Incidental Mutation 'IGL02097:Pglyrp4'
ID 279628
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp4
Ensembl Gene ENSMUSG00000042250
Gene Name peptidoglycan recognition protein 4
Synonyms LOC384997, LOC242097
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02097
Quality Score
Status
Chromosome 3
Chromosomal Location 90726906-90741517 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 90735603 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 263 (F263L)
Ref Sequence ENSEMBL: ENSMUSP00000040755 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047745] [ENSMUST00000169698]
AlphaFold Q0VB07
Predicted Effect probably benign
Transcript: ENSMUST00000047745
AA Change: F263L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000040755
Gene: ENSMUSG00000042250
AA Change: F263L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 213 1.14e-7 SMART
PGRP 212 353 2.13e-72 SMART
Ami_2 222 359 1.62e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156268
Predicted Effect probably benign
Transcript: ENSMUST00000169698
AA Change: F264L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000128113
Gene: ENSMUSG00000042250
AA Change: F264L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 200 2.12e-7 SMART
PGRP 213 354 2.13e-72 SMART
Ami_2 223 360 1.62e-21 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A T 5: 104,961,186 V415D possibly damaging Het
Adcy3 C T 12: 4,212,118 A1056V probably damaging Het
Adcy5 G A 16: 35,272,098 A610T probably damaging Het
Arhgap21 G A 2: 20,880,002 T788I probably benign Het
Asic1 T C 15: 99,694,686 probably benign Het
Cdhr4 T A 9: 107,993,000 M68K probably benign Het
Cdhr5 G T 7: 141,269,981 T637K probably damaging Het
Corin A T 5: 72,372,146 C289S probably damaging Het
Cpne4 T C 9: 104,686,502 V26A probably damaging Het
Csmd1 T C 8: 16,211,759 D908G probably null Het
Cyp2c29 A G 19: 39,307,620 D126G probably damaging Het
Ddx42 G A 11: 106,239,160 S426N probably benign Het
Dnah1 C T 14: 31,305,001 V689M possibly damaging Het
Dtwd1 A G 2: 126,164,795 T246A probably damaging Het
Fbn1 A T 2: 125,363,969 M1036K probably damaging Het
Fbxo10 T C 4: 45,048,527 N536S probably benign Het
Gnal G A 18: 67,217,208 probably benign Het
Gns A G 10: 121,390,693 T416A probably benign Het
Heatr5b G A 17: 78,817,514 T603I probably damaging Het
Hsp90b1 T A 10: 86,691,684 probably benign Het
Krt23 C T 11: 99,493,010 G19R probably benign Het
Lama2 C T 10: 27,138,960 R1584H probably benign Het
Lmbr1l C T 15: 98,917,891 V11M probably damaging Het
Man1a2 T C 3: 100,582,131 K511E possibly damaging Het
Mrgpra3 C A 7: 47,589,456 V241F possibly damaging Het
Myh3 A G 11: 67,082,924 D141G probably benign Het
Mylk2 G A 2: 152,915,136 C277Y probably damaging Het
Myo3b A T 2: 70,238,829 T471S probably damaging Het
Naip1 A G 13: 100,425,588 V1023A probably benign Het
Olfm5 T A 7: 104,154,231 T342S probably benign Het
Olfr1510 A G 14: 52,410,054 F273L probably benign Het
Olfr38 T A 6: 42,762,460 M136K probably damaging Het
Plekhh2 A T 17: 84,599,180 T1148S possibly damaging Het
Prrc2b T C 2: 32,191,501 probably benign Het
Rbm28 G T 6: 29,138,618 D398E possibly damaging Het
Rnf220 A G 4: 117,273,327 F234L probably benign Het
Sele T C 1: 164,053,093 S415P probably benign Het
Shpk T C 11: 73,203,995 L79P probably damaging Het
Slc35f4 C T 14: 49,306,246 A148T probably damaging Het
Slc6a20a G A 9: 123,660,619 P120S possibly damaging Het
Slc8a2 A G 7: 16,157,156 E701G possibly damaging Het
Slco1a1 T A 6: 141,940,039 I87F possibly damaging Het
Srebf1 T G 11: 60,202,824 D739A probably damaging Het
Thg1l A G 11: 45,950,228 Y175H probably benign Het
Traf3ip2 G A 10: 39,654,479 V540M probably damaging Het
Wdr48 A G 9: 119,924,263 D644G probably damaging Het
Zbtb1 A T 12: 76,386,597 K452N probably damaging Het
Zfhx2 C T 14: 55,062,894 G2467R probably damaging Het
Zfp334 A T 2: 165,381,723 Y133* probably null Het
Other mutations in Pglyrp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Pglyrp4 APN 3 90739028 missense probably damaging 1.00
IGL00575:Pglyrp4 APN 3 90730791 missense probably damaging 1.00
IGL01892:Pglyrp4 APN 3 90739041 missense probably benign 0.00
IGL02159:Pglyrp4 APN 3 90730853 missense possibly damaging 0.87
IGL02398:Pglyrp4 APN 3 90739117 splice site probably benign
IGL02565:Pglyrp4 APN 3 90735487 missense probably benign
IGL02619:Pglyrp4 APN 3 90735648 splice site probably null
R1160:Pglyrp4 UTSW 3 90728831 splice site probably null
R1420:Pglyrp4 UTSW 3 90728714 missense probably damaging 0.96
R1828:Pglyrp4 UTSW 3 90733003 missense probably damaging 1.00
R4974:Pglyrp4 UTSW 3 90733007 missense probably benign 0.04
R5268:Pglyrp4 UTSW 3 90726964 missense probably damaging 1.00
R5704:Pglyrp4 UTSW 3 90740274 splice site probably null
R7286:Pglyrp4 UTSW 3 90732974 missense probably damaging 1.00
R7787:Pglyrp4 UTSW 3 90732988 missense probably damaging 1.00
R8772:Pglyrp4 UTSW 3 90740400 missense possibly damaging 0.54
R9132:Pglyrp4 UTSW 3 90727931 nonsense probably null
R9607:Pglyrp4 UTSW 3 90730844 missense probably damaging 1.00
Z1176:Pglyrp4 UTSW 3 90739005 missense probably damaging 1.00
Posted On 2015-04-16