Mutagenetix > Incidental Mutation

Incidental Mutation 'R1469:Wnk1'

197812

Institutional Source

Beutler Lab

Gene Symbol

Wnk1

Ensembl Gene

ENSMUSG00000045962

Gene Name

WNK lysine deficient protein kinase 1

Synonyms

Prkwnk1, 6430573H23Rik, EG406236, Hsn2

MMRRC Submission

039522-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1469 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

119900930-120015633 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 119927645 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145304 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060043] [ENSMUST00000088644] [ENSMUST00000088646] [ENSMUST00000177761] [ENSMUST00000203030]

AlphaFold

P83741

Predicted Effect

probably benign
Transcript: ENSMUST00000060043

SMART Domains

Protein: ENSMUSP00000063001
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	101	115	N/A	INTRINSIC
low complexity region	127	141	N/A	INTRINSIC
low complexity region	171	193	N/A	INTRINSIC
Pfam:Pkinase_Tyr	221	477	1.5e-44	PFAM
Pfam:Pkinase	221	479	4.4e-58	PFAM
Pfam:OSR1_C	500	537	2e-22	PFAM
coiled coil region	563	597	N/A	INTRINSIC
low complexity region	734	746	N/A	INTRINSIC
low complexity region	865	876	N/A	INTRINSIC
low complexity region	1018	1028	N/A	INTRINSIC
low complexity region	1042	1058	N/A	INTRINSIC
internal_repeat_1	1136	1178	2.15e-5	PROSPERO
low complexity region	1289	1305	N/A	INTRINSIC
low complexity region	1345	1357	N/A	INTRINSIC
low complexity region	1379	1396	N/A	INTRINSIC
low complexity region	1398	1428	N/A	INTRINSIC
low complexity region	1429	1454	N/A	INTRINSIC
low complexity region	1496	1515	N/A	INTRINSIC
low complexity region	1542	1556	N/A	INTRINSIC
low complexity region	1586	1609	N/A	INTRINSIC
low complexity region	1670	1691	N/A	INTRINSIC
low complexity region	1698	1712	N/A	INTRINSIC
low complexity region	1738	1764	N/A	INTRINSIC
low complexity region	1882	1900	N/A	INTRINSIC
coiled coil region	2065	2092	N/A	INTRINSIC
low complexity region	2103	2114	N/A	INTRINSIC
low complexity region	2116	2140	N/A	INTRINSIC
low complexity region	2208	2232	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088644

SMART Domains

Protein: ENSMUSP00000086017
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	101	115	N/A	INTRINSIC
low complexity region	127	141	N/A	INTRINSIC
low complexity region	171	193	N/A	INTRINSIC
Pfam:Pkinase_Tyr	221	477	5.5e-44	PFAM
Pfam:Pkinase	221	479	4.3e-56	PFAM
Pfam:OSR1_C	500	537	1.9e-22	PFAM
coiled coil region	563	597	N/A	INTRINSIC
low complexity region	742	753	N/A	INTRINSIC
low complexity region	919	935	N/A	INTRINSIC
low complexity region	1050	1063	N/A	INTRINSIC
low complexity region	1067	1076	N/A	INTRINSIC
low complexity region	1146	1158	N/A	INTRINSIC
low complexity region	1276	1286	N/A	INTRINSIC
low complexity region	1300	1316	N/A	INTRINSIC
internal_repeat_1	1394	1436	2.19e-5	PROSPERO
low complexity region	1547	1563	N/A	INTRINSIC
low complexity region	1603	1615	N/A	INTRINSIC
low complexity region	1637	1654	N/A	INTRINSIC
low complexity region	1656	1686	N/A	INTRINSIC
low complexity region	1687	1712	N/A	INTRINSIC
low complexity region	1754	1773	N/A	INTRINSIC
low complexity region	1800	1814	N/A	INTRINSIC
low complexity region	1844	1867	N/A	INTRINSIC
low complexity region	1928	1949	N/A	INTRINSIC
low complexity region	1956	1970	N/A	INTRINSIC
low complexity region	1996	2022	N/A	INTRINSIC
low complexity region	2140	2158	N/A	INTRINSIC
coiled coil region	2323	2350	N/A	INTRINSIC
low complexity region	2361	2372	N/A	INTRINSIC
low complexity region	2374	2398	N/A	INTRINSIC
low complexity region	2466	2490	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088646

SMART Domains

Protein: ENSMUSP00000086019
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	101	115	N/A	INTRINSIC
low complexity region	127	141	N/A	INTRINSIC
low complexity region	171	193	N/A	INTRINSIC
Pfam:Pkinase_Tyr	221	477	1.3e-44	PFAM
Pfam:Pkinase	221	479	4e-58	PFAM
Pfam:OSR1_C	500	537	1.8e-22	PFAM
coiled coil region	563	597	N/A	INTRINSIC
low complexity region	734	746	N/A	INTRINSIC
low complexity region	864	874	N/A	INTRINSIC
low complexity region	888	904	N/A	INTRINSIC
internal_repeat_1	982	1024	7.56e-6	PROSPERO
low complexity region	1135	1151	N/A	INTRINSIC
low complexity region	1191	1203	N/A	INTRINSIC
low complexity region	1225	1242	N/A	INTRINSIC
low complexity region	1244	1274	N/A	INTRINSIC
low complexity region	1275	1300	N/A	INTRINSIC
low complexity region	1342	1361	N/A	INTRINSIC
low complexity region	1388	1402	N/A	INTRINSIC
low complexity region	1432	1455	N/A	INTRINSIC
low complexity region	1516	1537	N/A	INTRINSIC
low complexity region	1544	1558	N/A	INTRINSIC
low complexity region	1584	1610	N/A	INTRINSIC
low complexity region	1700	1718	N/A	INTRINSIC
coiled coil region	1883	1910	N/A	INTRINSIC
low complexity region	1921	1932	N/A	INTRINSIC
low complexity region	1934	1958	N/A	INTRINSIC
low complexity region	2026	2050	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159397

Predicted Effect

probably benign
Transcript: ENSMUST00000159785

SMART Domains

Protein: ENSMUSP00000124905
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	159	169	N/A	INTRINSIC
low complexity region	183	199	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160769

Predicted Effect

probably benign
Transcript: ENSMUST00000161048

SMART Domains

Protein: ENSMUSP00000125345
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
Blast:S_TKc	2	68	3e-34	BLAST
SCOP:d1phk__	3	70	2e-7	SMART
Pfam:OSR1_C	89	126	9.5e-21	PFAM
coiled coil region	151	185	N/A	INTRINSIC
low complexity region	323	335	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000177761

SMART Domains

Protein: ENSMUSP00000136777
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	101	115	N/A	INTRINSIC
low complexity region	127	141	N/A	INTRINSIC
low complexity region	171	193	N/A	INTRINSIC
Pfam:Pkinase_Tyr	221	477	1.7e-44	PFAM
Pfam:Pkinase	221	479	5.1e-58	PFAM
Pfam:OSR1_C	500	537	2.2e-22	PFAM
coiled coil region	563	597	N/A	INTRINSIC
low complexity region	710	722	N/A	INTRINSIC
low complexity region	828	839	N/A	INTRINSIC
low complexity region	1005	1021	N/A	INTRINSIC
low complexity region	1136	1149	N/A	INTRINSIC
low complexity region	1153	1162	N/A	INTRINSIC
low complexity region	1232	1244	N/A	INTRINSIC
low complexity region	1291	1307	N/A	INTRINSIC
internal_repeat_1	1385	1427	1.91e-5	PROSPERO
low complexity region	1538	1554	N/A	INTRINSIC
low complexity region	1594	1606	N/A	INTRINSIC
low complexity region	1628	1645	N/A	INTRINSIC
low complexity region	1647	1677	N/A	INTRINSIC
low complexity region	1678	1703	N/A	INTRINSIC
low complexity region	1745	1764	N/A	INTRINSIC
low complexity region	1791	1805	N/A	INTRINSIC
low complexity region	1835	1858	N/A	INTRINSIC
low complexity region	1919	1940	N/A	INTRINSIC
low complexity region	1947	1961	N/A	INTRINSIC
low complexity region	1987	2013	N/A	INTRINSIC
low complexity region	2131	2149	N/A	INTRINSIC
coiled coil region	2314	2341	N/A	INTRINSIC
low complexity region	2352	2363	N/A	INTRINSIC
low complexity region	2365	2389	N/A	INTRINSIC
low complexity region	2457	2481	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000203030

