Incidental Mutation 'IGL00959:Sult2a6'
ID27883
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a6
Ensembl Gene ENSMUSG00000070810
Gene Namesulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6
SynonymsGm6957
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL00959
Quality Score
Status
Chromosome7
Chromosomal Location14222403-14254870 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 14254709 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 42 (Y42C)
Ref Sequence ENSEMBL: ENSMUSP00000138842 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076576] [ENSMUST00000184731]
Predicted Effect probably damaging
Transcript: ENSMUST00000076576
AA Change: Y42C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075884
Gene: ENSMUSG00000070810
AA Change: Y42C

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 1.2e-81 PFAM
Pfam:Sulfotransfer_3 35 205 2.2e-11 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000184731
AA Change: Y42C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000138842
Gene: ENSMUSG00000070810
AA Change: Y42C

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 116 4.7e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12b A T 11: 69,166,243 H430L probably damaging Het
Aox4 G T 1: 58,239,174 V443F probably damaging Het
Bmpr2 A T 1: 59,815,315 I108F possibly damaging Het
Cflar G A 1: 58,729,162 probably null Het
Chchd3 A G 6: 32,968,253 V106A probably benign Het
Chl1 G T 6: 103,709,250 probably null Het
Clvs2 C T 10: 33,528,463 M252I probably benign Het
Cntnap5a T A 1: 116,184,327 L449Q probably benign Het
Col6a2 T A 10: 76,614,534 I188F probably damaging Het
Cyp2c55 A G 19: 39,038,143 D398G probably benign Het
Dennd1b T C 1: 139,143,888 probably benign Het
Dopey1 T A 9: 86,487,431 Y106N probably damaging Het
Dpy19l1 A T 9: 24,423,197 probably null Het
Extl3 C T 14: 65,076,912 V274I probably benign Het
Fras1 G A 5: 96,781,281 R3848H probably damaging Het
Gm11437 A C 11: 84,148,622 probably benign Het
Gss T A 2: 155,581,951 D2V probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Ilvbl G A 10: 78,583,905 D548N probably damaging Het
Jmjd6 A T 11: 116,842,376 D115E possibly damaging Het
Kidins220 T A 12: 25,051,133 S1110R possibly damaging Het
Kmt2c T A 5: 25,276,229 I4784F probably damaging Het
Mrpl52 T C 14: 54,427,037 V11A possibly damaging Het
Myo3b A G 2: 70,314,292 Y1036C probably damaging Het
Olfr769 T A 10: 129,112,024 M134L probably benign Het
Omp T C 7: 98,145,150 D90G probably damaging Het
Osmr T C 15: 6,824,605 I541V probably benign Het
Ppp1r32 A T 19: 10,477,523 probably null Het
Ppp2r1a A T 17: 20,961,578 probably benign Het
Ptpn13 T A 5: 103,517,571 probably null Het
Rock2 C A 12: 16,978,055 N1429K probably benign Het
Slc25a20 T G 9: 108,681,999 M188R possibly damaging Het
Slc28a1 T C 7: 81,169,068 probably benign Het
Tgfb2 A G 1: 186,704,587 V63A probably benign Het
Ugt2b38 A T 5: 87,411,823 N403K probably damaging Het
Vmn2r29 A G 7: 7,241,856 W340R probably benign Het
Wnt5a C T 14: 28,522,909 T351M probably damaging Het
Other mutations in Sult2a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01977:Sult2a6 APN 7 14253486 missense probably benign 0.00
IGL02524:Sult2a6 APN 7 14236686 missense possibly damaging 0.80
IGL03209:Sult2a6 APN 7 14225972 missense probably benign 0.36
IGL03379:Sult2a6 APN 7 14222586 missense probably benign 0.01
R1840:Sult2a6 UTSW 7 14254829 missense probably benign 0.03
R1893:Sult2a6 UTSW 7 14225889 missense probably benign 0.00
R2037:Sult2a6 UTSW 7 14254709 missense probably damaging 0.99
R2331:Sult2a6 UTSW 7 14225870 missense possibly damaging 0.94
R3871:Sult2a6 UTSW 7 14254776 missense probably benign 0.16
R3921:Sult2a6 UTSW 7 14254743 missense possibly damaging 0.83
R5599:Sult2a6 UTSW 7 14254704 nonsense probably null
R5761:Sult2a6 UTSW 7 14250358 missense probably damaging 0.97
R6744:Sult2a6 UTSW 7 14222545 missense probably damaging 1.00
R6956:Sult2a6 UTSW 7 14254823 missense possibly damaging 0.50
R7152:Sult2a6 UTSW 7 14222520 missense probably benign 0.36
R7869:Sult2a6 UTSW 7 14254812 missense not run
R7952:Sult2a6 UTSW 7 14254812 missense not run
Z1088:Sult2a6 UTSW 7 14225894 missense probably benign
Posted On2013-04-17