Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01649:Lzts3'

102759

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lzts3

Ensembl Gene

ENSMUSG00000037703

Gene Name

leucine zipper, putative tumor suppressor family member 3

Synonyms

Prosapip1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

IGL01649

Quality Score

Status

Chromosome

Chromosomal Location

130474759-130484723 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 130477351 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 480 (K480E)

Ref Sequence

ENSEMBL: ENSMUSP00000086990 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045761] [ENSMUST00000089561] [ENSMUST00000110260]

AlphaFold

A2AHG0

Predicted Effect

probably damaging
Transcript: ENSMUST00000045761
AA Change: K480E

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000037109
Gene: ENSMUSG00000037703
AA Change: K480E

Domain	Start	End	E-Value	Type
low complexity region	86	107	N/A	INTRINSIC
low complexity region	147	158	N/A	INTRINSIC
low complexity region	240	250	N/A	INTRINSIC
low complexity region	253	265	N/A	INTRINSIC
low complexity region	285	297	N/A	INTRINSIC
low complexity region	301	333	N/A	INTRINSIC
low complexity region	337	346	N/A	INTRINSIC
low complexity region	349	361	N/A	INTRINSIC
low complexity region	402	436	N/A	INTRINSIC
Pfam:Fez1	465	665	1.4e-62	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000089561
AA Change: K480E

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000086990
Gene: ENSMUSG00000037703
AA Change: K480E

Domain	Start	End	E-Value	Type
low complexity region	86	107	N/A	INTRINSIC
low complexity region	147	158	N/A	INTRINSIC
low complexity region	240	250	N/A	INTRINSIC
low complexity region	253	265	N/A	INTRINSIC
low complexity region	285	297	N/A	INTRINSIC
low complexity region	301	333	N/A	INTRINSIC
low complexity region	337	346	N/A	INTRINSIC
low complexity region	349	361	N/A	INTRINSIC
low complexity region	402	436	N/A	INTRINSIC
Pfam:Fez1	465	666	2.1e-74	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000110260
AA Change: K366E

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000105889
Gene: ENSMUSG00000037703
AA Change: K366E

Domain	Start	End	E-Value	Type
low complexity region	126	136	N/A	INTRINSIC
low complexity region	139	151	N/A	INTRINSIC
low complexity region	171	183	N/A	INTRINSIC
low complexity region	187	219	N/A	INTRINSIC
low complexity region	223	232	N/A	INTRINSIC
low complexity region	235	247	N/A	INTRINSIC
low complexity region	288	322	N/A	INTRINSIC
Pfam:Fez1	351	552	1.5e-74	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931429L15Rik	A	G	9: 46,217,116 (GRCm39)	S220P	probably benign	Het
Adam18	T	C	8: 25,104,912 (GRCm39)	N634S	possibly damaging	Het
Arhgef18	T	A	8: 3,491,211 (GRCm39)		probably benign	Het
Birc6	A	G	17: 74,911,541 (GRCm39)	S1518G	probably benign	Het
Cltc	A	G	11: 86,617,226 (GRCm39)	V341A	probably benign	Het
Dlg5	A	G	14: 24,188,759 (GRCm39)	V1721A	probably damaging	Het
Dnah10	A	T	5: 124,809,553 (GRCm39)	I274F	probably damaging	Het
Dock1	T	A	7: 134,379,139 (GRCm39)	L622Q	probably damaging	Het
Dysf	A	G	6: 84,176,821 (GRCm39)	D1960G	probably damaging	Het
Fat3	T	C	9: 16,288,015 (GRCm39)	T503A	possibly damaging	Het
Glb1	A	G	9: 114,253,016 (GRCm39)	Y73C	probably damaging	Het
Gm9396	G	T	3: 129,862,268 (GRCm39)		noncoding transcript	Het
Gml2	G	T	15: 74,696,070 (GRCm39)	E155*	probably null	Het
Ikzf4	G	A	10: 128,471,689 (GRCm39)	R323C	probably damaging	Het
Kiz	A	G	2: 146,731,229 (GRCm39)	T240A	probably benign	Het
Mcm7	T	C	5: 138,167,698 (GRCm39)	H105R	probably damaging	Het
Mpdz	A	G	4: 81,221,870 (GRCm39)	L1464P	probably damaging	Het
Mrgpra9	A	C	7: 46,884,900 (GRCm39)	L256V	probably benign	Het
Mrpl40	T	C	16: 18,691,329 (GRCm39)	Q127R	probably benign	Het
Myom2	G	T	8: 15,163,755 (GRCm39)	R1003L	probably benign	Het
Nav2	A	G	7: 49,225,477 (GRCm39)	T1806A	probably damaging	Het
Or10x4	T	C	1: 174,218,974 (GRCm39)	L113P	probably damaging	Het
Pibf1	A	T	14: 99,425,199 (GRCm39)	Y562F	possibly damaging	Het
Potefam1	A	T	2: 111,044,921 (GRCm39)		probably benign	Het
Ppm1n	A	T	7: 19,012,122 (GRCm39)		probably benign	Het
Psg17	A	G	7: 18,550,727 (GRCm39)	V376A	possibly damaging	Het
Septin8	T	A	11: 53,425,855 (GRCm39)	F143I	possibly damaging	Het
Sestd1	A	G	2: 77,029,389 (GRCm39)	Y330H	probably damaging	Het
Sntg1	C	T	1: 8,752,193 (GRCm39)		probably benign	Het
Stpg2	C	A	3: 139,125,623 (GRCm39)	P472Q	probably damaging	Het
Thbs1	A	G	2: 117,945,463 (GRCm39)	K314R	probably benign	Het
Vav3	T	C	3: 109,470,078 (GRCm39)	Y508H	probably benign	Het

Other mutations in Lzts3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01072:Lzts3	APN	2	130,477,365 (GRCm39)	missense	probably damaging	0.99
IGL01541:Lzts3	APN	2	130,478,126 (GRCm39)	missense	probably damaging	0.99
IGL02746:Lzts3	APN	2	130,478,261 (GRCm39)	missense	probably damaging	0.98
IGL02927:Lzts3	APN	2	130,479,877 (GRCm39)	utr 5 prime	probably benign
R0069:Lzts3	UTSW	2	130,478,460 (GRCm39)	missense	probably benign	0.16
R0069:Lzts3	UTSW	2	130,478,460 (GRCm39)	missense	probably benign	0.16
R0173:Lzts3	UTSW	2	130,476,688 (GRCm39)	makesense	probably null
R1381:Lzts3	UTSW	2	130,477,219 (GRCm39)	missense	probably damaging	0.99
R4127:Lzts3	UTSW	2	130,477,285 (GRCm39)	missense	probably damaging	0.99
R4301:Lzts3	UTSW	2	130,478,358 (GRCm39)	missense	probably damaging	0.99
R4588:Lzts3	UTSW	2	130,476,686 (GRCm39)	makesense	probably null
R5289:Lzts3	UTSW	2	130,478,021 (GRCm39)	missense	probably benign	0.18
R5878:Lzts3	UTSW	2	130,478,459 (GRCm39)	missense	probably damaging	1.00
R5964:Lzts3	UTSW	2	130,478,208 (GRCm39)	missense	probably damaging	0.99
R6193:Lzts3	UTSW	2	130,479,306 (GRCm39)	missense	probably damaging	0.97
R7692:Lzts3	UTSW	2	130,477,306 (GRCm39)	missense	probably benign	0.27
R8195:Lzts3	UTSW	2	130,477,105 (GRCm39)	missense	probably benign	0.01
R8273:Lzts3	UTSW	2	130,476,801 (GRCm39)	missense	possibly damaging	0.66
R9126:Lzts3	UTSW	2	130,477,248 (GRCm39)	missense	possibly damaging	0.66
R9129:Lzts3	UTSW	2	130,476,865 (GRCm39)	missense	possibly damaging	0.92

Posted On

2014-01-21