Incidental Mutation 'R4762:Zfp804b'
| ID |
356947 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp804b
|
| Ensembl Gene |
ENSMUSG00000092094 |
| Gene Name |
zinc finger protein 804B |
| Synonyms |
LOC207618 |
| MMRRC Submission |
042403-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.117)
|
| Stock # |
R4762 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
6819030-7394378 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 6822250 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 271
(N271S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143568
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164784]
[ENSMUST00000200317]
|
| AlphaFold |
A0A0G2JGH6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164784
AA Change: N235S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000130571
Gene: ENSMUSG00000092094
AA Change: N235S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
20 |
44 |
4.81e0 |
SMART |
|
low complexity region
|
922 |
934 |
N/A |
INTRINSIC |
|
low complexity region
|
1119 |
1143 |
N/A |
INTRINSIC |
|
low complexity region
|
1160 |
1171 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1198 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200317
AA Change: N271S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000143568
Gene: ENSMUSG00000092094
AA Change: N271S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
56 |
80 |
2e-2 |
SMART |
|
low complexity region
|
958 |
970 |
N/A |
INTRINSIC |
|
low complexity region
|
1155 |
1179 |
N/A |
INTRINSIC |
|
low complexity region
|
1196 |
1207 |
N/A |
INTRINSIC |
|
low complexity region
|
1215 |
1234 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
100% (86/86) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
T |
C |
1: 158,797,126 (GRCm39) |
|
noncoding transcript |
Het |
| 2310030G06Rik |
T |
C |
9: 50,651,967 (GRCm39) |
E87G |
probably damaging |
Het |
| Aknad1 |
A |
T |
3: 108,682,547 (GRCm39) |
H541L |
possibly damaging |
Het |
| Asb15 |
A |
G |
6: 24,567,236 (GRCm39) |
E519G |
possibly damaging |
Het |
| Atad2 |
T |
C |
15: 57,971,758 (GRCm39) |
D373G |
probably benign |
Het |
| Bbs12 |
G |
A |
3: 37,374,529 (GRCm39) |
V326M |
probably damaging |
Het |
| Birc6 |
T |
C |
17: 74,936,484 (GRCm39) |
I2617T |
probably damaging |
Het |
| Brca2 |
A |
G |
5: 150,454,581 (GRCm39) |
T115A |
probably benign |
Het |
| Casz1 |
T |
C |
4: 149,023,438 (GRCm39) |
L495P |
probably damaging |
Het |
| Ccdc30 |
T |
A |
4: 119,190,785 (GRCm39) |
I481F |
probably damaging |
Het |
| Cept1 |
A |
T |
3: 106,446,677 (GRCm39) |
Y56* |
probably null |
Het |
| Cfap54 |
A |
C |
10: 92,897,315 (GRCm39) |
|
probably null |
Het |
| Cyp2j8 |
G |
T |
4: 96,358,886 (GRCm39) |
D344E |
probably damaging |
Het |
| Dido1 |
A |
T |
2: 180,331,368 (GRCm39) |
W27R |
probably damaging |
Het |
| Disp3 |
A |
G |
4: 148,356,575 (GRCm39) |
I95T |
probably damaging |
Het |
| Engase |
G |
T |
11: 118,377,920 (GRCm39) |
V237F |
possibly damaging |
Het |
| Ephb6 |
G |
A |
6: 41,595,094 (GRCm39) |
E703K |
probably damaging |
Het |
| Fnip1 |
T |
A |
11: 54,356,997 (GRCm39) |
F35L |
probably damaging |
Het |
| Fnip1 |
A |
T |
11: 54,390,352 (GRCm39) |
T440S |
probably benign |
Het |
| Fras1 |
T |
A |
5: 96,879,477 (GRCm39) |
H2431Q |
probably benign |
Het |
| Fzd4 |
A |
T |
7: 89,056,924 (GRCm39) |
T324S |
probably damaging |
Het |
| Gm10192 |
C |
G |
4: 97,071,345 (GRCm39) |
S20T |
probably null |
Het |
| Gpr84 |
A |
T |
15: 103,217,027 (GRCm39) |
V350E |
probably damaging |
Het |
| Gsto2 |
T |
C |
19: 47,863,312 (GRCm39) |
Y63H |
probably damaging |
Het |
| Gtpbp6 |
T |
C |
5: 110,252,186 (GRCm39) |
T449A |
probably damaging |
Het |
| Herc2 |
G |
A |
7: 55,820,388 (GRCm39) |
V2876I |
probably benign |
Het |
| Hnrnpa3 |
A |
G |
2: 75,492,351 (GRCm39) |
I152V |
possibly damaging |
Het |
| Hpse2 |
T |
C |
19: 42,777,510 (GRCm39) |
D552G |
possibly damaging |
Het |
