Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02097:Or2f1b'

279631

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2f1b

Ensembl Gene

ENSMUSG00000095236

Gene Name

olfactory receptor family 2 subfamily F member 1B

Synonyms

18A, GA_x6K02T2P3E9-4797841-4796888, Olfr38, MOR257-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL02097

Quality Score

Status

Chromosome

Chromosomal Location

42756404-42763231 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 42762460 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 136 (M136K)

Ref Sequence

ENSEMBL: ENSMUSP00000149726 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074499] [ENSMUST00000215796]

AlphaFold

Q8VGP4

Predicted Effect

probably damaging
Transcript: ENSMUST00000074499
AA Change: M136K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000093654
Gene: ENSMUSG00000095236
AA Change: M136K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.8e-52	PFAM
Pfam:7tm_1	41	290	5.4e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215796
AA Change: M136K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

Meta Mutation Damage Score

0.3711

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	A	T	5: 104,961,186 (GRCm38)	V415D	possibly damaging	Het
Adcy3	C	T	12: 4,212,118 (GRCm38)	A1056V	probably damaging	Het
Adcy5	G	A	16: 35,272,098 (GRCm38)	A610T	probably damaging	Het
Arhgap21	G	A	2: 20,880,002 (GRCm38)	T788I	probably benign	Het
Asic1	T	C	15: 99,694,686 (GRCm38)		probably benign	Het
Cdhr4	T	A	9: 107,993,000 (GRCm38)	M68K	probably benign	Het
Cdhr5	G	T	7: 141,269,981 (GRCm38)	T637K	probably damaging	Het
Corin	A	T	5: 72,372,146 (GRCm38)	C289S	probably damaging	Het
Cpne4	T	C	9: 104,686,502 (GRCm38)	V26A	probably damaging	Het
Csmd1	T	C	8: 16,211,759 (GRCm38)	D908G	probably null	Het
Cyp2c29	A	G	19: 39,307,620 (GRCm38)	D126G	probably damaging	Het
Ddx42	G	A	11: 106,239,160 (GRCm38)	S426N	probably benign	Het
Dnah1	C	T	14: 31,305,001 (GRCm38)	V689M	possibly damaging	Het
Dtwd1	A	G	2: 126,164,795 (GRCm38)	T246A	probably damaging	Het
Fbn1	A	T	2: 125,363,969 (GRCm38)	M1036K	probably damaging	Het
Fbxo10	T	C	4: 45,048,527 (GRCm38)	N536S	probably benign	Het
Gnal	G	A	18: 67,217,208 (GRCm38)		probably benign	Het
Gns	A	G	10: 121,390,693 (GRCm38)	T416A	probably benign	Het
Heatr5b	G	A	17: 78,817,514 (GRCm38)	T603I	probably damaging	Het
Hsp90b1	T	A	10: 86,691,684 (GRCm38)		probably benign	Het
Krt23	C	T	11: 99,493,010 (GRCm38)	G19R	probably benign	Het
Lama2	C	T	10: 27,138,960 (GRCm38)	R1584H	probably benign	Het
Lmbr1l	C	T	15: 98,917,891 (GRCm38)	V11M	probably damaging	Het
Man1a2	T	C	3: 100,582,131 (GRCm38)	K511E	possibly damaging	Het
Mrgpra3	C	A	7: 47,589,456 (GRCm38)	V241F	possibly damaging	Het
Myh3	A	G	11: 67,082,924 (GRCm38)	D141G	probably benign	Het
Mylk2	G	A	2: 152,915,136 (GRCm38)	C277Y	probably damaging	Het
Myo3b	A	T	2: 70,238,829 (GRCm38)	T471S	probably damaging	Het
Naip1	A	G	13: 100,425,588 (GRCm38)	V1023A	probably benign	Het
Olfm5	T	A	7: 104,154,231 (GRCm38)	T342S	probably benign	Het
Or10g1	A	G	14: 52,410,054 (GRCm38)	F273L	probably benign	Het
Pglyrp4	T	C	3: 90,735,603 (GRCm38)	F263L	probably benign	Het
Plekhh2	A	T	17: 84,599,180 (GRCm38)	T1148S	possibly damaging	Het
Prrc2b	T	C	2: 32,191,501 (GRCm38)		probably benign	Het
Rbm28	G	T	6: 29,138,618 (GRCm38)	D398E	possibly damaging	Het
Rnf220	A	G	4: 117,273,327 (GRCm38)	F234L	probably benign	Het
Sele	T	C	1: 164,053,093 (GRCm38)	S415P	probably benign	Het
Shpk	T	C	11: 73,203,995 (GRCm38)	L79P	probably damaging	Het
Slc35f4	C	T	14: 49,306,246 (GRCm38)	A148T	probably damaging	Het
Slc6a20a	G	A	9: 123,660,619 (GRCm38)	P120S	possibly damaging	Het
Slc8a2	A	G	7: 16,157,156 (GRCm38)	E701G	possibly damaging	Het
Slco1a1	T	A	6: 141,940,039 (GRCm38)	I87F	possibly damaging	Het
Srebf1	T	G	11: 60,202,824 (GRCm38)	D739A	probably damaging	Het
Thg1l	A	G	11: 45,950,228 (GRCm38)	Y175H	probably benign	Het
Traf3ip2	G	A	10: 39,654,479 (GRCm38)	V540M	probably damaging	Het
Wdr48	A	G	9: 119,924,263 (GRCm38)	D644G	probably damaging	Het
Zbtb1	A	T	12: 76,386,597 (GRCm38)	K452N	probably damaging	Het
Zfhx2	C	T	14: 55,062,894 (GRCm38)	G2467R	probably damaging	Het
Zfp334	A	T	2: 165,381,723 (GRCm38)	Y133*	probably null	Het

Other mutations in Or2f1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01551:Or2f1b	APN	6	42,762,112 (GRCm38)	missense	probably damaging	0.99
IGL01567:Or2f1b	APN	6	42,762,727 (GRCm38)	missense	probably benign	0.07
IGL02186:Or2f1b	APN	6	42,762,946 (GRCm38)	missense	probably null	0.96
IGL02473:Or2f1b	APN	6	42,762,706 (GRCm38)	missense	probably damaging	1.00
R0541:Or2f1b	UTSW	6	42,762,220 (GRCm38)	missense	probably damaging	1.00
R1210:Or2f1b	UTSW	6	42,762,667 (GRCm38)	missense	possibly damaging	0.79
R1368:Or2f1b	UTSW	6	42,762,679 (GRCm38)	missense	possibly damaging	0.91
R2383:Or2f1b	UTSW	6	42,762,459 (GRCm38)	missense	probably benign	0.44
R4614:Or2f1b	UTSW	6	42,762,418 (GRCm38)	missense	probably benign	0.07
R4616:Or2f1b	UTSW	6	42,762,418 (GRCm38)	missense	probably benign	0.07
R4844:Or2f1b	UTSW	6	42,762,460 (GRCm38)	missense	probably damaging	0.98
R5121:Or2f1b	UTSW	6	42,762,997 (GRCm38)	nonsense	probably null
R5951:Or2f1b	UTSW	6	42,762,559 (GRCm38)	missense	probably damaging	1.00
R6061:Or2f1b	UTSW	6	42,762,965 (GRCm38)	missense	probably damaging	0.99
R6336:Or2f1b	UTSW	6	42,762,657 (GRCm38)	missense	probably damaging	1.00
R7414:Or2f1b	UTSW	6	42,762,828 (GRCm38)	missense	probably damaging	1.00
R8344:Or2f1b	UTSW	6	42,762,565 (GRCm38)	missense	probably benign	0.03
R9603:Or2f1b	UTSW	6	42,762,738 (GRCm38)	nonsense	probably null
X0018:Or2f1b	UTSW	6	42,762,935 (GRCm38)	missense	probably damaging	0.99
Z1177:Or2f1b	UTSW	6	42,762,207 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16