Incidental Mutation 'R1711:Olfr556'
ID 190555
Institutional Source Beutler Lab
Gene Symbol Olfr556
Ensembl Gene ENSMUSG00000073969
Gene Name olfactory receptor 556
Synonyms MOR41-1, GA_x6K02T2PBJ9-5386601-5387575
MMRRC Submission 039744-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R1711 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 102664899-102673270 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 102670162 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 81 (V81L)
Ref Sequence ENSEMBL: ENSMUSP00000150289 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098219] [ENSMUST00000213485] [ENSMUST00000217526]
AlphaFold E9Q549
Predicted Effect probably damaging
Transcript: ENSMUST00000098219
AA Change: V81L

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000095822
Gene: ENSMUSG00000073969
AA Change: V81L

Pfam:7tm_4 35 315 1.2e-85 PFAM
Pfam:7TM_GPCR_Srsx 39 192 1.5e-13 PFAM
Pfam:7tm_1 45 297 3.2e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213485
AA Change: V81L

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000217526
AA Change: V81L

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 111 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik C T 13: 77,269,920 (GRCm38) T741I possibly damaging Het
Acot3 A T 12: 84,053,573 (GRCm38) Q41L probably damaging Het
Actl7b G A 4: 56,740,165 (GRCm38) Q398* probably null Het
Adgrb2 C A 4: 129,992,624 (GRCm38) Q186K probably damaging Het
Akr1a1 A G 4: 116,637,974 (GRCm38) probably null Het
Ap3s2 A T 7: 79,880,490 (GRCm38) F192L probably damaging Het
Apobr T G 7: 126,584,979 (GRCm38) probably null Het
Arhgap5 A G 12: 52,519,345 (GRCm38) N1033S probably damaging Het
Arid3c G T 4: 41,725,947 (GRCm38) R219S probably damaging Het
Bves C T 10: 45,347,865 (GRCm38) T207M probably damaging Het
C330027C09Rik A C 16: 49,017,486 (GRCm38) I850L probably benign Het
Cacna1d T C 14: 30,066,056 (GRCm38) K1619R probably damaging Het
Caps2 A T 10: 112,190,978 (GRCm38) D223V possibly damaging Het
Cd163l1 G T 7: 140,220,609 (GRCm38) C101F probably damaging Het
Cd3g A C 9: 44,974,342 (GRCm38) L35R probably damaging Het
Cdh23 A T 10: 60,523,536 (GRCm38) V261E probably benign Het
Cfap54 T G 10: 93,011,020 (GRCm38) T1028P probably damaging Het
Ch25h C A 19: 34,474,286 (GRCm38) V281L probably benign Het
Clu G T 14: 65,980,905 (GRCm38) V405L possibly damaging Het
Col6a3 A T 1: 90,830,213 (GRCm38) H6Q probably damaging Het
Cps1 G A 1: 67,168,374 (GRCm38) probably null Het
Ctr9 T C 7: 111,055,663 (GRCm38) S1134P unknown Het
Cts7 C T 13: 61,352,810 (GRCm38) G308S probably damaging Het
Cyp2c39 C A 19: 39,566,891 (GRCm38) T385K probably damaging Het
Dennd5a A T 7: 109,918,712 (GRCm38) D596E probably benign Het
Disc1 T A 8: 125,124,610 (GRCm38) I413K probably benign Het
Dll3 C T 7: 28,294,497 (GRCm38) G505D probably damaging Het
Dnah3 A G 7: 120,078,571 (GRCm38) W377R probably damaging Het
Dopey2 A G 16: 93,799,926 (GRCm38) D1792G probably damaging Het
Dpep3 T A 8: 105,973,693 (GRCm38) R460S probably benign Het
Ebf4 A G 2: 130,358,831 (GRCm38) N302S probably damaging Het
Egflam T C 15: 7,289,915 (GRCm38) E194G possibly damaging Het
Ep400 A T 5: 110,693,308 (GRCm38) probably benign Het
Ercc6 T C 14: 32,526,176 (GRCm38) M228T probably damaging Het
Fbxo9 T C 9: 78,087,247 (GRCm38) T264A probably damaging Het
Fcrl5 C A 3: 87,457,414 (GRCm38) P486T possibly damaging Het
Fyb T C 15: 6,580,479 (GRCm38) F178L probably damaging Het
Gaa T A 11: 119,280,460 (GRCm38) I646N probably damaging Het
Gm11639 A G 11: 104,720,688 (GRCm38) K452R probably benign Het
Gm13124 A T 4: 144,555,406 (GRCm38) I272K probably damaging Het
Gm5431 A T 11: 48,895,026 (GRCm38) V174E possibly damaging Het
Gnpat T G 8: 124,886,952 (GRCm38) probably null Het
Gucy1a2 G T 9: 3,759,622 (GRCm38) R476I probably benign Het
Hars A G 18: 36,771,103 (GRCm38) L241P probably damaging Het
Haus5 G A 7: 30,657,903 (GRCm38) Q399* probably null Het
Hephl1 T C 9: 15,059,246 (GRCm38) E984G probably damaging Het
Hmces C T 6: 87,921,592 (GRCm38) Q132* probably null Het
Hsp90b1 G T 10: 86,694,525 (GRCm38) T490K probably damaging Het
Idh2 T G 7: 80,099,158 (GRCm38) E125A probably damaging Het
Ipo13 G T 4: 117,904,522 (GRCm38) H465Q probably benign Het
Isca2 C A 12: 84,773,619 (GRCm38) T31K probably damaging Het
Itga9 T C 9: 118,698,461 (GRCm38) V560A probably benign Het
Jhy G A 9: 40,911,157 (GRCm38) Q562* probably null Het
Kcnj5 A G 9: 32,322,569 (GRCm38) I150T probably damaging Het
Kmt2a A G 9: 44,841,621 (GRCm38) I1419T unknown Het
Lix1 T C 17: 17,446,058 (GRCm38) F160L possibly damaging Het
Lonrf2 G A 1: 38,813,276 (GRCm38) P165S probably benign Het
Map4k1 A T 7: 28,989,352 (GRCm38) Q276L possibly damaging Het
Mmp9 G A 2: 164,949,422 (GRCm38) G171S probably damaging Het
Mvp C A 7: 126,995,735 (GRCm38) probably null Het
Mylk3 T A 8: 85,364,831 (GRCm38) E115V probably damaging Het
Nebl T A 2: 17,388,754 (GRCm38) T603S probably damaging Het
Nudt15 T C 14: 73,523,336 (GRCm38) D105G probably benign Het
Olfr1369-ps1 G A 13: 21,116,306 (GRCm38) V205I probably benign Het
Olfr527 A C 7: 140,335,999 (GRCm38) T46P possibly damaging Het
Olfr65 T A 7: 103,906,699 (GRCm38) W87R probably damaging Het
Olfr685 A T 7: 105,180,760 (GRCm38) H199Q probably damaging Het
Olfr971 A G 9: 39,840,285 (GRCm38) M284V probably benign Het
Osbpl9 A T 4: 109,066,218 (GRCm38) C495S probably damaging Het
Pamr1 A G 2: 102,640,852 (GRCm38) T507A probably benign Het
Pcdhb9 T A 18: 37,403,327 (GRCm38) C791* probably null Het
Pcgf6 T C 19: 47,050,518 (GRCm38) E101G probably damaging Het
Pdgfrl A T 8: 40,985,794 (GRCm38) I256F probably benign Het
Pdzd7 T C 19: 45,045,511 (GRCm38) R45G possibly damaging Het
Pecr C T 1: 72,277,409 (GRCm38) V46I possibly damaging Het
Pgr A G 9: 8,922,714 (GRCm38) probably null Het
Pik3c2a A T 7: 116,417,927 (GRCm38) Y198* probably null Het
Pp2d1 T A 17: 53,515,310 (GRCm38) M243L possibly damaging Het
Ppp1r1a T A 15: 103,533,492 (GRCm38) I50L possibly damaging Het
Proc T C 18: 32,127,406 (GRCm38) D222G probably benign Het
Ptprq T A 10: 107,534,699 (GRCm38) R2044* probably null Het
Ranbp2 T C 10: 58,460,519 (GRCm38) V326A probably benign Het
Reep6 T A 10: 80,333,981 (GRCm38) F122I possibly damaging Het
