Incidental Mutation 'R4928:Adgre1'
| ID |
381054 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgre1
|
| Ensembl Gene |
ENSMUSG00000004730 |
| Gene Name |
adhesion G protein-coupled receptor E1 |
| Synonyms |
DD7A5-7, EGF-TM7, Emr1, Ly71, F4/80, TM7LN3 |
| MMRRC Submission |
042529-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.190)
|
| Stock # |
R4928 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
57665691-57790527 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 57751064 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 579
(Y579*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083971
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004850]
[ENSMUST00000086763]
|
| AlphaFold |
Q61549 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000004850
AA Change: Y579*
|
| SMART Domains |
Protein: ENSMUSP00000004850
Gene: ENSMUSG00000004730
AA Change: Y579*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
32 |
N/A |
INTRINSIC |
|
EGF
|
35 |
80 |
1.43e-1 |
SMART |
|
EGF_CA
|
81 |
122 |
3.59e-7 |
SMART |
|
EGF_CA
|
133 |
172 |
4.56e-9 |
SMART |
|
EGF_CA
|
173 |
221 |
1.29e-8 |
SMART |
|
EGF_CA
|
222 |
271 |
2.31e-10 |
SMART |
|
EGF_CA
|
272 |
318 |
1.06e-9 |
SMART |
|
EGF_CA
|
319 |
367 |
1.18e-7 |
SMART |
|
GPS
|
591 |
641 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
644 |
885 |
2.1e-63 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000086763
AA Change: Y579*
|
| SMART Domains |
Protein: ENSMUSP00000083971
Gene: ENSMUSG00000004730
AA Change: Y579*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
32 |
N/A |
INTRINSIC |
|
EGF
|
35 |
80 |
1.43e-1 |
SMART |
|
EGF_CA
|
81 |
122 |
3.59e-7 |
SMART |
|
EGF_CA
|
133 |
172 |
4.56e-9 |
SMART |
|
EGF_CA
|
173 |
221 |
1.29e-8 |
SMART |
|
EGF_CA
|
222 |
271 |
2.31e-10 |
SMART |
|
EGF_CA
|
272 |
318 |
1.06e-9 |
SMART |
|
EGF_CA
|
319 |
367 |
1.18e-7 |
SMART |
|
GPS
|
591 |
641 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
644 |
885 |
2.1e-63 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.5%
|
| Validation Efficiency |
98% (123/126) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T cell development. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted(3) Chemically induced(1)
|
| Other mutations in this stock |
Total: 110 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530021J07Rik |
G |
T |
7: 82,805,086 (GRCm39) |
|
noncoding transcript |
Het |
| Aasdh |
T |
A |
5: 77,044,535 (GRCm39) |
K118N |
possibly damaging |
Het |
| Abca14 |
A |
T |
7: 119,923,803 (GRCm39) |
N1620I |
possibly damaging |
Het |
| Acap1 |
A |
T |
11: 69,776,641 (GRCm39) |
S149T |
possibly damaging |
Het |
| Aifm3 |
T |
C |
16: 17,318,296 (GRCm39) |
|
probably benign |
Het |
| Aldh16a1 |
A |
G |
7: 44,791,385 (GRCm39) |
W107R |
probably damaging |
Het |
| Amer2 |
A |
T |
14: 60,616,894 (GRCm39) |
H363L |
possibly damaging |
Het |
| Arhgap10 |
A |
G |
8: 78,152,957 (GRCm39) |
|
probably null |
Het |
| Arhgef6 |
A |
T |
X: 56,280,238 (GRCm39) |
D742E |
probably damaging |
Het |
| Astn2 |
A |
T |
4: 65,647,644 (GRCm39) |
N731K |
probably damaging |
Het |
| Atp1a2 |
T |
C |
1: 172,105,954 (GRCm39) |
T904A |
possibly damaging |
Het |
| Atr |
C |
T |
9: 95,789,352 (GRCm39) |
R1503W |
probably damaging |
Het |
| Cdh3 |
G |
T |
8: 107,263,242 (GRCm39) |
R97L |
probably benign |
Het |
| Chst2 |
C |
T |
9: 95,288,059 (GRCm39) |
V96I |
probably benign |
Het |
| Cit |
T |
A |
5: 116,123,856 (GRCm39) |
N1464K |
probably benign |
Het |
| Col17a1 |
A |
T |
19: 47,658,897 (GRCm39) |
|
probably null |
Het |
| Col4a3 |
G |
A |
1: 82,688,698 (GRCm39) |
|
probably benign |
Het |
| Copz1 |
T |
A |
15: 103,199,757 (GRCm39) |
S57R |
probably damaging |
Het |
| Cpped1 |
A |
T |
16: 11,646,143 (GRCm39) |
F227Y |
probably damaging |
Het |
| Cyp2j12 |
A |
T |
4: 95,990,388 (GRCm39) |
|
probably null |
Het |
| Dctn1 |
T |
A |
6: 83,166,189 (GRCm39) |
I195N |
possibly damaging |
Het |
| Dhrs7b |
A |
G |
11: 60,742,751 (GRCm39) |
I148V |
probably benign |
Het |
| Dnah17 |
T |
C |
11: 117,918,259 (GRCm39) |
D4096G |
probably damaging |
Het |
| Dnajc13 |
T |
C |
9: 104,110,837 (GRCm39) |
N145D |
possibly damaging |
Het |
| Ecpas |
A |
G |
4: 58,827,073 (GRCm39) |
V1020A |
probably damaging |
Het |
| Entrep2 |
G |
T |
7: 64,409,116 (GRCm39) |
S426* |
probably null |
Het |
| Ercc6l2 |
T |
C |
13: 64,042,627 (GRCm39) |
|
probably benign |
Het |
| Fads6 |
T |
G |
11: 115,187,387 (GRCm39) |
I103L |
probably benign |
Het |
| Fat4 |
T |
G |
3: 39,064,614 (GRCm39) |
Y4857D |
probably damaging |
Het |
| Fbxl14 |
T |
A |
6: 119,457,671 (GRCm39) |
L284Q |
probably damaging |
Het |
| Fkbp9 |
T |
C |
6: 56,826,655 (GRCm39) |
V85A |
possibly damaging |
Het |
| Galnt13 |
T |
A |
2: 54,406,577 (GRCm39) |
V9E |
probably damaging |
Het |
| Gm14412 |
A |
T |
2: 177,006,373 (GRCm39) |
S507R |
probably benign |
Het |
| Gm15142 |
T |
A |
X: 153,421,415 (GRCm39) |
|
noncoding transcript |
Het |
| Gm4787 |
T |
C |
12: 81,425,612 (GRCm39) |
E182G |
probably benign |
Het |
| Gm6811 |
C |
A |
17: 21,314,893 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9791 |
A |
T |
3: 34,059,218 (GRCm39) |
|
noncoding transcript |
Het |
| Hoxb7 |
A |
T |
11: 96,180,336 (GRCm39) |
|
probably null |
Het |
| Ift122 |
T |
A |
6: 115,892,819 (GRCm39) |
|
probably benign |
Het |
| Krt28 |
C |
T |
11: 99,265,458 (GRCm39) |
V70I |
probably benign |
Het |
| Lig1 |
T |
C |
7: 13,032,664 (GRCm39) |
S459P |
probably damaging |
Het |
| Lrfn3 |
C |
T |
7: 30,060,048 (GRCm39) |
R59H |
possibly damaging |
Het |
| Mavs |
T |
C |
2: 131,088,663 (GRCm39) |
V489A |
probably benign |
Het |
| Mcm8 |
C |
T |
2: 132,681,399 (GRCm39) |
P625L |
probably benign |
Het |
| Megf10 |
G |
T |
18: 57,373,745 (GRCm39) |
R181L |
probably benign |
Het |
| Mgrn1 |
G |
A |
16: 4,745,726 (GRCm39) |
G440D |
probably benign |
Het |
| Mllt3 |
T |
C |
4: 87,700,642 (GRCm39) |
|
probably null |
Het |
| Muc5ac |
T |
A |
7: 141,371,639 (GRCm39) |
Y2613* |
probably null |
Het |
| Myh14 |
C |
T |
7: 44,284,926 (GRCm39) |
G662S |
probably benign |
Het |
| Myod1 |
T |
A |
7: 46,026,474 (GRCm39) |
N126K |
probably damaging |
Het |
| Nae1 |
A |
T |
8: 105,242,774 (GRCm39) |
H439Q |
possibly damaging |
Het |
| Narf |
T |
A |
11: 121,135,765 (GRCm39) |
V136E |
possibly damaging |
Het |
| Ncapd3 |
T |
A |
9: 26,983,031 (GRCm39) |
C926* |
probably null |
Het |
| Ndufv2 |
C |
A |
17: 66,399,653 (GRCm39) |
|
probably null |
Het |
| Neb |
T |
C |
2: 52,102,987 (GRCm39) |
S449G |
possibly damaging |
Het |
| Nek10 |
C |
T |
14: 14,930,577 (GRCm38) |
P698L |
probably damaging |
Het |
| Nox3 |
T |
A |
17: 3,685,550 (GRCm39) |
E566V |
probably null |
Het |
| Oas1a |
C |
T |
5: 121,043,787 (GRCm39) |
R115H |
probably benign |
Het |
| Or10ag60 |
C |
A |
2: 87,438,487 (GRCm39) |
L252I |
probably benign |
Het |
| Or51b6 |
A |
G |
7: 103,555,879 (GRCm39) |
T78A |
probably damaging |
Het |
| Or5w19 |
A |
G |
2: 87,698,574 (GRCm39) |
M80V |
probably benign |
Het |
| Or8k30 |
T |
A |
2: 86,339,469 (GRCm39) |
L222H |
probably damaging |
Het |
| Pbld2 |
A |
G |
10: 62,883,778 (GRCm39) |
H142R |
probably damaging |
Het |
| Pcdha4 |
C |
T |
18: 37,087,869 (GRCm39) |
T684M |
probably benign |
Het |
| Phc3 |
G |
T |
3: 31,005,068 (GRCm39) |
T175N |
probably damaging |
Het |
| Pigs |
G |
T |
11: 78,219,828 (GRCm39) |
V68L |
probably damaging |
Het |
| Pik3c2g |
T |
A |
6: 139,913,528 (GRCm39) |
D857E |
possibly damaging |
Het |
| Pitpnm3 |
G |
A |
11: 71,953,998 (GRCm39) |
P550S |
probably damaging |
Het |
| Pla2g15 |
G |
A |
8: 106,889,850 (GRCm39) |
W374* |
probably null |
Het |
| Ptpn14 |
G |
A |
1: 189,554,839 (GRCm39) |
C133Y |
probably damaging |
Het |
| Ptpn20 |
A |
G |
14: 33,336,446 (GRCm39) |
N95S |
probably benign |
Het |
| Ptrh2 |
G |
T |
11: 86,580,862 (GRCm39) |
V160F |
probably damaging |
Het |
| Rapgef3 |
T |
C |
15: 97,655,256 (GRCm39) |
D486G |
probably damaging |
Het |
| Rev3l |
T |
G |
10: 39,699,981 (GRCm39) |
S1493A |
probably benign |
Het |
| Rgs9 |
T |
A |
11: 109,116,570 (GRCm39) |
D411V |
probably benign |
Het |
| Rgsl1 |
A |
T |
1: 153,669,514 (GRCm39) |
Y291N |
probably damaging |
Het |
| Rprd2 |
A |
G |
3: 95,671,849 (GRCm39) |
Y1185H |
probably damaging |
Het |
| Rpusd3 |
A |
G |
6: 113,393,167 (GRCm39) |
|
probably benign |
Het |
| Scnn1a |
T |
C |
6: 125,299,136 (GRCm39) |
I72T |
probably damaging |
Het |
| Sdk1 |
A |
T |
5: 141,842,758 (GRCm39) |
|
probably benign |
Het |
| Sfmbt2 |
T |
C |
2: 10,450,556 (GRCm39) |
L277P |
probably benign |
Het |
| Sgf29 |
A |
G |
7: 126,264,154 (GRCm39) |
E73G |
probably damaging |
Het |
| Slc12a6 |
T |
A |
2: 112,183,306 (GRCm39) |
F764L |
probably damaging |
Het |
| Slc4a2 |
T |
C |
5: 24,640,340 (GRCm39) |
|
probably null |
Het |
| Slc9a3 |
T |
G |
13: 74,305,838 (GRCm39) |
V285G |
probably damaging |
Het |
| Slc9c1 |
A |
G |
16: 45,395,772 (GRCm39) |
T608A |
probably benign |
Het |
| Slfnl1 |
C |
T |
4: 120,392,882 (GRCm39) |
R325C |
probably damaging |
Het |
| Smarcad1 |
T |
A |
6: 65,051,898 (GRCm39) |
F344I |
probably benign |
Het |
| Snrnp70 |
A |
T |
7: 45,026,705 (GRCm39) |
|
probably null |
Het |
| Sod2 |
C |
T |
17: 13,227,073 (GRCm39) |
T9M |
probably benign |
Het |
| Spag5 |
T |
A |
11: 78,205,199 (GRCm39) |
S633T |
probably damaging |
Het |
| Spta1 |
A |
T |
1: 174,018,622 (GRCm39) |
I531L |
probably benign |
Het |
| Stra8 |
A |
G |
6: 34,910,091 (GRCm39) |
E60G |
probably benign |
Het |
| Sult2a3 |
T |
A |
7: 13,845,482 (GRCm39) |
I126F |
probably benign |
Het |
| Syt1 |
T |
C |
10: 108,340,373 (GRCm39) |
H315R |
possibly damaging |
Het |
| Tanc2 |
T |
C |
11: 105,758,588 (GRCm39) |
L783P |
probably damaging |
Het |
| Thbs2 |
C |
T |
17: 14,899,162 (GRCm39) |
C646Y |
probably damaging |
Het |
| Ticam2 |
T |
A |
18: 46,693,989 (GRCm39) |
K33* |
probably null |
Het |
| Trim17 |
T |
C |
11: 58,845,127 (GRCm39) |
|
probably benign |
Het |
| Tsr1 |
G |
A |
11: 74,798,705 (GRCm39) |
M691I |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,592,763 (GRCm39) |
I20790F |
probably damaging |
Het |
| Tubb2b |
A |
T |
13: 34,312,168 (GRCm39) |
Y208* |
probably null |
Het |
| Ubr1 |
T |
A |
2: 120,745,419 (GRCm39) |
I890F |
probably damaging |
Het |
| Usp54 |
T |
C |
14: 20,612,260 (GRCm39) |
E852G |
probably damaging |
Het |
| Vmn2r78 |
T |
C |
7: 86,603,835 (GRCm39) |
V671A |
probably damaging |
Het |
| Wipi1 |
T |
C |
11: 109,470,475 (GRCm39) |
K315E |
probably benign |
Het |
| Xrn2 |
T |
C |
2: 146,893,638 (GRCm39) |
V735A |
possibly damaging |
Het |
| Zdbf2 |
T |
A |
1: 63,347,973 (GRCm39) |
D2117E |
possibly damaging |
Het |
| Zfp287 |
A |
T |
11: 62,604,962 (GRCm39) |
C648* |
probably null |
Het |
| Zfp369 |
A |
G |
13: 65,444,614 (GRCm39) |
T586A |
possibly damaging |
Het |
|
| Other mutations in Adgre1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Adgre1
|
APN |
17 |
57,757,055 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00966:Adgre1
|
APN |
17 |
57,726,335 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01680:Adgre1
|
APN |
17 |
57,709,620 (GRCm39) |
missense |
unknown |
|
|
IGL01724:Adgre1
|
APN |
17 |
57,751,064 (GRCm39) |
nonsense |
probably null |
|
|
IGL02172:Adgre1
|
APN |
17 |
57,785,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02260:Adgre1
|
APN |
17 |
57,754,891 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02272:Adgre1
|
APN |
17 |
57,757,021 (GRCm39) |
nonsense |
probably null |
|
|
IGL02336:Adgre1
|
APN |
17 |
57,718,024 (GRCm39) |
nonsense |
probably null |
|
|
IGL02346:Adgre1
|
APN |
17 |
57,750,919 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02398:Adgre1
|
APN |
17 |
57,709,824 (GRCm39) |
nonsense |
probably null |
|
|
IGL02618:Adgre1
|
APN |
17 |
57,751,021 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02690:Adgre1
|
APN |
17 |
57,787,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02936:Adgre1
|
APN |
17 |
57,785,833 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03112:Adgre1
|
APN |
17 |
57,755,029 (GRCm39) |
splice site |
probably null |
|
|
IGL03350:Adgre1
|
APN |
17 |
57,708,908 (GRCm39) |
missense |
probably benign |
0.16 |
|
F480
|
UTSW |
17 |
57,751,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
lomax
|
UTSW |
17 |
57,709,811 (GRCm39) |
missense |
unknown |
|
|
Onion
|
UTSW |
17 |
57,709,841 (GRCm39) |
nonsense |
probably null |
|
|
Scallion
|
UTSW |
17 |
57,708,977 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0049:Adgre1
|
UTSW |
17 |
57,709,841 (GRCm39) |
nonsense |
probably null |
|
|
R0153:Adgre1
|
UTSW |
17 |
57,750,939 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0277:Adgre1
|
UTSW |
17 |
57,751,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0278:Adgre1
|
UTSW |
17 |
57,754,872 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0323:Adgre1
|
UTSW |
17 |
57,751,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Adgre1
|
UTSW |
17 |
57,713,839 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0492:Adgre1
|
UTSW |
17 |
57,709,742 (GRCm39) |
missense |
unknown |
|
|
R0621:Adgre1
|
UTSW |
17 |
57,748,359 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0647:Adgre1
|
UTSW |
17 |
57,718,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1310:Adgre1
|
UTSW |
17 |
57,754,936 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1601:Adgre1
|
UTSW |
17 |
57,748,353 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1689:Adgre1
|
UTSW |
17 |
57,756,921 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1708:Adgre1
|
UTSW |
17 |
57,708,974 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1796:Adgre1
|
UTSW |
17 |
57,748,350 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1839:Adgre1
|
UTSW |
17 |
57,748,299 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1860:Adgre1
|
UTSW |
17 |
57,748,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2165:Adgre1
|
UTSW |
17 |
57,726,338 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2219:Adgre1
|
UTSW |
17 |
57,708,912 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2519:Adgre1
|
UTSW |
17 |
57,717,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3874:Adgre1
|
UTSW |
17 |
57,708,925 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3911:Adgre1
|
UTSW |
17 |
57,754,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4190:Adgre1
|
UTSW |
17 |
57,709,811 (GRCm39) |
missense |
unknown |
|
|
R4439:Adgre1
|
UTSW |
17 |
57,754,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4513:Adgre1
|
UTSW |
17 |
57,717,947 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4529:Adgre1
|
UTSW |
17 |
57,727,519 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4543:Adgre1
|
UTSW |
17 |
57,713,874 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4610:Adgre1
|
UTSW |
17 |
57,757,073 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4665:Adgre1
|
UTSW |
17 |
57,787,947 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4911:Adgre1
|
UTSW |
17 |
57,754,832 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4942:Adgre1
|
UTSW |
17 |
57,713,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4946:Adgre1
|
UTSW |
17 |
57,750,918 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4953:Adgre1
|
UTSW |
17 |
57,748,321 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5107:Adgre1
|
UTSW |
17 |
57,708,977 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5366:Adgre1
|
UTSW |
17 |
57,709,817 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5590:Adgre1
|
UTSW |
17 |
57,752,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5619:Adgre1
|
UTSW |
17 |
57,727,437 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5699:Adgre1
|
UTSW |
17 |
57,788,007 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5734:Adgre1
|
UTSW |
17 |
57,750,990 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5860:Adgre1
|
UTSW |
17 |
57,752,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6039:Adgre1
|
UTSW |
17 |
57,713,859 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6039:Adgre1
|
UTSW |
17 |
57,713,859 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6149:Adgre1
|
UTSW |
17 |
57,752,018 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6478:Adgre1
|
UTSW |
17 |
57,708,955 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6709:Adgre1
|
UTSW |
17 |
57,713,917 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6864:Adgre1
|
UTSW |
17 |
57,785,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6945:Adgre1
|
UTSW |
17 |
57,727,399 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6945:Adgre1
|
UTSW |
17 |
57,717,844 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6988:Adgre1
|
UTSW |
17 |
57,715,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7019:Adgre1
|
UTSW |
17 |
57,717,945 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7154:Adgre1
|
UTSW |
17 |
57,751,087 (GRCm39) |
splice site |
probably null |
|
|
R7347:Adgre1
|
UTSW |
17 |
57,727,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7459:Adgre1
|
UTSW |
17 |
57,756,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7709:Adgre1
|
UTSW |
17 |
57,709,519 (GRCm39) |
missense |
unknown |
|
|
R7939:Adgre1
|
UTSW |
17 |
57,756,938 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7977:Adgre1
|
UTSW |
17 |
57,754,987 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7987:Adgre1
|
UTSW |
17 |
57,754,987 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8187:Adgre1
|
UTSW |
17 |
57,727,349 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8210:Adgre1
|
UTSW |
17 |
57,752,061 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8223:Adgre1
|
UTSW |
17 |
57,668,692 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Adgre1
|
UTSW |
17 |
57,715,459 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8698:Adgre1
|
UTSW |
17 |
57,709,003 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9236:Adgre1
|
UTSW |
17 |
57,709,782 (GRCm39) |
nonsense |
probably null |
|
|
R9262:Adgre1
|
UTSW |
17 |
57,754,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9303:Adgre1
|
UTSW |
17 |
57,748,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9305:Adgre1
|
UTSW |
17 |
57,748,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9605:Adgre1
|
UTSW |
17 |
57,718,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9661:Adgre1
|
UTSW |
17 |
57,748,368 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9678:Adgre1
|
UTSW |
17 |
57,750,997 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9751:Adgre1
|
UTSW |
17 |
57,757,101 (GRCm39) |
missense |
probably null |
0.06 |
|
R9785:Adgre1
|
UTSW |
17 |
57,785,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgre1
|
UTSW |
17 |
57,668,729 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
Z1177:Adgre1
|
UTSW |
17 |
57,726,374 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATGAGTGTACACATGTTGC -3'
(R):5'- GCACACAGCATCTCTCTAGTAAAG -3'
Sequencing Primer
(F):5'- ACACATGTTGCTGTGTGTACAC -3'
(R):5'- GCATCTCTCTAGTAAAGGAAAAATGG -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation