Incidental Mutation 'IGL01945:Or5k3'
ID 279215
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5k3
Ensembl Gene ENSMUSG00000062608
Gene Name olfactory receptor family 5 subfamily K member 3
Synonyms MOR184-5, GA_x54KRFPKG5P-55369823-55370749, Olfr195
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # IGL01945
Quality Score
Status
Chromosome 16
Chromosomal Location 58969215-58970141 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58969827 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 205 (S205P)
Ref Sequence ENSEMBL: ENSMUSP00000150249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075381] [ENSMUST00000216957]
AlphaFold Q8VGQ6
Predicted Effect probably benign
Transcript: ENSMUST00000075381
AA Change: S205P

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000073737
Gene: ENSMUSG00000062608
AA Change: S205P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 161 2.7e-8 PFAM
Pfam:7tm_1 41 307 9.4e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208239
Predicted Effect probably benign
Transcript: ENSMUST00000216957
AA Change: S205P

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A C 11: 109,974,130 (GRCm39) probably benign Het
Acta2 A G 19: 34,229,254 (GRCm39) V45A probably benign Het
Adam11 G A 11: 102,663,736 (GRCm39) V305M probably damaging Het
Adcy1 A G 11: 7,111,891 (GRCm39) K919E probably damaging Het
Afap1l1 T C 18: 61,889,934 (GRCm39) T101A probably benign Het
Apbb2 T A 5: 66,557,594 (GRCm39) D289V probably damaging Het
Appl1 A G 14: 26,650,612 (GRCm39) V520A possibly damaging Het
Atp5mc3 G A 2: 73,741,313 (GRCm39) R9C probably benign Het
Atp8a2 A G 14: 60,263,609 (GRCm39) L375P probably damaging Het
Cavin1 A T 11: 100,861,246 (GRCm39) F16Y probably benign Het
Ccdc185 C A 1: 182,576,441 (GRCm39) V83L probably benign Het
Ccdc80 T A 16: 44,938,608 (GRCm39) S772T probably damaging Het
Cntn4 T A 6: 106,414,865 (GRCm39) V132E probably damaging Het
Coa5 A T 1: 37,468,979 (GRCm39) C24S probably damaging Het
Col6a5 A T 9: 105,805,489 (GRCm39) V1139D unknown Het
Ddx46 C A 13: 55,802,885 (GRCm39) S469* probably null Het
Ep300 A G 15: 81,500,310 (GRCm39) probably benign Het
Fcna A T 2: 25,517,847 (GRCm39) M1K probably null Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gstm3 T C 3: 107,874,973 (GRCm39) E93G probably damaging Het
Gtse1 A G 15: 85,755,748 (GRCm39) T471A probably benign Het
Hepacam2 T A 6: 3,487,117 (GRCm39) Y4F probably benign Het
Hipk1 T C 3: 103,651,320 (GRCm39) I1148V possibly damaging Het
Il1r2 A G 1: 40,141,613 (GRCm39) T9A possibly damaging Het
Kl A T 5: 150,912,402 (GRCm39) D717V probably damaging Het
Krt75 G A 15: 101,478,599 (GRCm39) T345M possibly damaging Het
Myo5a T A 9: 75,047,953 (GRCm39) H260Q probably damaging Het
Nckap1l G A 15: 103,370,069 (GRCm39) G156D probably damaging Het
Nlrp1b T G 11: 71,072,233 (GRCm39) T537P probably damaging Het
Nudt17 A G 3: 96,614,355 (GRCm39) I201T probably damaging Het
Or6c8 A T 10: 128,915,172 (GRCm39) I220N probably damaging Het
Or7g27 A T 9: 19,250,628 (GRCm39) S291C probably damaging Het
Padi6 T C 4: 140,469,235 (GRCm39) D35G probably benign Het
Plcb1 A T 2: 135,062,711 (GRCm39) Y107F probably benign Het
Plek2 T A 12: 78,938,922 (GRCm39) H279L probably damaging Het
Plk2 A G 13: 110,535,588 (GRCm39) D470G possibly damaging Het
Ranbp17 T C 11: 33,278,520 (GRCm39) T116A possibly damaging Het
Rbck1 G A 2: 152,160,236 (GRCm39) P481L probably damaging Het
Reps1 A G 10: 17,969,584 (GRCm39) N229S probably benign Het
Rngtt T C 4: 33,339,073 (GRCm39) W293R probably damaging Het
Robo1 A T 16: 72,759,114 (GRCm39) I376F probably damaging Het
Ryr2 T A 13: 11,805,249 (GRCm39) I872F probably damaging Het
Sgip1 T C 4: 102,823,439 (GRCm39) Y707H probably damaging Het
Slc17a5 G T 9: 78,495,214 (GRCm39) D12E probably benign Het
Slco1a5 T A 6: 142,189,715 (GRCm39) probably null Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Strap A G 6: 137,718,333 (GRCm39) I146V probably benign Het
Tcim A T 8: 24,928,892 (GRCm39) H7Q probably benign Het
Tgfbr3 A G 5: 107,269,224 (GRCm39) probably null Het
Thada G T 17: 84,530,194 (GRCm39) T1725N probably benign Het
Trhr T C 15: 44,060,540 (GRCm39) V20A probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Wnt5a A G 14: 28,240,519 (GRCm39) N223S probably damaging Het
Other mutations in Or5k3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01937:Or5k3 APN 16 58,969,827 (GRCm39) missense probably benign 0.01
R0071:Or5k3 UTSW 16 58,969,578 (GRCm39) missense probably benign 0.23
R0390:Or5k3 UTSW 16 58,969,662 (GRCm39) missense probably benign 0.01
R0601:Or5k3 UTSW 16 58,970,117 (GRCm39) missense probably benign 0.00
R1499:Or5k3 UTSW 16 58,969,287 (GRCm39) missense probably benign
R1612:Or5k3 UTSW 16 58,969,987 (GRCm39) missense probably benign 0.00
R1785:Or5k3 UTSW 16 58,969,660 (GRCm39) missense probably damaging 1.00
R2082:Or5k3 UTSW 16 58,969,248 (GRCm39) missense probably damaging 0.99
R3605:Or5k3 UTSW 16 58,969,846 (GRCm39) missense probably damaging 1.00
R4168:Or5k3 UTSW 16 58,969,363 (GRCm39) missense probably benign 0.00
R4839:Or5k3 UTSW 16 58,969,393 (GRCm39) missense probably damaging 1.00
R4989:Or5k3 UTSW 16 58,969,981 (GRCm39) missense probably damaging 1.00
R5285:Or5k3 UTSW 16 58,969,633 (GRCm39) missense probably damaging 1.00
R7107:Or5k3 UTSW 16 58,969,279 (GRCm39) missense probably benign 0.10
R7136:Or5k3 UTSW 16 58,969,327 (GRCm39) missense probably damaging 1.00
R7317:Or5k3 UTSW 16 58,969,684 (GRCm39) missense possibly damaging 0.80
R7601:Or5k3 UTSW 16 58,969,597 (GRCm39) missense probably benign 0.01
R7729:Or5k3 UTSW 16 58,969,570 (GRCm39) missense probably damaging 1.00
R8004:Or5k3 UTSW 16 58,969,351 (GRCm39) missense probably damaging 1.00
R8208:Or5k3 UTSW 16 58,969,382 (GRCm39) missense probably benign 0.41
R8282:Or5k3 UTSW 16 58,969,529 (GRCm39) nonsense probably null
R8954:Or5k3 UTSW 16 58,969,319 (GRCm39) nonsense probably null
R9137:Or5k3 UTSW 16 58,969,635 (GRCm39) missense probably benign 0.30
R9197:Or5k3 UTSW 16 58,969,489 (GRCm39) missense probably damaging 0.99
R9396:Or5k3 UTSW 16 58,969,302 (GRCm39) missense probably damaging 0.97
R9547:Or5k3 UTSW 16 58,970,107 (GRCm39) missense possibly damaging 0.89
Posted On 2015-04-16