Mutagenetix > Incidental Mutation

Incidental Mutation 'R8369:Sult2a6'

646296

Institutional Source

Beutler Lab

Gene Symbol

Sult2a6

Ensembl Gene

ENSMUSG00000070810

Gene Name

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6

Synonyms

Gm6957

MMRRC Submission

067739-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

R8369 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

13956328-13988795 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to C at 13987327 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000075884 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076576] [ENSMUST00000184731]

AlphaFold

B2RVI8

Predicted Effect

probably null
Transcript: ENSMUST00000076576

SMART Domains

Protein: ENSMUSP00000075884
Gene: ENSMUSG00000070810

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	34	278	1.2e-81	PFAM
Pfam:Sulfotransfer_3	35	205	2.2e-11	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000184731

SMART Domains

Protein: ENSMUSP00000138842
Gene: ENSMUSG00000070810

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	34	116	4.7e-20	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438H23Rik	G	A	16: 90,852,657 (GRCm39)	H160Y	probably benign	Het
Abcc4	T	G	14: 118,864,869 (GRCm39)	I386L	probably benign	Het
Arap2	G	A	5: 62,761,669 (GRCm39)	R1686*	probably null	Het
Arfgef3	A	T	10: 18,465,477 (GRCm39)	I2122N	probably benign	Het
Arhgap44	A	T	11: 64,950,680 (GRCm39)	D119E	probably damaging	Het
Atp2b2	C	T	6: 113,790,747 (GRCm39)		probably null	Het
Bltp1	T	A	3: 37,065,752 (GRCm39)	L9M		Het
Brinp1	A	T	4: 68,716,936 (GRCm39)	L304Q	possibly damaging	Het
C2cd3	T	C	7: 100,044,465 (GRCm39)	V349A	probably benign	Het
Ccdc93	T	C	1: 121,405,597 (GRCm39)	Y347H	probably damaging	Het
Ccdc93	T	G	1: 121,422,126 (GRCm39)	I534S	probably benign	Het
Cyb5r4	A	T	9: 86,922,486 (GRCm39)	D165V	probably benign	Het
Cygb	G	A	11: 116,540,109 (GRCm39)	T180I	probably benign	Het
Cyp4f15	T	A	17: 32,916,939 (GRCm39)	S285R	probably benign	Het
Daxx	G	T	17: 34,131,590 (GRCm39)	C433F	probably damaging	Het
Dcaf6	T	C	1: 165,185,043 (GRCm39)	E483G	probably damaging	Het
Dennd1a	T	A	2: 37,938,766 (GRCm39)	I115F	probably damaging	Het
Dnajc5b	A	G	3: 19,664,796 (GRCm39)	D198G	probably damaging	Het
Ercc1	T	A	7: 19,088,377 (GRCm39)	C243*	probably null	Het
Ermard	T	C	17: 15,273,560 (GRCm39)	F382L	probably damaging	Het
Fer1l4	C	A	2: 155,861,680 (GRCm39)	G1879V	probably benign	Het
Focad	T	A	4: 88,150,905 (GRCm39)	H516Q	unknown	Het
Gcsam	T	A	16: 45,436,369 (GRCm39)	W51R	probably damaging	Het
Ikbkb	A	G	8: 23,181,097 (GRCm39)	V122A	probably benign	Het
Iqgap2	A	T	13: 95,798,111 (GRCm39)	S1065T	probably damaging	Het
Kif16b	G	A	2: 142,553,777 (GRCm39)	A1007V	probably benign	Het
Krt24	A	T	11: 99,173,534 (GRCm39)	C262*	probably null	Het
Lrat	T	C	3: 82,810,865 (GRCm39)	E52G	probably damaging	Het
Misp3	T	A	8: 84,737,627 (GRCm39)	H94L	unknown	Het
N4bp3	A	G	11: 51,535,253 (GRCm39)	L312P	probably damaging	Het
Naxe	T	C	3: 87,963,994 (GRCm39)	T246A	probably benign	Het
Pcolce2	A	T	9: 95,519,847 (GRCm39)	M1L	probably benign	Het
Slc7a6	G	A	8: 106,919,796 (GRCm39)	A270T	probably damaging	Het
Sord	T	A	2: 122,076,976 (GRCm39)	I27K	probably benign	Het
Srek1ip1	A	G	13: 104,970,798 (GRCm39)	E83G	probably benign	Het
Srgap3	A	C	6: 112,699,779 (GRCm39)	N1090K	probably benign	Het
Tacc2	T	A	7: 130,223,888 (GRCm39)	I191N	probably damaging	Het
Thoc3	A	G	13: 54,615,708 (GRCm39)	S119P	probably damaging	Het
Tirap	A	G	9: 35,100,052 (GRCm39)	S211P	probably benign	Het
Tle4	T	C	19: 14,429,876 (GRCm39)	T632A	probably benign	Het
Tnfaip8l2	T	A	3: 95,047,486 (GRCm39)	I126F	probably benign	Het
Txnrd1	A	G	10: 82,710,480 (GRCm39)	T114A	probably benign	Het
Vmn2r14	A	G	5: 109,369,342 (GRCm39)	L77P	probably damaging	Het
Wwc1	G	A	11: 35,758,198 (GRCm39)	T716I	probably damaging	Het
Yod1	A	G	1: 130,645,360 (GRCm39)	K47R	probably benign	Het
Zfhx2	A	T	14: 55,304,201 (GRCm39)	M1261K	probably benign	Het
Zfhx3	T	C	8: 109,583,448 (GRCm39)	I1105T	possibly damaging	Het
Zfp9	C	A	6: 118,441,353 (GRCm39)	K436N	probably damaging	Het
Zfp979	T	C	4: 147,697,548 (GRCm39)	H387R	possibly damaging	Het

Other mutations in Sult2a6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00959:Sult2a6	APN	7	13,988,634 (GRCm39)	missense	probably damaging	1.00
IGL01977:Sult2a6	APN	7	13,987,411 (GRCm39)	missense	probably benign	0.00
IGL02524:Sult2a6	APN	7	13,970,611 (GRCm39)	missense	possibly damaging	0.80
IGL03209:Sult2a6	APN	7	13,959,897 (GRCm39)	missense	probably benign	0.36
IGL03379:Sult2a6	APN	7	13,956,511 (GRCm39)	missense	probably benign	0.01
R1840:Sult2a6	UTSW	7	13,988,754 (GRCm39)	missense	probably benign	0.03
R1893:Sult2a6	UTSW	7	13,959,814 (GRCm39)	missense	probably benign	0.00
R2037:Sult2a6	UTSW	7	13,988,634 (GRCm39)	missense	probably damaging	0.99
R2331:Sult2a6	UTSW	7	13,959,795 (GRCm39)	missense	possibly damaging	0.94
R3871:Sult2a6	UTSW	7	13,988,701 (GRCm39)	missense	probably benign	0.16
R3921:Sult2a6	UTSW	7	13,988,668 (GRCm39)	missense	possibly damaging	0.83
R5599:Sult2a6	UTSW	7	13,988,629 (GRCm39)	nonsense	probably null
R5761:Sult2a6	UTSW	7	13,984,283 (GRCm39)	missense	probably damaging	0.97
R6744:Sult2a6	UTSW	7	13,956,470 (GRCm39)	missense	probably damaging	1.00
R6956:Sult2a6	UTSW	7	13,988,748 (GRCm39)	missense	possibly damaging	0.50
R7152:Sult2a6	UTSW	7	13,956,445 (GRCm39)	missense	probably benign	0.36
R7869:Sult2a6	UTSW	7	13,988,737 (GRCm39)	missense	not run
R7990:Sult2a6	UTSW	7	13,959,795 (GRCm39)	missense	possibly damaging	0.94
R8347:Sult2a6	UTSW	7	13,959,883 (GRCm39)	missense	probably benign	0.15
R8391:Sult2a6	UTSW	7	13,956,516 (GRCm39)	critical splice acceptor site	probably null
R8414:Sult2a6	UTSW	7	13,984,357 (GRCm39)	missense	probably damaging	1.00
R9317:Sult2a6	UTSW	7	13,970,615 (GRCm39)	nonsense	probably null
R9654:Sult2a6	UTSW	7	13,956,445 (GRCm39)	missense	probably benign	0.06
Z1088:Sult2a6	UTSW	7	13,959,819 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TTCTGTGTGATAGTCCAGATCATG -3'
(R):5'- CCATTCAGGAACAAACTGGCTG -3'

Sequencing Primer
(F):5'- CTCATCACCACCTAGTGT -3'
(R):5'- CTGCTTGATTCAGACCAAGGG -3'

Posted On

2020-09-02