Incidental Mutation 'R4762:Dido1'
| ID |
356934 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dido1
|
| Ensembl Gene |
ENSMUSG00000038914 |
| Gene Name |
death inducer-obliterator 1 |
| Synonyms |
D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik |
| MMRRC Submission |
042403-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.960)
|
| Stock # |
R4762 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
180299757-180351792 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 180331368 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 27
(W27R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087517]
[ENSMUST00000103055]
[ENSMUST00000103056]
[ENSMUST00000103057]
[ENSMUST00000130986]
|
| AlphaFold |
Q8C9B9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087517
AA Change: W27R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: W27R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
1e-22 |
PFAM |
|
low complexity region
|
1253 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1391 |
N/A |
INTRINSIC |
|
coiled coil region
|
1458 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1748 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1780 |
1792 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1815 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1816 |
1852 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1819 |
1859 |
6.92e-7 |
PROSPERO |
|
internal_repeat_2
|
1926 |
1964 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1940 |
1982 |
6.92e-7 |
PROSPERO |
|
low complexity region
|
2025 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2123 |
2160 |
N/A |
INTRINSIC |
|
low complexity region
|
2163 |
2177 |
N/A |
INTRINSIC |
|
low complexity region
|
2182 |
2239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000103054
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103055
AA Change: W27R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099344
Gene: ENSMUSG00000038914
AA Change: W27R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103056
AA Change: W27R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099345
Gene: ENSMUSG00000038914
AA Change: W27R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103057
AA Change: W27R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099346
Gene: ENSMUSG00000038914
AA Change: W27R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000130986
AA Change: W27R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000119689
Gene: ENSMUSG00000038914
AA Change: W27R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6114 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
100% (86/86) |
| MGI Phenotype |
FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(245) : Targeted, knock-out(1) Gene trapped(244) |
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
T |
C |
1: 158,797,126 (GRCm39) |
|
noncoding transcript |
Het |
| 2310030G06Rik |
T |
C |
9: 50,651,967 (GRCm39) |
E87G |
probably damaging |
Het |
| Aknad1 |
A |
T |
3: 108,682,547 (GRCm39) |
H541L |
possibly damaging |
Het |
| Asb15 |
A |
G |
6: 24,567,236 (GRCm39) |
E519G |
possibly damaging |
Het |
| Atad2 |
T |
C |
15: 57,971,758 (GRCm39) |
D373G |
probably benign |
Het |
| Bbs12 |
G |
A |
3: 37,374,529 (GRCm39) |
V326M |
probably damaging |
Het |
| Birc6 |
T |
C |
17: 74,936,484 (GRCm39) |
I2617T |
probably damaging |
Het |
| Brca2 |
A |
G |
5: 150,454,581 (GRCm39) |
T115A |
probably benign |
Het |
| Casz1 |
T |
C |
4: 149,023,438 (GRCm39) |
L495P |
probably damaging |
Het |
| Ccdc30 |
T |
A |
4: 119,190,785 (GRCm39) |
I481F |
probably damaging |
Het |
| Cept1 |
A |
T |
3: 106,446,677 (GRCm39) |
Y56* |
probably null |
Het |
| Cfap54 |
A |
C |
10: 92,897,315 (GRCm39) |
|
probably null |
Het |
| Cyp2j8 |
G |
T |
4: 96,358,886 (GRCm39) |
D344E |
probably damaging |
Het |
| Disp3 |
A |
G |
4: 148,356,575 (GRCm39) |
I95T |
probably damaging |
Het |
| Engase |
G |
T |
11: 118,377,920 (GRCm39) |
V237F |
possibly damaging |
Het |
| Ephb6 |
G |
A |
6: 41,595,094 (GRCm39) |
E703K |
probably damaging |
Het |
| Fnip1 |
T |
A |
11: 54,356,997 (GRCm39) |
F35L |
probably damaging |
Het |
| Fnip1 |
A |
T |
11: 54,390,352 (GRCm39) |
T440S |
probably benign |
Het |
| Fras1 |
T |
A |
5: 96,879,477 (GRCm39) |
H2431Q |
probably benign |
Het |
| Fzd4 |
A |
T |
7: 89,056,924 (GRCm39) |
T324S |
probably damaging |
Het |
| Gm10192 |
C |
G |
4: 97,071,345 (GRCm39) |
S20T |
probably null |
Het |
| Gpr84 |
A |
T |
15: 103,217,027 (GRCm39) |
V350E |
probably damaging |
Het |
| Gsto2 |
T |
C |
19: 47,863,312 (GRCm39) |
Y63H |
probably damaging |
Het |
| Gtpbp6 |
T |
C |
5: 110,252,186 (GRCm39) |
T449A |
probably damaging |
Het |
| Herc2 |
G |
A |
7: 55,820,388 (GRCm39) |
V2876I |
probably benign |
Het |
| Hnrnpa3 |
A |
G |
2: 75,492,351 (GRCm39) |
I152V |
possibly damaging |
Het |
| Hpse2 |
T |
C |
19: 42,777,510 (GRCm39) |
D552G |
possibly damaging |
Het |
| Itfg1 |
A |
G |
8: 86,459,070 (GRCm39) |
V460A |
possibly damaging |
Het |
| Jhy |
G |
A |
9: 40,822,494 (GRCm39) |
A548V |
probably benign |
Het |
| Klhl21 |
T |
A |
4: 152,094,268 (GRCm39) |
L290Q |
possibly damaging |
Het |
| Knl1 |
T |
C |
2: 118,902,417 (GRCm39) |
S1373P |
probably benign |
Het |
| Kpna2 |
A |
C |
11: 106,881,085 (GRCm39) |
M426R |
probably benign |
Het |
| Krt9 |
C |
T |
11: 100,081,675 (GRCm39) |
V285I |
probably damaging |
Het |
| Lpar1 |
T |
G |
4: 58,437,346 (GRCm39) |
H361P |
possibly damaging |
Het |
| Macf1 |
T |
C |
4: 123,349,237 (GRCm39) |
T2100A |
probably benign |
Het |
| Mfsd13b |
T |
C |
7: 120,590,549 (GRCm39) |
F97L |
probably damaging |
Het |
| Mmp15 |
A |
G |
8: 96,098,958 (GRCm39) |
K595R |
probably benign |
Het |
| Mrps25 |
C |
T |
6: 92,152,085 (GRCm39) |
G145D |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,574,916 (GRCm39) |
|
probably benign |
Het |
| Napa |
A |
T |
7: 15,849,196 (GRCm39) |
K245N |
probably benign |
Het |
| Or10p1 |
C |
A |
10: 129,444,043 (GRCm39) |
M102I |
probably damaging |
Het |
| Or14c39 |
A |
G |
7: 86,344,329 (GRCm39) |
T222A |
probably benign |
Het |
| Or2y1c |
A |
T |
11: 49,361,112 (GRCm39) |
I45F |
probably damaging |
Het |
| Or4g17 |
G |
A |
2: 111,210,082 (GRCm39) |
V246M |
probably damaging |
Het |
| Or4k39 |
T |
A |
2: 111,239,225 (GRCm39) |
|
noncoding transcript |
Het |
| Or5au1 |
T |
A |
14: 52,272,921 (GRCm39) |
I216F |
possibly damaging |
Het |
| Or8c20 |
A |
G |
9: 38,260,577 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or8k35 |
A |
G |
2: 86,424,381 (GRCm39) |
S264P |
possibly damaging |
Het |
| Papss2 |
A |
T |
19: 32,616,378 (GRCm39) |
T195S |
probably benign |
Het |
| Parp4 |
T |
A |
14: 56,848,267 (GRCm39) |
H694Q |
probably damaging |
Het |
| Patj |
C |
T |
4: 98,293,807 (GRCm39) |
R20* |
probably null |
Het |
| Pcdhgb8 |
T |
A |
18: 37,895,419 (GRCm39) |
V163E |
probably damaging |
Het |
| Pkd2l1 |
T |
A |
19: 44,144,060 (GRCm39) |
T338S |
probably benign |
Het |
| Ppargc1b |
A |
T |
18: 61,444,328 (GRCm39) |
S278R |
possibly damaging |
Het |
| Ppl |
T |
C |
16: 4,906,846 (GRCm39) |
T1150A |
probably benign |
Het |
| Ralgds |
A |
G |
2: 28,442,164 (GRCm39) |
D858G |
probably damaging |
Het |
| Rassf2 |
G |
A |
2: 131,844,783 (GRCm39) |
|
probably benign |
Het |
| Ring1 |
T |
C |
17: 34,240,971 (GRCm39) |
|
probably benign |
Het |
| Rusc1 |
A |
C |
3: 88,998,949 (GRCm39) |
S278A |
probably benign |
Het |
| Samd9l |
T |
C |
6: 3,375,623 (GRCm39) |
N546S |
probably benign |
Het |
| Sct |
A |
C |
7: 140,858,954 (GRCm39) |
|
probably benign |
Het |
| Slc22a12 |
T |
G |
19: 6,588,474 (GRCm39) |
H348P |
probably benign |
Het |
| Slc25a15 |
A |
G |
8: 22,873,248 (GRCm39) |
S143P |
probably damaging |
Het |
| Slc26a11 |
C |
A |
11: 119,247,657 (GRCm39) |
|
probably benign |
Het |
| Slc6a20b |
A |
G |