Rubcn C A 16: 32,843,101 (GRCm38) R388S probably damaging Het
Rusc1 A G 3: 89,089,293 (GRCm38) L62P probably damaging Het
Satb2 T C 1: 56,850,289 (GRCm38) N423S probably damaging Het
Serpinb9d A G 13: 33,200,748 (GRCm38) K236R probably benign Het
Slc4a7 A G 14: 14,765,709 (GRCm38) R680G probably benign Het
Slitrk1 T A 14: 108,913,096 (GRCm38) Y61F probably benign Het
Son A G 16: 91,660,226 (GRCm38) probably benign Het
Sparc T A 11: 55,395,776 (GRCm38) probably null Het
Spon2 A G 5: 33,216,385 (GRCm38) F194S probably damaging Het
Spta1 A G 1: 174,241,042 (GRCm38) E2136G probably damaging Het
Stat4 T C 1: 52,106,925 (GRCm38) S746P probably damaging Het
Stk31 T A 6: 49,469,304 (GRCm38) S958R probably benign Het
Stom T A 2: 35,315,917 (GRCm38) I267F probably damaging Het
Stx12 A T 4: 132,858,477 (GRCm38) D197E probably damaging Het
Taok3 A T 5: 117,255,926 (GRCm38) N588I possibly damaging Het
Tgs1 A G 4: 3,598,658 (GRCm38) D657G probably damaging Het
Trim6 A G 7: 104,232,837 (GRCm38) T432A probably damaging Het
Trim72 C G 7: 128,004,585 (GRCm38) C34W probably damaging Het
Trpc4ap A T 2: 155,657,744 (GRCm38) I286N probably benign Het
Ttn A G 2: 76,863,561 (GRCm38) V321A possibly damaging Het
Utp4 T A 8: 106,918,720 (GRCm38) I583N probably damaging Het
Wdfy2 G T 14: 62,944,097 (GRCm38) M225I probably benign Het
Wfdc1 A G 8: 119,681,037 (GRCm38) T134A probably benign Het
Wnt9b A G 11: 103,732,128 (GRCm38) S150P probably damaging Het
Zbtb46 A T 2: 181,411,684 (GRCm38) F412I probably damaging Het
Zc3h15 G A 2: 83,661,148 (GRCm38) R240H probably benign Het
Zfp11 A T 5: 129,656,673 (GRCm38) Y575N probably benign Het
Zfp687 T C 3: 95,011,889 (GRCm38) M191V probably benign Het
Other mutations in Olfr556
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Olfr556 APN 7 102,670,651 (GRCm38) missense probably damaging 1.00
IGL01662:Olfr556 APN 7 102,670,720 (GRCm38) missense probably damaging 1.00
IGL02989:Olfr556 APN 7 102,670,444 (GRCm38) missense possibly damaging 0.50
R0194:Olfr556 UTSW 7 102,670,199 (GRCm38) missense probably benign 0.01
R1670:Olfr556 UTSW 7 102,670,402 (GRCm38) missense possibly damaging 0.72
R1680:Olfr556 UTSW 7 102,670,733 (GRCm38) missense possibly damaging 0.82
R1768:Olfr556 UTSW 7 102,670,301 (GRCm38) missense probably damaging 1.00
R1950:Olfr556 UTSW 7 102,670,477 (GRCm38) missense probably benign 0.03
R4452:Olfr556 UTSW 7 102,670,049 (GRCm38) missense probably benign 0.00
R5564:Olfr556 UTSW 7 102,670,226 (GRCm38) missense probably damaging 1.00
R6623:Olfr556 UTSW 7 102,670,034 (GRCm38) missense possibly damaging 0.90
R7040:Olfr556 UTSW 7 102,670,730 (GRCm38) missense probably benign 0.00
R7244:Olfr556 UTSW 7 102,669,839 (GRCm38) start gained probably benign
R7300:Olfr556 UTSW 7 102,670,210 (GRCm38) missense probably benign 0.01
R8499:Olfr556 UTSW 7 102,670,805 (GRCm38) missense probably damaging 0.97
R9620:Olfr556 UTSW 7 102,670,804 (GRCm38) missense possibly damaging 0.95
R9694:Olfr556 UTSW 7 102,670,804 (GRCm38) missense possibly damaging 0.95
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-05-14