Incidental Mutation 'IGL02097:Pglyrp4'
ID 279628
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp4
Ensembl Gene ENSMUSG00000042250
Gene Name peptidoglycan recognition protein 4
Synonyms LOC384997, LOC242097
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02097
Quality Score
Chromosome 3
Chromosomal Location 90634213-90648824 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 90642910 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 263 (F263L)
Ref Sequence ENSEMBL: ENSMUSP00000040755 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047745] [ENSMUST00000169698]
AlphaFold Q0VB07
Predicted Effect probably benign
Transcript: ENSMUST00000047745
AA Change: F263L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000040755
Gene: ENSMUSG00000042250
AA Change: F263L

signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 213 1.14e-7 SMART
PGRP 212 353 2.13e-72 SMART
Ami_2 222 359 1.62e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156268
Predicted Effect probably benign
Transcript: ENSMUST00000169698
AA Change: F264L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000128113
Gene: ENSMUSG00000042250
AA Change: F264L

signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 200 2.12e-7 SMART
PGRP 213 354 2.13e-72 SMART
Ami_2 223 360 1.62e-21 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A T 5: 105,109,052 (GRCm39) V415D possibly damaging Het
Adcy3 C T 12: 4,262,118 (GRCm39) A1056V probably damaging Het
Adcy5 G A 16: 35,092,468 (GRCm39) A610T probably damaging Het
Arhgap21 G A 2: 20,884,813 (GRCm39) T788I probably benign Het
Asic1 T C 15: 99,592,567 (GRCm39) probably benign Het
Cdhr4 T A 9: 107,870,199 (GRCm39) M68K probably benign Het
Cdhr5 G T 7: 140,849,894 (GRCm39) T637K probably damaging Het
Corin A T 5: 72,529,489 (GRCm39) C289S probably damaging Het
Cpne4 T C 9: 104,563,701 (GRCm39) V26A probably damaging Het
Csmd1 T C 8: 16,261,773 (GRCm39) D908G probably null Het
Cyp2c29 A G 19: 39,296,064 (GRCm39) D126G probably damaging Het
Ddx42 G A 11: 106,129,986 (GRCm39) S426N probably benign Het
Dnah1 C T 14: 31,026,958 (GRCm39) V689M possibly damaging Het
Dtwd1 A G 2: 126,006,715 (GRCm39) T246A probably damaging Het
Fbn1 A T 2: 125,205,889 (GRCm39) M1036K probably damaging Het
Fbxo10 T C 4: 45,048,527 (GRCm39) N536S probably benign Het
Gnal G A 18: 67,350,279 (GRCm39) probably benign Het
Gns A G 10: 121,226,598 (GRCm39) T416A probably benign Het
Heatr5b G A 17: 79,124,943 (GRCm39) T603I probably damaging Het
Hsp90b1 T A 10: 86,527,548 (GRCm39) probably benign Het
Krt23 C T 11: 99,383,836 (GRCm39) G19R probably benign Het
Lama2 C T 10: 27,014,956 (GRCm39) R1584H probably benign Het
Lmbr1l C T 15: 98,815,772 (GRCm39) V11M probably damaging Het
Man1a2 T C 3: 100,489,447 (GRCm39) K511E possibly damaging Het
Mrgpra3 C A 7: 47,239,204 (GRCm39) V241F possibly damaging Het
Myh3 A G 11: 66,973,750 (GRCm39) D141G probably benign Het
Mylk2 G A 2: 152,757,056 (GRCm39) C277Y probably damaging Het
Myo3b A T 2: 70,069,173 (GRCm39) T471S probably damaging Het
Naip1 A G 13: 100,562,096 (GRCm39) V1023A probably benign Het
Olfm5 T A 7: 103,803,438 (GRCm39) T342S probably benign Het
Or10g1 A G 14: 52,647,511 (GRCm39) F273L probably benign Het
Or2f1b T A 6: 42,739,394 (GRCm39) M136K probably damaging Het
Plekhh2 A T 17: 84,906,608 (GRCm39) T1148S possibly damaging Het
Prrc2b T C 2: 32,081,513 (GRCm39) probably benign Het
Rbm28 G T 6: 29,138,617 (GRCm39) D398E possibly damaging Het
Rnf220 A G 4: 117,130,524 (GRCm39) F234L probably benign Het
Sele T C 1: 163,880,662 (GRCm39) S415P probably benign Het
Shpk T C 11: 73,094,821 (GRCm39) L79P probably damaging Het
Slc35f4 C T 14: 49,543,703 (GRCm39) A148T probably damaging Het
Slc6a20a G A 9: 123,489,684 (GRCm39) P120S possibly damaging Het
Slc8a2 A G 7: 15,891,081 (GRCm39) E701G possibly damaging Het
Slco1a1 T A 6: 141,885,765 (GRCm39) I87F possibly damaging Het
Srebf1 T G 11: 60,093,650 (GRCm39) D739A probably damaging Het
Thg1l A G 11: 45,841,055 (GRCm39) Y175H probably benign Het
Traf3ip2 G A 10: 39,530,475 (GRCm39) V540M probably damaging Het
Wdr48 A G 9: 119,753,329 (GRCm39) D644G probably damaging Het
Zbtb1 A T 12: 76,433,371 (GRCm39) K452N probably damaging Het
Zfhx2 C T 14: 55,300,351 (GRCm39) G2467R probably damaging Het
Zfp334 A T 2: 165,223,643 (GRCm39) Y133* probably null Het
Other mutations in Pglyrp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Pglyrp4 APN 3 90,646,335 (GRCm39) missense probably damaging 1.00
IGL00575:Pglyrp4 APN 3 90,638,098 (GRCm39) missense probably damaging 1.00
IGL01892:Pglyrp4 APN 3 90,646,348 (GRCm39) missense probably benign 0.00
IGL02159:Pglyrp4 APN 3 90,638,160 (GRCm39) missense possibly damaging 0.87
IGL02398:Pglyrp4 APN 3 90,646,424 (GRCm39) splice site probably benign
IGL02565:Pglyrp4 APN 3 90,642,794 (GRCm39) missense probably benign
IGL02619:Pglyrp4 APN 3 90,642,955 (GRCm39) splice site probably null
R1160:Pglyrp4 UTSW 3 90,636,138 (GRCm39) splice site probably null
R1420:Pglyrp4 UTSW 3 90,636,021 (GRCm39) missense probably damaging 0.96
R1828:Pglyrp4 UTSW 3 90,640,310 (GRCm39) missense probably damaging 1.00
R4974:Pglyrp4 UTSW 3 90,640,314 (GRCm39) missense probably benign 0.04
R5268:Pglyrp4 UTSW 3 90,634,271 (GRCm39) missense probably damaging 1.00
R5704:Pglyrp4 UTSW 3 90,647,581 (GRCm39) splice site probably null
R7286:Pglyrp4 UTSW 3 90,640,281 (GRCm39) missense probably damaging 1.00
R7787:Pglyrp4 UTSW 3 90,640,295 (GRCm39) missense probably damaging 1.00
R8772:Pglyrp4 UTSW 3 90,647,707 (GRCm39) missense possibly damaging 0.54
R9132:Pglyrp4 UTSW 3 90,635,238 (GRCm39) nonsense probably null
R9607:Pglyrp4 UTSW 3 90,638,151 (GRCm39) missense probably damaging 1.00
Z1176:Pglyrp4 UTSW 3 90,646,312 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16