Incidental Mutation 'R3416:Zfp560'
ID |
266804 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp560
|
Ensembl Gene |
ENSMUSG00000045519 |
Gene Name |
zinc finger protein 560 |
Synonyms |
2310030G09Rik |
MMRRC Submission |
040634-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R3416 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
9 |
Chromosomal Location |
20256432-20296473 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
A to T
at 20258974 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Stop codon
at position 629
(Y629*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000065620
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068079]
[ENSMUST00000143992]
|
AlphaFold |
Q3URI6 |
Predicted Effect |
probably null
Transcript: ENSMUST00000068079
AA Change: Y629*
|
SMART Domains |
Protein: ENSMUSP00000065620 Gene: ENSMUSG00000045519 AA Change: Y629*
Domain | Start | End | E-Value | Type |
KRAB
|
41 |
101 |
3.22e-27 |
SMART |
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
ZnF_C2H2
|
279 |
301 |
4.01e-5 |
SMART |
ZnF_C2H2
|
307 |
329 |
9.58e-3 |
SMART |
ZnF_C2H2
|
335 |
357 |
5.5e-3 |
SMART |
ZnF_C2H2
|
363 |
385 |
9.58e-3 |
SMART |
ZnF_C2H2
|
391 |
413 |
3.74e-5 |
SMART |
ZnF_C2H2
|
419 |
441 |
2.43e-4 |
SMART |
ZnF_C2H2
|
447 |
469 |
1.28e-3 |
SMART |
ZnF_C2H2
|
475 |
497 |
1.06e-4 |
SMART |
ZnF_C2H2
|
503 |
525 |
3.11e-2 |
SMART |
ZnF_C2H2
|
531 |
553 |
8.47e-4 |
SMART |
ZnF_C2H2
|
559 |
581 |
2.99e-4 |
SMART |
ZnF_C2H2
|
587 |
609 |
4.24e-4 |
SMART |
ZnF_C2H2
|
615 |
637 |
3.44e-4 |
SMART |
ZnF_C2H2
|
643 |
665 |
1.26e-2 |
SMART |
ZnF_C2H2
|
671 |
693 |
1.69e-3 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000143992
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214965
|
Meta Mutation Damage Score |
0.9755 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.2%
- 20x: 94.7%
|
Validation Efficiency |
100% (33/33) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1500009L16Rik |
T |
C |
10: 83,595,496 (GRCm39) |
|
probably null |
Het |
Abi1 |
T |
C |
2: 22,930,014 (GRCm39) |
S22G |
probably damaging |
Het |
Adgrl2 |
T |
C |
3: 148,564,965 (GRCm39) |
Y201C |
probably damaging |
Het |
Adnp2 |
T |
C |
18: 80,171,373 (GRCm39) |
E1012G |
possibly damaging |
Het |
Azin1 |
A |
T |
15: 38,493,790 (GRCm39) |
S278T |
possibly damaging |
Het |
Crocc |
G |
A |
4: 140,773,758 (GRCm39) |
T103I |
possibly damaging |
Het |
Cyb561d2 |
A |
G |
9: 107,417,325 (GRCm39) |
L142P |
probably damaging |
Het |
Cyp4f39 |
T |
C |
17: 32,708,716 (GRCm39) |
V421A |
possibly damaging |
Het |
Fryl |
T |
C |
5: 73,265,417 (GRCm39) |
Q510R |
possibly damaging |
Het |
Gfra1 |
T |
C |
19: 58,255,544 (GRCm39) |
Y301C |
probably damaging |
Het |
Igsf9b |
G |
A |
9: 27,220,774 (GRCm39) |
V47I |
possibly damaging |
Het |
Klhl42 |
G |
A |
6: 147,009,378 (GRCm39) |
V406M |
probably damaging |
Het |
Mfsd13a |
C |
T |
19: 46,360,431 (GRCm39) |
R328C |
probably damaging |
Het |
Mycs |
C |
T |
X: 5,380,810 (GRCm39) |
S90N |
possibly damaging |
Het |
Or5p80 |
G |
A |
7: 108,229,225 (GRCm39) |
V9I |
possibly damaging |
Het |
Pcdha8 |
A |
T |
18: 37,125,683 (GRCm39) |
Q55L |
probably benign |
Het |
Pkhd1l1 |
A |
G |
15: 44,410,760 (GRCm39) |
T2756A |
probably damaging |
Het |
Prl8a8 |
A |
T |
13: 27,695,532 (GRCm39) |
C71S |
probably damaging |
Het |
Ralgapa1 |
T |
A |
12: 55,817,398 (GRCm39) |
|
probably benign |
Het |
Rtl4 |
C |
T |
X: 143,902,901 (GRCm39) |
Q108* |
probably null |
Het |
Scn4a |
A |
T |
11: 106,221,239 (GRCm39) |
S807T |
probably benign |
Het |
Sla2 |
G |
A |
2: 156,717,862 (GRCm39) |
R137C |
probably damaging |
Het |
Smg1 |
G |
C |
7: 117,748,076 (GRCm39) |
|
probably benign |
Het |
Spata1 |
A |
T |
3: 146,193,263 (GRCm39) |
|
probably benign |
Het |
Strbp |
C |
G |
2: 37,480,737 (GRCm39) |
R610T |
possibly damaging |
Het |
Susd5 |
A |
G |
9: 113,924,726 (GRCm39) |
D203G |
possibly damaging |
Het |
Tas2r124 |
A |
T |
6: 132,732,601 (GRCm39) |
R303S |
probably benign |
Het |
Tgm3 |
G |
A |
2: 129,889,692 (GRCm39) |
V629M |
possibly damaging |
Het |
Tha1 |
T |
C |
11: 117,764,026 (GRCm39) |
D67G |
possibly damaging |
Het |
Vmn2r120 |
T |
A |
17: 57,816,241 (GRCm39) |
I705F |
possibly damaging |
Het |
Vrk3 |
C |
T |
7: 44,424,866 (GRCm39) |
T427M |
probably benign |
Het |
Zan |
T |
A |
5: 137,433,982 (GRCm39) |
E2250D |
unknown |
Het |
Zftraf1 |
A |
T |
15: 76,542,915 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Zfp560 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00933:Zfp560
|
APN |
9 |
20,260,104 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02400:Zfp560
|
APN |
9 |
20,261,896 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0002:Zfp560
|
UTSW |
9 |
20,258,813 (GRCm39) |
missense |
probably damaging |
1.00 |
R0004:Zfp560
|
UTSW |
9 |
20,259,263 (GRCm39) |
missense |
probably damaging |
1.00 |
R0019:Zfp560
|
UTSW |
9 |
20,259,656 (GRCm39) |
missense |
probably benign |
0.23 |
R1401:Zfp560
|
UTSW |
9 |
20,263,149 (GRCm39) |
missense |
possibly damaging |
0.71 |
R1481:Zfp560
|
UTSW |
9 |
20,260,086 (GRCm39) |
missense |
probably benign |
|
R1521:Zfp560
|
UTSW |
9 |
20,260,071 (GRCm39) |
splice site |
probably null |
|
R1569:Zfp560
|
UTSW |
9 |
20,260,011 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1579:Zfp560
|
UTSW |
9 |
20,259,287 (GRCm39) |
missense |
possibly damaging |
0.73 |
R1673:Zfp560
|
UTSW |
9 |
20,258,949 (GRCm39) |
missense |
probably benign |
0.37 |
R1694:Zfp560
|
UTSW |
9 |
20,259,282 (GRCm39) |
nonsense |
probably null |
|
R1796:Zfp560
|
UTSW |
9 |
20,263,226 (GRCm39) |
missense |
possibly damaging |
0.71 |
R2971:Zfp560
|
UTSW |
9 |
20,260,240 (GRCm39) |
missense |
probably benign |
0.00 |
R4182:Zfp560
|
UTSW |
9 |
20,258,744 (GRCm39) |
missense |
probably benign |
0.11 |
R4509:Zfp560
|
UTSW |
9 |
20,260,019 (GRCm39) |
missense |
probably damaging |
1.00 |
R4708:Zfp560
|
UTSW |
9 |
20,263,214 (GRCm39) |
missense |
possibly damaging |
0.85 |
R4735:Zfp560
|
UTSW |
9 |
20,260,347 (GRCm39) |
missense |
probably benign |
0.01 |
R4937:Zfp560
|
UTSW |
9 |
20,259,263 (GRCm39) |
missense |
probably damaging |
1.00 |
R5562:Zfp560
|
UTSW |
9 |
20,261,883 (GRCm39) |
nonsense |
probably null |
|
R6597:Zfp560
|
UTSW |
9 |
20,259,297 (GRCm39) |
missense |
probably benign |
0.00 |
R6852:Zfp560
|
UTSW |
9 |
20,259,339 (GRCm39) |
missense |
probably damaging |
0.99 |
R6863:Zfp560
|
UTSW |
9 |
20,259,795 (GRCm39) |
missense |
probably damaging |
0.99 |
R7267:Zfp560
|
UTSW |
9 |
20,259,384 (GRCm39) |
missense |
probably damaging |
0.96 |
R7619:Zfp560
|
UTSW |
9 |
20,260,206 (GRCm39) |
missense |
probably benign |
0.01 |
R7763:Zfp560
|
UTSW |
9 |
20,258,619 (GRCm39) |
missense |
possibly damaging |
0.96 |
R8220:Zfp560
|
UTSW |
9 |
20,260,348 (GRCm39) |
missense |
probably benign |
0.00 |
R8356:Zfp560
|
UTSW |
9 |
20,260,231 (GRCm39) |
missense |
probably benign |
0.25 |
R8858:Zfp560
|
UTSW |
9 |
20,260,403 (GRCm39) |
missense |
probably benign |
0.12 |
R8992:Zfp560
|
UTSW |
9 |
20,260,895 (GRCm39) |
missense |
probably benign |
|
Z1176:Zfp560
|
UTSW |
9 |
20,259,000 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- AACGACTGAAGGCTATTCCATC -3'
(R):5'- GGGAAGGCATTCACATGTTCTTC -3'
Sequencing Primer
(F):5'- GGCTATTCCATCACTTTTACAAGTG -3'
(R):5'- GAAAGCATTCACTGTGCGCTC -3'
|
Posted On |
2015-02-18 |