Incidental Mutation 'R6374:Trim24'
| ID |
513682 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trim24
|
| Ensembl Gene |
ENSMUSG00000029833 |
| Gene Name |
tripartite motif-containing 24 |
| Synonyms |
D430004I05Rik, A130082H20Rik, TIF1alpha, Tif1a |
| MMRRC Submission |
044524-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6374 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
37847746-37943231 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 37930484 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 576
(V576E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114001
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031859]
[ENSMUST00000120238]
[ENSMUST00000120428]
|
| AlphaFold |
Q64127 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000031859
AA Change: V646E
PolyPhen 2
Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000031859
Gene: ENSMUSG00000029833
AA Change: V646E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
23 |
N/A |
INTRINSIC |
|
RING
|
52 |
130 |
2.5e-10 |
SMART |
|
BBOX
|
158 |
205 |
2e-13 |
SMART |
|
BBOX
|
218 |
259 |
7e-14 |
SMART |
|
BBC
|
266 |
392 |
3e-44 |
SMART |
|
low complexity region
|
474 |
491 |
N/A |
INTRINSIC |
|
low complexity region
|
501 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
686 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
759 |
774 |
N/A |
INTRINSIC |
|
PHD
|
829 |
872 |
2.1e-13 |
SMART |
|
BROMO
|
902 |
1007 |
2.4e-40 |
SMART |
|
low complexity region
|
1025 |
1033 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120238
AA Change: V576E
PolyPhen 2
Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000114001
Gene: ENSMUSG00000029833
AA Change: V576E
| Domain | Start | End | E-Value | Type |
|---|
|
BBOX
|
88 |
135 |
2e-13 |
SMART |
|
BBOX
|
148 |
189 |
6.8e-14 |
SMART |
|
BBC
|
196 |
322 |
3e-44 |
SMART |
|
low complexity region
|
404 |
421 |
N/A |
INTRINSIC |
|
low complexity region
|
431 |
444 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
528 |
N/A |
INTRINSIC |
|
low complexity region
|
616 |
639 |
N/A |
INTRINSIC |
|
low complexity region
|
689 |
704 |
N/A |
INTRINSIC |
|
PHD
|
759 |
802 |
2e-13 |
SMART |
|
BROMO
|
832 |
937 |
2.4e-40 |
SMART |
|
low complexity region
|
955 |
963 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120428
AA Change: V612E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000113063
Gene: ENSMUSG00000029833
AA Change: V612E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
23 |
N/A |
INTRINSIC |
|
RING
|
52 |
130 |
5.22e-8 |
SMART |
|
BBOX
|
158 |
205 |
6.27e-11 |
SMART |
|
BBOX
|
218 |
259 |
2.22e-11 |
SMART |
|
BBC
|
266 |
392 |
5.86e-42 |
SMART |
|
low complexity region
|
539 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
652 |
675 |
N/A |
INTRINSIC |
|
low complexity region
|
725 |
740 |
N/A |
INTRINSIC |
|
PHD
|
795 |
838 |
3.15e-11 |
SMART |
|
BROMO
|
868 |
973 |
3.95e-38 |
SMART |
|
low complexity region
|
991 |
999 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135387
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.5%
- 20x: 92.4%
|
| Validation Efficiency |
99% (75/76) |
| MGI Phenotype |
FUNCTION: The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased hepatocyte ploidy and uncontrolled hepatocellular proliferation; most adult mice develop malignant hepatocellular carcinomas. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921509C19Rik |
A |
C |
2: 151,314,800 (GRCm39) |
S293A |
possibly damaging |
Het |
| 5430401F13Rik |
A |
T |
6: 131,529,892 (GRCm39) |
Q162L |
unknown |
Het |
| Abca8a |
A |
T |
11: 109,974,216 (GRCm39) |
Y239* |
probably null |
Het |
| Aox3 |
T |
C |
1: 58,211,320 (GRCm39) |
I959T |
probably benign |
Het |
| Atad2b |
T |
C |
12: 5,068,002 (GRCm39) |
V1000A |
probably damaging |
Het |
| Atic |
C |
T |
1: 71,604,100 (GRCm39) |
T221M |
probably damaging |
Het |
| Atp1a2 |
C |
T |
1: 172,116,942 (GRCm39) |
R225H |
probably damaging |
Het |
| BC024139 |
A |
G |
15: 76,004,657 (GRCm39) |
|
probably null |
Het |
| Bpi |
A |
T |
2: 158,113,974 (GRCm39) |
T291S |
probably damaging |
Het |
| Ccdc170 |
C |
T |
10: 4,499,746 (GRCm39) |
Q556* |
probably null |
Het |
| Cd3e |
G |
A |
9: 44,920,661 (GRCm39) |
L12F |
probably benign |
Het |
| Cdc42ep1 |
A |
T |
15: 78,731,649 (GRCm39) |
R31S |
probably damaging |
Het |
| Cyp21a1 |
G |
T |
17: 35,023,110 (GRCm39) |
|
probably null |
Het |
| Dnase1l3 |
A |
G |
14: 7,974,115 (GRCm38) |
M192T |
probably damaging |
Het |
| Dnmt1 |
A |
T |
9: 20,835,341 (GRCm39) |
H330Q |
possibly damaging |
Het |
| Enah |
T |
C |
1: 181,751,145 (GRCm39) |
E232G |
unknown |
Het |
| Etnppl |
C |
T |
3: 130,414,342 (GRCm39) |
T73I |
probably damaging |
Het |
| Fam83b |
T |
A |
9: 76,400,189 (GRCm39) |
I305F |
probably benign |
Het |
| Galnt15 |
T |
A |
14: 31,780,116 (GRCm39) |
I471N |
probably damaging |
Het |
| Gm19965 |
T |
A |
1: 116,750,021 (GRCm39) |
N567K |
probably benign |
Het |
| Golga1 |
T |
C |
2: 38,924,080 (GRCm39) |
Q435R |
probably benign |
Het |
| Gpat2 |
G |
C |
2: 127,273,838 (GRCm39) |
G294R |
possibly damaging |
Het |
| Hao1 |
T |
G |
2: 134,365,024 (GRCm39) |
D201A |
probably benign |
Het |
| Heg1 |
T |
C |
16: 33,547,499 (GRCm39) |
L786P |
possibly damaging |
Het |
| Hnrnpll |
A |
T |
17: 80,357,303 (GRCm39) |
C238S |
possibly damaging |
Het |
| Hrg |
A |
G |
16: 22,779,742 (GRCm39) |
Y340C |
probably damaging |
Het |
| Kyat3 |
A |
T |
3: 142,443,998 (GRCm39) |
I411F |
probably damaging |
Het |
| Myo1a |
T |
C |
10: 127,543,549 (GRCm39) |
Y202H |
probably damaging |
Het |
| Nags |
T |
C |
11: 102,037,337 (GRCm39) |
C143R |
possibly damaging |
Het |
| Ncoa6 |
T |
C |
2: 155,263,076 (GRCm39) |
N453D |
probably damaging |
Het |
| Nup35 |
G |
T |
2: 80,488,730 (GRCm39) |
M322I |
probably benign |
Het |
| Oprl1 |
T |
C |
2: 181,357,721 (GRCm39) |
V69A |
probably damaging |
Het |
| Or51v14 |
A |
G |
7: 103,261,128 (GRCm39) |
L144P |
probably benign |
Het |
| Pappa2 |
T |
A |
1: 158,784,215 (GRCm39) |
Y265F |
probably damaging |
Het |
| Pcsk6 |
C |
T |
7: 65,629,903 (GRCm39) |
P343L |
possibly damaging |
Het |
| Peak1 |
C |
A |
9: 56,164,950 (GRCm39) |
D993Y |
probably damaging |
Het |
| Polr2a |
T |
C |
11: 69,627,758 (GRCm39) |
Y1383C |
probably damaging |
Het |
| Ppme1 |
A |
G |
7: 99,990,272 (GRCm39) |
S226P |
probably damaging |
Het |
| Prom1 |
C |
T |
5: 44,213,325 (GRCm39) |
C127Y |
probably damaging |
Het |
| Ptpn6 |
A |
T |
6: 124,709,532 (GRCm39) |
|
probably null |
Het |
| Reln |
T |
C |
5: 22,285,712 (GRCm39) |
E419G |
probably benign |
Het |
| Rnf32 |
C |
T |
5: 29,430,266 (GRCm39) |
Q362* |
probably null |
Het |
| Sbspon |
T |
C |
1: 15,953,887 (GRCm39) |
D131G |
probably benign |
Het |
| Scyl3 |
T |
C |
1: 163,776,783 (GRCm39) |
S392P |
probably benign |
Het |
| Shtn1 |
T |
A |
19: 59,026,728 (GRCm39) |
D121V |
possibly damaging |
Het |
| Sin3a |
A |
G |
9: 57,024,765 (GRCm39) |
T1042A |
probably benign |
Het |
| Sipa1l2 |
A |
T |
8: 126,171,369 (GRCm39) |
V1371D |
probably damaging |
Het |
| Slc20a2 |
T |
C |
8: 23,055,668 (GRCm39) |
V584A |
possibly damaging |
Het |
| Smc6 |
T |
A |
12: 11,355,874 (GRCm39) |
|
probably null |
Het |
| Spata31h1 |
T |
A |
10: 82,124,731 (GRCm39) |
|
probably benign |
Het |
| Specc1 |
C |
T |
11: 62,047,418 (GRCm39) |
T849I |
possibly damaging |
Het |
| Spta1 |
T |
A |
1: 174,041,734 (GRCm39) |
L1368H |
probably damaging |
Het |
| Sqle |
A |
G |
15: 59,187,959 (GRCm39) |
E89G |
possibly damaging |
Het |
| Strbp |
A |
G |
2: 37,493,020 (GRCm39) |
V422A |
probably damaging |
Het |
| Sult6b1 |
G |
T |
17: 79,214,360 (GRCm39) |
T21K |
probably benign |
Het |
| Tex15 |
A |
G |
8: 34,065,940 (GRCm39) |
E1790G |
probably damaging |
Het |
| Tmem88b |
T |
A |
4: 155,870,221 (GRCm39) |
|
probably benign |
Het |
| Traf3ip3 |
T |
C |
1: 192,864,318 (GRCm39) |
D355G |
possibly damaging |
Het |
| Trim30c |
C |
T |
7: 104,039,609 (GRCm39) |
G62D |
probably benign |
Het |
| Trim66 |
T |
G |
7: 109,085,269 (GRCm39) |
K100N |
probably benign |
Het |
| Tsnaxip1 |
A |
T |
8: 106,568,172 (GRCm39) |
T313S |
possibly damaging |
Het |
| Ugt2b37 |
A |
T |
5: 87,390,279 (GRCm39) |
I389N |
probably damaging |
Het |
| Unc13a |
C |
T |
8: 72,094,097 (GRCm39) |
V1335M |
possibly damaging |
Het |
| Urah |
A |
G |
7: 140,415,124 (GRCm39) |
T5A |
probably benign |
Het |
| Usp34 |
T |
C |
11: 23,388,914 (GRCm39) |
Y2185H |
probably damaging |
Het |
| Usp44 |
T |
C |
10: 93,692,172 (GRCm39) |
S643P |
probably benign |
Het |
| Vars2 |
A |
G |
17: 35,970,937 (GRCm39) |
V631A |
probably damaging |
Het |
| Vmn2r11 |
G |
A |
5: 109,201,679 (GRCm39) |
T275I |
possibly damaging |
Het |
| Vmn2r54 |
C |
A |
7: 12,349,420 (GRCm39) |
V721F |
probably damaging |
Het |
| Vmn2r79 |
T |
C |
7: 86,651,498 (GRCm39) |
I299T |
probably benign |
Het |
| Vps13d |
T |
C |
4: 144,849,251 (GRCm39) |
T2387A |
probably damaging |
Het |
| Washc5 |
A |
T |
15: 59,209,044 (GRCm39) |
L610Q |
probably benign |
Het |
| Zbtb21 |
T |
C |
16: 97,751,568 (GRCm39) |
E905G |
probably damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,309,095 (GRCm39) |
T774A |
probably damaging |
Het |
| Zfp534 |
T |
C |
4: 147,759,299 (GRCm39) |
I457V |
probably benign |
Het |
| Zfp964 |
T |
C |
8: 70,111,994 (GRCm39) |
Y29H |
possibly damaging |
Het |
| Znrf4 |
A |
G |
17: 56,818,702 (GRCm39) |
F202L |
probably damaging |
Het |
|
| Other mutations in Trim24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Trim24
|
APN |
6 |
37,880,583 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01307:Trim24
|
APN |
6 |
37,942,570 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL01790:Trim24
|
APN |
6 |
37,922,548 (GRCm39) |
missense |
probably benign |
|
|
IGL02525:Trim24
|
APN |
6 |
37,922,653 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02557:Trim24
|
APN |
6 |
37,942,434 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02671:Trim24
|
APN |
6 |
37,937,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02795:Trim24
|
APN |
6 |
37,896,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02877:Trim24
|
APN |
6 |
37,942,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02889:Trim24
|
APN |
6 |
37,934,696 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02930:Trim24
|
APN |
6 |
37,928,380 (GRCm39) |
splice site |
probably benign |
|
|
IGL03076:Trim24
|
APN |
6 |
37,942,567 (GRCm39) |
missense |
probably damaging |
0.98 |
|
accomodating
|
UTSW |
6 |
37,896,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
apprehensive
|
UTSW |
6 |
37,934,435 (GRCm39) |
splice site |
probably benign |
|
|
Flexible
|
UTSW |
6 |
37,880,588 (GRCm39) |
critical splice donor site |
probably benign |
|
|
Lithe
|
UTSW |
6 |
37,935,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Nervous
|
UTSW |
6 |
37,934,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
perturbed
|
UTSW |
6 |
37,896,427 (GRCm39) |
critical splice donor site |
probably null |
|
|
pliant
|
UTSW |
6 |
37,896,426 (GRCm39) |
critical splice donor site |
probably null |
|
|
qualmish
|
UTSW |
6 |
37,880,587 (GRCm39) |
critical splice donor site |
probably null |
|
|
Queasy
|
UTSW |
6 |
37,885,240 (GRCm39) |
missense |
probably damaging |
0.99 |
|
squeamish
|
UTSW |
6 |
37,892,137 (GRCm39) |
nonsense |
probably null |
|
|
uneasy
|
UTSW |
6 |
37,933,412 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4651001:Trim24
|
UTSW |
6 |
37,877,667 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0037:Trim24
|
UTSW |
6 |
37,934,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0037:Trim24
|
UTSW |
6 |
37,934,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0183:Trim24
|
UTSW |
6 |
37,920,415 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0471:Trim24
|
UTSW |
6 |
37,892,130 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0485:Trim24
|
UTSW |
6 |
37,934,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0606:Trim24
|
UTSW |
6 |
37,848,169 (GRCm39) |
missense |
probably benign |
|
|
R0609:Trim24
|
UTSW |
6 |
37,934,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0637:Trim24
|
UTSW |
6 |
37,935,494 (GRCm39) |
splice site |
probably null |
|
|
R0734:Trim24
|
UTSW |
6 |
37,896,400 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0855:Trim24
|
UTSW |
6 |
37,892,137 (GRCm39) |
nonsense |
probably null |
|
|
R1131:Trim24
|
UTSW |
6 |
37,934,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1141:Trim24
|
UTSW |
6 |
37,892,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1159:Trim24
|
UTSW |
6 |
37,933,412 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1460:Trim24
|
UTSW |
6 |
37,941,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1672:Trim24
|
UTSW |
6 |
37,892,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1868:Trim24
|
UTSW |
6 |
37,928,447 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1888:Trim24
|
UTSW |
6 |
37,934,013 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1888:Trim24
|
UTSW |
6 |
37,934,013 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1894:Trim24
|
UTSW |
6 |
37,934,013 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1913:Trim24
|
UTSW |
6 |
37,934,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2254:Trim24
|
UTSW |
6 |
37,935,612 (GRCm39) |
missense |
probably benign |
|
|
R2511:Trim24
|
UTSW |
6 |
37,880,587 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2849:Trim24
|
UTSW |
6 |
37,933,388 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3878:Trim24
|
UTSW |
6 |
37,941,708 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4084:Trim24
|
UTSW |
6 |
37,892,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Trim24
|
UTSW |
6 |
37,941,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4292:Trim24
|
UTSW |
6 |
37,877,627 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4633:Trim24
|
UTSW |
6 |
37,933,371 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4651:Trim24
|
UTSW |
6 |
37,934,774 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4652:Trim24
|
UTSW |
6 |
37,934,774 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4686:Trim24
|
UTSW |
6 |
37,885,240 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5000:Trim24
|
UTSW |
6 |
37,935,547 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5213:Trim24
|
UTSW |
6 |
37,934,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5258:Trim24
|
UTSW |
6 |
37,896,335 (GRCm39) |
missense |
probably benign |
0.37 |
|
R5292:Trim24
|
UTSW |
6 |
37,880,539 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5395:Trim24
|
UTSW |
6 |
37,934,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5547:Trim24
|
UTSW |
6 |
37,942,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5666:Trim24
|
UTSW |
6 |
37,942,536 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5670:Trim24
|
UTSW |
6 |
37,942,536 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5849:Trim24
|
UTSW |
6 |
37,934,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5927:Trim24
|
UTSW |
6 |
37,935,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5932:Trim24
|
UTSW |
6 |
37,934,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6286:Trim24
|
UTSW |
6 |
37,896,426 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6449:Trim24
|
UTSW |
6 |
37,880,587 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6723:Trim24
|
UTSW |
6 |
37,928,403 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6731:Trim24
|
UTSW |
6 |
37,920,420 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6975:Trim24
|
UTSW |
6 |
37,896,427 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7000:Trim24
|
UTSW |
6 |
37,935,613 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7067:Trim24
|
UTSW |
6 |
37,934,775 (GRCm39) |
splice site |
probably null |
|
|
R7126:Trim24
|
UTSW |
6 |
37,896,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7162:Trim24
|
UTSW |
6 |
37,942,456 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7486:Trim24
|
UTSW |
6 |
37,934,774 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7779:Trim24
|
UTSW |
6 |
37,896,333 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7779:Trim24
|
UTSW |
6 |
37,896,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Trim24
|
UTSW |
6 |
37,934,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8096:Trim24
|
UTSW |
6 |
37,935,592 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8184:Trim24
|
UTSW |
6 |
37,848,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8323:Trim24
|
UTSW |
6 |
37,892,233 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8476:Trim24
|
UTSW |
6 |
37,922,578 (GRCm39) |
nonsense |
probably null |
|
|
R8705:Trim24
|
UTSW |
6 |
37,880,588 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R8770:Trim24
|
UTSW |
6 |
37,934,435 (GRCm39) |
splice site |
probably benign |
|
|
R9021:Trim24
|
UTSW |
6 |
37,933,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9166:Trim24
|
UTSW |
6 |
37,934,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9212:Trim24
|
UTSW |
6 |
37,896,335 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9350:Trim24
|
UTSW |
6 |
37,892,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9678:Trim24
|
UTSW |
6 |
37,942,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF007:Trim24
|
UTSW |
6 |
37,930,471 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGGAAGTTGTCTGACAGAACT -3'
(R):5'- AAAATCGAGGCAGAACCCTC -3'
Sequencing Primer
(F):5'- TTAGTCTCAGCATTCCAGAGGCAG -3'
(R):5'- TCATCACCACCAAAAATGAGGCTG -3'
|
| Posted On |
2018-04-27 |
Incidental Mutation