Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02373:Myg1'

291000

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myg1

Ensembl Gene

ENSMUSG00000001285

Gene Name

melanocyte proliferating gene 1

Synonyms

Gamm1

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.255) question?

Stock #

IGL02373

Quality Score

Status

Chromosome

Chromosomal Location

102240144-102246574 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 102245268 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 158 (M158K)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000001331] [ENSMUST00000041208] [ENSMUST00000113682] [ENSMUST00000166658] [ENSMUST00000230481] [ENSMUST00000229900] [ENSMUST00000228959] [ENSMUST00000231061]

AlphaFold

Q9JK81

Predicted Effect

probably benign
Transcript: ENSMUST00000001331

SMART Domains

Protein: ENSMUSP00000001331
Gene: ENSMUSG00000001285

Domain	Start	End	E-Value	Type
Pfam:UPF0160	41	161	4.8e-54	PFAM
Pfam:UPF0160	158	312	1.3e-59	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000041208

SMART Domains

Protein: ENSMUSP00000044604
Gene: ENSMUSG00000036678

Domain	Start	End	E-Value	Type
WD40	136	179	3.7e0	SMART
WD40	181	221	4.75e1	SMART
WD40	232	273	1.17e-5	SMART
WD40	278	315	2.66e0	SMART
Blast:WD40	319	357	2e-15	BLAST
low complexity region	534	545	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000113682
AA Change: M163K

PolyPhen 2 Score 0.806 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000109312
Gene: ENSMUSG00000001285
AA Change: M163K

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:UPF0160	45	365	1.5e-143	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000164019

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000164961

Predicted Effect

probably benign
Transcript: ENSMUST00000166658

SMART Domains

Protein: ENSMUSP00000129178
Gene: ENSMUSG00000001289

Domain	Start	End	E-Value	Type
Pfam:Prefoldin	22	143	8.6e-32	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000168547

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000171733

Predicted Effect

probably damaging
Transcript: ENSMUST00000171244
AA Change: M158K

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000129494
Gene: ENSMUSG00000001285
AA Change: M158K

Domain	Start	End	E-Value	Type
Pfam:UPF0160	41	209	1.7e-76	PFAM
Pfam:UPF0160	204	306	3.3e-43	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170713

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170078

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170281

Predicted Effect

probably benign
Transcript: ENSMUST00000230481

Predicted Effect

probably benign
Transcript: ENSMUST00000229900

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230812

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229315

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229589

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230710

Predicted Effect

probably benign
Transcript: ENSMUST00000230406

Predicted Effect

probably benign
Transcript: ENSMUST00000230239

Predicted Effect

probably benign
Transcript: ENSMUST00000228959

Predicted Effect

probably benign
Transcript: ENSMUST00000231061

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231099

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null mutation display no gross abnormalities but altered sex-dependent anxiety-like behaviors in different tests. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl1	C	T	4: 86,168,042 (GRCm39)	L462F	probably damaging	Het
Adgrv1	T	C	13: 81,607,832 (GRCm39)	D4080G	possibly damaging	Het
Apc	A	C	18: 34,449,212 (GRCm39)	D2002A	probably damaging	Het
Apobr	T	A	7: 126,184,563 (GRCm39)	F25I	probably damaging	Het
Cyp4a10	T	A	4: 115,378,274 (GRCm39)	L120*	probably null	Het
Daam2	A	G	17: 49,780,408 (GRCm39)	S704P	probably damaging	Het
Dcst1	G	T	3: 89,265,198 (GRCm39)	N217K	probably damaging	Het
Efr3b	C	T	12: 4,033,391 (GRCm39)	V139I	probably benign	Het
Fmn1	C	A	2: 113,194,471 (GRCm39)	P57Q	unknown	Het
Galnt1	G	A	18: 24,413,092 (GRCm39)	G464D	possibly damaging	Het
Ggcx	T	A	6: 72,404,902 (GRCm39)	W437R	probably damaging	Het
Igkv13-54-1	T	C	6: 69,594,304 (GRCm39)		noncoding transcript	Het
Iglon5	T	C	7: 43,128,643 (GRCm39)	E58G	probably benign	Het
Met	C	T	6: 17,491,528 (GRCm39)	P97S	probably damaging	Het
Msantd5f6	T	C	4: 73,321,880 (GRCm39)	M52V	probably benign	Het
Ncald	T	A	15: 37,372,453 (GRCm39)	M131L	probably benign	Het
Nipa2	T	C	7: 55,582,876 (GRCm39)	I290V	probably benign	Het
Or4f14b	C	A	2: 111,775,178 (GRCm39)	V208L	probably benign	Het
Or5p79	A	T	7: 108,221,310 (GRCm39)	Y97F	probably benign	Het
Or6c219	A	G	10: 129,781,334 (GRCm39)	L84S	probably benign	Het
Ppfia3	C	T	7: 45,008,273 (GRCm39)	R48Q	probably damaging	Het
Rab12	A	G	17: 66,805,060 (GRCm39)	L156P	probably damaging	Het
Slc28a3	C	T	13: 58,726,218 (GRCm39)		probably null	Het
Slc4a11	T	C	2: 130,526,818 (GRCm39)	N770S	probably benign	Het
Tanc1	T	C	2: 59,626,372 (GRCm39)		probably null	Het
Vmn2r130	A	T	17: 23,295,866 (GRCm39)	R679*	probably null	Het
Vwa5b2	G	A	16: 20,423,594 (GRCm39)	R1169H	probably damaging	Het

Other mutations in Myg1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01369:Myg1	APN	15	102,242,773 (GRCm39)	missense	probably benign	0.00
IGL02188:Myg1	APN	15	102,245,876 (GRCm39)	missense	probably benign	0.08
IGL02885:Myg1	APN	15	102,240,594 (GRCm39)	missense	probably damaging	1.00
IGL03066:Myg1	APN	15	102,242,801 (GRCm39)	unclassified	probably benign
R0583:Myg1	UTSW	15	102,246,225 (GRCm39)	nonsense	probably null
R0631:Myg1	UTSW	15	102,240,284 (GRCm39)	missense	probably benign	0.00
R0835:Myg1	UTSW	15	102,240,537 (GRCm39)	missense	probably damaging	1.00
R1016:Myg1	UTSW	15	102,242,786 (GRCm39)	missense	possibly damaging	0.50
R1466:Myg1	UTSW	15	102,245,825 (GRCm39)	missense	probably damaging	1.00
R1466:Myg1	UTSW	15	102,245,825 (GRCm39)	missense	probably damaging	1.00
R1757:Myg1	UTSW	15	102,240,264 (GRCm39)	missense	probably benign
R2400:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R2428:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R2429:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R2431:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R2997:Myg1	UTSW	15	102,245,945 (GRCm39)	missense	probably null	1.00
R3683:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R3826:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R3827:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R3829:Myg1	UTSW	15	102,246,171 (GRCm39)	missense	probably damaging	1.00
R4923:Myg1	UTSW	15	102,240,288 (GRCm39)	missense	probably benign
R5363:Myg1	UTSW	15	102,246,259 (GRCm39)	missense	probably benign	0.00
R5419:Myg1	UTSW	15	102,245,397 (GRCm39)	missense	probably damaging	0.99
R9389:Myg1	UTSW	15	102,245,372 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16