Mutagenetix > Incidental Mutation

Incidental Mutation 'R1536:Zfp944'

169555

Institutional Source

Beutler Lab

Gene Symbol

Zfp944

Ensembl Gene

ENSMUSG00000033972

Gene Name

zinc finger protein 944

Synonyms

6330416L07Rik

MMRRC Submission

039575-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.196) question?

Stock #

R1536 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

22337989-22361400 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 22339716 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 183 (Y183*)

Ref Sequence

ENSEMBL: ENSMUSP00000111197 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115535]

AlphaFold

E9PUS4

Predicted Effect

probably null
Transcript: ENSMUST00000115535
AA Change: Y183*

SMART Domains

Protein: ENSMUSP00000111197
Gene: ENSMUSG00000033972
AA Change: Y183*

Domain	Start	End	E-Value	Type
KRAB	13	76	2.08e-21	SMART
ZnF_C2H2	183	205	1.01e-1	SMART
ZnF_C2H2	211	233	1.07e0	SMART
ZnF_C2H2	239	261	1.95e-3	SMART
ZnF_C2H2	267	289	1.22e-4	SMART
ZnF_C2H2	295	317	2.24e-3	SMART
ZnF_C2H2	323	345	1.82e-3	SMART
ZnF_C2H2	351	373	5.99e-4	SMART
ZnF_C2H2	379	401	4.79e-3	SMART
ZnF_C2H2	407	429	2.99e-4	SMART
ZnF_C2H2	435	457	4.17e-3	SMART
ZnF_C2H2	463	485	1.36e-2	SMART

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.3%
20x: 89.5%

Validation Efficiency

98% (59/60)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310003L06Rik	A	T	5: 87,970,665	I3F	probably benign	Het
4930590J08Rik	A	G	6: 91,917,035	N211S	probably benign	Het
A2ml1	A	T	6: 128,547,233	Y1145*	probably null	Het
Abca7	A	G	10: 80,014,230	D1972G	probably benign	Het
Adamts19	A	T	18: 59,052,615	D1187V	probably damaging	Het
Adcy6	G	C	15: 98,600,007	I421M	probably damaging	Het
Afap1	C	A	5: 35,974,491	H387Q	probably damaging	Het
Atp8b1	C	T	18: 64,545,264	V854M	probably damaging	Het
Auts2	C	T	5: 131,487,463		probably benign	Het
Cbll1	T	C	12: 31,487,856	D300G	probably damaging	Het
Cd200r4	A	T	16: 44,833,049	T61S	possibly damaging	Het
Chmp4c	G	T	3: 10,389,684	V207L	probably benign	Het
Cntn5	T	C	9: 9,976,316	T413A	possibly damaging	Het
Cox7a2	T	A	9: 79,758,581		probably null	Het
Cwc27	A	G	13: 104,797,306	L236P	probably damaging	Het
Diaph1	A	G	18: 37,896,093		probably null	Het
Dst	T	A	1: 34,260,372		probably benign	Het
Ear1	T	A	14: 43,819,126	H95L	probably damaging	Het
Enpp1	T	A	10: 24,641,834	H898L	probably benign	Het
Entpd5	G	A	12: 84,382,295	R321*	probably null	Het
Ercc6l2	C	A	13: 63,824,871	N177K	possibly damaging	Het
Ergic1	T	C	17: 26,641,706		probably null	Het
Erich6	A	T	3: 58,626,598	I336N	probably benign	Het
Fmnl2	A	G	2: 53,105,537	E424G	probably damaging	Het
Galnt3	A	T	2: 66,084,206	D622E	probably damaging	Het
Gjd4	T	A	18: 9,280,569	T170S	probably damaging	Het
Gm5611	G	A	9: 17,030,607		noncoding transcript	Het
Gpc5	T	A	14: 115,399,250	N448K	probably benign	Het
Klra3	G	C	6: 130,333,144	R138G	probably benign	Het
Man2b2	T	C	5: 36,820,927	T338A	probably benign	Het
Mbtps1	A	T	8: 119,546,125	S94T	probably benign	Het
Muc3a	A	T	5: 137,210,081	S205T	unknown	Het
Nav2	C	A	7: 49,545,934	D1019E	probably damaging	Het
Neurl4	T	A	11: 69,903,426	L236*	probably null	Het
Olfr272	A	G	4: 52,911,260	V178A	probably benign	Het
Plcxd3	T	C	15: 4,516,611		probably benign	Het
Pprc1	T	C	19: 46,071,526		probably benign	Het
Prkaa2	T	A	4: 105,075,450	N67I	probably damaging	Het
Prom1	T	A	5: 44,018,353	Y508F	probably benign	Het
Prx	A	G	7: 27,517,258	M534V	probably damaging	Het
Rps6kc1	C	T	1: 190,871,768	R219Q	possibly damaging	Het
Sbf2	T	C	7: 110,378,043	Y628C	probably damaging	Het
Slc1a2	A	T	2: 102,777,510	D501V	probably benign	Het
Spata31	A	T	13: 64,921,382	Q448L	probably damaging	Het
Stk35	T	C	2: 129,811,235		probably benign	Het
Stxbp5	T	A	10: 9,838,092	R234S	probably damaging	Het
Tifab	A	G	13: 56,176,288	V114A	probably benign	Het
Tiprl	A	G	1: 165,228,406	M49T	probably benign	Het
Tlr12	A	G	4: 128,617,752	L235P	possibly damaging	Het
Tmem57	A	G	4: 134,804,507	V617A	probably damaging	Het
Trim43b	A	T	9: 89,085,358	C407*	probably null	Het
Txndc17	C	A	11: 72,207,707	F28L	probably damaging	Het
Vmn2r27	T	C	6: 124,200,690	R452G	probably damaging	Het
Vmn2r3	T	A	3: 64,275,117	D387V	probably damaging	Het
Vps13b	T	C	15: 35,875,566	I2699T	probably damaging	Het