9: 123,427,625 (GRCm39) |
M428T |
probably damaging |
Het |
| Smim17 |
G |
A |
7: 6,432,321 (GRCm39) |
V88M |
probably damaging |
Het |
| Smoc1 |
G |
T |
12: 81,214,425 (GRCm39) |
W269L |
probably damaging |
Het |
| Sox5 |
C |
T |
6: 143,807,109 (GRCm39) |
|
probably null |
Het |
| Sp100 |
A |
G |
1: 85,629,179 (GRCm39) |
*483W |
probably null |
Het |
| Sptbn5 |
T |
A |
2: 119,907,703 (GRCm39) |
|
noncoding transcript |
Het |
| Sun5 |
G |
A |
2: 153,707,283 (GRCm39) |
R132* |
probably null |
Het |
| Tedc2 |
A |
G |
17: 24,435,354 (GRCm39) |
V345A |
probably benign |
Het |
| Tlr6 |
T |
A |
5: 65,111,739 (GRCm39) |
R389S |
probably benign |
Het |
| Ttc17 |
G |
T |
2: 94,202,113 (GRCm39) |
H396Q |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,773,383 (GRCm39) |
S2340P |
probably damaging |
Het |
| Vmn1r219 |
C |
T |
13: 23,346,999 (GRCm39) |
Q63* |
probably null |
Het |
| Vmn1r224 |
A |
G |
17: 20,639,902 (GRCm39) |
T160A |
possibly damaging |
Het |
| Vmn2r11 |
T |
C |
5: 109,195,436 (GRCm39) |
N630S |
probably damaging |
Het |
| Zfp1005 |
T |
A |
2: 150,109,549 (GRCm39) |
C80S |
possibly damaging |
Het |
| Zfp747 |
A |
G |
7: 126,973,498 (GRCm39) |
V224A |
possibly damaging |
Het |
| Zfp804b |
T |
C |
5: 6,822,250 (GRCm39) |
N271S |
probably benign |
Het |
|
| Other mutations in Dido1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Dido1
|
APN |
2 |
180,325,782 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Dido1
|
APN |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01317:Dido1
|
APN |
2 |
180,313,550 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01588:Dido1
|
APN |
2 |
180,330,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01834:Dido1
|
APN |
2 |
180,325,824 (GRCm39) |
splice site |
probably benign |
|
|
IGL02102:Dido1
|
APN |
2 |
180,304,040 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL02556:Dido1
|
APN |
2 |
180,331,128 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02756:Dido1
|
APN |
2 |
180,303,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02826:Dido1
|
APN |
2 |
180,325,751 (GRCm39) |
missense |
probably benign |
|
|
IGL02970:Dido1
|
APN |
2 |
180,331,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03110:Dido1
|
APN |
2 |
180,331,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03116:Dido1
|
APN |
2 |
180,312,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3370:Dido1
|
UTSW |
2 |
180,313,335 (GRCm39) |
missense |
probably benign |
|
|
A4554:Dido1
|
UTSW |
2 |
180,317,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8441:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0127:Dido1
|
UTSW |
2 |
180,313,617 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0620:Dido1
|
UTSW |
2 |
180,301,644 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0734:Dido1
|
UTSW |
2 |
180,301,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1390:Dido1
|
UTSW |
2 |
180,326,917 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1445:Dido1
|
UTSW |
2 |
180,313,263 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dido1
|
UTSW |
2 |
180,302,513 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Dido1
|
UTSW |
2 |
180,326,763 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1584:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Dido1
|
UTSW |
2 |
180,301,378 (GRCm39) |
missense |
unknown |
|
|
R2025:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2026:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2027:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2089:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2495:Dido1
|
UTSW |
2 |
180,331,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2931:Dido1
|
UTSW |
2 |
180,303,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Dido1
|
UTSW |
2 |
180,302,728 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3735:Dido1
|
UTSW |
2 |
180,325,829 (GRCm39) |
splice site |
probably benign |
|
|
R4523:Dido1
|
UTSW |
2 |
180,314,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Dido1
|
UTSW |
2 |
180,329,352 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4729:Dido1
|
UTSW |
2 |
180,329,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4786:Dido1
|
UTSW |
2 |
180,312,664 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4817:Dido1
|
UTSW |
2 |
180,303,209 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4892:Dido1
|
UTSW |
2 |
180,316,822 (GRCm39) |
nonsense |
probably null |
|
|
R4979:Dido1
|
UTSW |
2 |
180,302,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5510:Dido1
|
UTSW |
2 |
180,326,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Dido1
|
UTSW |
2 |
180,301,445 (GRCm39) |
nonsense |
probably null |
|
|
R5672:Dido1
|
UTSW |
2 |
180,313,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5863:Dido1
|
UTSW |
2 |
180,303,566 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5943:Dido1
|
UTSW |
2 |
180,303,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5974:Dido1
|
UTSW |
2 |
180,313,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6123:Dido1
|
UTSW |
2 |
180,325,760 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6214:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Dido1
|
UTSW |
2 |
180,302,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Dido1
|
UTSW |
2 |
180,302,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6349:Dido1
|
UTSW |
2 |
180,302,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6437:Dido1
|
UTSW |
2 |
180,316,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Dido1
|
UTSW |
2 |
180,302,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6836:Dido1
|
UTSW |
2 |
180,304,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7055:Dido1
|
UTSW |
2 |
180,303,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7289:Dido1
|
UTSW |
2 |
180,301,424 (GRCm39) |
missense |
unknown |
|
|
R7304:Dido1
|
UTSW |
2 |
180,329,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Dido1
|
UTSW |
2 |
180,316,914 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7363:Dido1
|
UTSW |
2 |
180,304,310 (GRCm39) |
nonsense |
probably null |
|
|
R7429:Dido1
|
UTSW |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7594:Dido1
|
UTSW |
2 |
180,316,905 (GRCm39) |
missense |
probably benign |
|
|
R7629:Dido1
|
UTSW |
2 |
180,303,266 (GRCm39) |
missense |
probably benign |
|
|
R7899:Dido1
|
UTSW |
2 |
180,313,390 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7946:Dido1
|
UTSW |
2 |
180,303,501 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7951:Dido1
|
UTSW |
2 |
180,312,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8033:Dido1
|
UTSW |
2 |
180,316,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Dido1
|
UTSW |
2 |
180,302,705 (GRCm39) |
missense |
probably benign |
|
|
R8331:Dido1
|
UTSW |
2 |
180,302,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8479:Dido1
|
UTSW |
2 |
180,315,022 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8936:Dido1
|
UTSW |
2 |
180,303,195 (GRCm39) |
missense |
probably benign |
|
|
R9089:Dido1
|
UTSW |
2 |
180,303,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9647:Dido1
|
UTSW |
2 |
180,315,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9648:Dido1
|
UTSW |
2 |
180,302,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9784:Dido1
|
UTSW |
2 |
180,325,354 (GRCm39) |
missense |
probably benign |
0.27 |
|
V1024:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0011:Dido1
|
UTSW |
2 |
180,302,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Dido1
|
UTSW |
2 |
180,313,365 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATGTGGGCTCACTGGAATC -3'
(R):5'- TGCTCCTGTCAGAAACCCTATC -3'
Sequencing Primer
(F):5'- GGGACACCGGCACATTCTTTTTC -3'
(R):5'- AGAAACCCTATCTTACCACCCTTTG -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation