Incidental Mutation 'IGL02244:Fndc3a'
ID 286126
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fndc3a
Ensembl Gene ENSMUSG00000033487
Gene Name fibronectin type III domain containing 3A
Synonyms sys, F730017H24Rik, Fndc3, D14Ertd453e, 1700094E19Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.509) question?
Stock # IGL02244
Quality Score
Status
Chromosome 14
Chromosomal Location 72775386-72947443 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 72793807 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000089017]
AlphaFold Q8BX90
Predicted Effect probably benign
Transcript: ENSMUST00000089017
SMART Domains Protein: ENSMUSP00000086411
Gene: ENSMUSG00000033487

DomainStartEndE-ValueType
low complexity region 120 136 N/A INTRINSIC
low complexity region 202 216 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
FN3 266 358 3.05e-6 SMART
FN3 371 452 3.42e-9 SMART
FN3 467 549 1.84e-9 SMART
FN3 564 647 1.06e-5 SMART
FN3 662 744 2.19e-7 SMART
FN3 759 838 5.48e-8 SMART
FN3 864 937 2.28e-5 SMART
FN3 951 1032 3.22e-5 SMART
FN3 1047 1127 5.63e0 SMART
transmembrane domain 1175 1197 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162825
SMART Domains Protein: ENSMUSP00000124218
Gene: ENSMUSG00000033487

DomainStartEndE-ValueType
low complexity region 76 92 N/A INTRINSIC
low complexity region 158 172 N/A INTRINSIC
low complexity region 184 200 N/A INTRINSIC
FN3 222 314 3.05e-6 SMART
FN3 327 408 3.42e-9 SMART
FN3 423 505 1.84e-9 SMART
FN3 520 603 1.06e-5 SMART
FN3 618 700 2.19e-7 SMART
FN3 715 794 5.48e-8 SMART
FN3 820 893 2.28e-5 SMART
FN3 907 988 3.22e-5 SMART
FN3 1003 1083 5.63e0 SMART
transmembrane domain 1131 1153 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Males homozygous for an insertional mutation are sterile; females are fertile. In mutant males, spermatids form multinucleated syncytia and fail to mature, while Sertoli cells exhibit abnormal cytoplasmic vacuoles. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik G T 16: 90,853,085 (GRCm39) T17K probably benign Het
Agbl1 T C 7: 76,416,120 (GRCm39) S714P probably damaging Het
Araf A G X: 20,719,835 (GRCm39) probably benign Het
Armc3 G A 2: 19,290,948 (GRCm39) probably null Het
Armc8 A T 9: 99,365,227 (GRCm39) D638E probably benign Het
Bpifb5 C T 2: 154,067,068 (GRCm39) T107I possibly damaging Het
Ces1e A C 8: 93,938,977 (GRCm39) probably null Het
Col4a3 C A 1: 82,647,492 (GRCm39) probably benign Het
Col4a5 A G X: 140,382,669 (GRCm39) probably benign Het
Crocc T C 4: 140,765,231 (GRCm39) H477R probably benign Het
Dgkd C A 1: 87,842,863 (GRCm39) N130K probably benign Het
Dock1 C T 7: 134,379,174 (GRCm39) Q634* probably null Het
Dzip3 C T 16: 48,801,351 (GRCm39) V58I probably benign Het
Glp2r C T 11: 67,612,817 (GRCm39) R379H probably damaging Het
Kctd12b T A X: 152,472,330 (GRCm39) M120L probably benign Het
Krt33b A G 11: 99,916,189 (GRCm39) V258A probably benign Het
Lpin1 T A 12: 16,591,770 (GRCm39) N819I probably damaging Het
Lurap1l T C 4: 80,871,866 (GRCm39) S120P probably damaging Het
Lysmd4 T C 7: 66,875,672 (GRCm39) S112P probably damaging Het
Myo1e A G 9: 70,274,971 (GRCm39) K708R probably benign Het
Nr3c1 T A 18: 39,554,610 (GRCm39) probably benign Het
Nup62cl G T X: 138,922,780 (GRCm39) N239K probably benign Het
Nwd1 A T 8: 73,434,210 (GRCm39) E1269V probably damaging Het
Or52e7 C T 7: 104,685,152 (GRCm39) T249M probably damaging Het
Pcdh9 A C 14: 93,564,204 (GRCm39) L1084R probably damaging Het
Plxnd1 A G 6: 115,955,218 (GRCm39) M543T probably benign Het
Prss53 T A 7: 127,487,964 (GRCm39) T173S possibly damaging Het
Reep2 C A 18: 34,973,807 (GRCm39) probably benign Het
Rp1 T C 1: 4,419,003 (GRCm39) D703G probably benign Het
Sbf2 T G 7: 110,159,502 (GRCm39) D36A probably damaging Het
Sh3kbp1 C T X: 158,586,724 (GRCm39) R99W probably damaging Het
Sis T A 3: 72,863,523 (GRCm39) R238S probably benign Het
Slc35e2 T A 4: 155,703,019 (GRCm39) V344D probably damaging Het
Specc1 G A 11: 62,019,194 (GRCm39) V678I probably benign Het
Supt6 T C 11: 78,123,623 (GRCm39) D49G possibly damaging Het
Tecpr1 G A 5: 144,146,821 (GRCm39) A515V probably benign Het
Tlr4 G A 4: 66,752,298 (GRCm39) probably null Het
Tmco5b A G 2: 113,118,619 (GRCm39) E114G probably damaging Het
Tspear A T 10: 77,688,690 (GRCm39) probably benign Het
Txlnb T A 10: 17,719,116 (GRCm39) V649E probably benign Het
Utp20 A G 10: 88,651,818 (GRCm39) probably benign Het
Virma G A 4: 11,546,031 (GRCm39) R1673Q probably damaging Het
Vmn2r70 T A 7: 85,214,211 (GRCm39) T314S probably benign Het
Zfp938 G T 10: 82,061,906 (GRCm39) T238K possibly damaging Het
Other mutations in Fndc3a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00563:Fndc3a APN 14 72,796,797 (GRCm39) splice site probably benign
IGL01120:Fndc3a APN 14 72,794,102 (GRCm39) missense probably benign 0.05
IGL01577:Fndc3a APN 14 72,827,298 (GRCm39) missense probably damaging 0.99
IGL01810:Fndc3a APN 14 72,803,581 (GRCm39) missense probably benign 0.01
IGL01965:Fndc3a APN 14 72,777,842 (GRCm39) missense probably benign 0.09
IGL01992:Fndc3a APN 14 72,811,996 (GRCm39) missense probably benign 0.25
IGL02639:Fndc3a APN 14 72,811,797 (GRCm39) missense probably benign 0.08
IGL03076:Fndc3a APN 14 72,793,908 (GRCm39) missense possibly damaging 0.82
IGL03096:Fndc3a APN 14 72,836,559 (GRCm39) missense probably damaging 1.00
PIT4677001:Fndc3a UTSW 14 72,812,035 (GRCm39) missense probably benign 0.02
R0112:Fndc3a UTSW 14 72,777,935 (GRCm39) splice site probably benign
R0379:Fndc3a UTSW 14 72,794,049 (GRCm39) missense probably damaging 1.00
R0381:Fndc3a UTSW 14 72,794,067 (GRCm39) missense probably benign 0.05
R0544:Fndc3a UTSW 14 72,795,062 (GRCm39) splice site probably benign
R1079:Fndc3a UTSW 14 72,827,247 (GRCm39) missense possibly damaging 0.81
R1299:Fndc3a UTSW 14 72,803,638 (GRCm39) splice site probably benign
R1424:Fndc3a UTSW 14 72,811,811 (GRCm39) missense probably damaging 1.00
R1453:Fndc3a UTSW 14 72,777,768 (GRCm39) nonsense probably null
R1478:Fndc3a UTSW 14 72,795,072 (GRCm39) critical splice donor site probably null
R1573:Fndc3a UTSW 14 72,806,384 (GRCm39) missense probably damaging 0.98
R1574:Fndc3a UTSW 14 72,793,997 (GRCm39) missense probably damaging 1.00
R1574:Fndc3a UTSW 14 72,793,997 (GRCm39) missense probably damaging 1.00
R1743:Fndc3a UTSW 14 72,889,521 (GRCm39) missense probably damaging 1.00
R1852:Fndc3a UTSW 14 72,794,283 (GRCm39) missense probably damaging 0.96
R2097:Fndc3a UTSW 14 72,811,791 (GRCm39) critical splice donor site probably null
R2396:Fndc3a UTSW 14 72,921,123 (GRCm39) missense possibly damaging 0.92
R2512:Fndc3a UTSW 14 72,793,715 (GRCm39) missense probably benign 0.00
R3722:Fndc3a UTSW 14 72,777,648 (GRCm39) missense probably benign 0.39
R5470:Fndc3a UTSW 14 72,812,008 (GRCm39) missense possibly damaging 0.83
R5757:Fndc3a UTSW 14 72,794,025 (GRCm39) missense probably benign
R5931:Fndc3a UTSW 14 72,806,307 (GRCm39) missense probably benign
R6188:Fndc3a UTSW 14 72,827,401 (GRCm39) missense probably damaging 0.99
R6297:Fndc3a UTSW 14 72,800,980 (GRCm39) missense probably damaging 0.98
R6638:Fndc3a UTSW 14 72,796,688 (GRCm39) nonsense probably null
R7221:Fndc3a UTSW 14 72,793,597 (GRCm39) missense probably benign
R7571:Fndc3a UTSW 14 72,827,336 (GRCm39) missense probably damaging 0.99
R7677:Fndc3a UTSW 14 72,804,854 (GRCm39) missense probably benign
R7744:Fndc3a UTSW 14 72,799,156 (GRCm39) missense possibly damaging 0.95
R7849:Fndc3a UTSW 14 72,802,100 (GRCm39) missense probably benign 0.01
R8027:Fndc3a UTSW 14 72,790,983 (GRCm39) missense probably benign 0.04
R8152:Fndc3a UTSW 14 72,811,820 (GRCm39) missense probably damaging 1.00
R8225:Fndc3a UTSW 14 72,795,117 (GRCm39) missense probably benign 0.00
R8295:Fndc3a UTSW 14 72,789,959 (GRCm39) missense probably benign 0.03
R8799:Fndc3a UTSW 14 72,793,955 (GRCm39) missense probably benign 0.00
R8955:Fndc3a UTSW 14 72,794,410 (GRCm39) missense probably benign
R9019:Fndc3a UTSW 14 72,811,840 (GRCm39) missense probably benign 0.01
R9120:Fndc3a UTSW 14 72,802,133 (GRCm39) missense probably benign
R9155:Fndc3a UTSW 14 72,921,162 (GRCm39) missense possibly damaging 0.50
R9281:Fndc3a UTSW 14 72,799,097 (GRCm39) missense probably benign 0.00
R9512:Fndc3a UTSW 14 72,827,424 (GRCm39) missense probably damaging 1.00
R9742:Fndc3a UTSW 14 72,777,693 (GRCm39) nonsense probably null
R9744:Fndc3a UTSW 14 72,777,693 (GRCm39) nonsense probably null
Z1176:Fndc3a UTSW 14 72,804,813 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16