Incidental Mutation 'IGL00896:Prrxl1'
ID28919
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prrxl1
Ensembl Gene ENSMUSG00000041730
Gene Namepaired related homeobox protein-like 1
SynonymsDrg11
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.490) question?
Stock #IGL00896
Quality Score
Status
Chromosome14
Chromosomal Location32599407-32649246 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) C to T at 32605214 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154801 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068938] [ENSMUST00000186452] [ENSMUST00000187377] [ENSMUST00000189022] [ENSMUST00000228878]
Predicted Effect probably benign
Transcript: ENSMUST00000068938
SMART Domains Protein: ENSMUSP00000064107
Gene: ENSMUSG00000041730

DomainStartEndE-ValueType
HOX 33 95 9.62e-29 SMART
low complexity region 111 122 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186452
SMART Domains Protein: ENSMUSP00000139756
Gene: ENSMUSG00000041730

DomainStartEndE-ValueType
HOX 33 95 9.62e-29 SMART
low complexity region 111 122 N/A INTRINSIC
Pfam:OAR 199 219 4.4e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000187377
SMART Domains Protein: ENSMUSP00000140687
Gene: ENSMUSG00000041730

DomainStartEndE-ValueType
HOX 33 95 9.62e-29 SMART
low complexity region 111 122 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000189022
SMART Domains Protein: ENSMUSP00000140337
Gene: ENSMUSG00000041730

DomainStartEndE-ValueType
HOX 33 95 9.62e-29 SMART
low complexity region 111 122 N/A INTRINSIC
Pfam:OAR 199 219 4.4e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000228878
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice had delayed projection of sensory afferent neurons in the dorsal, but not the ventral, spinal cord during embryonic development. This delayed development resulted in abnormal responses to noxious stimuli in adults, but normal locomotion and sensory motor function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 37,039,462 T4352A probably benign Het
Adam6a A G 12: 113,545,410 T468A possibly damaging Het
Ankrd35 A G 3: 96,684,276 E626G probably damaging Het
Arhgef4 A G 1: 34,811,696 Y1812C possibly damaging Het
Aurkc T C 7: 7,002,514 Y260H possibly damaging Het
Cpb1 A G 3: 20,252,029 V329A probably benign Het
Cyp2d11 G T 15: 82,391,074 probably benign Het
Dnase1 G A 16: 4,039,212 S28N probably benign Het
Evpl C A 11: 116,222,584 E1427* probably null Het
Gimap6 T C 6: 48,702,460 N214S probably benign Het
Htr1f A T 16: 64,926,106 H274Q probably benign Het
Ipo9 A T 1: 135,400,059 V538E probably damaging Het
Lmf2 T C 15: 89,353,336 K308E probably benign Het
Mog T A 17: 37,017,485 probably null Het
Myo19 T C 11: 84,909,498 V903A probably benign Het
Myt1l A G 12: 29,826,886 T179A unknown Het
Nckap1 C T 2: 80,580,953 V5M possibly damaging Het
Olfr382 T C 11: 73,516,341 N286S probably damaging Het
Olfr459 A T 6: 41,772,113 L62Q probably damaging Het
Olfr630 T C 7: 103,755,006 D193G probably damaging Het
Pcdhb5 T G 18: 37,322,785 probably null Het
Pcm1 C A 8: 41,276,123 Q711K possibly damaging Het
Pde6a A G 18: 61,220,792 D63G possibly damaging Het
Piezo1 T C 8: 122,497,870 M711V possibly damaging Het
Rev1 G A 1: 38,098,940 T88I probably damaging Het
Sntg1 A T 1: 8,595,410 probably null Het
Sult2a1 T A 7: 13,832,640 T137S probably benign Het
Txndc15 G A 13: 55,725,675 A283T probably damaging Het
Zswim8 A G 14: 20,716,001 E785G probably damaging Het
Other mutations in Prrxl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01868:Prrxl1 APN 14 32608377 missense probably damaging 0.99
R0436:Prrxl1 UTSW 14 32608083 missense probably damaging 1.00
R1395:Prrxl1 UTSW 14 32608369 missense probably benign 0.05
R1574:Prrxl1 UTSW 14 32605324 splice site probably benign
R2093:Prrxl1 UTSW 14 32647155 intron probably benign
R3700:Prrxl1 UTSW 14 32628861 missense probably damaging 1.00
R4922:Prrxl1 UTSW 14 32608406 missense probably damaging 1.00
R4944:Prrxl1 UTSW 14 32608249 missense probably damaging 1.00
R4962:Prrxl1 UTSW 14 32647144 intron probably benign
R5512:Prrxl1 UTSW 14 32600044 missense probably damaging 0.99
R5989:Prrxl1 UTSW 14 32608188 missense probably benign 0.01
R7423:Prrxl1 UTSW 14 32628821 missense probably damaging 1.00
R7790:Prrxl1 UTSW 14 32628888 missense probably damaging 1.00
Posted On2013-04-17