|Institutional Source||Beutler Lab|
|Gene Name||vesicle transport through interaction with t-SNAREs 1A|
|Synonyms||1110018K19Rik, 1110014F16Rik, 4921537J05Rik, Vti1-rp2|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3736 (G1)|
|Chromosomal Location||55316295-55627309 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to A at 55380932 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000153392 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000095950] [ENSMUST00000223690] [ENSMUST00000225529]|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (53/53)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Vti1a||
(F):5'- AACACTCCCAGTCGCTCTTG -3'
(R):5'- TGCTAATACTGTTAGGGAGCAGC -3'
(F):5'- CCCAGTCGCTCTTGTTTTAATAAC -3'
(R):5'- CTAATACTGTTAGGGAGCAGCTTGAG -3'