Incidental Mutation 'IGL02419:Or10v1'
ID 292562
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10v1
Ensembl Gene ENSMUSG00000060878
Gene Name olfactory receptor family 10 subfamily V member 1
Synonyms Olfr1420, GA_x6K02T2RE5P-2247227-2248156, MOR266-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # IGL02419
Quality Score
Chromosome 19
Chromosomal Location 11873387-11874316 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 11874186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 267 (Y267F)
Ref Sequence ENSEMBL: ENSMUSP00000149208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072784] [ENSMUST00000217281]
AlphaFold Q8VF55
Predicted Effect probably benign
Transcript: ENSMUST00000072784
AA Change: Y267F

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000072563
Gene: ENSMUSG00000060878
AA Change: Y267F

Pfam:7tm_4 31 308 5.3e-54 PFAM
Pfam:7tm_1 41 291 3.4e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215766
Predicted Effect probably benign
Transcript: ENSMUST00000217281
AA Change: Y267F

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik T C 8: 88,312,727 (GRCm39) F171L possibly damaging Het
Abca2 A G 2: 25,336,849 (GRCm39) N2291D probably benign Het
Adamts9 A G 6: 92,773,978 (GRCm39) V1145A probably benign Het
Adcy2 A G 13: 69,130,482 (GRCm39) V135A probably benign Het
Akr1c14 A T 13: 4,130,617 (GRCm39) probably null Het
Aptx G T 4: 40,691,032 (GRCm39) A229E probably benign Het
Ash1l T C 3: 88,892,872 (GRCm39) S1584P probably benign Het
Catsper3 A T 13: 55,955,881 (GRCm39) T329S possibly damaging Het
Cntrl A G 2: 35,024,055 (GRCm39) D27G probably damaging Het
Cobll1 A T 2: 64,981,392 (GRCm39) I98K probably damaging Het
Ctdp1 T C 18: 80,463,799 (GRCm39) K79R probably damaging Het
Cwf19l2 T C 9: 3,418,777 (GRCm39) probably null Het
Cyp11b2 A T 15: 74,722,904 (GRCm39) F498Y probably damaging Het
Dnpep A G 1: 75,292,332 (GRCm39) I162T probably damaging Het
Efcab9 T C 11: 32,472,950 (GRCm39) I166V probably benign Het
Ep400 A T 5: 110,845,242 (GRCm39) probably null Het
Gata6 G A 18: 11,054,220 (GRCm39) G50R probably damaging Het
Gm9631 G A 11: 121,834,478 (GRCm39) Het
Grifin T C 5: 140,550,455 (GRCm39) T20A probably benign Het
Hnf4a A T 2: 163,408,202 (GRCm39) I352F probably damaging Het
Ifi204 T C 1: 173,576,946 (GRCm39) T552A possibly damaging Het
Ifi205 C T 1: 173,845,180 (GRCm39) A201T probably damaging Het
Kcnk6 A G 7: 28,924,627 (GRCm39) V259A probably benign Het
Kif21b A G 1: 136,079,005 (GRCm39) N451S probably benign Het
Klhl24 T A 16: 19,926,118 (GRCm39) Y215* probably null Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Mical1 A G 10: 41,358,273 (GRCm39) K429E possibly damaging Het
Misp A G 10: 79,663,705 (GRCm39) probably benign Het
Mon2 T C 10: 122,852,352 (GRCm39) N1007S probably benign Het
Or14a260 C A 7: 85,984,870 (GRCm39) V245F probably damaging Het
Or51v8 A T 7: 103,319,682 (GRCm39) C185* probably null Het
Or8k41 T A 2: 86,313,259 (GRCm39) I276F probably damaging Het
Pex6 C A 17: 47,035,361 (GRCm39) T840N possibly damaging Het
Prox1 C T 1: 189,893,327 (GRCm39) A373T probably benign Het
Rapgef3 G T 15: 97,648,171 (GRCm39) N679K probably benign Het
Serpina3n T C 12: 104,379,777 (GRCm39) V390A possibly damaging Het
Sirpb1a A G 3: 15,491,398 (GRCm39) F23S probably benign Het
Slc44a3 T C 3: 121,283,906 (GRCm39) T449A probably benign Het
Smad6 G A 9: 63,860,800 (GRCm39) probably benign Het
Sos2 C T 12: 69,663,764 (GRCm39) M573I probably benign Het
St8sia1 A T 6: 142,774,661 (GRCm39) I306N probably damaging Het
Tnks1bp1 T C 2: 84,902,125 (GRCm39) S1674P possibly damaging Het
Trim47 G A 11: 115,997,027 (GRCm39) R576W probably damaging Het
Wdr86 A T 5: 24,927,702 (GRCm39) I79N probably damaging Het
Wwp2 T A 8: 108,276,447 (GRCm39) V473D probably damaging Het
Zc3h12a T C 4: 125,013,581 (GRCm39) T428A probably benign Het
Zfp592 A G 7: 80,687,993 (GRCm39) E973G probably damaging Het
Other mutations in Or10v1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02703:Or10v1 APN 19 11,873,606 (GRCm39) missense possibly damaging 0.96
IGL02948:Or10v1 APN 19 11,874,145 (GRCm39) nonsense probably null
R1514:Or10v1 UTSW 19 11,873,978 (GRCm39) missense probably benign
R1539:Or10v1 UTSW 19 11,873,855 (GRCm39) missense possibly damaging 0.88
R1852:Or10v1 UTSW 19 11,874,249 (GRCm39) missense probably damaging 1.00
R1903:Or10v1 UTSW 19 11,873,913 (GRCm39) missense probably benign 0.24
R2061:Or10v1 UTSW 19 11,873,921 (GRCm39) missense probably damaging 0.98
R3768:Or10v1 UTSW 19 11,873,676 (GRCm39) missense probably damaging 0.99
R3977:Or10v1 UTSW 19 11,873,880 (GRCm39) missense probably damaging 1.00
R4479:Or10v1 UTSW 19 11,873,922 (GRCm39) missense probably damaging 0.99
R4592:Or10v1 UTSW 19 11,874,126 (GRCm39) missense probably benign
R5934:Or10v1 UTSW 19 11,874,293 (GRCm39) missense probably benign
R6058:Or10v1 UTSW 19 11,873,388 (GRCm39) start codon destroyed probably null 1.00
R6536:Or10v1 UTSW 19 11,873,760 (GRCm39) missense probably benign 0.05
R7752:Or10v1 UTSW 19 11,873,898 (GRCm39) missense probably benign 0.01
R7901:Or10v1 UTSW 19 11,873,898 (GRCm39) missense probably benign 0.01
R8250:Or10v1 UTSW 19 11,873,741 (GRCm39) missense probably damaging 1.00
R9434:Or10v1 UTSW 19 11,873,393 (GRCm39) missense probably benign
Posted On 2015-04-16