|Institutional Source||Beutler Lab|
|Gene Name||interleukin 17A|
|Synonyms||Ctla8, Il17, Ctla-8, IL-17A|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5932 (G1)|
|Chromosomal Location||20730905-20734496 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 20733753 bp|
|Amino Acid Change||Valine to Alanine at position 124 (V124A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027061 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027061]|
|Predicted Effect||probably damaging
AA Change: V124A
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: V124A
|Coding Region Coverage||
|MGI Phenotype||Strain: 5438791
FUNCTION: This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced contact, delayed-type and airway hypersensitivity responses and impaired T-dependent antibody production. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il17a||
(F):5'- AGCAGGACTTCATTTCCTCC -3'
(R):5'- CTGAATCTGCCTCTGAATCCAC -3'
(F):5'- GGACTTCATTTCCTCCTGGCTTTTG -3'
(R):5'- TCCTTGCTGAAAATCAATAGCACG -3'