Incidental Mutation 'IGL00917:Zfp944'
| ID |
29266 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp944
|
| Ensembl Gene |
ENSMUSG00000033972 |
| Gene Name |
zinc finger protein 944 |
| Synonyms |
6330416L07Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.223)
|
| Stock # |
IGL00917
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
22556970-22580381 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 22558765 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 161
(L161F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111197
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000115535]
|
| AlphaFold |
E9PUS4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115535
AA Change: L161F
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000111197
Gene: ENSMUSG00000033972
AA Change: L161F
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
76 |
2.08e-21 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.01e-1 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
1.07e0 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
5.99e-4 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
1.36e-2 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc5 |
A |
T |
16: 20,241,107 (GRCm39) |
V26E |
probably benign |
Het |
| Adcy4 |
T |
A |
14: 56,011,120 (GRCm39) |
|
probably null |
Het |
| Adgrl3 |
C |
T |
5: 81,841,421 (GRCm39) |
T766I |
possibly damaging |
Het |
| Atad2b |
A |
T |
12: 5,015,837 (GRCm39) |
|
probably benign |
Het |
| Atp8b4 |
A |
T |
2: 126,216,453 (GRCm39) |
S664R |
probably benign |
Het |
| Cand1 |
A |
C |
10: 119,046,841 (GRCm39) |
I883S |
possibly damaging |
Het |
| Cfap53 |
A |
G |
18: 74,432,367 (GRCm39) |
D85G |
probably benign |
Het |
| Chd4 |
G |
A |
6: 125,081,909 (GRCm39) |
R514Q |
possibly damaging |
Het |
| Cnst |
T |
C |
1: 179,452,557 (GRCm39) |
|
probably benign |
Het |
| Col6a6 |
T |
C |
9: 105,661,453 (GRCm39) |
|
probably benign |
Het |
| Cux2 |
A |
C |
5: 122,007,168 (GRCm39) |
L831R |
probably null |
Het |
| Elf2 |
T |
A |
3: 51,215,467 (GRCm39) |
|
probably benign |
Het |
| Frey1 |
T |
A |
2: 92,213,563 (GRCm39) |
S39T |
probably benign |
Het |
| Glp1r |
A |
G |
17: 31,138,443 (GRCm39) |
|
probably benign |
Het |
| Hus1b |
A |
G |
13: 31,131,527 (GRCm39) |
M44T |
probably benign |
Het |
| Mbd6 |
A |
G |
10: 127,119,988 (GRCm39) |
|
probably benign |
Het |
| Med31 |
T |
A |
11: 72,102,905 (GRCm39) |
|
probably null |
Het |
| Mmrn1 |
C |
T |
6: 60,952,894 (GRCm39) |
Q392* |
probably null |
Het |
| Mrpl3 |
T |
G |
9: 104,934,240 (GRCm39) |
V121G |
probably damaging |
Het |
| Or10am5 |
A |
G |
7: 6,517,577 (GRCm39) |
S284P |
probably damaging |
Het |
| Or14c46 |
A |
T |
7: 85,918,649 (GRCm39) |
M116K |
probably damaging |
Het |
| Palld |
A |
G |
8: 61,968,969 (GRCm39) |
V879A |
possibly damaging |
Het |
| Pkn2 |
G |
T |
3: 142,559,386 (GRCm39) |
D46E |
probably damaging |
Het |
| Prkdc |
T |
A |
16: 15,557,428 (GRCm39) |
C2244S |
probably damaging |
Het |
| Prss50 |
T |
A |
9: 110,691,474 (GRCm39) |
H259Q |
possibly damaging |
Het |
| Rab8b |
C |
T |
9: 66,761,969 (GRCm39) |
W102* |
probably null |
Het |
| Rad54l2 |
A |
T |
9: 106,587,638 (GRCm39) |
L709Q |
possibly damaging |
Het |
| Rapgef1 |
T |
C |
2: 29,592,535 (GRCm39) |
V471A |
probably benign |
Het |
| Rbms3 |
A |
G |
9: 116,939,183 (GRCm39) |
S27P |
probably damaging |
Het |
| Rpl35a |
A |
G |
16: 32,879,101 (GRCm39) |
K73E |
possibly damaging |
Het |
| Sugct |
A |
T |
13: 17,032,503 (GRCm39) |
Y416* |
probably null |
Het |
| Top2b |
A |
G |
14: 16,407,354 (GRCm38) |
I713V |
probably benign |
Het |
| Unc79 |
A |
T |
12: 103,054,766 (GRCm39) |
R777S |
possibly damaging |
Het |
| Vps37a |
T |
A |
8: 40,993,779 (GRCm39) |
M258K |
probably benign |
Het |
|
| Other mutations in Zfp944 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00595:Zfp944
|
APN |
17 |
22,558,186 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01093:Zfp944
|
APN |
17 |
22,562,615 (GRCm39) |
splice site |
probably benign |
|
|
IGL02113:Zfp944
|
APN |
17 |
22,558,047 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02694:Zfp944
|
APN |
17 |
22,558,899 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03135:Zfp944
|
APN |
17 |
22,558,737 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03172:Zfp944
|
APN |
17 |
22,559,018 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0121:Zfp944
|
UTSW |
17 |
22,558,249 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0336:Zfp944
|
UTSW |
17 |
22,558,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0755:Zfp944
|
UTSW |
17 |
22,558,889 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1536:Zfp944
|
UTSW |
17 |
22,558,697 (GRCm39) |
nonsense |
probably null |
|
|
R1708:Zfp944
|
UTSW |
17 |
22,558,026 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1886:Zfp944
|
UTSW |
17 |
22,558,960 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1928:Zfp944
|
UTSW |
17 |
22,560,065 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1950:Zfp944
|
UTSW |
17 |
22,558,681 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2075:Zfp944
|
UTSW |
17 |
22,558,178 (GRCm39) |
nonsense |
probably null |
|
|
R2101:Zfp944
|
UTSW |
17 |
22,558,809 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2433:Zfp944
|
UTSW |
17 |
22,558,193 (GRCm39) |
nonsense |
probably null |
|
|
R4698:Zfp944
|
UTSW |
17 |
22,558,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Zfp944
|
UTSW |
17 |
22,558,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6451:Zfp944
|
UTSW |
17 |
22,557,846 (GRCm39) |
missense |
probably benign |
0.40 |
|
R6566:Zfp944
|
UTSW |
17 |
22,558,726 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6752:Zfp944
|
UTSW |
17 |
22,558,500 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7064:Zfp944
|
UTSW |
17 |
22,558,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8193:Zfp944
|
UTSW |
17 |
22,558,861 (GRCm39) |
nonsense |
probably null |
|
|
R8323:Zfp944
|
UTSW |
17 |
22,558,235 (GRCm39) |
missense |
probably benign |
|
|
R8328:Zfp944
|
UTSW |
17 |
22,558,705 (GRCm39) |
nonsense |
probably null |
|
|
R8902:Zfp944
|
UTSW |
17 |
22,558,761 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8915:Zfp944
|
UTSW |
17 |
22,558,507 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9130:Zfp944
|
UTSW |
17 |
22,560,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9248:Zfp944
|
UTSW |
17 |
22,562,619 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Posted On |
2013-04-17 |
Incidental Mutation