| Itfg1 |
A |
G |
8: 86,459,070 (GRCm39) |
V460A |
possibly damaging |
Het |
| Jhy |
G |
A |
9: 40,822,494 (GRCm39) |
A548V |
probably benign |
Het |
| Klhl21 |
T |
A |
4: 152,094,268 (GRCm39) |
L290Q |
possibly damaging |
Het |
| Knl1 |
T |
C |
2: 118,902,417 (GRCm39) |
S1373P |
probably benign |
Het |
| Kpna2 |
A |
C |
11: 106,881,085 (GRCm39) |
M426R |
probably benign |
Het |
| Krt9 |
C |
T |
11: 100,081,675 (GRCm39) |
V285I |
probably damaging |
Het |
| Lpar1 |
T |
G |
4: 58,437,346 (GRCm39) |
H361P |
possibly damaging |
Het |
| Macf1 |
T |
C |
4: 123,349,237 (GRCm39) |
T2100A |
probably benign |
Het |
| Mfsd13b |
T |
C |
7: 120,590,549 (GRCm39) |
F97L |
probably damaging |
Het |
| Mmp15 |
A |
G |
8: 96,098,958 (GRCm39) |
K595R |
probably benign |
Het |
| Mrps25 |
C |
T |
6: 92,152,085 (GRCm39) |
G145D |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,574,916 (GRCm39) |
|
probably benign |
Het |
| Napa |
A |
T |
7: 15,849,196 (GRCm39) |
K245N |
probably benign |
Het |
| Or10p1 |
C |
A |
10: 129,444,043 (GRCm39) |
M102I |
probably damaging |
Het |
| Or14c39 |
A |
G |
7: 86,344,329 (GRCm39) |
T222A |
probably benign |
Het |
| Or2y1c |
A |
T |
11: 49,361,112 (GRCm39) |
I45F |
probably damaging |
Het |
| Or4g17 |
G |
A |
2: 111,210,082 (GRCm39) |
V246M |
probably damaging |
Het |
| Or4k39 |
T |
A |
2: 111,239,225 (GRCm39) |
|
noncoding transcript |
Het |
| Or5au1 |
T |
A |
14: 52,272,921 (GRCm39) |
I216F |
possibly damaging |
Het |
| Or8c20 |
A |
G |
9: 38,260,577 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or8k35 |
A |
G |
2: 86,424,381 (GRCm39) |
S264P |
possibly damaging |
Het |
| Papss2 |
A |
T |
19: 32,616,378 (GRCm39) |
T195S |
probably benign |
Het |
| Parp4 |
T |
A |
14: 56,848,267 (GRCm39) |
H694Q |
probably damaging |
Het |
| Patj |
C |
T |
4: 98,293,807 (GRCm39) |
R20* |
probably null |
Het |
| Pcdhgb8 |
T |
A |
18: 37,895,419 (GRCm39) |
V163E |
probably damaging |
Het |
| Pkd2l1 |
T |
A |
19: 44,144,060 (GRCm39) |
T338S |
probably benign |
Het |
| Ppargc1b |
A |
T |
18: 61,444,328 (GRCm39) |
S278R |
possibly damaging |
Het |
| Ppl |
T |
C |
16: 4,906,846 (GRCm39) |
T1150A |
probably benign |
Het |
| Ralgds |
A |
G |
2: 28,442,164 (GRCm39) |
D858G |
probably damaging |
Het |
| Rassf2 |
G |
A |
2: 131,844,783 (GRCm39) |
|
probably benign |
Het |
| Ring1 |
T |
C |
17: 34,240,971 (GRCm39) |
|
probably benign |
Het |
| Rusc1 |
A |
C |
3: 88,998,949 (GRCm39) |
S278A |
probably benign |
Het |
| Samd9l |
T |
C |
6: 3,375,623 (GRCm39) |
N546S |
probably benign |
Het |
| Sct |
A |
C |
7: 140,858,954 (GRCm39) |
|
probably benign |
Het |
| Slc22a12 |
T |
G |
19: 6,588,474 (GRCm39) |
H348P |
probably benign |
Het |
| Slc25a15 |
A |
G |
8: 22,873,248 (GRCm39) |
S143P |
probably damaging |
Het |
| Slc26a11 |
C |
A |
11: 119,247,657 (GRCm39) |
|
probably benign |
Het |
| Slc6a20b |
A |
G |
9: 123,427,625 (GRCm39) |
M428T |
probably damaging |
Het |
| Smim17 |
G |
A |
7: 6,432,321 (GRCm39) |
V88M |
probably damaging |
Het |
| Smoc1 |
G |
T |
12: 81,214,425 (GRCm39) |
W269L |
probably damaging |
Het |
| Sox5 |
C |
T |
6: 143,807,109 (GRCm39) |
|
probably null |
Het |
| Sp100 |
A |
G |
1: 85,629,179 (GRCm39) |
*483W |
probably null |
Het |
| Sptbn5 |
T |
A |
2: 119,907,703 (GRCm39) |
|
noncoding transcript |
Het |
| Sun5 |
G |
A |
2: 153,707,283 (GRCm39) |
R132* |
probably null |
Het |
| Tedc2 |
A |
G |
17: 24,435,354 (GRCm39) |
V345A |
probably benign |
Het |
| Tlr6 |
T |
A |
5: 65,111,739 (GRCm39) |
R389S |
probably benign |
Het |
| Ttc17 |
G |
T |
2: 94,202,113 (GRCm39) |
H396Q |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,773,383 (GRCm39) |
S2340P |
probably damaging |
Het |
| Vmn1r219 |
C |
T |
13: 23,346,999 (GRCm39) |
Q63* |
probably null |
Het |
| Vmn1r224 |
A |
G |
17: 20,639,902 (GRCm39) |
T160A |
possibly damaging |
Het |
| Vmn2r11 |
T |
C |
5: 109,195,436 (GRCm39) |
N630S |
probably damaging |
Het |
| Zfp1005 |
T |
A |
2: 150,109,549 (GRCm39) |
C80S |
possibly damaging |
Het |
| Zfp747 |
A |
G |
7: 126,973,498 (GRCm39) |
V224A |
possibly damaging |
Het |
|
| Other mutations in Zfp804b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01085:Zfp804b
|
APN |
5 |
6,820,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01726:Zfp804b
|
APN |
5 |
7,230,707 (GRCm39) |
intron |
probably benign |
|
|
IGL02020:Zfp804b
|
APN |
5 |
6,819,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02567:Zfp804b
|
APN |
5 |
6,819,989 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02679:Zfp804b
|
APN |
5 |
6,821,392 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03245:Zfp804b
|
APN |
5 |
6,822,253 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03352:Zfp804b
|
APN |
5 |
6,820,039 (GRCm39) |
missense |
probably benign |
0.45 |
|
Flush
|
UTSW |
5 |
6,820,217 (GRCm39) |
missense |
probably benign |
0.27 |
|
gozinta
|
UTSW |
5 |
6,820,153 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
healthy
|
UTSW |
5 |
6,820,013 (GRCm39) |
missense |
probably benign |
0.04 |
|
Paluka
|
UTSW |
5 |
6,820,534 (GRCm39) |
missense |
probably benign |
|
|
PIT4142001:Zfp804b
|
UTSW |
5 |
6,819,422 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0025:Zfp804b
|
UTSW |
5 |
6,821,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Zfp804b
|
UTSW |
5 |
6,819,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0137:Zfp804b
|
UTSW |
5 |
6,820,534 (GRCm39) |
missense |
probably benign |
|
|
R0330:Zfp804b
|
UTSW |
5 |
6,821,994 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R0330:Zfp804b
|
UTSW |
5 |
6,821,029 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0522:Zfp804b
|
UTSW |
5 |
6,822,014 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1463:Zfp804b
|
UTSW |
5 |
7,229,372 (GRCm39) |
intron |
probably benign |
|
|
R1497:Zfp804b
|
UTSW |
5 |
6,821,105 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1511:Zfp804b
|
UTSW |
5 |
6,819,771 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1633:Zfp804b
|
UTSW |
5 |
7,229,513 (GRCm39) |
intron |
probably benign |
|
|
R1666:Zfp804b
|
UTSW |
5 |
6,821,323 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1668:Zfp804b
|
UTSW |
5 |
6,821,323 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1677:Zfp804b
|
UTSW |
5 |
7,229,533 (GRCm39) |
intron |
probably benign |
|
|
R1698:Zfp804b
|
UTSW |
5 |
6,819,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1716:Zfp804b
|
UTSW |
5 |
6,819,673 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Zfp804b
|
UTSW |
5 |
6,821,938 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1747:Zfp804b
|
UTSW |
5 |
6,820,217 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1776:Zfp804b
|
UTSW |
5 |
6,819,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Zfp804b
|
UTSW |
5 |
6,821,938 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1804:Zfp804b
|
UTSW |
5 |
6,821,756 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1885:Zfp804b
|
UTSW |
5 |
6,820,376 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1887:Zfp804b
|
UTSW |
5 |
6,820,376 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1900:Zfp804b
|
UTSW |
5 |
6,819,283 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1929:Zfp804b
|
UTSW |
5 |
6,819,748 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2141:Zfp804b
|
UTSW |
5 |
6,822,583 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2181:Zfp804b
|
UTSW |
5 |
6,821,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2401:Zfp804b
|
UTSW |
5 |
6,819,445 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2408:Zfp804b
|
UTSW |
5 |
7,229,410 (GRCm39) |
intron |
probably benign |
|
|
R3237:Zfp804b
|
UTSW |
5 |
6,819,239 (GRCm39) |
missense |
probably benign |
|
|
R3429:Zfp804b
|
UTSW |
5 |
7,230,625 (GRCm39) |
intron |
probably benign |
|
|
R3785:Zfp804b
|
UTSW |
5 |
6,820,153 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4459:Zfp804b
