Incidental Mutation 'R7488:Pcnx3'
| ID |
580379 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pcnx3
|
| Ensembl Gene |
ENSMUSG00000054874 |
| Gene Name |
pecanex homolog 3 |
| Synonyms |
Pcnxl3 |
| MMRRC Submission |
045562-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7488 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
5714663-5738936 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 5717487 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Tryptophan
at position 1541
(R1541W)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109245
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068169]
[ENSMUST00000071857]
[ENSMUST00000080824]
[ENSMUST00000113615]
[ENSMUST00000164304]
[ENSMUST00000169854]
|
| AlphaFold |
Q8VI59 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000068169
AA Change: R1133W
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000063786
Gene: ENSMUSG00000054874
AA Change: R1133W
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
36 |
53 |
N/A |
INTRINSIC |
|
transmembrane domain
|
57 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
111 |
N/A |
INTRINSIC |
|
low complexity region
|
370 |
376 |
N/A |
INTRINSIC |
|
transmembrane domain
|
385 |
407 |
N/A |
INTRINSIC |
|
transmembrane domain
|
411 |
428 |
N/A |
INTRINSIC |
|
transmembrane domain
|
441 |
463 |
N/A |
INTRINSIC |
|
transmembrane domain
|
473 |
492 |
N/A |
INTRINSIC |
|
transmembrane domain
|
501 |
523 |
N/A |
INTRINSIC |
|
transmembrane domain
|
538 |
560 |
N/A |
INTRINSIC |
|
transmembrane domain
|
573 |
592 |
N/A |
INTRINSIC |
|
transmembrane domain
|
645 |
667 |
N/A |
INTRINSIC |
|
transmembrane domain
|
669 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
1011 |
1025 |
N/A |
INTRINSIC |
|
Pfam:Pecanex_C
|
1159 |
1389 |
7.5e-124 |
PFAM |
|
low complexity region
|
1462 |
1479 |
N/A |
INTRINSIC |
|
low complexity region
|
1481 |
1510 |
N/A |
INTRINSIC |
|
low complexity region
|
1525 |
1538 |
N/A |
INTRINSIC |
|
low complexity region
|
1558 |
1569 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071857
|
| SMART Domains |
Protein: ENSMUSP00000073618
Gene: ENSMUSG00000056917
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
59 |
70 |
N/A |
INTRINSIC |
|
low complexity region
|
90 |
103 |
N/A |
INTRINSIC |
|
low complexity region
|
164 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
278 |
292 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
346 |
529 |
7.2e-64 |
PFAM |
|
low complexity region
|
580 |
593 |
N/A |
INTRINSIC |
|
PDZ
|
692 |
758 |
9.51e-7 |
SMART |
|
low complexity region
|
828 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
883 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080824
|
| SMART Domains |
Protein: ENSMUSP00000079637
Gene: ENSMUSG00000056917
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
59 |
70 |
N/A |
INTRINSIC |
|
low complexity region
|
90 |
103 |
N/A |
INTRINSIC |
|
low complexity region
|
164 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
278 |
292 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
346 |
535 |
4.4e-60 |
PFAM |
|
low complexity region
|
580 |
593 |
N/A |
INTRINSIC |
|
PDZ
|
692 |
758 |
9.51e-7 |
SMART |
|
low complexity region
|
828 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
883 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000113615
AA Change: R1541W
PolyPhen 2
Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000109245
Gene: ENSMUSG00000054874
AA Change: R1541W
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
36 |
53 |
N/A |
INTRINSIC |
|
transmembrane domain
|
57 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
111 |
N/A |
INTRINSIC |
|
low complexity region
|
438 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
778 |
784 |
N/A |
INTRINSIC |
|
transmembrane domain
|
793 |
815 |
N/A |
INTRINSIC |
|
transmembrane domain
|
819 |
836 |
N/A |
INTRINSIC |
|
transmembrane domain
|
849 |
871 |
N/A |
INTRINSIC |
|
transmembrane domain
|
881 |
900 |
N/A |
INTRINSIC |
|
transmembrane domain
|
909 |
931 |
N/A |
INTRINSIC |
|
transmembrane domain
|
946 |
968 |
N/A |
INTRINSIC |
|
transmembrane domain
|
981 |
1000 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1053 |
1075 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1077 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1419 |
1433 |
N/A |
INTRINSIC |
|
Pfam:Pecanex_C
|
1570 |
1796 |
5.9e-116 |
PFAM |
|
low complexity region
|
1870 |
1887 |
N/A |
INTRINSIC |
|
low complexity region
|
1889 |
1918 |
N/A |
INTRINSIC |
|
low complexity region
|
1933 |
1946 |
N/A |
INTRINSIC |
|
low complexity region
|
1966 |
1977 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133136
|
| SMART Domains |
Protein: ENSMUSP00000123666
Gene: ENSMUSG00000054874
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pecanex_C
|
1 |
129 |
7.9e-61 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164304
|
| SMART Domains |
Protein: ENSMUSP00000128208
Gene: ENSMUSG00000056917
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
59 |
70 |
N/A |
INTRINSIC |
|
low complexity region
|
90 |
103 |
N/A |
INTRINSIC |
|
low complexity region
|
164 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
278 |
292 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
346 |
535 |
4.4e-60 |
PFAM |
|
low complexity region
|
580 |
593 |
N/A |
INTRINSIC |
|
PDZ
|
692 |
758 |
9.51e-7 |
SMART |
|
low complexity region
|
828 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
883 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169854
|
| SMART Domains |
Protein: ENSMUSP00000132345
Gene: ENSMUSG00000056917
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
59 |
70 |
N/A |
INTRINSIC |
|
low complexity region
|
90 |
103 |
N/A |
INTRINSIC |
|
low complexity region
|
164 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
278 |
292 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
346 |
535 |
4.4e-60 |
PFAM |
|
low complexity region
|
580 |
593 |
N/A |
INTRINSIC |
|
PDZ
|
692 |
758 |
9.51e-7 |
SMART |
|
low complexity region
|
828 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
883 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1023 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
T |
A |
12: 71,197,179 (GRCm39) |
F251I |
possibly damaging |
Het |
| Abcb11 |
C |
T |
2: 69,108,146 (GRCm39) |
G717D |
probably benign |
Het |
| Abcc1 |
G |
A |
16: 14,207,763 (GRCm39) |
W47* |
probably null |
Het |
| Ahnak2 |
A |
G |
12: 112,748,641 (GRCm39) |
I402T |
|
Het |
| Ankfy1 |
G |
A |
11: 72,650,769 (GRCm39) |
R984Q |
probably benign |
Het |
| Apaf1 |
A |
G |
10: 90,890,242 (GRCm39) |
I598T |
probably benign |
Het |
| Apobec1 |
G |
T |
6: 122,558,521 (GRCm39) |
P78Q |
possibly damaging |
Het |
| Asap1 |
A |
T |
15: 63,991,974 (GRCm39) |
I737N |
probably benign |
Het |
| Aste1 |
T |
A |
9: 105,279,904 (GRCm39) |
|
probably null |
Het |
| Bcr |
A |
C |
10: 74,996,162 (GRCm39) |
D902A |
possibly damaging |
Het |
| Bicra |
T |
C |
7: 15,723,367 (GRCm39) |
|
probably null |
Het |
| Ccdc27 |
T |
C |
4: 154,117,424 (GRCm39) |
T508A |
probably benign |
Het |
| Ccz1 |
T |
A |
5: 143,928,401 (GRCm39) |
N383I |
probably damaging |
Het |
| Cdh24 |
T |
C |
14: 54,869,637 (GRCm39) |
D760G |
possibly damaging |
Het |
| Cdhr2 |
T |
C |
13: 54,865,728 (GRCm39) |
I242T |
probably benign |
Het |
| Cdk4 |
T |
A |
10: 126,900,106 (GRCm39) |
M1K |
probably null |
Het |
| Cfap96 |
A |
G |
8: 46,415,331 (GRCm39) |
V225A |
probably benign |
Het |
| Cntn5 |
A |
T |
9: 9,970,570 (GRCm39) |
S302T |
probably damaging |
Het |
| Col25a1 |
G |
T |
3: 130,378,350 (GRCm39) |
G601V |
probably damaging |
Het |
| Cpb1 |
A |
G |
3: 20,324,488 (GRCm39) |
L62P |
possibly damaging |
Het |
| Cpne1 |
T |
C |
2: 155,919,857 (GRCm39) |
T264A |
probably benign |
Het |
| Cpvl |
T |
A |
6: 53,924,727 (GRCm39) |
N198Y |
probably damaging |
Het |
| Cyp2u1 |
A |
C |
3: 131,091,596 (GRCm39) |
L308R |
probably damaging |
Het |
| Ddx54 |
G |
T |
5: 120,762,789 (GRCm39) |
V637L |
probably benign |
Het |
| Dglucy |
C |
A |
12: 100,823,310 (GRCm39) |
P472T |
possibly damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,124,855 (GRCm39) |
Y2006H |
probably benign |
Het |
| Eif5b |
T |
C |
1: 38,089,387 (GRCm39) |
M1121T |
possibly damaging |
Het |
| Emsy |
A |
G |
7: 98,264,762 (GRCm39) |
V545A |
possibly damaging |
Het |
| Ezh1 |
G |
A |
11: 101,091,726 (GRCm39) |
L480F |
possibly damaging |
Het |
| Fbln2 |
T |
A |
6: 91,242,845 (GRCm39) |
|
probably null |
Het |
| Gja10 |
T |
A |
4: 32,602,058 (GRCm39) |
K109* |
probably null |
Het |
| Gm28042 |
A |
G |
2: 119,870,438 (GRCm39) |
N762S |
probably benign |
Het |
| Gnb1l |
C |
A |
16: 18,359,220 (GRCm39) |
P7Q |
possibly damaging |
Het |
| Grem2 |
A |
T |
1: 174,664,685 (GRCm39) |
S55T |
probably damaging |
Het |
| Gsn |
A |
T |
2: 35,186,433 (GRCm39) |
N393I |
possibly damaging |
Het |
| H6pd |
T |
A |
4: 150,067,093 (GRCm39) |
Q439L |
probably benign |
Het |
| Hmcn2 |
G |
A |
2: 31,310,842 (GRCm39) |
G3362E |
probably damaging |
Het |
| Ighv11-2 |
T |
C |
12: 114,011,978 (GRCm39) |
Y79C |
probably damaging |
Het |
| Ikzf2 |
T |
A |
1: 69,578,544 (GRCm39) |
N322Y |
probably benign |
Het |
| Il25 |
A |
G |
14: 55,170,459 (GRCm39) |
I11V |
probably benign |
Het |
| Jak2 |
C |
T |
19: 29,275,783 (GRCm39) |
T741I |
probably damaging |
Het |
| Kdm3b |
T |
C |
18: 34,957,934 (GRCm39) |
S1300P |
probably damaging |
Het |
| Ldb3 |
T |
A |
14: 34,289,402 (GRCm39) |
Q268L |
probably damaging |
Het |
| Lrrc23 |
T |
A |
6: 124,756,075 (GRCm39) |
D6V |
unknown |
Het |
| Megf10 |
A |
G |
18: 57,324,187 (GRCm39) |
Y76C |
probably damaging |
Het |
| Neb |
A |
T |
2: 52,110,233 (GRCm39) |
M205K |
probably benign |
Het |
| Or12e8 |
T |
C |
2: 87,188,597 (GRCm39) |
S270P |
probably damaging |
Het |
| Or6c2b |
G |
T |
10: 128,947,605 (GRCm39) |
Q230K |
probably benign |
Het |
| Or8a1 |
A |
G |
9: 37,641,983 (GRCm39) |
S99P |
probably damaging |
Het |
| Pdgfd |
A |
G |
9: 6,359,739 (GRCm39) |
Y270C |
probably damaging |
Het |
| Pds5b |
A |
T |
5: 150,646,802 (GRCm39) |
D197V |
probably damaging |
Het |
| Pknox2 |
A |
G |
9: 36,866,127 (GRCm39) |
M30T |
probably benign |
Het |
| Plekhg1 |
A |
T |
10: 3,907,491 (GRCm39) |
S858C |
|
Het |
| Por |
A |
T |
5: 135,762,498 (GRCm39) |
E400D |
probably benign |
Het |
| Pou2af2 |
C |
A |
9: 51,201,360 (GRCm39) |
R232L |
probably damaging |
Het |
| Psip1 |
A |
G |
4: 83,391,275 (GRCm39) |
|
probably null |
Het |
| Retreg1 |
G |
T |
15: 25,889,628 (GRCm39) |
V111F |
|
Het |
| Rock1 |
G |
A |
18: 10,122,762 (GRCm39) |
A353V |
probably damaging |
Het |
| Rpl6 |
C |
G |
5: 121,346,591 (GRCm39) |
R231G |
probably benign |
Het |
| Scn7a |
C |
T |
2: 66,587,574 (GRCm39) |
R43H |
probably benign |
Het |
| Scnn1g |
T |
A |
7: 121,362,657 (GRCm39) |
N488K |
probably benign |
Het |
| Slc24a1 |
A |
G |
9: 64,831,764 (GRCm39) |
V1111A |
probably benign |
Het |
| Snapc1 |
C |
T |
12: 74,029,285 (GRCm39) |
S356L |
probably benign |
Het |
| Spata31e2 |
T |
C |
1: 26,723,039 (GRCm39) |
T714A |
possibly damaging |
Het |
| Ssbp2 |
T |
A |
13: 91,823,209 (GRCm39) |
N201K |
probably damaging |
Het |
| Tfdp2 |
A |
G |
9: 96,179,695 (GRCm39) |
N43D |
probably damaging |
Het |
| Tmprss11d |
A |
G |
5: 86,474,309 (GRCm39) |
I216T |
probably damaging |
Het |
| Tmprss4 |
A |
G |
9: 45,086,853 (GRCm39) |
S303P |
probably benign |
Het |
| Tnpo2 |
A |
G |
8: 85,781,663 (GRCm39) |
E815G |
probably benign |
Het |
| Trav6-1 |
A |
C |
14: 52,875,972 (GRCm39) |
M1L |
possibly damaging |
Het |
| Trpm3 |
T |
C |
19: 22,955,937 (GRCm39) |
V1133A |
probably damaging |
Het |
| Trpv1 |
C |
T |
11: 73,129,355 (GRCm39) |
P91S |
probably benign |
Het |
| Trpv2 |
T |
C |
11: 62,480,576 (GRCm39) |
Y338H |
probably damaging |
Het |
| Txnip |
T |
C |
3: 96,467,539 (GRCm39) |
M336T |
probably benign |
Het |
| Vmn1r61 |
A |
T |
7: 5,613,767 (GRCm39) |
H182Q |
possibly damaging |
Het |
| Vmn2r105 |
A |
G |
17: 20,429,045 (GRCm39) |
V677A |
probably damaging |
Het |
| Wwp1 |
G |
T |
4: 19,627,660 (GRCm39) |
T745K |
probably damaging |
Het |
| Xkr5 |
C |
A |
8: 18,983,608 (GRCm39) |
E645* |
probably null |
Het |
| Zfp451 |
C |
T |
1: 33,818,221 (GRCm39) |
R303H |
probably benign |
Het |
| Zyg11b |
T |
C |
4: 108,123,655 (GRCm39) |
H104R |
possibly damaging |
Het |
|
| Other mutations in Pcnx3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01616:Pcnx3
|
APN |
19 |
5,717,287 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01667:Pcnx3
|
APN |
19 |
5,736,658 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01704:Pcnx3
|
APN |
19 |
5,717,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01752:Pcnx3
|
APN |
19 |
5,715,365 (GRCm39) |
nonsense |
probably null |
|
|
IGL01791:Pcnx3
|
APN |
19 |
5,723,295 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01937:Pcnx3
|
APN |
19 |
5,727,691 (GRCm39) |
missense |
probably benign |
|
|
IGL01987:Pcnx3
|
APN |
19 |
5,727,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02073:Pcnx3
|
APN |
19 |
5,729,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02417:Pcnx3
|
APN |
19 |
5,736,509 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03143:Pcnx3
|
APN |
19 |
5,735,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
buns
|
UTSW |
19 |
5,733,368 (GRCm39) |
start codon destroyed |
probably null |
|
|
Pastries
|
UTSW |
19 |
5,733,367 (GRCm39) |
nonsense |
probably null |
|
|
pie
|
UTSW |
19 |
5,717,186 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7096_pcnx3_526
|
UTSW |
19 |
5,722,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
swirls
|
UTSW |
19 |
5,722,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
tip
|
UTSW |
19 |
5,733,808 (GRCm39) |
splice site |
probably benign |
|
|
PIT4453001:Pcnx3
|
UTSW |
19 |
5,722,784 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0234:Pcnx3
|
UTSW |
19 |
5,722,646 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0234:Pcnx3
|
UTSW |
19 |
5,722,646 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0360:Pcnx3
|
UTSW |
19 |
5,715,611 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0687:Pcnx3
|
UTSW |
19 |
5,734,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Pcnx3
|
UTSW |
19 |
5,727,756 (GRCm39) |
splice site |
probably benign |
|
|
R0840:Pcnx3
|
UTSW |
19 |
5,735,729 (GRCm39) |
splice site |
probably null |
|
|
R0907:Pcnx3
|
UTSW |
19 |
5,721,553 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1251:Pcnx3
|
UTSW |
19 |
5,727,210 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1373:Pcnx3
|
UTSW |
19 |
5,715,544 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1467:Pcnx3
|
UTSW |
19 |
5,724,922 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1467:Pcnx3
|
UTSW |
19 |
5,724,922 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1572:Pcnx3
|
UTSW |
19 |
5,735,375 (GRCm39) |
nonsense |
probably null |
|
|
R1602:Pcnx3
|
UTSW |
19 |
5,722,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Pcnx3
|
UTSW |
19 |
5,736,093 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1635:Pcnx3
|
UTSW |
19 |
5,715,773 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1670:Pcnx3
|
UTSW |
19 |
5,723,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1889:Pcnx3
|
UTSW |
19 |
5,722,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1898:Pcnx3
|
UTSW |
19 |
5,722,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2113:Pcnx3
|
UTSW |
19 |
5,721,584 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2147:Pcnx3
|
UTSW |
19 |
5,717,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Pcnx3
|
UTSW |
19 |
5,733,368 (GRCm39) |
start codon destroyed |
probably null |
|
|
R2358:Pcnx3
|
UTSW |
19 |
5,733,367 (GRCm39) |
nonsense |
probably null |
|
|
R2871:Pcnx3
|
UTSW |
19 |
5,733,774 (GRCm39) |
intron |
probably benign |
|
|
R3699:Pcnx3
|
UTSW |
19 |
5,722,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3712:Pcnx3
|
UTSW |
19 |
5,733,368 (GRCm39) |
start codon destroyed |
probably null |
|
|
R3712:Pcnx3
|
UTSW |
19 |
5,733,367 (GRCm39) |
nonsense |
probably null |
|
|
R3798:Pcnx3
|
UTSW |
19 |
5,728,696 (GRCm39) |
nonsense |
probably null |
|
|
R3856:Pcnx3
|
UTSW |
19 |
5,728,995 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3953:Pcnx3
|
UTSW |
19 |
5,733,808 (GRCm39) |
splice site |
probably benign |
|
|
R4613:Pcnx3
|
UTSW |
19 |
5,717,247 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4781:Pcnx3
|
UTSW |
19 |
5,737,158 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4816:Pcnx3
|
UTSW |
19 |
5,738,023 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5338:Pcnx3
|
UTSW |
19 |
5,722,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Pcnx3
|
UTSW |
19 |
5,731,607 (GRCm39) |
intron |
probably benign |
|
|
R5950:Pcnx3
|
UTSW |
19 |
5,717,186 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5951:Pcnx3
|
UTSW |
19 |
5,721,708 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5969:Pcnx3
|
UTSW |
19 |
5,735,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6543:Pcnx3
|
UTSW |
19 |
5,715,275 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6704:Pcnx3
|
UTSW |
19 |
5,736,515 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7096:Pcnx3
|
UTSW |
19 |
5,722,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7177:Pcnx3
|
UTSW |
19 |
5,737,527 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7308:Pcnx3
|
UTSW |
19 |
5,736,175 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7387:Pcnx3
|
UTSW |
19 |
5,723,364 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7670:Pcnx3
|
UTSW |
19 |
5,727,210 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7831:Pcnx3
|
UTSW |
19 |
5,735,989 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7850:Pcnx3
|
UTSW |
19 |
5,728,960 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8120:Pcnx3
|
UTSW |
19 |
5,717,574 (GRCm39) |
missense |
probably benign |
|
|
R8139:Pcnx3
|
UTSW |
19 |
5,715,773 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8258:Pcnx3
|
UTSW |
19 |
5,715,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8259:Pcnx3
|
UTSW |
19 |
5,715,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Pcnx3
|
UTSW |
19 |
5,715,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8261:Pcnx3
|
UTSW |
19 |
5,715,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8262:Pcnx3
|
UTSW |
19 |
5,715,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8350:Pcnx3
|
UTSW |
19 |
5,723,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8411:Pcnx3
|
UTSW |
19 |
5,729,618 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8429:Pcnx3
|
UTSW |
19 |
5,715,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8431:Pcnx3
|
UTSW |
19 |
5,715,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8443:Pcnx3
|
UTSW |
19 |
5,736,670 (GRCm39) |
missense |
probably benign |
|
|
R8450:Pcnx3
|
UTSW |
19 |
5,723,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Pcnx3
|
UTSW |
19 |
5,725,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8790:Pcnx3
|
UTSW |
19 |
5,735,206 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8939:Pcnx3
|
UTSW |
19 |
5,730,347 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9065:Pcnx3
|
UTSW |
19 |
5,717,582 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9070:Pcnx3
|
UTSW |
19 |
5,715,601 (GRCm39) |
missense |
probably benign |
0.33 |
|
X0028:Pcnx3
|
UTSW |
19 |
5,734,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0053:Pcnx3
|
UTSW |
19 |
5,736,650 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Pcnx3
|
UTSW |
19 |
5,737,248 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Pcnx3
|
UTSW |
19 |
5,721,654 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTCAGCACAGCTCAGTGTG -3'
(R):5'- ATCACATTGTGGCTCAGGC -3'
Sequencing Primer
(F):5'- AGACTGAGAGTCACCCA -3'
(R):5'- ATGGAGTTGCCCCTGACAC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation