Incidental Mutation 'IGL01649:Lzts3'
ID |
102759 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Lzts3
|
Ensembl Gene |
ENSMUSG00000037703 |
Gene Name |
leucine zipper, putative tumor suppressor family member 3 |
Synonyms |
Prosapip1 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.206)
|
Stock # |
IGL01649
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
130474759-130484723 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 130477351 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Glutamic Acid
at position 480
(K480E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000086990
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045761]
[ENSMUST00000089561]
[ENSMUST00000110260]
|
AlphaFold |
A2AHG0 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000045761
AA Change: K480E
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000037109 Gene: ENSMUSG00000037703 AA Change: K480E
Domain | Start | End | E-Value | Type |
low complexity region
|
86 |
107 |
N/A |
INTRINSIC |
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
low complexity region
|
240 |
250 |
N/A |
INTRINSIC |
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
low complexity region
|
285 |
297 |
N/A |
INTRINSIC |
low complexity region
|
301 |
333 |
N/A |
INTRINSIC |
low complexity region
|
337 |
346 |
N/A |
INTRINSIC |
low complexity region
|
349 |
361 |
N/A |
INTRINSIC |
low complexity region
|
402 |
436 |
N/A |
INTRINSIC |
Pfam:Fez1
|
465 |
665 |
1.4e-62 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000089561
AA Change: K480E
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000086990 Gene: ENSMUSG00000037703 AA Change: K480E
Domain | Start | End | E-Value | Type |
low complexity region
|
86 |
107 |
N/A |
INTRINSIC |
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
low complexity region
|
240 |
250 |
N/A |
INTRINSIC |
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
low complexity region
|
285 |
297 |
N/A |
INTRINSIC |
low complexity region
|
301 |
333 |
N/A |
INTRINSIC |
low complexity region
|
337 |
346 |
N/A |
INTRINSIC |
low complexity region
|
349 |
361 |
N/A |
INTRINSIC |
low complexity region
|
402 |
436 |
N/A |
INTRINSIC |
Pfam:Fez1
|
465 |
666 |
2.1e-74 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110260
AA Change: K366E
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000105889 Gene: ENSMUSG00000037703 AA Change: K366E
Domain | Start | End | E-Value | Type |
low complexity region
|
126 |
136 |
N/A |
INTRINSIC |
low complexity region
|
139 |
151 |
N/A |
INTRINSIC |
low complexity region
|
171 |
183 |
N/A |
INTRINSIC |
low complexity region
|
187 |
219 |
N/A |
INTRINSIC |
low complexity region
|
223 |
232 |
N/A |
INTRINSIC |
low complexity region
|
235 |
247 |
N/A |
INTRINSIC |
low complexity region
|
288 |
322 |
N/A |
INTRINSIC |
Pfam:Fez1
|
351 |
552 |
1.5e-74 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4931429L15Rik |
A |
G |
9: 46,217,116 (GRCm39) |
S220P |
probably benign |
Het |
Adam18 |
T |
C |
8: 25,104,912 (GRCm39) |
N634S |
possibly damaging |
Het |
Arhgef18 |
T |
A |
8: 3,491,211 (GRCm39) |
|
probably benign |
Het |
Birc6 |
A |
G |
17: 74,911,541 (GRCm39) |
S1518G |
probably benign |
Het |
Cltc |
A |
G |
11: 86,617,226 (GRCm39) |
V341A |
probably benign |
Het |
Dlg5 |
A |
G |
14: 24,188,759 (GRCm39) |
V1721A |
probably damaging |
Het |
Dnah10 |
A |
T |
5: 124,809,553 (GRCm39) |
I274F |
probably damaging |
Het |
Dock1 |
T |
A |
7: 134,379,139 (GRCm39) |
L622Q |
probably damaging |
Het |
Dysf |
A |
G |
6: 84,176,821 (GRCm39) |
D1960G |
probably damaging |
Het |
Fat3 |
T |
C |
9: 16,288,015 (GRCm39) |
T503A |
possibly damaging |
Het |
Glb1 |
A |
G |
9: 114,253,016 (GRCm39) |
Y73C |
probably damaging |
Het |
Gm9396 |
G |
T |
3: 129,862,268 (GRCm39) |
|
noncoding transcript |
Het |
Gml2 |
G |
T |
15: 74,696,070 (GRCm39) |
E155* |
probably null |
Het |
Ikzf4 |
G |
A |
10: 128,471,689 (GRCm39) |
R323C |
probably damaging |
Het |
Kiz |
A |
G |
2: 146,731,229 (GRCm39) |
T240A |
probably benign |
Het |
Mcm7 |
T |
C |
5: 138,167,698 (GRCm39) |
H105R |
probably damaging |
Het |
Mpdz |
A |
G |
4: 81,221,870 (GRCm39) |
L1464P |
probably damaging |
Het |
Mrgpra9 |
A |
C |
7: 46,884,900 (GRCm39) |
L256V |
probably benign |
Het |
Mrpl40 |
T |
C |
16: 18,691,329 (GRCm39) |
Q127R |
probably benign |
Het |
Myom2 |
G |
T |
8: 15,163,755 (GRCm39) |
R1003L |
probably benign |
Het |
Nav2 |
A |
G |
7: 49,225,477 (GRCm39) |
T1806A |
probably damaging |
Het |
Or10x4 |
T |
C |
1: 174,218,974 (GRCm39) |
L113P |
probably damaging |
Het |
Pibf1 |
A |
T |
14: 99,425,199 (GRCm39) |
Y562F |
possibly damaging |
Het |
Potefam1 |
A |
T |
2: 111,044,921 (GRCm39) |
|
probably benign |
Het |
Ppm1n |
A |
T |
7: 19,012,122 (GRCm39) |
|
probably benign |
Het |
Psg17 |
A |
G |
7: 18,550,727 (GRCm39) |
V376A |
possibly damaging |
Het |
Septin8 |
T |
A |
11: 53,425,855 (GRCm39) |
F143I |
possibly damaging |
Het |
Sestd1 |
A |
G |
2: 77,029,389 (GRCm39) |
Y330H |
probably damaging |
Het |
Sntg1 |
C |
T |
1: 8,752,193 (GRCm39) |
|
probably benign |
Het |
Stpg2 |
C |
A |
3: 139,125,623 (GRCm39) |
P472Q |
probably damaging |
Het |
Thbs1 |
A |
G |
2: 117,945,463 (GRCm39) |
K314R |
probably benign |
Het |
Vav3 |
T |
C |
3: 109,470,078 (GRCm39) |
Y508H |
probably benign |
Het |
|
Other mutations in Lzts3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01072:Lzts3
|
APN |
2 |
130,477,365 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01541:Lzts3
|
APN |
2 |
130,478,126 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02746:Lzts3
|
APN |
2 |
130,478,261 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02927:Lzts3
|
APN |
2 |
130,479,877 (GRCm39) |
utr 5 prime |
probably benign |
|
R0069:Lzts3
|
UTSW |
2 |
130,478,460 (GRCm39) |
missense |
probably benign |
0.16 |
R0069:Lzts3
|
UTSW |
2 |
130,478,460 (GRCm39) |
missense |
probably benign |
0.16 |
R0173:Lzts3
|
UTSW |
2 |
130,476,688 (GRCm39) |
makesense |
probably null |
|
R1381:Lzts3
|
UTSW |
2 |
130,477,219 (GRCm39) |
missense |
probably damaging |
0.99 |
R4127:Lzts3
|
UTSW |
2 |
130,477,285 (GRCm39) |
missense |
probably damaging |
0.99 |
R4301:Lzts3
|
UTSW |
2 |
130,478,358 (GRCm39) |
missense |
probably damaging |
0.99 |
R4588:Lzts3
|
UTSW |
2 |
130,476,686 (GRCm39) |
makesense |
probably null |
|
R5289:Lzts3
|
UTSW |
2 |
130,478,021 (GRCm39) |
missense |
probably benign |
0.18 |
R5878:Lzts3
|
UTSW |
2 |
130,478,459 (GRCm39) |
missense |
probably damaging |
1.00 |
R5964:Lzts3
|
UTSW |
2 |
130,478,208 (GRCm39) |
missense |
probably damaging |
0.99 |
R6193:Lzts3
|
UTSW |
2 |
130,479,306 (GRCm39) |
missense |
probably damaging |
0.97 |
R7692:Lzts3
|
UTSW |
2 |
130,477,306 (GRCm39) |
missense |
probably benign |
0.27 |
R8195:Lzts3
|
UTSW |
2 |
130,477,105 (GRCm39) |
missense |
probably benign |
0.01 |
R8273:Lzts3
|
UTSW |
2 |
130,476,801 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9126:Lzts3
|
UTSW |
2 |
130,477,248 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9129:Lzts3
|
UTSW |
2 |
130,476,865 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Posted On |
2014-01-21 |