Incidental Mutation 'R4959:Vps8'
| ID |
382204 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
042556-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4959 (G1)
|
| Quality Score |
202 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 21278536 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 267
(S267P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112636
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
[ENSMUST00000122235]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096191
AA Change: S265P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: S265P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096192
AA Change: S267P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: S267P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115397
AA Change: S267P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: S267P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117598
AA Change: S265P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: S265P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118923
AA Change: S267P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: S267P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000112622
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
WD40
|
184 |
225 |
2.66e0 |
SMART |
|
WD40
|
228 |
269 |
5.5e1 |
SMART |
|
low complexity region
|
371 |
386 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
491 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.7150 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 95.6%
- 20x: 89.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 6820408C15Rik |
T |
A |
2: 152,282,808 (GRCm39) |
I221K |
possibly damaging |
Het |
| Aadacl3 |
A |
T |
4: 144,183,656 (GRCm39) |
C136S |
probably benign |
Het |
| Abhd16a |
T |
A |
17: 35,321,318 (GRCm39) |
S498T |
probably benign |
Het |
| Acrv1 |
G |
A |
9: 36,605,996 (GRCm39) |
|
probably null |
Het |
| Adamts18 |
G |
A |
8: 114,463,357 (GRCm39) |
R830* |
probably null |
Het |
| Art3 |
A |
G |
5: 92,551,478 (GRCm39) |
Y279C |
probably damaging |
Het |
| Atm |
A |
T |
9: 53,426,601 (GRCm39) |
D552E |
probably benign |
Het |
| Ccdc154 |
T |
C |
17: 25,389,888 (GRCm39) |
L508P |
probably damaging |
Het |
| Ccser2 |
A |
T |
14: 36,662,753 (GRCm39) |
S144T |
probably benign |
Het |
| Cgn |
C |
T |
3: 94,685,564 (GRCm39) |
A320T |
probably benign |
Het |
| Cklf |
A |
G |
8: 104,988,184 (GRCm39) |
K106E |
probably benign |
Het |
| Clec12a |
C |
A |
6: 129,330,628 (GRCm39) |
T70K |
probably benign |
Het |
| CN725425 |
G |
A |
15: 91,129,904 (GRCm39) |
A256T |
possibly damaging |
Het |
| Crb2 |
G |
T |
2: 37,680,482 (GRCm39) |
R470L |
probably damaging |
Het |
| Csn1s1 |
T |
G |
5: 87,821,120 (GRCm39) |
S33A |
probably benign |
Het |
| D630045J12Rik |
C |
T |
6: 38,125,302 (GRCm39) |
V1571M |
possibly damaging |
Het |
| Deup1 |
G |
A |
9: 15,523,310 (GRCm39) |
Q58* |
probably null |
Het |
| Dph2 |
T |
A |
4: 117,748,527 (GRCm39) |
D82V |
probably damaging |
Het |
| Dsp |
C |
T |
13: 38,375,686 (GRCm39) |
A1157V |
probably benign |
Het |
| Evi5l |
G |
T |
8: 4,255,406 (GRCm39) |
V477L |
probably benign |
Het |
| Fam187b |
T |
A |
7: 30,681,687 (GRCm39) |
H131Q |
probably damaging |
Het |
| Fam193b |
A |
G |
13: 55,691,097 (GRCm39) |
I259T |
probably damaging |
Het |
| Fam91a1 |
A |
G |
15: 58,303,059 (GRCm39) |
T323A |
probably benign |
Het |
| Fat4 |
T |
G |
3: 39,037,195 (GRCm39) |
S3616A |
probably benign |
Het |
| Fbxo38 |
A |
T |
18: 62,655,578 (GRCm39) |
N369K |
probably benign |
Het |
| Fitm1 |
T |
A |
14: 55,813,831 (GRCm39) |
|
probably null |
Het |
| Fkbp5 |
T |
C |
17: 28,647,343 (GRCm39) |
E164G |
probably damaging |
Het |
| Fpr-rs3 |
T |
C |
17: 20,844,211 (GRCm39) |
Y310C |
possibly damaging |
Het |
| Fryl |
A |
T |
5: 73,192,401 (GRCm39) |
M2678K |
probably benign |
Het |
| Fsip2 |
T |
C |
2: 82,815,169 (GRCm39) |
I3634T |
probably benign |
Het |
| Gm3233 |
T |
C |
10: 77,595,399 (GRCm39) |
|
probably benign |
Het |
| Gzmd |
T |
G |
14: 56,369,955 (GRCm39) |
T9P |
unknown |
Het |
| Htr2b |
A |
T |
1: 86,027,813 (GRCm39) |
I231N |
probably damaging |
Het |
| Il2ra |
A |
G |
2: 11,681,664 (GRCm39) |
T90A |
possibly damaging |
Het |
| Kbtbd2 |
A |
G |
6: 56,758,943 (GRCm39) |
F60S |
probably benign |
Het |
| Kif21b |
G |
A |
1: 136,076,108 (GRCm39) |
C299Y |
possibly damaging |
Het |
| Lsm5 |
A |
T |
6: 56,680,309 (GRCm39) |
D44E |
probably damaging |
Het |
| Mapk1 |
T |
A |
16: 16,836,170 (GRCm39) |
M106K |
probably damaging |
Het |
| Mpp2 |
A |
G |
11: 101,954,117 (GRCm39) |
V193A |
probably damaging |
Het |
| Muc4 |
T |
C |
16: 32,575,437 (GRCm39) |
S1398P |
possibly damaging |
Het |
| Ndufs2 |
A |
G |
1: 171,065,578 (GRCm39) |
Y282H |
probably damaging |
Het |
| Nes |
T |
A |
3: 87,882,983 (GRCm39) |
L414Q |
probably damaging |
Het |
| Neurl2 |
T |
A |
2: 164,675,122 (GRCm39) |
|
probably null |
Het |
| Ngef |
A |
G |
1: 87,431,070 (GRCm39) |
F159S |
possibly damaging |
Het |
| Nlrx1 |
T |
C |
9: 44,165,448 (GRCm39) |
H816R |
possibly damaging |
Het |
| Or10v5 |
A |
G |
19: 11,806,300 (GRCm39) |
L30P |
probably benign |
Het |
| Or1e22 |
A |
T |
11: 73,376,893 (GRCm39) |
Y252* |
probably null |
Het |
| Or2f1 |
T |
C |
6: 42,721,621 (GRCm39) |
S217P |
probably damaging |
Het |
| Or4c106 |
T |
C |
2: 88,682,516 (GRCm39) |
V74A |
possibly damaging |
Het |
| Or4f17-ps1 |
T |
A |
2: 111,357,969 (GRCm39) |
F103L |
probably damaging |
Het |
| Or4p7 |
T |
A |
2: 88,221,674 (GRCm39) |
L28I |
probably benign |
Het |
| Or7g35 |
A |
G |
9: 19,496,504 (GRCm39) |
T224A |
probably benign |
Het |
| Pcgf2 |
A |
T |
11: 97,582,515 (GRCm39) |
Y7N |
possibly damaging |
Het |
| Pdlim5 |
G |
A |
3: 142,017,740 (GRCm39) |
|
probably benign |
Het |
| Pdzd2 |
A |
G |
15: 12,375,734 (GRCm39) |
V1467A |
probably damaging |
Het |
| Pigp |
C |
A |
16: 94,160,006 (GRCm39) |
G134V |
probably benign |
Het |
| Pik3c2g |
T |
C |
6: 139,789,657 (GRCm39) |
Y385H |
possibly damaging |
Het |
| Pnliprp2 |
G |
A |
19: 58,754,750 (GRCm39) |
E265K |
probably benign |
Het |
| Prl3c1 |
G |
T |
13: 27,386,471 (GRCm39) |
|
probably null |
Het |
| Ptpn4 |
A |
T |
1: 119,692,826 (GRCm39) |
Y110* |
probably null |
Het |
| Ptprq |
C |
T |
10: 107,522,416 (GRCm39) |
V546I |
probably damaging |
Het |
| Rd3l |
C |
T |
12: 111,946,578 (GRCm39) |
|
probably null |
Het |
| Rpl37 |
G |
A |
15: 5,147,128 (GRCm39) |
R56Q |
possibly damaging |
Het |
| Rttn |
A |
T |
18: 89,060,292 (GRCm39) |
H998L |
probably damaging |
Het |
| Rufy1 |
A |
T |
11: 50,292,315 (GRCm39) |
F491L |
probably benign |
Het |
| Simc1 |
T |
G |
13: 54,673,131 (GRCm39) |
V493G |
possibly damaging |
Het |
| Slc22a14 |
CTTTCCTGAA |
C |
9: 119,003,101 (GRCm39) |
|
probably benign |
Het |
| Slc25a46 |
A |
T |
18: 31,735,807 (GRCm39) |
I144N |
possibly damaging |
Het |
| Smtn |
A |
T |
11: 3,477,825 (GRCm39) |
M1K |
probably null |
Het |
| Snd1 |
C |
A |
6: 28,884,250 (GRCm39) |
Y766* |
probably null |
Het |
| Spata31d1d |
C |
T |
13: 59,875,102 (GRCm39) |
G811D |
probably damaging |
Het |
| Spta1 |
A |
C |
1: 174,074,174 (GRCm39) |
D2371A |
probably damaging |
Het |
| Stard6 |
A |
C |
18: 70,631,631 (GRCm39) |
D74A |
possibly damaging |
Het |
| Stim2 |
G |
T |
5: 54,262,712 (GRCm39) |
R318L |
probably benign |
Het |
| Sufu |
C |
T |
19: 46,463,991 (GRCm39) |
T401I |
possibly damaging |
Het |
| Suz12 |
G |
A |
11: 79,920,057 (GRCm39) |
G539D |
probably damaging |
Het |
| Sytl2 |
C |
G |
7: 90,025,245 (GRCm39) |
S411C |
probably damaging |
Het |
| Taf6 |
G |
A |
5: 138,181,465 (GRCm39) |
Q156* |
probably null |
Het |
| Tead4 |
T |
C |
6: 128,247,950 (GRCm39) |
D29G |
probably damaging |
Het |
| Thada |
T |
C |
17: 84,751,611 (GRCm39) |
Y455C |
probably damaging |
Het |
| Tlr6 |
G |
C |
5: 65,111,002 (GRCm39) |
T635S |
possibly damaging |
Het |
| Tlr9 |
A |
G |
9: 106,101,876 (GRCm39) |
D389G |
probably benign |
Het |
| Tmem54 |
A |
T |
4: 129,002,073 (GRCm39) |
H40L |
probably damaging |
Het |
| Trappc9 |
G |
T |
15: 72,808,905 (GRCm39) |
N540K |
probably damaging |
Het |
| Trbv28 |
C |
T |
6: 41,248,788 (GRCm39) |
S106F |
probably damaging |
Het |
| Trrap |
A |
T |
5: 144,793,770 (GRCm39) |
H3384L |
probably damaging |
Het |
| Usp16 |
T |
A |
16: 87,277,802 (GRCm39) |
M684K |
probably damaging |
Het |
| Vat1 |
G |
A |
11: 101,351,426 (GRCm39) |
T305M |
probably damaging |
Het |
| Vmn2r85 |
A |
G |
10: 130,257,302 (GRCm39) |
S544P |
probably damaging |
Het |
| Ylpm1 |
T |
A |
12: 85,096,719 (GRCm39) |
V1242E |
probably damaging |
Het |
| Zfp267 |
C |
T |
3: 36,218,285 (GRCm39) |
R102C |
possibly damaging |
Het |
| Zfp322a |
T |
C |
13: 23,541,052 (GRCm39) |
Y230C |
probably damaging |
Het |
| Zfp352 |
T |
A |
4: 90,112,376 (GRCm39) |
V172E |
probably benign |
Het |
| Zfp936 |
A |
T |
7: 42,839,034 (GRCm39) |
H167L |
probably damaging |
Het |
| Zkscan14 |
A |
G |
5: 145,132,302 (GRCm39) |
Y410H |
probably benign |
Het |
| Zkscan17 |
A |
G |
11: 59,394,538 (GRCm39) |
M21T |
probably damaging |
Het |
| Zswim4 |
G |
T |
8: 84,938,852 (GRCm39) |
A1010D |
probably benign |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTCAGTTATTTAACGATACTGAG -3'
(R):5'- CATATGTTGTATAGAGCTCCCCAG -3'
Sequencing Primer
(F):5'- TGGAAGTAAGGACAATTTGTACAC -3'
(R):5'- GTTGTATAGAGCTCCCCAGGTAAC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation