81W |
probably damaging |
Het |
| Neil1 |
T |
C |
9: 57,051,030 (GRCm39) |
|
probably benign |
Het |
| Neto2 |
A |
G |
8: 86,367,673 (GRCm39) |
I357T |
possibly damaging |
Het |
| Nfat5 |
C |
T |
8: 108,065,707 (GRCm39) |
R156W |
probably damaging |
Het |
| Nkx6-3 |
T |
C |
8: 23,643,607 (GRCm39) |
S3P |
probably benign |
Het |
| Or52h7 |
A |
T |
7: 104,214,210 (GRCm39) |
I261L |
probably benign |
Het |
| Plce1 |
T |
C |
19: 38,512,863 (GRCm39) |
I54T |
possibly damaging |
Het |
| Prex2 |
A |
T |
1: 11,355,267 (GRCm39) |
|
probably benign |
Het |
| Psapl1 |
T |
A |
5: 36,361,975 (GRCm39) |
V189E |
probably damaging |
Het |
| Ptdss2 |
T |
G |
7: 140,735,232 (GRCm39) |
|
probably benign |
Het |
| Rnf213 |
T |
C |
11: 119,307,322 (GRCm39) |
C661R |
probably benign |
Het |
| Rpap1 |
T |
C |
2: 119,595,380 (GRCm39) |
|
probably null |
Het |
| Rrp1b |
A |
G |
17: 32,279,426 (GRCm39) |
T696A |
probably benign |
Het |
| Sacm1l |
T |
A |
9: 123,377,982 (GRCm39) |
H87Q |
probably benign |
Het |
| Serpinb11 |
T |
A |
1: 107,305,260 (GRCm39) |
M212K |
probably damaging |
Het |
| Tbc1d22a |
C |
A |
15: 86,183,885 (GRCm39) |
T248K |
probably damaging |
Het |
| Tcerg1 |
C |
T |
18: 42,701,679 (GRCm39) |
|
probably benign |
Het |
| Tpst1 |
T |
A |
5: 130,130,627 (GRCm39) |
H32Q |
probably damaging |
Het |
| Tsc2 |
A |
T |
17: 24,818,600 (GRCm39) |
V1412E |
possibly damaging |
Het |
| Usp19 |
C |
A |
9: 108,378,514 (GRCm39) |
P1326Q |
possibly damaging |
Het |
| Vmn1r235 |
T |
A |
17: 21,482,596 (GRCm39) |
M307K |
probably damaging |
Het |
| Vps13a |
G |
A |
19: 16,637,863 (GRCm39) |
T2406I |
possibly damaging |
Het |
| Zbtb26 |
T |
A |
2: 37,326,053 (GRCm39) |
M328L |
probably benign |
Het |
| Zp2 |
A |
G |
7: 119,736,423 (GRCm39) |
F340S |
probably damaging |
Het |
|
| Other mutations in Vmn2r58 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Vmn2r58
|
APN |
7 |
41,513,854 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL00924:Vmn2r58
|
APN |
7 |
41,486,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01291:Vmn2r58
|
APN |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01480:Vmn2r58
|
APN |
7 |
41,514,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01551:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01591:Vmn2r58
|
APN |
7 |
41,514,753 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01940:Vmn2r58
|
APN |
7 |
41,487,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01994:Vmn2r58
|
APN |
7 |
41,486,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02041:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02222:Vmn2r58
|
APN |
7 |
41,513,449 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02317:Vmn2r58
|
APN |
7 |
41,486,765 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02614:Vmn2r58
|
APN |
7 |
41,486,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02673:Vmn2r58
|
APN |
7 |
41,514,082 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03323:Vmn2r58
|
APN |
7 |
41,511,295 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03337:Vmn2r58
|
APN |
7 |
41,513,810 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03380:Vmn2r58
|
APN |
7 |
41,513,874 (GRCm39) |
missense |
probably benign |
0.00 |
|
ANU05:Vmn2r58
|
UTSW |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0141:Vmn2r58
|
UTSW |
7 |
41,511,309 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0421:Vmn2r58
|
UTSW |
7 |
41,514,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0604:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0854:Vmn2r58
|
UTSW |
7 |
41,486,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Vmn2r58
|
UTSW |
7 |
41,513,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1441:Vmn2r58
|
UTSW |
7 |
41,486,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1678:Vmn2r58
|
UTSW |
7 |
41,513,480 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1691:Vmn2r58
|
UTSW |
7 |
41,486,913 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1699:Vmn2r58
|
UTSW |
7 |
41,509,951 (GRCm39) |
missense |
probably benign |
|
|
R1865:Vmn2r58
|
UTSW |
7 |
41,486,682 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2008:Vmn2r58
|
UTSW |
7 |
41,509,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Vmn2r58
|
UTSW |
7 |
41,513,417 (GRCm39) |
missense |
probably benign |
|
|
R2202:Vmn2r58
|
UTSW |
7 |
41,513,594 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3787:Vmn2r58
|
UTSW |
7 |
41,513,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3883:Vmn2r58
|
UTSW |
7 |
41,513,914 (GRCm39) |
nonsense |
probably null |
|
|
R3944:Vmn2r58
|
UTSW |
7 |
41,513,885 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3949:Vmn2r58
|
UTSW |
7 |
41,513,348 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4232:Vmn2r58
|
UTSW |
7 |
41,487,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4409:Vmn2r58
|
UTSW |
7 |
41,522,051 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4411:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4413:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4600:Vmn2r58
|
UTSW |
7 |
41,522,046 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4610:Vmn2r58
|
UTSW |
7 |
41,487,117 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r58
|
UTSW |
7 |
41,509,935 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4793:Vmn2r58
|
UTSW |
7 |
41,514,495 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4870:Vmn2r58
|
UTSW |
7 |
41,486,639 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4981:Vmn2r58
|
UTSW |
7 |
41,486,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r58
|
UTSW |
7 |
41,487,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5024:Vmn2r58
|
UTSW |
7 |
41,513,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5064:Vmn2r58
|
UTSW |
7 |
41,486,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5330:Vmn2r58
|
UTSW |
7 |
41,513,384 (GRCm39) |
nonsense |
probably null |
|
|
R5526:Vmn2r58
|
UTSW |
7 |
41,522,069 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5980:Vmn2r58
|
UTSW |
7 |
41,514,480 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6163:Vmn2r58
|
UTSW |
7 |
41,486,825 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6365:Vmn2r58
|
UTSW |
7 |
41,513,607 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6567:Vmn2r58
|
UTSW |
7 |
41,514,673 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6594:Vmn2r58
|
UTSW |
7 |
41,486,535 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6980:Vmn2r58
|
UTSW |
7 |
41,513,662 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7373:Vmn2r58
|
UTSW |
7 |
41,487,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Vmn2r58
|
UTSW |
7 |
41,487,123 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7630:Vmn2r58
|
UTSW |
7 |
41,513,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7807:Vmn2r58
|
UTSW |
7 |
41,521,910 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8114:Vmn2r58
|
UTSW |
7 |
41,511,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Vmn2r58
|
UTSW |
7 |
41,514,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8313:Vmn2r58
|
UTSW |
7 |
41,521,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8412:Vmn2r58
|
UTSW |
7 |
41,513,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8530:Vmn2r58
|
UTSW |
7 |
41,513,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8851:Vmn2r58
|
UTSW |
7 |
41,487,219 (GRCm39) |
missense |
probably benign |
|
|
R8881:Vmn2r58
|
UTSW |
7 |
41,486,609 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8936:Vmn2r58
|
UTSW |
7 |
41,513,981 (GRCm39) |
missense |
|
|
|
R9045:Vmn2r58
|
UTSW |
7 |
41,487,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Vmn2r58
|
UTSW |
7 |
41,513,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9706:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF006:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
RF027:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn2r58
|
UTSW |
7 |
41,513,789 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAGGTAACCAGCCAGATTCCACAG -3'
(R):5'- TGCAAACTCAGAGAAGAGCCACTG -3'
Sequencing Primer
(F):5'- CTGTGGCCTTGAATGCAATAAC -3'
(R):5'- TGCCTCCAAAAATCTGTGAGC -3'
|
| Posted On |
2014-05-13 |
Incidental Mutation