Incidental Mutation 'IGL01835:Tas2r139'
ID154925
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r139
Ensembl Gene ENSMUSG00000047102
Gene Nametaste receptor, type 2, member 139
Synonymsmt2r34, Tas2r39
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01835
Quality Score
Status
Chromosome6
Chromosomal Location42140936-42141895 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 42141432 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 166 (N166I)
Ref Sequence ENSEMBL: ENSMUSP00000062919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057686]
Predicted Effect probably benign
Transcript: ENSMUST00000057686
AA Change: N166I

PolyPhen 2 Score 0.211 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000062919
Gene: ENSMUSG00000047102
AA Change: N166I

DomainStartEndE-ValueType
Pfam:TAS2R 13 311 2.5e-64 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,167,181 Y727* probably null Het
2700049A03Rik T A 12: 71,167,183 M728K probably benign Het
Adam23 T C 1: 63,543,119 Y309H probably damaging Het
Ash2l C T 8: 25,839,840 V97M probably damaging Het
Cyp4f13 A G 17: 32,930,614 F83L probably benign Het
Dnah6 A T 6: 73,135,801 S1607T probably damaging Het
Dock2 T A 11: 34,310,435 M969L possibly damaging Het
Dse T A 10: 34,160,217 probably benign Het
Dusp22 C T 13: 30,708,683 probably null Het
F5 G A 1: 164,194,368 V1471I probably benign Het
Gm14403 A T 2: 177,507,256 E48D probably damaging Het
Gm6309 G A 5: 146,168,275 A276V probably damaging Het
Icam4 A T 9: 21,029,790 T113S probably damaging Het
Ipo5 T C 14: 120,926,238 V236A probably benign Het
Mrc2 T G 11: 105,336,677 F579V probably damaging Het
Myl4 T A 11: 104,577,453 M1K probably null Het
Oas3 A T 5: 120,766,128 C560* probably null Het
Olfr225 T C 11: 59,613,339 V125A probably damaging Het
Olfr670 T C 7: 104,960,462 N90S probably benign Het
Prlr G A 15: 10,329,043 V535I probably damaging Het
Ptprd T C 4: 76,246,821 T48A probably benign Het
Rasa4 A G 5: 136,102,607 H485R possibly damaging Het
Rnf13 A T 3: 57,820,586 H229L probably damaging Het
Rpap3 T C 15: 97,703,239 D39G possibly damaging Het
Sec23ip T A 7: 128,755,311 probably null Het
Sirpa T A 2: 129,615,564 F186Y possibly damaging Het
Slc26a11 T C 11: 119,377,214 Y473H probably benign Het
Slc36a2 T C 11: 55,162,733 I360V probably benign Het
Spg11 G A 2: 122,088,224 R975C probably benign Het
Sppl2b T A 10: 80,865,341 I350N probably damaging Het
Trav14n-3 A G 14: 53,370,329 T39A possibly damaging Het
Vmn2r61 A G 7: 42,300,591 M812V probably benign Het
Vmn2r87 A C 10: 130,479,109 F203V probably damaging Het
Vwde A C 6: 13,186,824 V888G probably benign Het
Zbtb17 T C 4: 141,465,438 probably null Het
Other mutations in Tas2r139
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00863:Tas2r139 APN 6 42141121 missense probably damaging 1.00
IGL01593:Tas2r139 APN 6 42140957 missense probably benign 0.01
IGL02990:Tas2r139 APN 6 42141104 missense probably damaging 1.00
R0517:Tas2r139 UTSW 6 42141491 missense probably damaging 0.98
R1106:Tas2r139 UTSW 6 42141545 missense probably benign 0.36
R1352:Tas2r139 UTSW 6 42140940 missense probably benign 0.28
R4352:Tas2r139 UTSW 6 42141755 missense probably damaging 1.00
R4632:Tas2r139 UTSW 6 42141498 missense probably damaging 1.00
R4785:Tas2r139 UTSW 6 42141284 missense probably damaging 1.00
R4947:Tas2r139 UTSW 6 42141566 missense possibly damaging 0.82
R5888:Tas2r139 UTSW 6 42141496 missense probably damaging 1.00
R6796:Tas2r139 UTSW 6 42141592 missense probably damaging 1.00
Posted On2014-02-04