Incidental Mutation 'R4601:Dennd3'
ID 345665
Institutional Source Beutler Lab
Gene Symbol Dennd3
Ensembl Gene ENSMUSG00000036661
Gene Name DENN domain containing 3
Synonyms E030003N15Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R4601 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 73384409-73444091 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 73439009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 1126 (W1126R)
Ref Sequence ENSEMBL: ENSMUSP00000134002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043414] [ENSMUST00000160267] [ENSMUST00000173292]
AlphaFold A2RT67
Predicted Effect probably benign
Transcript: ENSMUST00000043414
AA Change: W1126R

PolyPhen 2 Score 0.316 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000046774
Gene: ENSMUSG00000036661
AA Change: W1126R

DomainStartEndE-ValueType
Blast:uDENN 12 161 3e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
WD40 1232 1272 1.1e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159322
Predicted Effect probably benign
Transcript: ENSMUST00000160267
SMART Domains Protein: ENSMUSP00000124538
Gene: ENSMUSG00000036661

DomainStartEndE-ValueType
Blast:WD40 51 90 2e-9 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160727
Predicted Effect
SMART Domains Protein: ENSMUSP00000125657
Gene: ENSMUSG00000036661
AA Change: W1002R

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Blast:DENN 33 104 5e-28 BLAST
DENN 116 302 1.54e-62 SMART
dDENN 312 376 5.63e-6 SMART
WD40 892 931 3.68e1 SMART
WD40 934 975 3.32e-5 SMART
WD40 1109 1149 1.1e1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000173292
AA Change: W1126R

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000134002
Gene: ENSMUSG00000036661
AA Change: W1126R

DomainStartEndE-ValueType
Blast:uDENN 12 161 2e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 91 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 T A 17: 45,827,847 (GRCm39) D555E probably damaging Het
Abca16 T G 7: 120,035,920 (GRCm39) F334L probably damaging Het
Abcc4 T A 14: 118,869,575 (GRCm39) M186L probably benign Het
Agap3 T C 5: 24,681,406 (GRCm39) L120P probably damaging Het
Ak7 G A 12: 105,679,834 (GRCm39) V123M probably benign Het
Aldh1a7 A T 19: 20,693,343 (GRCm39) V192D probably damaging Het
Ankrd36 A G 11: 5,520,102 (GRCm39) D59G probably benign Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Cacna1e A G 1: 154,347,359 (GRCm39) V936A probably benign Het
Camkv T C 9: 107,823,295 (GRCm39) V107A probably damaging Het
Camp T C 9: 109,677,730 (GRCm39) E80G probably damaging Het
Cblif A C 19: 11,729,554 (GRCm39) D171A probably damaging Het
Ccdc66 T C 14: 27,222,377 (GRCm39) N122S probably damaging Het
Cd101 G A 3: 100,901,204 (GRCm39) T960M possibly damaging Het
Cdk18 A G 1: 132,044,657 (GRCm39) V323A possibly damaging Het
Celf2 G T 2: 6,590,831 (GRCm39) N279K possibly damaging Het
Cemip T C 7: 83,600,826 (GRCm39) I932V probably damaging Het
Cep250 C A 2: 155,803,973 (GRCm39) Q28K probably benign Het
Ces2f T C 8: 105,676,596 (GRCm39) C97R probably damaging Het
Cfap126 G T 1: 170,941,627 (GRCm39) G41C possibly damaging Het
Cfap96 A T 8: 46,423,505 (GRCm39) I69N probably damaging Het
Chat T C 14: 32,146,112 (GRCm39) M354V probably benign Het
Clca4b A T 3: 144,632,945 (GRCm39) D168E possibly damaging Het
Cpxm1 T A 2: 130,235,496 (GRCm39) M499L possibly damaging Het
Dgkb T C 12: 38,652,819 (GRCm39) S735P probably damaging Het
Dlec1 T C 9: 118,976,202 (GRCm39) probably null Het
Dnajc6 T C 4: 101,468,461 (GRCm39) F166L probably damaging Het
Dph5 A G 3: 115,693,426 (GRCm39) N115D possibly damaging Het
Ercc3 G A 18: 32,378,624 (GRCm39) A202T probably benign Het
Erich3 A T 3: 154,470,375 (GRCm39) D136V unknown Het
Exoc2 T C 13: 31,066,251 (GRCm39) N475S probably benign Het
Fam217a T C 13: 35,095,285 (GRCm39) D310G probably damaging Het
Fam53a C T 5: 33,758,007 (GRCm39) S372N probably benign Het
Fbn2 C G 18: 58,186,805 (GRCm39) G1699R probably damaging Het
Fbxo46 T C 7: 18,869,489 (GRCm39) V36A probably benign Het
Fhip1a T C 3: 85,648,487 (GRCm39) M26V probably damaging Het
G6pc1 A G 11: 101,263,567 (GRCm39) Y127C probably damaging Het
Gba2 A G 4: 43,573,810 (GRCm39) F161L probably damaging Het
Gja1 T C 10: 56,264,325 (GRCm39) L228P probably damaging Het
Gm20834 A G Y: 10,323,178 (GRCm39) V86A probably benign Het
Hmcn1 A T 1: 150,614,396 (GRCm39) C1337S probably damaging Het
Il1rl1 T A 1: 40,480,460 (GRCm39) S30T possibly damaging Het
Itgb4 A G 11: 115,896,548 (GRCm39) T1436A probably damaging Het
Itk T A 11: 46,227,342 (GRCm39) Q427L probably benign Het
Klhdc4 T C 8: 122,526,266 (GRCm39) E291G probably damaging Het
Map4 T A 9: 109,881,887 (GRCm39) S250R possibly damaging Het
Mnt T A 11: 74,727,285 (GRCm39) V57E possibly damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Mtcl2 T C 2: 156,881,844 (GRCm39) K736R probably benign Het
Musk A T 4: 58,301,625 (GRCm39) I128F probably damaging Het
Myh4 G A 11: 67,141,136 (GRCm39) A733T possibly damaging Het
Myo5a T A 9: 75,043,670 (GRCm39) F220I probably damaging Het
Npas3 A G 12: 54,091,361 (GRCm39) H305R probably damaging Het
Nrcam A T 12: 44,637,839 (GRCm39) Y1132F probably damaging Het
Nt5c3b A C 11: 100,323,744 (GRCm39) D189E probably benign Het
Nuf2 A G 1: 169,333,683 (GRCm39) L331P probably damaging Het
Nup214 C T 2: 31,887,977 (GRCm39) T646I probably benign Het
Or14j9 T C 17: 37,875,076 (GRCm39) N42S probably damaging Het
Pcdh18 T C 3: 49,699,174 (GRCm39) E1096G probably damaging Het
Pgm2 T A 5: 64,265,070 (GRCm39) F364I probably benign Het
Pikfyve A G 1: 65,273,421 (GRCm39) N612S probably damaging Het
Pla2g4e T G 2: 120,016,863 (GRCm39) H226P possibly damaging Het
Ppp3cb T C 14: 20,570,714 (GRCm39) N339S possibly damaging Het
Prkd2 G T 7: 16,577,573 (GRCm39) probably benign Het
Rnf133 T C 6: 23,649,041 (GRCm39) E296G possibly damaging Het
Sav1 A T 12: 70,031,095 (GRCm39) D142E probably benign Het
Scn3b C A 9: 40,199,719 (GRCm39) P212T probably damaging Het
Sel1l A T 12: 91,799,827 (GRCm39) probably null Het
Septin9 A G 11: 117,251,310 (GRCm39) K543E probably damaging Het
Serpinb12 T A 1: 106,876,883 (GRCm39) D66E probably benign Het
Slc35e2 T C 4: 155,702,106 (GRCm39) F290S probably benign Het
Snrpa A G 7: 26,894,958 (GRCm39) M1T probably null Het
Sptlc3 G A 2: 139,478,600 (GRCm39) V520I probably benign Het
Srpk3 A G X: 72,818,547 (GRCm39) H79R possibly damaging Het
Stox2 A G 8: 47,645,970 (GRCm39) S497P probably damaging Het
Stradb G A 1: 59,032,731 (GRCm39) S361N probably damaging Het
Sult3a2 T C 10: 33,658,083 (GRCm39) K10R probably benign Het
Susd4 A G 1: 182,686,025 (GRCm39) N192D probably damaging Het
Tcp10a T A 17: 7,593,374 (GRCm39) D32E probably benign Het
Tdpoz4 T A 3: 93,704,339 (GRCm39) V212D probably damaging Het
Tdrd5 T A 1: 156,111,944 (GRCm39) T479S probably benign Het
Tex10 T C 4: 48,452,946 (GRCm39) D671G probably benign Het
Tex55 A G 16: 38,648,380 (GRCm39) V243A probably benign Het
Traj37 T C 14: 54,418,996 (GRCm39) probably benign Het
Ttc7b G A 12: 100,466,376 (GRCm39) R79C probably damaging Het
Vmn2r115 T A 17: 23,565,373 (GRCm39) L420Q probably benign Het
Wdr24 T A 17: 26,047,181 (GRCm39) probably null Het
Wdr81 T A 11: 75,336,484 (GRCm39) Q516L probably damaging Het
Zfp516 A G 18: 82,974,164 (GRCm39) T121A probably benign Het
Zmat1 A T X: 133,873,694 (GRCm39) S566T probably damaging Homo
Other mutations in Dennd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Dennd3 APN 15 73,438,982 (GRCm39) missense probably benign 0.26
IGL00579:Dennd3 APN 15 73,412,691 (GRCm39) missense possibly damaging 0.63
IGL02101:Dennd3 APN 15 73,399,794 (GRCm39) missense possibly damaging 0.81
IGL02164:Dennd3 APN 15 73,416,297 (GRCm39) missense probably benign 0.26
IGL02389:Dennd3 APN 15 73,438,905 (GRCm39) missense probably damaging 1.00
IGL02604:Dennd3 APN 15 73,428,252 (GRCm39) missense probably damaging 1.00
IGL02697:Dennd3 APN 15 73,396,085 (GRCm39) missense possibly damaging 0.82
IGL02885:Dennd3 APN 15 73,440,545 (GRCm39) missense probably benign
IGL03356:Dennd3 APN 15 73,440,482 (GRCm39) missense probably benign 0.19
IGL03388:Dennd3 APN 15 73,416,208 (GRCm39) missense probably damaging 0.98
BB006:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
BB016:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R0118:Dennd3 UTSW 15 73,436,925 (GRCm39) missense probably damaging 1.00
R0925:Dennd3 UTSW 15 73,405,284 (GRCm39) missense probably damaging 1.00
R1076:Dennd3 UTSW 15 73,412,582 (GRCm39) missense probably damaging 1.00
R1355:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1370:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1480:Dennd3 UTSW 15 73,404,695 (GRCm39) missense probably benign 0.20
R1727:Dennd3 UTSW 15 73,436,977 (GRCm39) missense possibly damaging 0.95
R1732:Dennd3 UTSW 15 73,409,267 (GRCm39) splice site probably benign
R1771:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1776:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1779:Dennd3 UTSW 15 73,394,357 (GRCm39) critical splice donor site probably null
R1838:Dennd3 UTSW 15 73,436,949 (GRCm39) missense probably damaging 1.00
R2146:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2146:Dennd3 UTSW 15 73,395,345 (GRCm39) missense probably damaging 1.00
R2147:Dennd3 UTSW 15 73,395,336 (GRCm39) missense probably damaging 1.00
