Incidental Mutation 'IGL02431:Dcaf10'
| ID |
293148 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Dcaf10
|
| Ensembl Gene |
ENSMUSG00000035572 |
| Gene Name |
DDB1 and CUL4 associated factor 10 |
| Synonyms |
Wdr32 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02431
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
45342101-45379759 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 45342630 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 155
(M155V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117082
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000155551]
|
| AlphaFold |
A2AKB9 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000107798
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000117307
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130821
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152056
|
| SMART Domains |
Protein: ENSMUSP00000115532
Gene: ENSMUSG00000028322
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:S1
|
24 |
93 |
8e-38 |
BLAST |
|
Pfam:KH_6
|
109 |
145 |
8e-13 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155551
AA Change: M155V
PolyPhen 2
Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000117082
Gene: ENSMUSG00000035572
AA Change: M155V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
46 |
N/A |
INTRINSIC |
|
low complexity region
|
80 |
107 |
N/A |
INTRINSIC |
|
low complexity region
|
110 |
132 |
N/A |
INTRINSIC |
|
WD40
|
166 |
203 |
1.71e1 |
SMART |
|
WD40
|
206 |
245 |
7.85e-7 |
SMART |
|
WD40
|
249 |
288 |
2.59e-7 |
SMART |
|
WD40
|
295 |
334 |
2.05e1 |
SMART |
|
low complexity region
|
352 |
374 |
N/A |
INTRINSIC |
|
Blast:WD40
|
468 |
506 |
3e-10 |
BLAST |
|
WD40
|
524 |
563 |
1.31e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca17 |
T |
A |
17: 24,517,958 (GRCm39) |
I784L |
probably benign |
Het |
| Abcc1 |
T |
A |
16: 14,237,598 (GRCm39) |
V473E |
probably damaging |
Het |
| Agap3 |
A |
G |
5: 24,706,010 (GRCm39) |
E758G |
probably damaging |
Het |
| C6 |
A |
T |
15: 4,789,343 (GRCm39) |
K263* |
probably null |
Het |
| Cep78 |
T |
C |
19: 15,936,943 (GRCm39) |
T588A |
probably benign |
Het |
| Cfap20dc |
T |
C |
14: 8,659,424 (GRCm38) |
N57S |
probably damaging |
Het |
| Col4a3 |
C |
T |
1: 82,657,344 (GRCm39) |
Q815* |
probably null |
Het |
| Fam228b |
T |
C |
12: 4,812,370 (GRCm39) |
Y136C |
probably damaging |
Het |
| Fryl |
A |
T |
5: 73,255,651 (GRCm39) |
H793Q |
probably benign |
Het |
| Gm10134 |
T |
C |
2: 28,396,429 (GRCm39) |
|
probably benign |
Het |
| Gm6505 |
T |
C |
3: 28,819,169 (GRCm39) |
|
noncoding transcript |
Het |
| Il31ra |
A |
G |
13: 112,666,830 (GRCm39) |
F416S |
probably damaging |
Het |
| Lipc |
A |
G |
9: 70,841,750 (GRCm39) |
|
probably benign |
Het |
| Lrp4 |
A |
G |
2: 91,306,982 (GRCm39) |
K368E |
possibly damaging |
Het |
| Lrriq1 |
A |
T |
10: 103,036,500 (GRCm39) |
N884K |
probably damaging |
Het |
| Mrgprx1 |
T |
C |
7: 47,670,875 (GRCm39) |
R291G |
probably benign |
Het |
| Myo15a |
T |
A |
11: 60,401,465 (GRCm39) |
V3057E |
possibly damaging |
Het |
| Or11g1 |
T |
A |
14: 50,651,226 (GRCm39) |
I75N |
probably damaging |
Het |
| Or14j8 |
T |
A |
17: 38,263,413 (GRCm39) |
R167S |
probably benign |
Het |
| Postn |
A |
T |
3: 54,282,517 (GRCm39) |
I493F |
probably damaging |
Het |
| Ptpn22 |
C |
A |
3: 103,810,713 (GRCm39) |
F713L |
probably benign |
Het |
| Pygm |
T |
C |
19: 6,438,148 (GRCm39) |
V239A |
probably damaging |
Het |
| Rangrf |
C |
A |
11: 68,863,565 (GRCm39) |
C147F |
probably benign |
Het |
| Rnf112 |
C |
T |
11: 61,341,205 (GRCm39) |
R460H |
probably benign |
Het |
| Sh3d19 |
A |
G |
3: 86,014,305 (GRCm39) |
E423G |
probably damaging |
Het |
| Tasor2 |
A |
G |
13: 3,624,736 (GRCm39) |
V1738A |
possibly damaging |
Het |
| Tipin |
A |
G |
9: 64,208,467 (GRCm39) |
K204E |
probably benign |
Het |
| Traf3ip1 |
A |
T |
1: 91,427,357 (GRCm39) |
Q109L |
unknown |
Het |
| Ttc21b |
A |
T |
2: 66,082,229 (GRCm39) |
|
probably benign |
Het |
| Ttn |
C |
A |
2: 76,804,460 (GRCm39) |
A271S |
probably benign |
Het |
| Vegfb |
C |
A |
19: 6,963,386 (GRCm39) |
|
probably null |
Het |
| Vmn1r15 |
T |
A |
6: 57,235,888 (GRCm39) |
L252H |
possibly damaging |
Het |
| Wipi1 |
A |
T |
11: 109,494,617 (GRCm39) |
V72D |
probably damaging |
Het |
| Zmym1 |
G |
A |
4: 126,941,557 (GRCm39) |
Q944* |
probably null |
Het |
|
| Other mutations in Dcaf10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02660:Dcaf10
|
APN |
4 |
45,372,769 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0048:Dcaf10
|
UTSW |
4 |
45,374,262 (GRCm39) |
nonsense |
probably null |
|
|
R0550:Dcaf10
|
UTSW |
4 |
45,372,753 (GRCm39) |
missense |
probably benign |
|
|
R0611:Dcaf10
|
UTSW |
4 |
45,373,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2289:Dcaf10
|
UTSW |
4 |
45,359,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2973:Dcaf10
|
UTSW |
4 |
45,373,957 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3610:Dcaf10
|
UTSW |
4 |
45,372,962 (GRCm39) |
nonsense |
probably null |
|
|
R3735:Dcaf10
|
UTSW |
4 |
45,348,117 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4655:Dcaf10
|
UTSW |
4 |
45,372,769 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4665:Dcaf10
|
UTSW |
4 |
45,372,769 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4690:Dcaf10
|
UTSW |
4 |
45,372,769 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4724:Dcaf10
|
UTSW |
4 |
45,372,769 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4725:Dcaf10
|
UTSW |
4 |
45,372,769 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4735:Dcaf10
|
UTSW |
4 |
45,372,769 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4743:Dcaf10
|
UTSW |
4 |
45,370,409 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5220:Dcaf10
|
UTSW |
4 |
45,373,909 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5254:Dcaf10
|
UTSW |
4 |
45,370,415 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5855:Dcaf10
|
UTSW |
4 |
45,342,558 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6833:Dcaf10
|
UTSW |
4 |
45,373,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7132:Dcaf10
|
UTSW |
4 |
45,342,391 (GRCm39) |
missense |
probably benign |
|
|
R7345:Dcaf10
|
UTSW |
4 |
45,342,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7366:Dcaf10
|
UTSW |
4 |
45,373,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7832:Dcaf10
|
UTSW |
4 |
45,348,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation