Incidental Mutation 'IGL00933:Zfp560'
| ID |
28181 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp560
|
| Ensembl Gene |
ENSMUSG00000045519 |
| Gene Name |
zinc finger protein 560 |
| Synonyms |
2310030G09Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00933
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
20256432-20296473 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20260104 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 253
(S253P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000065620
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068079]
[ENSMUST00000143992]
|
| AlphaFold |
Q3URI6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000068079
AA Change: S253P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000065620
Gene: ENSMUSG00000045519
AA Change: S253P
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
41 |
101 |
3.22e-27 |
SMART |
|
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
279 |
301 |
4.01e-5 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
363 |
385 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
3.74e-5 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
2.43e-4 |
SMART |
|
ZnF_C2H2
|
447 |
469 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
475 |
497 |
1.06e-4 |
SMART |
|
ZnF_C2H2
|
503 |
525 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
531 |
553 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
559 |
581 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
587 |
609 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
615 |
637 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
643 |
665 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
671 |
693 |
1.69e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143992
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214965
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arrdc3 |
T |
A |
13: 81,039,174 (GRCm39) |
|
probably benign |
Het |
| Brca2 |
A |
G |
5: 150,465,869 (GRCm39) |
S1878G |
probably benign |
Het |
| Cpa6 |
T |
C |
1: 10,407,595 (GRCm39) |
H314R |
probably benign |
Het |
| Ehbp1l1 |
A |
G |
19: 5,767,961 (GRCm39) |
I1114T |
probably benign |
Het |
| Eml3 |
G |
A |
19: 8,913,762 (GRCm39) |
W73* |
probably null |
Het |
| Fmo4 |
G |
T |
1: 162,621,592 (GRCm39) |
Q540K |
probably benign |
Het |
| Fstl4 |
G |
A |
11: 53,077,588 (GRCm39) |
G782R |
possibly damaging |
Het |
| Itga11 |
T |
C |
9: 62,676,587 (GRCm39) |
I925T |
possibly damaging |
Het |
| Itsn2 |
T |
G |
12: 4,757,540 (GRCm39) |
F1411C |
probably damaging |
Het |
| Lmna |
A |
T |
3: 88,389,856 (GRCm39) |
C590S |
possibly damaging |
Het |
| Magi3 |
A |
G |
3: 103,923,163 (GRCm39) |
Y1185H |
probably benign |
Het |
| Marf1 |
A |
G |
16: 13,935,221 (GRCm39) |
Y1516H |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,871,874 (GRCm39) |
D2306G |
probably damaging |
Het |
| Ncoa6 |
A |
G |
2: 155,257,317 (GRCm39) |
V742A |
probably damaging |
Het |
| Nol4l |
A |
G |
2: 153,319,856 (GRCm39) |
F175S |
probably damaging |
Het |
| Or9k2b |
A |
T |
10: 130,016,083 (GRCm39) |
M222K |
probably benign |
Het |
| Orm2 |
T |
C |
4: 63,282,389 (GRCm39) |
|
probably benign |
Het |
| Pik3cb |
T |
A |
9: 98,983,339 (GRCm39) |
T90S |
probably damaging |
Het |
| Plekhg2 |
G |
A |
7: 28,060,114 (GRCm39) |
P1072S |
probably benign |
Het |
| Rgr |
A |
T |
14: 36,760,875 (GRCm39) |
Y227* |
probably null |
Het |
| Snd1 |
T |
C |
6: 28,512,985 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Zfp560 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02400:Zfp560
|
APN |
9 |
20,261,896 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0002:Zfp560
|
UTSW |
9 |
20,258,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0004:Zfp560
|
UTSW |
9 |
20,259,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0019:Zfp560
|
UTSW |
9 |
20,259,656 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1401:Zfp560
|
UTSW |
9 |
20,263,149 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1481:Zfp560
|
UTSW |
9 |
20,260,086 (GRCm39) |
missense |
probably benign |
|
|
R1521:Zfp560
|
UTSW |
9 |
20,260,071 (GRCm39) |
splice site |
probably null |
|
|
R1569:Zfp560
|
UTSW |
9 |
20,260,011 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1579:Zfp560
|
UTSW |
9 |
20,259,287 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1673:Zfp560
|
UTSW |
9 |
20,258,949 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1694:Zfp560
|
UTSW |
9 |
20,259,282 (GRCm39) |
nonsense |
probably null |
|
|
R1796:Zfp560
|
UTSW |
9 |
20,263,226 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2971:Zfp560
|
UTSW |
9 |
20,260,240 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3416:Zfp560
|
UTSW |
9 |
20,258,974 (GRCm39) |
nonsense |
probably null |
|
|
R4182:Zfp560
|
UTSW |
9 |
20,258,744 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4509:Zfp560
|
UTSW |
9 |
20,260,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Zfp560
|
UTSW |
9 |
20,263,214 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4735:Zfp560
|
UTSW |
9 |
20,260,347 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4937:Zfp560
|
UTSW |
9 |
20,259,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5562:Zfp560
|
UTSW |
9 |
20,261,883 (GRCm39) |
nonsense |
probably null |
|
|
R6597:Zfp560
|
UTSW |
9 |
20,259,297 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6852:Zfp560
|
UTSW |
9 |
20,259,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Zfp560
|
UTSW |
9 |
20,259,795 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7267:Zfp560
|
UTSW |
9 |
20,259,384 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7619:Zfp560
|
UTSW |
9 |
20,260,206 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Zfp560
|
UTSW |
9 |
20,258,619 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8220:Zfp560
|
UTSW |
9 |
20,260,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8356:Zfp560
|
UTSW |
9 |
20,260,231 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8858:Zfp560
|
UTSW |
9 |
20,260,403 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8992:Zfp560
|
UTSW |
9 |
20,260,895 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Zfp560
|
UTSW |
9 |
20,259,000 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2013-04-17 |
Incidental Mutation