Incidental Mutation 'R1934:Pde4dip'
| ID |
215651 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pde4dip
|
| Ensembl Gene |
ENSMUSG00000038170 |
| Gene Name |
phosphodiesterase 4D interacting protein (myomegalin) |
| Synonyms |
Usmg4, D3Bwg1078e, D130016K21Rik, 9430063L05Rik, 4732458A06Rik |
| MMRRC Submission |
039952-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1934 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
97597144-97796023 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 97600007 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 2403
(V2403A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088254
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090750]
[ENSMUST00000168438]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000090750
AA Change: V2403A
PolyPhen 2
Score 0.740 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000088254
Gene: ENSMUSG00000038170
AA Change: V2403A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Cnn_1N
|
124 |
196 |
3.2e-26 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
4.03e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
6.59e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
4.03e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
6.59e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1780 |
N/A |
INTRINSIC |
|
low complexity region
|
1836 |
1851 |
N/A |
INTRINSIC |
|
low complexity region
|
1860 |
1874 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1951 |
N/A |
INTRINSIC |
|
coiled coil region
|
1962 |
2138 |
N/A |
INTRINSIC |
|
coiled coil region
|
2162 |
2197 |
N/A |
INTRINSIC |
|
coiled coil region
|
2387 |
2431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168438
AA Change: V2352A
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000131170
Gene: ENSMUSG00000038170
AA Change: V2352A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Microtub_assoc
|
124 |
198 |
1.4e-31 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
3.56e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
5.83e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
3.56e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
5.83e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1769 |
N/A |
INTRINSIC |
|
low complexity region
|
1785 |
1800 |
N/A |
INTRINSIC |
|
low complexity region
|
1809 |
1823 |
N/A |
INTRINSIC |
|
low complexity region
|
1889 |
1900 |
N/A |
INTRINSIC |
|
coiled coil region
|
1911 |
2087 |
N/A |
INTRINSIC |
|
coiled coil region
|
2111 |
2146 |
N/A |
INTRINSIC |
|
coiled coil region
|
2336 |
2380 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197791
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200063
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit partial (in utero or perinatal) lethality, hyperactivity, and increased vertical activity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
T |
C |
6: 121,626,792 (GRCm39) |
L548P |
probably damaging |
Het |
| Abca6 |
A |
G |
11: 110,100,909 (GRCm39) |
|
probably null |
Het |
| Abcb5 |
A |
G |
12: 118,871,235 (GRCm39) |
|
probably null |
Het |
| Acacb |
G |
A |
5: 114,336,343 (GRCm39) |
A686T |
probably benign |
Het |
| Acot6 |
T |
C |
12: 84,153,367 (GRCm39) |
V203A |
probably benign |
Het |
| Adam25 |
A |
T |
8: 41,207,922 (GRCm39) |
Y396F |
probably benign |
Het |
| Adamts9 |
A |
G |
6: 92,920,102 (GRCm39) |
L12P |
possibly damaging |
Het |
| Adamtsl2 |
A |
T |
2: 26,979,605 (GRCm39) |
D258V |
probably damaging |
Het |
| Aox4 |
G |
A |
1: 58,285,095 (GRCm39) |
V616I |
probably benign |
Het |
| Ap1m1 |
A |
G |
8: 73,009,637 (GRCm39) |
I382V |
probably damaging |
Het |
| Arhgef2 |
G |
A |
3: 88,537,098 (GRCm39) |
R8Q |
probably damaging |
Het |
| Arhgef37 |
T |
G |
18: 61,657,014 (GRCm39) |
E17A |
probably benign |
Het |
| Arhgef7 |
C |
A |
8: 11,858,713 (GRCm39) |
|
probably null |
Het |
| Arih1 |
T |
C |
9: 59,302,215 (GRCm39) |
D431G |
probably damaging |
Het |
| Astn2 |
C |
T |
4: 65,353,426 (GRCm39) |
V1115M |
probably damaging |
Het |
| Atg7 |
T |
A |