Other mutations in Zfp944

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00595:Zfp944	APN	17	22339205	missense	probably benign	0.10
IGL00917:Zfp944	APN	17	22339784	missense	probably benign	0.00
IGL01093:Zfp944	APN	17	22343634	splice site	probably benign
IGL02113:Zfp944	APN	17	22339066	missense	possibly damaging	0.88
IGL02694:Zfp944	APN	17	22339918	missense	probably benign	0.05
IGL03135:Zfp944	APN	17	22339756	missense	probably benign	0.00
IGL03172:Zfp944	APN	17	22340037	missense	probably damaging	0.98
R0121:Zfp944	UTSW	17	22339268	missense	possibly damaging	0.69
R0336:Zfp944	UTSW	17	22339028	missense	probably damaging	1.00
R0755:Zfp944	UTSW	17	22339908	missense	possibly damaging	0.63
R1708:Zfp944	UTSW	17	22339045	missense	probably damaging	0.98
R1886:Zfp944	UTSW	17	22339979	missense	probably benign	0.04
R1928:Zfp944	UTSW	17	22341084	missense	probably damaging	0.96
R1950:Zfp944	UTSW	17	22339700	missense	probably benign	0.16
R2075:Zfp944	UTSW	17	22339197	nonsense	probably null
R2101:Zfp944	UTSW	17	22339828	missense	probably benign	0.41
R2433:Zfp944	UTSW	17	22339212	nonsense	probably null
R4698:Zfp944	UTSW	17	22339199	missense	probably damaging	1.00
R4986:Zfp944	UTSW	17	22339230	missense	probably damaging	1.00
R6451:Zfp944	UTSW	17	22338865	missense	probably benign	0.40
R6566:Zfp944	UTSW	17	22339745	missense	possibly damaging	0.96
R6752:Zfp944	UTSW	17	22339519	missense	probably benign	0.01
R7064:Zfp944	UTSW	17	22339579	missense	probably damaging	1.00
R8193:Zfp944	UTSW	17	22339880	nonsense	probably null
R8323:Zfp944	UTSW	17	22339254	missense	probably benign
R8328:Zfp944	UTSW	17	22339724	nonsense	probably null
R8902:Zfp944	UTSW	17	22339780	missense	probably benign	0.41
R8915:Zfp944	UTSW	17	22339526	missense	probably benign	0.05
R9130:Zfp944	UTSW	17	22341050	missense	probably damaging	1.00
R9248:Zfp944	UTSW	17	22343638	critical splice donor site	probably null

Predicted Primers

Posted On

2014-04-13