|
UTSW |
5 |
6,821,481 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4460:Zfp804b
|
UTSW |
5 |
6,821,481 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4608:Zfp804b
|
UTSW |
5 |
6,822,584 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4871:Zfp804b
|
UTSW |
5 |
6,926,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4910:Zfp804b
|
UTSW |
5 |
6,820,540 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4973:Zfp804b
|
UTSW |
5 |
6,821,198 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5199:Zfp804b
|
UTSW |
5 |
6,820,013 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5219:Zfp804b
|
UTSW |
5 |
6,820,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5411:Zfp804b
|
UTSW |
5 |
6,820,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6001:Zfp804b
|
UTSW |
5 |
6,819,043 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6041:Zfp804b
|
UTSW |
5 |
6,821,231 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6151:Zfp804b
|
UTSW |
5 |
6,819,910 (GRCm39) |
missense |
probably benign |
|
|
R6252:Zfp804b
|
UTSW |
5 |
6,819,478 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6283:Zfp804b
|
UTSW |
5 |
6,819,908 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6346:Zfp804b
|
UTSW |
5 |
6,820,534 (GRCm39) |
missense |
probably benign |
|
|
R6520:Zfp804b
|
UTSW |
5 |
6,819,283 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6714:Zfp804b
|
UTSW |
5 |
6,819,239 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6924:Zfp804b
|
UTSW |
5 |
6,819,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6966:Zfp804b
|
UTSW |
5 |
6,821,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7027:Zfp804b
|
UTSW |
5 |
6,820,372 (GRCm39) |
missense |
probably benign |
|
|
R7042:Zfp804b
|
UTSW |
5 |
6,820,042 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7076:Zfp804b
|
UTSW |
5 |
6,819,751 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7099:Zfp804b
|
UTSW |
5 |
6,822,161 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7574:Zfp804b
|
UTSW |
5 |
6,822,301 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7609:Zfp804b
|
UTSW |
5 |
6,820,066 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7654:Zfp804b
|
UTSW |
5 |
6,819,458 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7669:Zfp804b
|
UTSW |
5 |
6,819,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7717:Zfp804b
|
UTSW |
5 |
6,821,293 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7721:Zfp804b
|
UTSW |
5 |
6,821,263 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7830:Zfp804b
|
UTSW |
5 |
6,821,124 (GRCm39) |
missense |
probably benign |
|
|
R7937:Zfp804b
|
UTSW |
5 |
6,821,866 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7941:Zfp804b
|
UTSW |
5 |
6,820,042 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8093:Zfp804b
|
UTSW |
5 |
6,820,082 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8275:Zfp804b
|
UTSW |
5 |
6,822,289 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8714:Zfp804b
|
UTSW |
5 |
6,822,378 (GRCm39) |
nonsense |
probably null |
|
|
R8788:Zfp804b
|
UTSW |
5 |
6,822,635 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9206:Zfp804b
|
UTSW |
5 |
6,822,154 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9223:Zfp804b
|
UTSW |
5 |
6,821,496 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9276:Zfp804b
|
UTSW |
5 |
6,821,398 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9285:Zfp804b
|
UTSW |
5 |
6,820,723 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9534:Zfp804b
|
UTSW |
5 |
6,819,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Zfp804b
|
UTSW |
5 |
6,821,257 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCTCTGAAACATGGAAGTGAGAC -3'
(R):5'- CAGATAGGCGGCACTTGTTTG -3'
Sequencing Primer
(F):5'- CTTAGAGAAAGCCATGTGAGTGCC -3'
(R):5'- CGGCACTTGTTTGGGAATATGATAAC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation