Incidental Mutation 'IGL02049:Zfp263'
| ID |
185039 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp263
|
| Ensembl Gene |
ENSMUSG00000022529 |
| Gene Name |
zinc finger protein 263 |
| Synonyms |
mFPM315, NT2, 1200014J04Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.121)
|
| Stock # |
IGL02049
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
16 |
| Chromosomal Location |
3561957-3568654 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 3562482 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 82
(I82V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023176
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023176]
[ENSMUST00000161630]
[ENSMUST00000162207]
|
| AlphaFold |
Q8CF60 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000023176
AA Change: I82V
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000023176
Gene: ENSMUSG00000022529
AA Change: I82V
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
39 |
151 |
5.15e-71 |
SMART |
|
KRAB
|
219 |
279 |
1.86e-9 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
6.52e-5 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
600 |
622 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
628 |
650 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
656 |
678 |
1.72e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159060
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159425
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159469
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160923
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000161630
AA Change: I82V
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000123725
Gene: ENSMUSG00000022529
AA Change: I82V
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
39 |
143 |
1.61e-63 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162207
|
| SMART Domains |
Protein: ENSMUSP00000124433
Gene: ENSMUSG00000022529
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
90 |
112 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
146 |
168 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
174 |
196 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
202 |
224 |
6.52e-5 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
284 |
306 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
312 |
334 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
340 |
362 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
368 |
390 |
1.72e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930568D16Rik |
T |
A |
2: 35,254,801 (GRCm39) |
R27S |
probably benign |
Het |
| 4930596D02Rik |
C |
A |
14: 35,533,535 (GRCm39) |
V78L |
probably benign |
Het |
| Abca3 |
T |
A |
17: 24,595,704 (GRCm39) |
C352* |
probably null |
Het |
| Acat3 |
T |
A |
17: 13,144,207 (GRCm39) |
Y324F |
probably benign |
Het |
| Adamts8 |
T |
C |
9: 30,862,650 (GRCm39) |
V285A |
probably damaging |
Het |
| Anpep |
A |
G |
7: 79,484,929 (GRCm39) |
I652T |
probably damaging |
Het |
| Arhgef6 |
T |
A |
X: 56,321,271 (GRCm39) |
Q320L |
probably damaging |
Het |
| Armh1 |
A |
T |
4: 117,094,860 (GRCm39) |
I60K |
probably benign |
Het |
| Atp11b |
T |
C |
3: 35,854,642 (GRCm39) |
V145A |
probably damaging |
Het |
| Cacna1c |
T |
C |
6: 118,580,880 (GRCm39) |
T1674A |
probably benign |
Het |
| Capn2 |
A |
T |
1: 182,301,519 (GRCm39) |
|
probably benign |
Het |
| Cfd |
A |
G |
10: 79,726,776 (GRCm39) |
Y6C |
probably benign |
Het |
| Cps1 |
A |
G |
1: 67,183,113 (GRCm39) |
K157R |
possibly damaging |
Het |
| Csmd3 |
T |
A |
15: 47,864,870 (GRCm39) |
R786S |
possibly damaging |
Het |
| Dna2 |
A |
T |
10: 62,792,815 (GRCm39) |
I277L |
probably damaging |
Het |
| Gm5168 |
A |
T |
X: 25,999,005 (GRCm39) |
D50E |
probably damaging |
Het |
| Grik4 |
T |
A |
9: 42,455,049 (GRCm39) |
|
probably benign |
Het |
| Ift56 |
A |
G |
6: 38,402,067 (GRCm39) |
T520A |
probably benign |
Het |
| Iqgap2 |
A |
G |
13: 95,811,913 (GRCm39) |
|
probably benign |
Het |
| Klk10 |
A |
T |
7: 43,433,882 (GRCm39) |
|
probably benign |
Het |
| Kng1 |
A |
G |
16: 22,892,187 (GRCm39) |
Y250C |
probably damaging |
Het |
| Las1l |
A |
T |
X: 94,981,059 (GRCm39) |
M690K |
probably benign |
Het |
| Mug1 |
T |
A |
6: 121,848,295 (GRCm39) |
M673K |
probably benign |
Het |
| Myh9 |
T |
C |
15: 77,654,070 (GRCm39) |
H1245R |
probably benign |
Het |
| Oprk1 |
C |
T |
1: 5,669,067 (GRCm39) |
T171I |
probably damaging |
Het |
| Pgm5 |
A |
T |
19: 24,801,782 (GRCm39) |
S149T |
probably benign |
Het |
| Pla2g4a |
T |
C |
1: 149,736,847 (GRCm39) |
N424S |
probably benign |
Het |
| Plec |
A |
T |
15: 76,063,149 (GRCm39) |
L2334Q |
probably damaging |
Het |
| Pus7l |
G |
A |
15: 94,438,059 (GRCm39) |
S262F |
probably damaging |
Het |
| Rps24 |
C |
A |
14: 24,541,823 (GRCm39) |
D3E |
probably benign |
Het |
| Rxfp1 |
T |
C |
3: 79,557,799 (GRCm39) |
N560D |
probably damaging |
Het |
| Sema3c |
C |
T |
5: 17,926,923 (GRCm39) |
|
probably benign |
Het |
| Slc47a2 |
A |
G |
11: 61,233,365 (GRCm39) |
F55S |
probably damaging |
Het |
| Slco1a6 |
A |
G |
6: 142,047,309 (GRCm39) |
|
probably benign |
Het |
| Taf4b |
A |
T |
18: 14,963,196 (GRCm39) |
E645D |
probably benign |
Het |
| Tmem161a |
T |
A |
8: 70,631,624 (GRCm39) |
V158E |
probably damaging |
Het |
| Trav13-2 |
A |
G |
14: 53,872,604 (GRCm39) |
S27G |
possibly damaging |
Het |
| Trav13-2 |
G |
T |
14: 53,872,603 (GRCm39) |
Q26H |
probably damaging |
Het |
| Trav13-2 |
A |
T |
14: 53,872,602 (GRCm39) |
Q26L |
possibly damaging |
Het |
| Vmn2r108 |
T |
A |
17: 20,691,608 (GRCm39) |
H305L |
probably benign |
Het |
|
| Other mutations in Zfp263 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00489:Zfp263
|
APN |
16 |
3,563,710 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01112:Zfp263
|
APN |
16 |
3,566,776 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02534:Zfp263
|
APN |
16 |
3,564,279 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02674:Zfp263
|
APN |
16 |
3,564,629 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03065:Zfp263
|
APN |
16 |
3,564,344 (GRCm39) |
missense |
probably benign |
|
|
IGL03105:Zfp263
|
APN |
16 |
3,566,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03153:Zfp263
|
APN |
16 |
3,564,744 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02796:Zfp263
|
UTSW |
16 |
3,564,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1201:Zfp263
|
UTSW |
16 |
3,567,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1414:Zfp263
|
UTSW |
16 |
3,567,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1448:Zfp263
|
UTSW |
16 |
3,564,323 (GRCm39) |
missense |
probably benign |
0.18 |
|
R3085:Zfp263
|
UTSW |
16 |
3,567,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Zfp263
|
UTSW |
16 |
3,562,770 (GRCm39) |
unclassified |
probably benign |
|
|
R4989:Zfp263
|
UTSW |
16 |
3,566,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5072:Zfp263
|
UTSW |
16 |
3,564,704 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5073:Zfp263
|
UTSW |
16 |
3,564,704 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5074:Zfp263
|
UTSW |
16 |
3,564,704 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5122:Zfp263
|
UTSW |
16 |
3,567,719 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5705:Zfp263
|
UTSW |
16 |
3,564,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Zfp263
|
UTSW |
16 |
3,566,081 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6879:Zfp263
|
UTSW |
16 |
3,567,719 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7133:Zfp263
|
UTSW |
16 |
3,567,255 (GRCm39) |
nonsense |
probably null |
|
|
R7216:Zfp263
|
UTSW |
16 |
3,562,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8517:Zfp263
|
UTSW |
16 |
3,564,760 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8822:Zfp263
|
UTSW |
16 |
3,562,004 (GRCm39) |
unclassified |
probably benign |
|
|
R9130:Zfp263
|
UTSW |
16 |
3,567,701 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9172:Zfp263
|
UTSW |
16 |
3,567,323 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9512:Zfp263
|
UTSW |
16 |
3,564,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9616:Zfp263
|
UTSW |
16 |
3,567,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation