Incidental Mutation 'IGL02097:Or2f1b'
ID 279631
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2f1b
Ensembl Gene ENSMUSG00000095236
Gene Name olfactory receptor family 2 subfamily F member 1B
Synonyms 18A, GA_x6K02T2P3E9-4797841-4796888, Olfr38, MOR257-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # IGL02097
Quality Score
Chromosome 6
Chromosomal Location 42756404-42763231 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42762460 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 136 (M136K)
Ref Sequence ENSEMBL: ENSMUSP00000149726 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074499] [ENSMUST00000215796]
AlphaFold Q8VGP4
Predicted Effect probably damaging
Transcript: ENSMUST00000074499
AA Change: M136K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000093654
Gene: ENSMUSG00000095236
AA Change: M136K

Pfam:7tm_4 31 307 1.8e-52 PFAM
Pfam:7tm_1 41 290 5.4e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215796
AA Change: M136K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Meta Mutation Damage Score 0.3711 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A T 5: 104,961,186 (GRCm38) V415D possibly damaging Het
Adcy3 C T 12: 4,212,118 (GRCm38) A1056V probably damaging Het
Adcy5 G A 16: 35,272,098 (GRCm38) A610T probably damaging Het
Arhgap21 G A 2: 20,880,002 (GRCm38) T788I probably benign Het
Asic1 T C 15: 99,694,686 (GRCm38) probably benign Het
Cdhr4 T A 9: 107,993,000 (GRCm38) M68K probably benign Het
Cdhr5 G T 7: 141,269,981 (GRCm38) T637K probably damaging Het
Corin A T 5: 72,372,146 (GRCm38) C289S probably damaging Het
Cpne4 T C 9: 104,686,502 (GRCm38) V26A probably damaging Het
Csmd1 T C 8: 16,211,759 (GRCm38) D908G probably null Het
Cyp2c29 A G 19: 39,307,620 (GRCm38) D126G probably damaging Het
Ddx42 G A 11: 106,239,160 (GRCm38) S426N probably benign Het
Dnah1 C T 14: 31,305,001 (GRCm38) V689M possibly damaging Het
Dtwd1 A G 2: 126,164,795 (GRCm38) T246A probably damaging Het
Fbn1 A T 2: 125,363,969 (GRCm38) M1036K probably damaging Het
Fbxo10 T C 4: 45,048,527 (GRCm38) N536S probably benign Het
Gnal G A 18: 67,217,208 (GRCm38) probably benign Het
Gns A G 10: 121,390,693 (GRCm38) T416A probably benign Het
Heatr5b G A 17: 78,817,514 (GRCm38) T603I probably damaging Het
Hsp90b1 T A 10: 86,691,684 (GRCm38) probably benign Het
Krt23 C T 11: 99,493,010 (GRCm38) G19R probably benign Het
Lama2 C T 10: 27,138,960 (GRCm38) R1584H probably benign Het
Lmbr1l C T 15: 98,917,891 (GRCm38) V11M probably damaging Het
Man1a2 T C 3: 100,582,131 (GRCm38) K511E possibly damaging Het
Mrgpra3 C A 7: 47,589,456 (GRCm38) V241F possibly damaging Het
Myh3 A G 11: 67,082,924 (GRCm38) D141G probably benign Het
Mylk2 G A 2: 152,915,136 (GRCm38) C277Y probably damaging Het
Myo3b A T 2: 70,238,829 (GRCm38) T471S probably damaging Het
Naip1 A G 13: 100,425,588 (GRCm38) V1023A probably benign Het
Olfm5 T A 7: 104,154,231 (GRCm38) T342S probably benign Het
Or10g1 A G 14: 52,410,054 (GRCm38) F273L probably benign Het
Pglyrp4 T C 3: 90,735,603 (GRCm38) F263L probably benign Het
Plekhh2 A T 17: 84,599,180 (GRCm38) T1148S possibly damaging Het
Prrc2b T C 2: 32,191,501 (GRCm38) probably benign Het
Rbm28 G T 6: 29,138,618 (GRCm38) D398E possibly damaging Het
Rnf220 A G 4: 117,273,327 (GRCm38) F234L probably benign Het
Sele T C 1: 164,053,093 (GRCm38) S415P probably benign Het
Shpk T C 11: 73,203,995 (GRCm38) L79P probably damaging Het
Slc35f4 C T 14: 49,306,246 (GRCm38) A148T probably damaging Het
Slc6a20a G A 9: 123,660,619 (GRCm38) P120S possibly damaging Het
Slc8a2 A G 7: 16,157,156 (GRCm38) E701G possibly damaging Het
Slco1a1 T A 6: 141,940,039 (GRCm38) I87F possibly damaging Het
Srebf1 T G 11: 60,202,824 (GRCm38) D739A probably damaging Het
Thg1l A G 11: 45,950,228 (GRCm38) Y175H probably benign Het
Traf3ip2 G A 10: 39,654,479 (GRCm38) V540M probably damaging Het
Wdr48 A G 9: 119,924,263 (GRCm38) D644G probably damaging Het
Zbtb1 A T 12: 76,386,597 (GRCm38) K452N probably damaging Het
Zfhx2 C T 14: 55,062,894 (GRCm38) G2467R probably damaging Het
Zfp334 A T 2: 165,381,723 (GRCm38) Y133* probably null Het
Other mutations in Or2f1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01551:Or2f1b APN 6 42,762,112 (GRCm38) missense probably damaging 0.99
IGL01567:Or2f1b APN 6 42,762,727 (GRCm38) missense probably benign 0.07
IGL02186:Or2f1b APN 6 42,762,946 (GRCm38) missense probably null 0.96
IGL02473:Or2f1b APN 6 42,762,706 (GRCm38) missense probably damaging 1.00
R0541:Or2f1b UTSW 6 42,762,220 (GRCm38) missense probably damaging 1.00
R1210:Or2f1b UTSW 6 42,762,667 (GRCm38) missense possibly damaging 0.79
R1368:Or2f1b UTSW 6 42,762,679 (GRCm38) missense possibly damaging 0.91
R2383:Or2f1b UTSW 6 42,762,459 (GRCm38) missense probably benign 0.44
R4614:Or2f1b UTSW 6 42,762,418 (GRCm38) missense probably benign 0.07
R4616:Or2f1b UTSW 6 42,762,418 (GRCm38) missense probably benign 0.07
R4844:Or2f1b UTSW 6 42,762,460 (GRCm38) missense probably damaging 0.98
R5121:Or2f1b UTSW 6 42,762,997 (GRCm38) nonsense probably null
R5951:Or2f1b UTSW 6 42,762,559 (GRCm38) missense probably damaging 1.00
R6061:Or2f1b UTSW 6 42,762,965 (GRCm38) missense probably damaging 0.99
R6336:Or2f1b UTSW 6 42,762,657 (GRCm38) missense probably damaging 1.00
R7414:Or2f1b UTSW 6 42,762,828 (GRCm38) missense probably damaging 1.00
R8344:Or2f1b UTSW 6 42,762,565 (GRCm38) missense probably benign 0.03
R9603:Or2f1b UTSW 6 42,762,738 (GRCm38) nonsense probably null
X0018:Or2f1b UTSW 6 42,762,935 (GRCm38) missense probably damaging 0.99
Z1177:Or2f1b UTSW 6 42,762,207 (GRCm38) missense probably damaging 1.00
Posted On 2015-04-16