R2148:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2149:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2150:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2174:Dennd3 UTSW 15 73,427,154 (GRCm39) missense probably damaging 1.00
R2295:Dennd3 UTSW 15 73,395,404 (GRCm39) critical splice donor site probably null
R2905:Dennd3 UTSW 15 73,429,495 (GRCm39) missense probably damaging 1.00
R3106:Dennd3 UTSW 15 73,436,973 (GRCm39) nonsense probably null
R3757:Dennd3 UTSW 15 73,394,083 (GRCm39) missense probably benign 0.00
R3785:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3786:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3787:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3847:Dennd3 UTSW 15 73,414,581 (GRCm39) missense possibly damaging 0.64
R4369:Dennd3 UTSW 15 73,412,658 (GRCm39) missense probably damaging 0.98
R4666:Dennd3 UTSW 15 73,442,709 (GRCm39) missense probably damaging 1.00
R4680:Dennd3 UTSW 15 73,405,225 (GRCm39) missense possibly damaging 0.82
R4708:Dennd3 UTSW 15 73,395,344 (GRCm39) missense probably damaging 1.00
R4789:Dennd3 UTSW 15 73,394,131 (GRCm39) missense probably damaging 1.00
R4920:Dennd3 UTSW 15 73,412,574 (GRCm39) missense probably benign 0.13
R5043:Dennd3 UTSW 15 73,399,785 (GRCm39) missense probably benign 0.00
R5074:Dennd3 UTSW 15 73,419,144 (GRCm39) missense probably damaging 1.00
R5410:Dennd3 UTSW 15 73,419,297 (GRCm39) missense probably benign 0.02
R5421:Dennd3 UTSW 15 73,438,964 (GRCm39) missense probably benign
R5560:Dennd3 UTSW 15 73,404,744 (GRCm39) missense probably damaging 1.00
R6008:Dennd3 UTSW 15 73,438,929 (GRCm39) missense possibly damaging 0.88
R6357:Dennd3 UTSW 15 73,428,321 (GRCm39) missense possibly damaging 0.49
R6563:Dennd3 UTSW 15 73,416,229 (GRCm39) missense probably damaging 0.98
R6687:Dennd3 UTSW 15 73,428,215 (GRCm39) missense possibly damaging 0.64
R6837:Dennd3 UTSW 15 73,429,542 (GRCm39) missense probably damaging 1.00
R6910:Dennd3 UTSW 15 73,426,965 (GRCm39) missense probably benign 0.01
R7125:Dennd3 UTSW 15 73,405,140 (GRCm39) missense possibly damaging 0.50
R7297:Dennd3 UTSW 15 73,429,459 (GRCm39) missense probably damaging 1.00
R7524:Dennd3 UTSW 15 73,396,095 (GRCm39) nonsense probably null
R7580:Dennd3 UTSW 15 73,428,296 (GRCm39) missense possibly damaging 0.89
R7653:Dennd3 UTSW 15 73,434,275 (GRCm39) missense probably damaging 0.99
R7731:Dennd3 UTSW 15 73,434,216 (GRCm39) missense probably damaging 0.99
R7767:Dennd3 UTSW 15 73,394,079 (GRCm39) missense probably benign
R7806:Dennd3 UTSW 15 73,442,624 (GRCm39) missense possibly damaging 0.87
R7860:Dennd3 UTSW 15 73,412,657 (GRCm39) missense probably damaging 0.97
R7902:Dennd3 UTSW 15 73,439,964 (GRCm39) critical splice donor site probably benign
R7929:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R8218:Dennd3 UTSW 15 73,384,622 (GRCm39) missense probably benign 0.31
R8436:Dennd3 UTSW 15 73,434,198 (GRCm39) missense probably damaging 1.00
R8444:Dennd3 UTSW 15 73,442,672 (GRCm39) missense probably benign 0.09
R8698:Dennd3 UTSW 15 73,394,154 (GRCm39) missense possibly damaging 0.52
R8967:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R9147:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9148:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9194:Dennd3 UTSW 15 73,419,153 (GRCm39) missense probably benign 0.04
R9449:Dennd3 UTSW 15 73,429,477 (GRCm39) missense probably damaging 1.00
R9501:Dennd3 UTSW 15 73,419,041 (GRCm39) missense probably benign 0.01
R9616:Dennd3 UTSW 15 73,440,563 (GRCm39) missense probably benign
R9730:Dennd3 UTSW 15 73,426,959 (GRCm39) missense probably damaging 1.00
RF006:Dennd3 UTSW 15 73,419,441 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTACTGTGAATGGTGCCTTTC -3'
(R):5'- GCCATCTATACACCAGCCTG -3'

Sequencing Primer
(F):5'- CCCCCAAGGTTAGATGTGAG -3'
(R):5'- ATCTATACACCAGCCTGTCAAG -3'
Posted On 2015-09-25