SMART Domains

Protein: ENSMUSP00000145304
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	101	115	N/A	INTRINSIC
low complexity region	127	141	N/A	INTRINSIC
low complexity region	171	193	N/A	INTRINSIC
Pfam:Pkinase_Tyr	221	477	4.1e-44	PFAM
Pfam:Pkinase	221	479	3.2e-56	PFAM
Pfam:OSR1_C	500	537	1.5e-22	PFAM
coiled coil region	563	597	N/A	INTRINSIC
low complexity region	734	746	N/A	INTRINSIC
low complexity region	793	809	N/A	INTRINSIC
internal_repeat_1	887	929	5.8e-6	PROSPERO
low complexity region	1040	1056	N/A	INTRINSIC
low complexity region	1096	1108	N/A	INTRINSIC
low complexity region	1130	1147	N/A	INTRINSIC
low complexity region	1149	1179	N/A	INTRINSIC
low complexity region	1180	1205	N/A	INTRINSIC
low complexity region	1247	1266	N/A	INTRINSIC
low complexity region	1293	1307	N/A	INTRINSIC
low complexity region	1337	1360	N/A	INTRINSIC
low complexity region	1421	1442	N/A	INTRINSIC
low complexity region	1449	1463	N/A	INTRINSIC
low complexity region	1489	1515	N/A	INTRINSIC
low complexity region	1633	1651	N/A	INTRINSIC
coiled coil region	1816	1843	N/A	INTRINSIC
low complexity region	1854	1865	N/A	INTRINSIC
low complexity region	1867	1891	N/A	INTRINSIC
low complexity region	1959	1983	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161185

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204207

Predicted Effect

probably benign
Transcript: ENSMUST00000162541

SMART Domains

Protein: ENSMUSP00000125193
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	63	84	N/A	INTRINSIC
low complexity region	91	105	N/A	INTRINSIC
low complexity region	131	157	N/A	INTRINSIC
low complexity region	247	265	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162368

SMART Domains

Protein: ENSMUSP00000125383
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	83	95	N/A	INTRINSIC
low complexity region	142	158	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000161802

SMART Domains

Protein: ENSMUSP00000124724
Gene: ENSMUSG00000045962

Domain	Start	End	E-Value	Type
low complexity region	24	50	N/A	INTRINSIC

Coding Region Coverage

1x: 97.4%
3x: 96.7%
10x: 94.8%
20x: 90.6%

Validation Efficiency

98% (95/97)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 103 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	A	T	5: 77,039,526 (GRCm39)	V261E	probably damaging	Het
Abca15	A	G	7: 119,981,720 (GRCm39)	E1058G	probably benign	Het
Abcb5	T	G	12: 118,831,681 (GRCm39)	I1224L	possibly damaging	Het
Actn4	G	A	7: 28,597,691 (GRCm39)		probably benign	Het
Actn4	A	G	7: 28,604,753 (GRCm39)	V348A	probably benign	Het
Agtr1b	A	T	3: 20,369,664 (GRCm39)	L314H	probably damaging	Het
Ankrd55	T	C	13: 112,504,460 (GRCm39)	M402T	probably benign	Het
Antxrl	T	C	14: 33,789,388 (GRCm39)		probably benign	Het
Asap2	A	G	12: 21,263,180 (GRCm39)	Q265R	probably benign	Het
Atp2b4	G	A	1: 133,634,677 (GRCm39)	R1124C	probably damaging	Het
Atp2c1	A	T	9: 105,312,351 (GRCm39)	C353*	probably null	Het
Atp8b5	T	A	4: 43,291,733 (GRCm39)		probably null	Het
Baz1b	T	A	5: 135,246,833 (GRCm39)	Y761N	probably damaging	Het
Bend6	A	G	1: 33,903,824 (GRCm39)	V38A	probably benign	Het
Camk1g	T	C	1: 193,044,399 (GRCm39)	E5G	possibly damaging	Het
Ccdc14	T	A	16: 34,527,152 (GRCm39)	H352Q	probably damaging	Het
Cdh2	A	G	18: 16,757,324 (GRCm39)	V641A	possibly damaging	Het
Celsr2	C	A	3: 108,321,424 (GRCm39)	D463Y	probably damaging	Het
Cldn16	C	A	16: 26,292,930 (GRCm39)		probably benign	Het
Clec7a	A	C	6: 129,449,535 (GRCm39)		probably benign	Het
Cnih2	T	C	19: 5,143,730 (GRCm39)	Y142C	probably damaging	Het
Coa5	T	A	1: 37,459,681 (GRCm39)	R71*	probably null	Het
Csmd3	A	T	15: 47,532,598 (GRCm39)	Y2532*	probably null	Het
Cytl1	A	T	5: 37,892,991 (GRCm39)	M34L	probably benign	Het
Dctn1	T	A	6: 83,169,871 (GRCm39)	I590N	probably damaging	Het
Dhx57	T	C	17: 80,561,847 (GRCm39)	H889R	probably damaging	Het
Dock10	A	G	1: 80,490,275 (GRCm39)	I1948T	probably benign	Het
Dock3	A	T	9: 106,832,908 (GRCm39)	N1034K	probably benign	Het
Dzip1l	G	A	9: 99,541,829 (GRCm39)		probably null	Het
Eif4g1	T	A	16: 20,498,758 (GRCm39)	V439E	possibly damaging	Het
Eml5	T	C	12: 98,825,082 (GRCm39)	I712V	probably benign	Het
Entrep1	G	A	19: 23,950,970 (GRCm39)	T537I	probably benign	Het
Epha3	C	T	16: 63,473,857 (GRCm39)	G300D	probably damaging	Het
Erbb4	A	C	1: 68,599,841 (GRCm39)	S79A	probably damaging	Het
Gclc	T	C	9: 77,688,419 (GRCm39)	V205A	probably benign	Het
Gdpd4	A	G	7: 97,623,673 (GRCm39)		probably null	Het
Gm11564	C	T	11: 99,706,058 (GRCm39)	C124Y	unknown	Het
Gm16494	T	C	17: 47,327,770 (GRCm39)	E38G	probably damaging	Het
Gtf2h1	T	C	7: 46,454,549 (GRCm39)		probably null	Het
Gtsf2	G	T	15: 103,349,644 (GRCm39)	R68S	probably benign	Het
Heatr5b	T	C	17: 79,115,813 (GRCm39)	Q881R	probably damaging	Het
Hmox1	C	A	8: 75,825,463 (GRCm39)	L236I	probably benign	Het
Ighv8-12	T	C	12: 115,611,963 (GRCm39)	I7V	probably benign	Het
Itprip	A	G	19: 47,885,314 (GRCm39)	Y434H	probably damaging	Het
Izumo1	T	C	7: 45,272,437 (GRCm39)	S73P	probably damaging	Het
Kifbp	A	T	10: 62,395,229 (GRCm39)	F471Y	probably damaging	Het
Knl1	A	G	2: 118,901,827 (GRCm39)	N1176S	possibly damaging	Het
Limch1	T	C	5: 67,039,323 (GRCm39)		probably benign	Het
Mecom	A	T	3: 30,034,197 (GRCm39)	L493Q	probably damaging	Het
Mprip	T	C	11: 59,650,016 (GRCm39)	V1240A	probably damaging	Het
Mrpl3	T	C	9: 104,954,201 (GRCm39)	S302P	probably damaging	Het
Muc19	T	C	15: 91,758,498 (GRCm39)		noncoding transcript	Het
Mycbp2	T	C	14: 103,425,956 (GRCm39)	T2390A	probably damaging	Het
Myo1c	T	C	11: 75,560,787 (GRCm39)	S766P	probably damaging	Het
Myo9b	A	G	8: 71,743,680 (GRCm39)	Q247R	probably damaging	Het
Nav3	G	A	10: 109,596,369 (GRCm39)	T1423I	probably damaging	Het
Nefh	A	T	11: 4,890,066 (GRCm39)	I851N	probably benign	Het
Nup98	T	C	7: 101,788,008 (GRCm39)	T1004A	probably benign	Het
Or1e17	T	C	11: 73,831,383 (GRCm39)	F104L	probably benign	Het
Or1e22	G	A	11: 73,377,149 (GRCm39)	S167L	possibly damaging	Het
Or5k8	G	A	16: 58,644,973 (GRCm39)	T33I	probably benign	Het
Or5p76	T	C	7: 108,122,411 (GRCm39)	T249A	probably benign	Het
Osgin1	G	T	8: 120,172,124 (GRCm39)	R306L	possibly damaging	Het
Otof	A	G	5: 30,537,571 (GRCm39)	L1246P	probably benign	Het
Pde8a	T	A	7: 80,952,019 (GRCm39)	N273K	probably damaging	Het
Phf14	T	A	6: 11,933,726 (GRCm39)	M196K	possibly damaging	Het
Pkd1l3	T	C	8: 110,373,585 (GRCm39)	S1374P	possibly damaging	Het
Pkhd1l1	T	C	15: 44,400,282 (GRCm39)	V2142A	probably benign	Het
Plb1	A	G	5: 32,512,170 (GRCm39)	E1318G	possibly damaging	Het
Plekhh2	A	G	17: 84,883,199 (GRCm39)	I756V	probably benign	Het
Prag1	A	T	8: 36,613,452 (GRCm39)		probably benign	Het
Primpol	A	G	8: 47,046,672 (GRCm39)	V208A	probably benign	Het
Ptch2	C	A	4: 116,965,662 (GRCm39)	A389E	probably benign	Het
Pzp	A	G	6: 128,489,319 (GRCm39)	Y431H	probably benign	Het
Rnf43	G	A	11: 87,622,233 (GRCm39)	G445R	probably damaging	Het
Scn5a	A	T	9: 119,362,727 (GRCm39)		probably null	Het
Sf3a1	A	T	11: 4,125,380 (GRCm39)		probably benign	Het
Shisa9	T	A	16: 11,802,935 (GRCm39)	M164K	probably damaging	Het
Skint1	A	G	4: 111,882,708 (GRCm39)	I251V	probably benign	Het
Slc16a14	C	T	1: 84,907,182 (GRCm39)	D31N	probably damaging	Het
Slc22a13	T	C	9: 119,022,361 (GRCm39)	S548G	possibly damaging	Het
Slc4a9	T	C	18: 36,664,154 (GRCm39)	F316L	probably benign	Het
Smchd1	C	T	17: 71,656,725 (GRCm39)	R1914H	probably damaging	Het
Snx16	C	T	3: 10,499,431 (GRCm39)	D200N	probably damaging	Het
Spock3	A	G	8: 63,404,934 (GRCm39)	D34G	probably damaging	Het
Sspo	T	C	6: 48,467,916 (GRCm39)	C4154R	probably damaging	Het
Sytl3	C	T	17: 6,954,723 (GRCm39)	A131V	probably benign	Het
Tacc1	T	A	8: 25,672,271 (GRCm39)	D319V	probably benign	Het
Tead1	A	T	7: 112,475,391 (GRCm39)	K234I	probably damaging	Het
Tgfbrap1	C	T	1: 43,114,618 (GRCm39)	V161I	probably benign	Het
Tmem94	T	C	11: 115,685,917 (GRCm39)		probably benign	Het
Tnfaip3	A	G	10: 18,884,017 (GRCm39)	V121A	probably damaging	Het
Tnnt2	A	G	1: 135,779,793 (GRCm39)	T297A	possibly damaging	Het
Trappc11	G	A	8: 47,957,000 (GRCm39)	L809F	probably damaging	Het
Ttn	T	C	2: 76,601,869 (GRCm39)	I18598V	probably benign	Het
Ube2o	A	G	11: 116,436,650 (GRCm39)		probably benign	Het
Unc5a	A	G	13: 55,144,232 (GRCm39)	N186D	probably damaging	Het
Uqcrfs1	C	A	13: 30,724,784 (GRCm39)	G252V	probably damaging	Het
Vmn2r115	T	C	17: 23,564,992 (GRCm39)	I293T	probably damaging	Het
Vmn2r9	T	C	5: 108,991,694 (GRCm39)	T556A	probably benign	Het
Ythdc2	T	A	18: 44,997,529 (GRCm39)	Y1029N	probably benign	Het
Zfp451	T	A	1: 33,808,894 (GRCm39)	K989M	possibly damaging	Het
Zfpm1	C	T	8: 123,062,585 (GRCm39)	T548M	probably damaging	Het

Other mutations in Wnk1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00901:Wnk1	APN	6	119,937,669 (GRCm39)	missense	probably damaging	1.00
IGL01364:Wnk1	APN	6	119,914,372 (GRCm39)	missense	probably damaging	1.00
IGL01715:Wnk1	APN	6	119,925,358 (GRCm39)	missense	probably damaging	1.00
IGL01951:Wnk1	APN	6	119,940,446 (GRCm39)	missense	probably damaging	0.99
IGL02043:Wnk1	APN	6	119,926,039 (GRCm39)	unclassified	probably benign
IGL02268:Wnk1	APN	6	119,914,334 (GRCm39)	nonsense	probably null
IGL02348:Wnk1	APN	6	119,940,289 (GRCm39)	missense	probably damaging	0.98
IGL02425:Wnk1	APN	6	119,940,415 (GRCm39)	missense	probably damaging	1.00
IGL02850:Wnk1	APN	6	119,914,823 (GRCm39)	missense	probably benign	0.26
IGL03160:Wnk1	APN	6	119,903,594 (GRCm39)	missense	probably damaging	1.00
IGL03387:Wnk1	APN	6	119,931,148 (GRCm39)	missense	possibly damaging	0.76
IGL03405:Wnk1	APN	6	119,930,856 (GRCm39)	missense	probably benign	0.41
Actor	UTSW	6	119,947,939 (GRCm39)	missense	probably damaging	1.00
Bad	UTSW	6	119,942,639 (GRCm39)	intron	probably benign
Blink	UTSW	6	119,979,234 (GRCm39)	nonsense	probably null
Knock	UTSW	6	119,920,839 (GRCm39)	splice site	probably null
Narrow	UTSW	6	119,969,369 (GRCm39)	missense	probably damaging	1.00
nictitate	UTSW	6	119,979,241 (GRCm39)	missense	possibly damaging	0.88
opportunity	UTSW	6	119,928,029 (GRCm39)	missense	probably damaging	1.00
path	UTSW	6	120,014,110 (GRCm39)	missense	probably damaging	0.99
Stormy	UTSW	6	119,969,408 (GRCm39)	missense	probably damaging	1.00
tear	UTSW	6	119,940,431 (GRCm39)	missense	probably damaging	0.98
Tic	UTSW	6	119,927,044 (GRCm39)	missense	probably damaging	1.00
Unforgiving	UTSW	6	119,925,243 (GRCm39)	missense	probably damaging	1.00
Window	UTSW	6	119,969,414 (GRCm39)	missense	probably damaging	1.00
Woke	UTSW	6	119,939,916 (GRCm39)	missense	probably benign	0.12
IGL03052:Wnk1	UTSW	6	119,921,760 (GRCm39)	splice site	probably benign
PIT4480001:Wnk1	UTSW	6	119,940,328 (GRCm39)	nonsense	probably null
R0044:Wnk1	UTSW	6	120,014,110 (GRCm39)	missense	probably damaging	0.99
R0207:Wnk1	UTSW	6	119,929,694 (GRCm39)	missense	probably damaging	1.00
R0333:Wnk1	UTSW	6	119,905,124 (GRCm39)	intron	probably benign
R0453:Wnk1	UTSW	6	119,940,112 (GRCm39)	missense	probably damaging	0.99
R0457:Wnk1	UTSW	6	119,946,293 (GRCm39)	missense	probably damaging	1.00
R0501:Wnk1	UTSW	6	119,939,764 (GRCm39)	missense	probably damaging	1.00
R0525:Wnk1	UTSW	6	119,903,525 (GRCm39)	missense	probably damaging	1.00
R0526:Wnk1	UTSW	6	119,928,953 (GRCm39)	missense	probably damaging	0.99
R0606:Wnk1	UTSW	6	119,903,644 (GRCm39)	missense	probably damaging	1.00
R0658:Wnk1	UTSW	6	119,925,466 (GRCm39)	missense	probably damaging	0.98
R1148:Wnk1	UTSW	6	119,928,967 (GRCm39)	splice site	probably benign
R1188:Wnk1	UTSW	6	119,925,670 (GRCm39)	nonsense	probably null
R1245:Wnk1	UTSW	6	119,925,418 (GRCm39)	missense	probably benign	0.26
R1449:Wnk1	UTSW	6	119,929,779 (GRCm39)	missense	probably damaging	1.00
R1869:Wnk1	UTSW	6	119,928,050 (GRCm39)	missense	probably damaging	1.00
R1871:Wnk1	UTSW	6	119,928,050 (GRCm39)	missense	probably damaging	1.00
R1928:Wnk1	UTSW	6	119,929,884 (GRCm39)	missense	probably damaging	1.00
R1959:Wnk1	UTSW	6	119,946,208 (GRCm39)	missense	probably damaging	0.98
R1961:Wnk1	UTSW	6	119,946,208 (GRCm39)	missense	probably damaging	0.98
R1964:Wnk1	UTSW	6	119,911,343 (GRCm39)	missense	possibly damaging	0.86
R1983:Wnk1	UTSW	6	119,914,539 (GRCm39)	missense	probably damaging	1.00
R2062:Wnk1	UTSW	6	119,905,118 (GRCm39)	splice site	probably null
R2144:Wnk1	UTSW	6	119,925,949 (GRCm39)	unclassified	probably benign
R2186:Wnk1	UTSW	6	119,925,528 (GRCm39)	missense	probably benign	0.26
R2281:Wnk1	UTSW	6	119,940,601 (GRCm39)	splice site	probably null
R2338:Wnk1	UTSW	6	119,946,495 (GRCm39)	missense	probably benign	0.42
R2420:Wnk1	UTSW	6	119,913,328 (GRCm39)	critical splice donor site	probably null
R3727:Wnk1	UTSW	6	119,969,414 (GRCm39)	missense	probably damaging	1.00
R3773:Wnk1	UTSW	6	119,979,241 (GRCm39)	missense	possibly damaging	0.88
R3836:Wnk1	UTSW	6	119,927,004 (GRCm39)	missense	probably damaging	1.00
R3837:Wnk1	UTSW	6	119,927,004 (GRCm39)	missense	probably damaging	1.00
R3847:Wnk1	UTSW	6	119,946,315 (GRCm39)	missense	possibly damaging	0.70
R3903:Wnk1	UTSW	6	119,926,012 (GRCm39)	missense	probably damaging	1.00
R4031:Wnk1	UTSW	6	119,928,029 (GRCm39)	missense	probably damaging	1.00
R4095:Wnk1	UTSW	6	119,925,087 (GRCm39)	missense	probably damaging	1.00
R4232:Wnk1	UTSW	6	119,926,222 (GRCm39)	missense	possibly damaging	0.90
R4422:Wnk1	UTSW	6	119,930,856 (GRCm39)	missense	probably benign	0.41
R4423:Wnk1	UTSW	6	119,903,387 (GRCm39)	missense	probably damaging	1.00
R4572:Wnk1	UTSW	6	119,928,872 (GRCm39)	missense	possibly damaging	0.49
R4704:Wnk1	UTSW	6	119,942,705 (GRCm39)	missense	possibly damaging	0.83
R4755:Wnk1	UTSW	6	119,940,431 (GRCm39)	missense	probably damaging	0.98
R4812:Wnk1	UTSW	6	119,929,732 (GRCm39)	missense	probably benign	0.16
R4822:Wnk1	UTSW	6	119,939,399 (GRCm39)	missense	probably benign	0.02
R4879:Wnk1	UTSW	6	119,926,338 (GRCm39)	missense	probably damaging	1.00
R4970:Wnk1	UTSW	6	119,942,696 (GRCm39)	intron	probably benign
R5002:Wnk1	UTSW	6	119,914,924 (GRCm39)	missense	probably benign	0.13
R5037:Wnk1	UTSW	6	119,942,696 (GRCm39)	intron	probably benign
R5152:Wnk1	UTSW	6	119,979,241 (GRCm39)	missense	possibly damaging	0.88
R5257:Wnk1	UTSW	6	120,014,149 (GRCm39)	missense	probably benign	0.00
R5354:Wnk1	UTSW	6	119,945,484 (GRCm39)	missense	probably benign	0.01
R5421:Wnk1	UTSW	6	119,929,779 (GRCm39)	missense	probably damaging	1.00
R5564:Wnk1	UTSW	6	119,925,852 (GRCm39)	unclassified	probably benign
R5600:Wnk1	UTSW	6	119,926,319 (GRCm39)	missense	probably damaging	1.00
R5847:Wnk1	UTSW	6	119,969,369 (GRCm39)	missense	probably damaging	1.00
R6083:Wnk1	UTSW	6	120,014,562 (GRCm39)	missense	probably damaging	0.99
R6110:Wnk1	UTSW	6	119,949,958 (GRCm39)	intron	probably benign
R6128:Wnk1	UTSW	6	119,940,747 (GRCm39)	splice site	probably null
R6237:Wnk1	UTSW	6	119,929,728 (GRCm39)	missense	probably damaging	1.00
R6341:Wnk1	UTSW	6	119,925,546 (GRCm39)	missense	probably damaging	1.00
R6467:Wnk1	UTSW	6	119,939,916 (GRCm39)	missense	probably benign	0.12
R6696:Wnk1	UTSW	6	119,925,243 (GRCm39)	missense	probably damaging	1.00
R6888:Wnk1	UTSW	6	119,925,742 (GRCm39)	missense	probably benign	0.26
R6923:Wnk1	UTSW	6	119,942,639 (GRCm39)	intron	probably benign
R7024:Wnk1	UTSW	6	119,942,687 (GRCm39)	intron	probably benign
R7072:Wnk1	UTSW	6	119,914,822 (GRCm39)	missense	unknown
R7087:Wnk1	UTSW	6	120,014,491 (GRCm39)	missense	possibly damaging	0.94
R7102:Wnk1	UTSW	6	119,925,268 (GRCm39)	missense	unknown
R7134:Wnk1	UTSW	6	119,903,389 (GRCm39)	missense	unknown
R7137:Wnk1	UTSW	6	120,015,173 (GRCm39)	unclassified	probably benign
R7142:Wnk1	UTSW	6	119,926,240 (GRCm39)	missense	probably benign	0.09
R7174:Wnk1	UTSW	6	119,947,939 (GRCm39)	missense	probably damaging	1.00
R7205:Wnk1	UTSW	6	119,920,839 (GRCm39)	splice site	probably null
R7218:Wnk1	UTSW	6	119,979,234 (GRCm39)	nonsense	probably null
R7498:Wnk1	UTSW	6	119,904,157 (GRCm39)	missense	unknown
R7599:Wnk1	UTSW	6	119,906,789 (GRCm39)	missense	possibly damaging	0.83
R7615:Wnk1	UTSW	6	119,909,699 (GRCm39)	missense	probably benign	0.27
R7799:Wnk1	UTSW	6	119,926,137 (GRCm39)	missense	probably benign	0.04
R7979:Wnk1	UTSW	6	120,014,409 (GRCm39)	missense	probably damaging	1.00
R8075:Wnk1	UTSW	6	119,909,675 (GRCm39)	missense	probably damaging	0.99
R8331:Wnk1	UTSW	6	119,930,794 (GRCm39)	missense	probably benign	0.09
R8343:Wnk1	UTSW	6	119,940,454 (GRCm39)	missense	probably damaging	0.99
R8348:Wnk1	UTSW	6	119,906,960 (GRCm39)	splice site	probably null
R8359:Wnk1	UTSW	6	119,969,408 (GRCm39)	missense	probably damaging	1.00
R8424:Wnk1	UTSW	6	119,911,388 (GRCm39)	missense	unknown
R8519:Wnk1	UTSW	6	119,927,044 (GRCm39)	missense	probably damaging	1.00
R8930:Wnk1	UTSW	6	119,940,226 (GRCm39)	missense	probably damaging	0.99
R8932:Wnk1	UTSW	6	119,940,226 (GRCm39)	missense	probably damaging	0.99
R8933:Wnk1	UTSW	6	120,013,959 (GRCm39)	missense	probably damaging	1.00
R9005:Wnk1	UTSW	6	119,939,393 (GRCm39)	missense	probably damaging	1.00
R9147:Wnk1	UTSW	6	119,925,631 (GRCm39)	missense	unknown
R9148:Wnk1	UTSW	6	119,925,631 (GRCm39)	missense	unknown
R9354:Wnk1	UTSW	6	119,942,660 (GRCm39)	missense	unknown
R9379:Wnk1	UTSW	6	119,928,678 (GRCm39)	missense	probably damaging	1.00
X0064:Wnk1	UTSW	6	120,013,993 (GRCm39)	missense	possibly damaging	0.93
Z1177:Wnk1	UTSW	6	119,925,166 (GRCm39)	missense	unknown

Predicted Primers

Posted On

2014-05-23