6: 114,678,196 (GRCm39) |
M280K |
probably damaging |
Het |
| Birc2 |
T |
C |
9: 7,854,500 (GRCm39) |
T397A |
possibly damaging |
Het |
| Ccdc110 |
A |
G |
8: 46,396,287 (GRCm39) |
N726S |
probably damaging |
Het |
| Cdadc1 |
A |
T |
14: 59,827,309 (GRCm39) |
S121T |
possibly damaging |
Het |
| Cdh16 |
A |
G |
8: 105,344,595 (GRCm39) |
V7A |
possibly damaging |
Het |
| Cenpb |
A |
G |
2: 131,021,184 (GRCm39) |
S205P |
probably benign |
Het |
| Chsy1 |
T |
C |
7: 65,821,991 (GRCm39) |
V742A |
probably damaging |
Het |
| Col12a1 |
G |
A |
9: 79,511,804 (GRCm39) |
R133* |
probably null |
Het |
| Col18a1 |
A |
C |
10: 76,948,578 (GRCm39) |
S311R |
possibly damaging |
Het |
| Col9a3 |
G |
A |
2: 180,248,927 (GRCm39) |
V260M |
probably damaging |
Het |
| Coq2 |
T |
A |
5: 100,809,731 (GRCm39) |
R17S |
probably damaging |
Het |
| Ctf1 |
A |
G |
7: 127,311,936 (GRCm39) |
R4G |
probably damaging |
Het |
| Cwc27 |
T |
C |
13: 104,768,184 (GRCm39) |
D437G |
probably benign |
Het |
| Cyp4f14 |
T |
C |
17: 33,125,289 (GRCm39) |
N430D |
probably damaging |
Het |
| Dars2 |
A |
G |
1: 160,890,811 (GRCm39) |
|
probably null |
Het |
| Dgkz |
A |
T |
2: 91,767,449 (GRCm39) |
M848K |
possibly damaging |
Het |
| Dnhd1 |
T |
G |
7: 105,357,789 (GRCm39) |
V3208G |
probably benign |
Het |
| Dsg1b |
A |
G |
18: 20,528,963 (GRCm39) |
Y233C |
probably damaging |
Het |
| Edem3 |
A |
T |
1: 151,680,034 (GRCm39) |
D460V |
probably damaging |
Het |
| Ednra |
A |
G |
8: 78,415,747 (GRCm39) |
S167P |
possibly damaging |
Het |
| Eif3m |
A |
T |
2: 104,831,624 (GRCm39) |
V180D |
probably damaging |
Het |
| Fam217a |
T |
A |
13: 35,094,864 (GRCm39) |
R207S |
probably damaging |
Het |
| Fcgbp |
G |
A |
7: 27,806,518 (GRCm39) |
G2162D |
probably damaging |
Het |
| Fhod3 |
A |
T |
18: 25,223,335 (GRCm39) |
I894F |
probably benign |
Het |
| Fpgs |
A |
T |
2: 32,577,993 (GRCm39) |
I143N |
probably damaging |
Het |
| Fpr-rs6 |
A |
G |
17: 20,403,152 (GRCm39) |
S70P |
probably benign |
Het |
| Frs2 |
T |
C |
10: 116,914,806 (GRCm39) |
M38V |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,810,902 (GRCm39) |
N2407S |
possibly damaging |
Het |
| Gabrg2 |
T |
A |
11: 41,811,297 (GRCm39) |
T283S |
probably benign |
Het |
| Gas2l1 |
T |
A |
11: 5,011,408 (GRCm39) |
T474S |
probably benign |
Het |
| Gli1 |
A |
T |
10: 127,167,108 (GRCm39) |
M715K |
possibly damaging |
Het |
| Glra3 |
G |
T |
8: 56,393,942 (GRCm39) |
A18S |
probably benign |
Het |
| Gm5800 |
T |
A |
14: 51,949,396 (GRCm39) |
N183I |
possibly damaging |
Het |
| Gm8674 |
T |
A |
13: 50,055,471 (GRCm39) |
|
noncoding transcript |
Het |
| Gnat3 |
A |
T |
5: 18,224,508 (GRCm39) |
I303F |
possibly damaging |
Het |
| Grin2d |
C |
T |
7: 45,506,251 (GRCm39) |
V547M |
probably damaging |
Het |
| Grpr |
C |
A |
X: 162,332,137 (GRCm39) |
V53L |
probably benign |
Het |
| Heatr5b |
T |
C |
17: 79,103,347 (GRCm39) |
I1169V |
possibly damaging |
Het |
| Icam5 |
A |
G |
9: 20,946,082 (GRCm39) |
T305A |
probably benign |
Het |
| Itga11 |
T |
A |
9: 62,651,796 (GRCm39) |
N309K |
probably damaging |
Het |
| Itgb6 |
T |
C |
2: 60,499,493 (GRCm39) |
D100G |
probably benign |
Het |
| Kdm3b |
A |
G |
18: 34,946,597 (GRCm39) |
K862R |
probably benign |
Het |
| Kif7 |
T |
C |
7: 79,361,286 (GRCm39) |
D135G |
probably benign |
Het |
| Lrp4 |
A |
G |
2: 91,310,777 (GRCm39) |
D606G |
probably damaging |
Het |
| Lrrtm1 |
A |
T |
6: 77,221,949 (GRCm39) |
|
probably null |
Het |
| Metap1d |
A |
T |
2: 71,352,927 (GRCm39) |
H252L |
possibly damaging |
Het |
| Mfhas1 |
A |
G |
8: 36,058,251 (GRCm39) |
K909E |
possibly damaging |
Het |
| Mrgprh |
C |
T |
17: 13,095,838 (GRCm39) |
T26I |
probably damaging |
Het |
| Myo15b |
T |
C |
11: 115,754,310 (GRCm39) |
S937P |
probably benign |
Het |
| Neto2 |
A |
T |
8: 86,397,033 (GRCm39) |
I73N |
possibly damaging |
Het |
| Nod2 |
T |
C |
8: 89,390,347 (GRCm39) |
I196T |
probably benign |
Het |
| Nvl |
T |
G |
1: 180,926,693 (GRCm39) |
T788P |
probably damaging |
Het |
| Or13a25 |
C |
A |
7: 140,247,951 (GRCm39) |
C243* |
probably null |
Het |
| Or2h2 |
A |
T |
17: 37,396,906 (GRCm39) |
D50E |
possibly damaging |
Het |
| Pax3 |
G |
A |
1: 78,080,117 (GRCm39) |
T423I |
possibly damaging |
Het |
| Phip |
C |
T |
9: 82,785,235 (GRCm39) |
V827I |
probably benign |
Het |
| Plcb3 |
A |
G |
19: 6,941,977 (GRCm39) |
F285L |
probably damaging |
Het |
| Pnp2 |
A |
G |
14: 51,193,675 (GRCm39) |
I16V |
probably benign |
Het |
| Pola2 |
A |
G |
19: 6,003,769 (GRCm39) |
L202P |
probably damaging |
Het |
| Ppfia1 |
A |
T |
7: 144,058,847 (GRCm39) |
N651K |
probably benign |
Het |
| Prss53 |
T |
C |
7: 127,485,920 (GRCm39) |
|
probably null |
Het |
| Rasgrf1 |
G |
T |
9: 89,835,966 (GRCm39) |
Q231H |
probably damaging |
Het |
| Rasgrf2 |
A |
T |
13: 92,131,825 (GRCm39) |
|
probably null |
Het |
| Rccd1 |
T |
A |
7: 79,970,272 (GRCm39) |
N115I |
possibly damaging |
Het |
| Rpgrip1 |
A |
T |
14: 52,352,101 (GRCm39) |
T26S |
possibly damaging |
Het |
| Rpn1 |
T |
A |
6: 88,070,841 (GRCm39) |
V237E |
probably damaging |
Het |
| Sema4f |
G |
T |
6: 82,907,908 (GRCm39) |
P180Q |
probably damaging |
Het |
| Slc36a4 |
T |
C |
9: 15,632,085 (GRCm39) |
V87A |
probably damaging |
Het |
| Slc5a4b |
A |
T |
10: 75,917,307 (GRCm39) |
V243E |
possibly damaging |
Het |
| Sos2 |
T |
G |
12: 69,695,315 (GRCm39) |
I141L |
probably damaging |
Het |
| Srbd1 |
A |
G |
17: 86,410,321 (GRCm39) |
V537A |
probably damaging |
Het |
| Sugp1 |
A |
G |
8: 70,509,225 (GRCm39) |
E166G |
possibly damaging |
Het |
| Tktl2 |
G |
A |
8: 66,964,999 (GRCm39) |
V186M |
probably damaging |
Het |
| Tshr |
T |
C |
12: 91,503,955 (GRCm39) |
S298P |
probably damaging |
Het |
| Tspan14 |
T |
C |
14: 40,656,209 (GRCm39) |
Y6C |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,577,384 (GRCm39) |
V24503E |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,851,045 (GRCm39) |
N1305I |
probably damaging |
Het |
| Vmn2r81 |
A |
G |
10: 79,083,628 (GRCm39) |
M1V |
probably null |
Het |
| Vps39 |
A |
T |
2: 120,148,558 (GRCm39) |
V873E |
probably damaging |
Het |
| Vstm2a |
A |
T |
11: 16,359,734 (GRCm39) |
D270V |
unknown |
Het |
| Wdr24 |
A |
T |
17: 26,043,240 (GRCm39) |
M21L |
possibly damaging |
Het |
| Wee1 |
A |
G |
7: 109,721,698 (GRCm39) |
T48A |
probably benign |
Het |
| Zfp369 |
T |
C |
13: 65,444,965 (GRCm39) |
C703R |
probably damaging |
Het |
| Zfp532 |
A |
T |
18: 65,818,682 (GRCm39) |
D1114V |
probably damaging |
Het |
| Zfp758 |
A |
G |
17: 22,592,633 (GRCm39) |
T46A |
probably damaging |
Het |
|
| Other mutations in Pde4dip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00332:Pde4dip
|
APN |
3 |
97,674,593 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00543:Pde4dip
|
APN |
3 |
97,664,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL00979:Pde4dip
|
APN |
3 |
97,655,074 (GRCm39) |
splice site |
probably benign |
|
|
IGL01483:Pde4dip
|
APN |
3 |
97,661,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02122:Pde4dip
|
APN |
3 |
97,674,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02398:Pde4dip
|
APN |
3 |
97,674,097 (GRCm39) |
missense |
probably benign |
|
|
IGL02814:Pde4dip
|
APN |
3 |
97,674,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02826:Pde4dip
|
APN |
3 |
97,674,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D3080:Pde4dip
|
UTSW |
3 |
97,674,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Pde4dip
|
UTSW |
3 |
97,660,442 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Pde4dip
|
UTSW |
3 |
97,674,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0277:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0304:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0616:Pde4dip
|
UTSW |
3 |
97,654,849 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0676:Pde4dip
|
UTSW |
3 |
97,624,413 (GRCm39) |
splice site |
probably benign |
|
|
R1166:Pde4dip
|
UTSW |
3 |
97,620,512 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Pde4dip
|
UTSW |
3 |
97,631,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1550:Pde4dip
|
UTSW |
3 |
97,627,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1700:Pde4dip
|
UTSW |
3 |
97,610,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1704:Pde4dip
|
UTSW |
3 |
97,661,576 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1769:Pde4dip
|
UTSW |
3 |
97,603,246 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1980:Pde4dip
|
UTSW |
3 |
97,664,312 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2088:Pde4dip
|
UTSW |
3 |
97,661,749 (GRCm39) |
missense |
probably null |
1.00 |
|
R2143:Pde4dip
|
UTSW |
3 |
97,795,835 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2149:Pde4dip
|
UTSW |
3 |
97,700,152 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2156:Pde4dip
|
UTSW |
3 |
97,631,534 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2158:Pde4dip
|
UTSW |
3 |
97,664,937 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2240:Pde4dip
|
UTSW |
3 |
97,631,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2249:Pde4dip
|
UTSW |
3 |
97,700,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2256:Pde4dip
|
UTSW |
3 |
97,625,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Pde4dip
|
UTSW |
3 |
97,608,933 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2921:Pde4dip
|
UTSW |
3 |
97,626,885 (GRCm39) |
missense |
probably benign |
|
|
R3407:Pde4dip
|
UTSW |
3 |
97,661,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3736:Pde4dip
|
UTSW |
3 |
97,631,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3787:Pde4dip
|
UTSW |
3 |
97,622,868 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3883:Pde4dip
|
UTSW |
3 |
97,620,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4437:Pde4dip
|
UTSW |
3 |
97,673,885 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4528:Pde4dip
|
UTSW |
3 |
97,624,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Pde4dip
|
UTSW |
3 |
97,661,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4600:Pde4dip
|
UTSW |
3 |
97,603,260 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4653:Pde4dip
|
UTSW |
3 |
97,674,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4678:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4679:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Pde4dip
|
UTSW |
3 |
97,750,993 (GRCm39) |
nonsense |
probably null |
|
|
R4770:Pde4dip
|
UTSW |
3 |
97,674,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4841:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Pde4dip
|
UTSW |
3 |
97,616,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Pde4dip
|
UTSW |
3 |
97,622,644 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4943:Pde4dip
|
UTSW |
3 |
97,662,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5131:Pde4dip
|
UTSW |
3 |
97,616,830 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5408:Pde4dip
|
UTSW |
3 |
97,704,052 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5583:Pde4dip
|
UTSW |
3 |
97,654,892 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5677:Pde4dip
|
UTSW |
3 |
97,748,964 (GRCm39) |
nonsense |
probably null |
|
|
R5689:Pde4dip
|
UTSW |
3 |
97,599,683 (GRCm39) |
nonsense |
probably null |
|
|
R5696:Pde4dip
|
UTSW |
3 |
97,616,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5860:Pde4dip
|
UTSW |
3 |
97,631,504 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6279:Pde4dip
|
UTSW |
3 |
97,606,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6341:Pde4dip
|
UTSW |
3 |
97,602,227 (GRCm39) |
missense |
probably benign |
|
|
R6440:Pde4dip
|
UTSW |
3 |
97,674,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Pde4dip
|
UTSW |
3 |
97,617,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Pde4dip
|
UTSW |
3 |
97,662,907 (GRCm39) |
nonsense |
probably null |
|
|
R6706:Pde4dip
|
UTSW |
3 |
97,648,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6722:Pde4dip
|
UTSW |
3 |
97,625,555 (GRCm39) |
nonsense |
probably null |
|
|
R6798:Pde4dip
|
UTSW |
3 |
97,795,850 (GRCm39) |
missense |
probably benign |
|
|
R6804:Pde4dip
|
UTSW |
3 |
97,700,564 (GRCm39) |
nonsense |
probably null |
|
|
R6862:Pde4dip
|
UTSW |
3 |
97,674,340 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6957:Pde4dip
|
UTSW |
3 |
97,731,649 (GRCm39) |
splice site |
probably null |
|
|
R6983:Pde4dip
|
UTSW |
3 |
97,625,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7014:Pde4dip
|
UTSW |
3 |
97,622,738 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7025:Pde4dip
|
UTSW |
3 |
97,631,499 (GRCm39) |
nonsense |
probably null |
|
|
R7136:Pde4dip
|
UTSW |
3 |
97,601,379 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7178:Pde4dip
|
UTSW |
3 |
97,622,946 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7269:Pde4dip
|
UTSW |
3 |
97,674,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Pde4dip
|
UTSW |
3 |
97,666,198 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7354:Pde4dip
|
UTSW |
3 |
97,626,646 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7357:Pde4dip
|
UTSW |
3 |
97,622,857 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7360:Pde4dip
|
UTSW |
3 |
97,625,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7371:Pde4dip
|
UTSW |
3 |
97,664,587 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7432:Pde4dip
|
UTSW |
3 |
97,602,408 (GRCm39) |
missense |
probably benign |
|
|
R7536:Pde4dip
|
UTSW |
3 |
97,664,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7542:Pde4dip
|
UTSW |
3 |
97,673,971 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7609:Pde4dip
|
UTSW |
3 |
97,622,881 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7650:Pde4dip
|
UTSW |
3 |
97,606,423 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7800:Pde4dip
|
UTSW |
3 |
97,622,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Pde4dip
|
UTSW |
3 |
97,622,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Pde4dip
|
UTSW |
3 |
97,622,539 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Pde4dip
|
UTSW |
3 |
97,614,254 (GRCm39) |
missense |
probably null |
0.94 |
|
R8139:Pde4dip
|
UTSW |
3 |
97,604,309 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8144:Pde4dip
|
UTSW |
3 |
97,622,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Pde4dip
|
UTSW |
3 |
97,674,848 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8294:Pde4dip
|
UTSW |
3 |
97,674,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8406:Pde4dip
|
UTSW |
3 |
97,606,428 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8911:Pde4dip
|
UTSW |
3 |
97,650,917 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8912:Pde4dip
|
UTSW |
3 |
97,617,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8960:Pde4dip
|
UTSW |
3 |
97,700,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8993:Pde4dip
|
UTSW |
3 |
97,673,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9031:Pde4dip
|
UTSW |
3 |
97,599,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9032:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9085:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9103:Pde4dip
|
UTSW |
3 |
97,749,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9163:Pde4dip
|
UTSW |
3 |
97,659,123 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9182:Pde4dip
|
UTSW |
3 |
97,602,314 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9185:Pde4dip
|
UTSW |
3 |
97,666,132 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9286:Pde4dip
|
UTSW |
3 |
97,607,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9357:Pde4dip
|
UTSW |
3 |
97,625,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9415:Pde4dip
|
UTSW |
3 |
97,660,468 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9500:Pde4dip
|
UTSW |
3 |
97,795,896 (GRCm39) |
missense |
unknown |
|
|
R9595:Pde4dip
|
UTSW |
3 |
97,602,207 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9689:Pde4dip
|
UTSW |
3 |
97,649,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Pde4dip
|
UTSW |
3 |
97,603,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGCAGGGTCTCAGCTACTG -3'
(R):5'- TGTCTCCTGCTGGCATTAGG -3'
Sequencing Primer
(F):5'- TGGCCTGTTGCTAGCCAC -3'
(R):5'- CATTACAGATGGTTGTGAGCCACC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation