Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02552:Kcnma1'

298172

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Kcnma1

Ensembl Gene

ENSMUSG00000063142

Gene Name

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Synonyms

MaxiK, BKCa, 5730414M22Rik, BK channel alpha subunit, Slo, Slo1, mSlo1

Accession Numbers

Essential gene?

Probably essential (E-score: 0.856) question?

Stock #

IGL02552

Quality Score

Status

Chromosome

Chromosomal Location

23342356-24055173 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 23436327 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000152959 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065788] [ENSMUST00000074983] [ENSMUST00000100831] [ENSMUST00000112423] [ENSMUST00000145596] [ENSMUST00000163322] [ENSMUST00000172099] [ENSMUST00000190985] [ENSMUST00000179836] [ENSMUST00000179097] [ENSMUST00000190044] [ENSMUST00000177634] [ENSMUST00000188210] [ENSMUST00000188991] [ENSMUST00000188285] [ENSMUST00000223727] [ENSMUST00000224077] [ENSMUST00000223655] [ENSMUST00000223749] [ENSMUST00000224285] [ENSMUST00000225794] [ENSMUST00000225556] [ENSMUST00000224468] [ENSMUST00000224787] [ENSMUST00000225431] [ENSMUST00000224812] [ENSMUST00000225471] [ENSMUST00000224232] [ENSMUST00000225315]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000065788

SMART Domains

Protein: ENSMUSP00000065293
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
transmembrane domain	54	73	N/A	INTRINSIC
Pfam:Ion_trans	91	262	2.2e-18	PFAM
Pfam:Ion_trans_2	180	268	5.7e-16	PFAM
Pfam:TrkA_N	314	413	7.5e-7	PFAM
Pfam:BK_channel_a	411	509	6.4e-31	PFAM
low complexity region	835	843	N/A	INTRINSIC
low complexity region	891	902	N/A	INTRINSIC
low complexity region	1005	1031	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000074983

SMART Domains

Protein: ENSMUSP00000074511
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
transmembrane domain	54	73	N/A	INTRINSIC
Pfam:Ion_trans	91	262	2.2e-18	PFAM
Pfam:Ion_trans_2	180	268	5.7e-16	PFAM
Pfam:TrkA_N	314	413	7.5e-7	PFAM
Pfam:BK_channel_a	411	509	6.4e-31	PFAM
low complexity region	894	902	N/A	INTRINSIC
low complexity region	950	961	N/A	INTRINSIC
low complexity region	1064	1090	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000100831

SMART Domains

Protein: ENSMUSP00000098393
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
transmembrane domain	54	73	N/A	INTRINSIC
Pfam:Ion_trans	91	262	2.1e-18	PFAM
Pfam:Ion_trans_2	180	268	5.5e-16	PFAM
Pfam:TrkA_N	314	413	7.3e-7	PFAM
Pfam:BK_channel_a	411	509	6.2e-31	PFAM
low complexity region	865	873	N/A	INTRINSIC
low complexity region	921	932	N/A	INTRINSIC
low complexity region	1035	1061	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000112423

SMART Domains

Protein: ENSMUSP00000108042
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
transmembrane domain	2	19	N/A	INTRINSIC
Pfam:Ion_trans	37	208	2.1e-18	PFAM
Pfam:Ion_trans_2	126	214	5.3e-16	PFAM
Pfam:TrkA_N	260	359	7e-7	PFAM
Pfam:BK_channel_a	357	455	6e-31	PFAM
low complexity region	781	789	N/A	INTRINSIC
low complexity region	837	848	N/A	INTRINSIC
low complexity region	951	977	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000145596

Predicted Effect

probably null
Transcript: ENSMUST00000163322

SMART Domains

Protein: ENSMUSP00000128553
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
transmembrane domain	54	73	N/A	INTRINSIC
Pfam:Ion_trans	91	262	3.2e-18	PFAM
Pfam:Ion_trans_2	180	268	1.1e-15	PFAM
Pfam:TrkA_N	314	413	7e-7	PFAM
Pfam:BK_channel_a	411	509	6e-31	PFAM
low complexity region	832	840	N/A	INTRINSIC
low complexity region	888	899	N/A	INTRINSIC
low complexity region	1002	1028	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000172099

SMART Domains

Protein: ENSMUSP00000132204
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
transmembrane domain	54	73	N/A	INTRINSIC
Pfam:Ion_trans	91	262	2.2e-18	PFAM
Pfam:Ion_trans_2	180	268	5.7e-16	PFAM
Pfam:TrkA_N	314	413	7.6e-7	PFAM
Pfam:BK_channel_a	411	509	6.5e-31	PFAM
low complexity region	897	905	N/A	INTRINSIC
low complexity region	953	964	N/A	INTRINSIC
low complexity region	1067	1093	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190985

Predicted Effect

probably null
Transcript: ENSMUST00000179836

SMART Domains

Protein: ENSMUSP00000137141
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
transmembrane domain	54	73	N/A	INTRINSIC
Pfam:Ion_trans	91	262	4.2e-18	PFAM
Pfam:Ion_trans_2	180	268	9.5e-16	PFAM
Pfam:BK_channel_a	389	457	2.4e-15	PFAM
low complexity region	838	846	N/A	INTRINSIC
low complexity region	894	905	N/A	INTRINSIC
low complexity region	1008	1034	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000179097

SMART Domains

Protein: ENSMUSP00000136568
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
transmembrane domain	54	73	N/A	INTRINSIC
Pfam:Ion_trans	91	262	4.6e-18	PFAM
Pfam:Ion_trans_2	180	268	1e-15	PFAM
Pfam:TrkA_N	314	413	1.1e-7	PFAM
Pfam:BK_channel_a	411	509	3.2e-31	PFAM
low complexity region	859	867	N/A	INTRINSIC
low complexity region	915	926	N/A	INTRINSIC
low complexity region	1029	1055	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000190044

SMART Domains

Protein: ENSMUSP00000140033
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	1.3e-18	PFAM
Pfam:Ion_trans_2	305	393	5.1e-16	PFAM
Pfam:TrkA_N	439	538	7.5e-7	PFAM
Pfam:BK_channel_a	536	634	4.9e-31	PFAM
low complexity region	957	965	N/A	INTRINSIC
low complexity region	1013	1024	N/A	INTRINSIC
low complexity region	1127	1153	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000177634

SMART Domains

Protein: ENSMUSP00000136447
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	20	31	N/A	INTRINSIC
Pfam:Ion_trans	53	272	4.9e-19	PFAM
Pfam:Ion_trans_2	180	267	1.2e-15	PFAM
Pfam:BK_channel_a	413	508	1.2e-35	PFAM
low complexity region	862	870	N/A	INTRINSIC
low complexity region	918	929	N/A	INTRINSIC
low complexity region	1032	1058	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000188210

SMART Domains

Protein: ENSMUSP00000141069
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	1.3e-18	PFAM
Pfam:Ion_trans_2	305	393	5.2e-16	PFAM
Pfam:TrkA_N	439	538	7.8e-7	PFAM
Pfam:BK_channel_a	536	634	5e-31	PFAM
low complexity region	988	996	N/A	INTRINSIC
low complexity region	1044	1055	N/A	INTRINSIC
low complexity region	1158	1184	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000188991

SMART Domains

Protein: ENSMUSP00000140751
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	3.3e-18	PFAM
Pfam:Ion_trans_2	305	393	1.1e-15	PFAM
Pfam:TrkA_N	439	538	3.7e-7	PFAM
Pfam:BK_channel_a	536	634	3.4e-31	PFAM
low complexity region	1015	1023	N/A	INTRINSIC
low complexity region	1071	1082	N/A	INTRINSIC
low complexity region	1185	1211	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000188285

SMART Domains

Protein: ENSMUSP00000140275
Gene: ENSMUSG00000063142

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
transmembrane domain	86	108	N/A	INTRINSIC
low complexity region	145	156	N/A	INTRINSIC
transmembrane domain	179	198	N/A	INTRINSIC
Pfam:Ion_trans	216	387	1.3e-18	PFAM
Pfam:Ion_trans_2	305	393	5.4e-16	PFAM
Pfam:TrkA_N	439	538	8e-7	PFAM
Pfam:BK_channel_a	536	634	5.2e-31	PFAM
low complexity region	1019	1027	N/A	INTRINSIC
low complexity region	1075	1086	N/A	INTRINSIC
low complexity region	1189	1215	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212542

Predicted Effect

probably null
Transcript: ENSMUST00000223727

Predicted Effect

probably null
Transcript: ENSMUST00000224077

Predicted Effect

probably null
Transcript: ENSMUST00000224025

Predicted Effect

probably null
Transcript: ENSMUST00000223655

Predicted Effect

probably null
Transcript: ENSMUST00000223749

Predicted Effect

probably null
Transcript: ENSMUST00000224285

Predicted Effect

probably benign
Transcript: ENSMUST00000225794

Predicted Effect

probably null
Transcript: ENSMUST00000225556

Predicted Effect

probably null
Transcript: ENSMUST00000224468

Predicted Effect

probably null
Transcript: ENSMUST00000224787

Predicted Effect

probably null
Transcript: ENSMUST00000225431

Predicted Effect

probably null
Transcript: ENSMUST00000224812

Predicted Effect

probably null
Transcript: ENSMUST00000225471

Predicted Effect

probably null
Transcript: ENSMUST00000224232

Predicted Effect

probably null
Transcript: ENSMUST00000225315

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous inactivation of this gene leads to cerebellar ataxia, Purkinje cell dysfunction, uneven gait patterns, bladder hyperactivity, urinary incontinence, abnormal colonic K+ secretion, and hearing impairment. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	G	3: 124,208,145 (GRCm39)	L178S	probably damaging	Het
Abca12	A	G	1: 71,333,906 (GRCm39)	Y1199H	probably damaging	Het
Abcc9	T	C	6: 142,551,645 (GRCm39)	D1221G	possibly damaging	Het
Apc	T	A	18: 34,446,035 (GRCm39)	M977K	possibly damaging	Het
Arhgap30	T	A	1: 171,235,324 (GRCm39)	L566Q	probably damaging	Het
Arhgap40	T	A	2: 158,388,721 (GRCm39)	W552R	probably benign	Het
Astn1	C	T	1: 158,332,965 (GRCm39)	S349F	possibly damaging	Het
Bard1	T	C	1: 71,104,815 (GRCm39)		probably benign	Het
Batf2	T	A	19: 6,221,537 (GRCm39)	Y116N	probably benign	Het
Bltp3b	T	A	10: 89,642,605 (GRCm39)	L10*	probably null	Het
Cbx6	T	C	15: 79,713,094 (GRCm39)	H111R	probably damaging	Het
Cd44	T	A	2: 102,679,076 (GRCm39)	N242I	probably benign	Het
Cdnf	C	T	2: 3,525,012 (GRCm39)	Q184*	probably null	Het
Chd2	C	A	7: 73,097,068 (GRCm39)		probably benign	Het
Cmtm6	G	A	9: 114,566,374 (GRCm39)	V88M	probably damaging	Het
Col24a1	C	A	3: 145,179,962 (GRCm39)	S1151R	possibly damaging	Het
Csta2	A	G	16: 36,073,459 (GRCm39)	E15G	probably damaging	Het
Degs1l	T	A	1: 180,882,463 (GRCm39)	V75E	possibly damaging	Het
Dnajc2	T	C	5: 21,988,061 (GRCm39)	D6G	probably damaging	Het
Eif3a	G	A	19: 60,751,664 (GRCm39)		probably benign	Het
Fbn1	C	A	2: 125,254,633 (GRCm39)	C210F	possibly damaging	Het
Fmn2	T	A	1: 174,523,286 (GRCm39)	D1380E	probably damaging	Het
Fry	A	T	5: 150,304,375 (GRCm39)	K588N	probably damaging	Het
Gm18856	G	A	13: 14,139,805 (GRCm39)		probably benign	Het
Gpr37	G	T	6: 25,688,686 (GRCm39)	T137K	probably benign	Het
Gzmc	T	C	14: 56,472,039 (GRCm39)	M1V	probably null	Het
Htr5a	T	C	5: 28,047,958 (GRCm39)	V171A	probably benign	Het
Ints6l	T	C	X: 55,500,557 (GRCm39)		probably benign	Het
Krt35	C	T	11: 99,983,899 (GRCm39)	G367D	probably benign	Het
Nlrp1b	C	T	11: 71,063,057 (GRCm39)	V668I	possibly damaging	Het
Nlrp1b	C	T	11: 71,072,878 (GRCm39)	V322I	possibly damaging	Het
Ntf3	T	C	6: 126,078,823 (GRCm39)	N228D	probably damaging	Het
Nup133	G	A	8: 124,655,994 (GRCm39)	R496W	possibly damaging	Het
Or4c10	T	C	2: 89,760,903 (GRCm39)	V250A	probably benign	Het
Or51i1	C	A	7: 103,671,463 (GRCm39)	G21W	probably damaging	Het
Pah	C	T	10: 87,414,707 (GRCm39)		probably benign	Het
Pan2	G	T	10: 128,154,896 (GRCm39)	W1112L	probably damaging	Het
Pkn3	G	A	2: 29,970,879 (GRCm39)	R209Q	probably damaging	Het
Plaa	C	T	4: 94,470,717 (GRCm39)		probably null	Het
Qprt	C	T	7: 126,708,027 (GRCm39)	A135T	probably damaging	Het
Rbbp6	T	G	7: 122,582,204 (GRCm39)	S108A	probably damaging	Het
Smg1	T	A	7: 117,795,117 (GRCm39)		probably benign	Het
Spink5	T	A	18: 44,125,235 (GRCm39)	C368S	possibly damaging	Het
Sptan1	T	A	2: 29,908,486 (GRCm39)	I1734N	probably damaging	Het
Stk38l	C	T	6: 146,669,031 (GRCm39)	L170F	probably damaging	Het
Tesmin	C	T	19: 3,452,483 (GRCm39)		probably benign	Het
Tjp1	A	T	7: 64,949,530 (GRCm39)	C1697*	probably null	Het
Tmco4	T	C	4: 138,785,690 (GRCm39)	S587P	probably benign	Het
Tmem208	G	A	8: 106,055,329 (GRCm39)		probably null	Het
Trim30d	T	C	7: 104,121,623 (GRCm39)	Q224R	probably damaging	Het
Trpm7	T	A	2: 126,682,699 (GRCm39)	D390V	probably damaging	Het
Uba7	A	G	9: 107,858,589 (GRCm39)	I807V	probably benign	Het
Utp18	C	A	11: 93,759,160 (GRCm39)	C438F	probably damaging	Het
Vps13d	T	C	4: 144,899,707 (GRCm39)	K191E	possibly damaging	Het
Wdr27	A	G	17: 15,146,453 (GRCm39)	S181P	probably damaging	Het
Zfp462	T	C	4: 55,010,613 (GRCm39)	Y860H	probably damaging	Het

Other mutations in Kcnma1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01318:Kcnma1	APN	14	23,364,390 (GRCm39)	splice site	probably benign
IGL01520:Kcnma1	APN	14	23,551,211 (GRCm39)	missense	possibly damaging	0.94
IGL01977:Kcnma1	APN	14	23,580,367 (GRCm39)	splice site	probably benign
IGL02140:Kcnma1	APN	14	23,359,113 (GRCm39)	missense	probably damaging	1.00
IGL02165:Kcnma1	APN	14	23,387,035 (GRCm39)	missense	possibly damaging	0.93
IGL02186:Kcnma1	APN	14	23,576,881 (GRCm39)	missense	probably benign	0.28
IGL02268:Kcnma1	APN	14	23,593,144 (GRCm39)	missense	probably damaging	1.00
IGL02353:Kcnma1	APN	14	23,641,681 (GRCm39)	missense	probably damaging	1.00
IGL02360:Kcnma1	APN	14	23,641,681 (GRCm39)	missense	probably damaging	1.00
IGL02491:Kcnma1	APN	14	23,361,757 (GRCm39)	missense	probably damaging	1.00
IGL02625:Kcnma1	APN	14	23,413,900 (GRCm39)	missense	probably damaging	1.00
IGL02677:Kcnma1	APN	14	23,513,224 (GRCm39)	missense	probably damaging	1.00
IGL02706:Kcnma1	APN	14	23,359,222 (GRCm39)	missense	probably damaging	1.00
G1citation:Kcnma1	UTSW	14	24,053,812 (GRCm39)	splice site	probably null
PIT4495001:Kcnma1	UTSW	14	23,475,665 (GRCm39)	missense	probably benign	0.00
PIT4514001:Kcnma1	UTSW	14	23,359,103 (GRCm39)	splice site	probably null
PIT4576001:Kcnma1	UTSW	14	23,359,103 (GRCm39)	splice site	probably null
R0071:Kcnma1	UTSW	14	23,576,835 (GRCm39)	missense	probably damaging	1.00
R0071:Kcnma1	UTSW	14	23,576,835 (GRCm39)	missense	probably damaging	1.00
R0115:Kcnma1	UTSW	14	23,364,243 (GRCm39)	missense	probably damaging	1.00
R0172:Kcnma1	UTSW	14	23,853,234 (GRCm39)	missense	probably damaging	1.00
R0178:Kcnma1	UTSW	14	23,576,835 (GRCm39)	missense	probably damaging	1.00
R0183:Kcnma1	UTSW	14	23,558,120 (GRCm39)	missense	probably damaging	1.00
R0240:Kcnma1	UTSW	14	23,544,647 (GRCm39)	missense	probably damaging	1.00
R0240:Kcnma1	UTSW	14	23,544,647 (GRCm39)	missense	probably damaging	1.00
R0328:Kcnma1	UTSW	14	23,423,265 (GRCm39)	missense	probably damaging	1.00
R0501:Kcnma1	UTSW	14	23,361,784 (GRCm39)	missense	possibly damaging	0.80
R0631:Kcnma1	UTSW	14	23,559,852 (GRCm39)	splice site	probably benign
R0668:Kcnma1	UTSW	14	23,417,563 (GRCm39)	missense	probably damaging	1.00
R0811:Kcnma1	UTSW	14	23,350,086 (GRCm39)	missense	probably damaging	0.96
R0812:Kcnma1	UTSW	14	23,350,086 (GRCm39)	missense	probably damaging	0.96
R1080:Kcnma1	UTSW	14	23,544,675 (GRCm39)	missense	probably damaging	1.00
R1419:Kcnma1	UTSW	14	23,417,710 (GRCm39)	missense	probably damaging	0.99
R1446:Kcnma1	UTSW	14	23,361,792 (GRCm39)	missense	probably damaging	1.00
R1454:Kcnma1	UTSW	14	23,513,268 (GRCm39)	missense	probably damaging	1.00
R1651:Kcnma1	UTSW	14	23,364,262 (GRCm39)	missense	probably damaging	1.00
R1826:Kcnma1	UTSW	14	23,380,997 (GRCm39)	missense	probably damaging	1.00
R1827:Kcnma1	UTSW	14	23,380,997 (GRCm39)	missense	probably damaging	1.00
R1828:Kcnma1	UTSW	14	23,380,997 (GRCm39)	missense	probably damaging	1.00
R1864:Kcnma1	UTSW	14	23,853,230 (GRCm39)	missense	probably damaging	1.00
R2002:Kcnma1	UTSW	14	23,387,097 (GRCm39)	missense	probably damaging	0.99
R2140:Kcnma1	UTSW	14	23,364,288 (GRCm39)	missense	probably damaging	1.00
R2278:Kcnma1	UTSW	14	23,593,151 (GRCm39)	nonsense	probably null
R2866:Kcnma1	UTSW	14	23,423,275 (GRCm39)	missense	probably benign	0.16
R2867:Kcnma1	UTSW	14	23,423,275 (GRCm39)	missense	probably benign	0.16
R2867:Kcnma1	UTSW	14	23,423,275 (GRCm39)	missense	probably benign	0.16
R2900:Kcnma1	UTSW	14	23,853,228 (GRCm39)	missense	probably damaging	1.00
R3820:Kcnma1	UTSW	14	23,350,006 (GRCm39)	missense	possibly damaging	0.66
R3821:Kcnma1	UTSW	14	23,417,679 (GRCm39)	missense	probably damaging	1.00
R3901:Kcnma1	UTSW	14	23,555,323 (GRCm39)	missense	probably damaging	0.98
R3975:Kcnma1	UTSW	14	24,053,815 (GRCm39)	critical splice donor site	probably null
R3976:Kcnma1	UTSW	14	24,053,815 (GRCm39)	critical splice donor site	probably null
R4352:Kcnma1	UTSW	14	23,361,720 (GRCm39)	missense	probably damaging	1.00
R4517:Kcnma1	UTSW	14	23,387,097 (GRCm39)	missense	probably damaging	1.00
R4598:Kcnma1	UTSW	14	23,853,228 (GRCm39)	missense	probably damaging	1.00
R4604:Kcnma1	UTSW	14	23,359,106 (GRCm39)	critical splice donor site	probably null
R4743:Kcnma1	UTSW	14	23,853,270 (GRCm39)	missense	probably damaging	1.00
R4754:Kcnma1	UTSW	14	23,413,904 (GRCm39)	missense	probably damaging	0.96
R4908:Kcnma1	UTSW	14	23,359,220 (GRCm39)	missense	probably damaging	0.99
R4960:Kcnma1	UTSW	14	24,054,186 (GRCm39)	intron	probably benign
R5175:Kcnma1	UTSW	14	23,386,106 (GRCm39)	critical splice donor site	probably null
R5218:Kcnma1	UTSW	14	23,513,253 (GRCm39)	missense	probably damaging	0.96
R5435:Kcnma1	UTSW	14	23,578,472 (GRCm39)	nonsense	probably null
R5705:Kcnma1	UTSW	14	24,053,839 (GRCm39)	missense	possibly damaging	0.73
R5746:Kcnma1	UTSW	14	23,544,635 (GRCm39)	missense	probably damaging	1.00
R5780:Kcnma1	UTSW	14	23,436,419 (GRCm39)	nonsense	probably null
R5793:Kcnma1	UTSW	14	23,359,103 (GRCm39)	splice site	probably null
R6039:Kcnma1	UTSW	14	23,359,105 (GRCm39)	missense	probably benign	0.42
R6039:Kcnma1	UTSW	14	23,359,105 (GRCm39)	missense	probably benign	0.42
R6133:Kcnma1	UTSW	14	24,053,936 (GRCm39)	missense	probably damaging	0.98
R6271:Kcnma1	UTSW	14	23,559,957 (GRCm39)	missense	probably damaging	1.00
R6490:Kcnma1	UTSW	14	23,386,165 (GRCm39)	missense	possibly damaging	0.46
R6704:Kcnma1	UTSW	14	24,052,882 (GRCm39)	nonsense	probably null
R6822:Kcnma1	UTSW	14	24,053,812 (GRCm39)	splice site	probably null
R6855:Kcnma1	UTSW	14	23,417,679 (GRCm39)	missense	probably damaging	1.00
R6920:Kcnma1	UTSW	14	23,576,602 (GRCm39)	critical splice donor site	probably null
R7017:Kcnma1	UTSW	14	23,544,711 (GRCm39)	missense	possibly damaging	0.79
R7081:Kcnma1	UTSW	14	23,350,086 (GRCm39)	missense	probably damaging	0.96
R7113:Kcnma1	UTSW	14	23,513,224 (GRCm39)	missense	probably damaging	1.00
R7131:Kcnma1	UTSW	14	23,417,562 (GRCm39)	missense	probably damaging	1.00
R7172:Kcnma1	UTSW	14	23,576,691 (GRCm39)	missense	probably damaging	1.00
R7207:Kcnma1	UTSW	14	23,359,083 (GRCm39)	makesense	probably null
R7308:Kcnma1	UTSW	14	23,381,003 (GRCm39)	missense	probably damaging	0.99
R7371:Kcnma1	UTSW	14	23,544,638 (GRCm39)	missense	possibly damaging	0.94
R7404:Kcnma1	UTSW	14	24,052,902 (GRCm39)	missense	unknown
R7560:Kcnma1	UTSW	14	23,580,310 (GRCm39)	missense	probably benign	0.15
R7693:Kcnma1	UTSW	14	23,417,680 (GRCm39)	missense	probably damaging	1.00
R7763:Kcnma1	UTSW	14	23,350,074 (GRCm39)	missense	possibly damaging	0.66
R7809:Kcnma1	UTSW	14	23,423,324 (GRCm39)	missense	probably benign	0.16
R7832:Kcnma1	UTSW	14	23,440,991 (GRCm39)	missense	probably benign
R7884:Kcnma1	UTSW	14	23,387,057 (GRCm39)	missense	probably benign	0.01
R8013:Kcnma1	UTSW	14	23,423,211 (GRCm39)	missense	probably benign	0.31
R8014:Kcnma1	UTSW	14	23,423,211 (GRCm39)	missense	probably benign	0.31
R8066:Kcnma1	UTSW	14	23,361,744 (GRCm39)	missense	probably benign	0.00
R8097:Kcnma1	UTSW	14	23,381,032 (GRCm39)	missense	probably damaging	1.00
R8154:Kcnma1	UTSW	14	23,361,822 (GRCm39)	missense	possibly damaging	0.62
R8507:Kcnma1	UTSW	14	23,641,706 (GRCm39)	missense	probably benign	0.00
R8672:Kcnma1	UTSW	14	23,551,230 (GRCm39)	missense	probably damaging	1.00
R8677:Kcnma1	UTSW	14	23,436,418 (GRCm39)	missense	probably benign	0.36
R8725:Kcnma1	UTSW	14	23,436,332 (GRCm39)	missense	probably benign	0.00
R8727:Kcnma1	UTSW	14	23,436,332 (GRCm39)	missense	probably benign	0.00
R8827:Kcnma1	UTSW	14	23,417,548 (GRCm39)	missense	probably damaging	1.00
R8880:Kcnma1	UTSW	14	23,417,718 (GRCm39)	missense	probably damaging	1.00
R8997:Kcnma1	UTSW	14	23,513,037 (GRCm39)	intron	probably benign
R9056:Kcnma1	UTSW	14	23,700,214 (GRCm39)	missense	possibly damaging	0.80
R9346:Kcnma1	UTSW	14	23,700,233 (GRCm39)	missense	possibly damaging	0.94
R9403:Kcnma1	UTSW	14	23,593,145 (GRCm39)	missense	probably benign	0.05
R9438:Kcnma1	UTSW	14	23,417,653 (GRCm39)	missense	probably benign	0.00
R9482:Kcnma1	UTSW	14	23,441,033 (GRCm39)	missense	probably benign
R9511:Kcnma1	UTSW	14	23,361,793 (GRCm39)	missense	possibly damaging	0.90
R9649:Kcnma1	UTSW	14	23,501,666 (GRCm39)	critical splice donor site	probably null
R9663:Kcnma1	UTSW	14	24,053,897 (GRCm39)	missense	probably benign	0.15
R9673:Kcnma1	UTSW	14	23,558,123 (GRCm39)	missense	probably benign	0.01
RF001:Kcnma1	UTSW	14	23,361,765 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16