Incidental Mutation 'IGL02477:Hspa14'
ID 295015
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hspa14
Ensembl Gene ENSMUSG00000109865
Gene Name heat shock protein 14
Synonyms HSP70L1, 70kDa, NST-1, Hsp70-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.201) question?
Stock # IGL02477
Quality Score
Status
Chromosome 2
Chromosomal Location 3489891-3513851 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 3497661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 277 (S277N)
Ref Sequence ENSEMBL: ENSMUSP00000027961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027961]
AlphaFold Q99M31
Predicted Effect probably damaging
Transcript: ENSMUST00000027961
AA Change: S277N

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000027961
Gene: ENSMUSG00000109865
AA Change: S277N

DomainStartEndE-ValueType
Pfam:HSP70 3 509 6.3e-115 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135157
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139485
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156008
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik T A 4: 103,127,943 (GRCm39) I61F probably benign Het
Abr T C 11: 76,352,186 (GRCm39) K280E probably damaging Het
Acaca T C 11: 84,197,994 (GRCm39) probably benign Het
Cep131 C T 11: 119,961,406 (GRCm39) V582I probably damaging Het
Colec12 A G 18: 9,859,858 (GRCm39) N613D unknown Het
Cyp4f39 A G 17: 32,708,619 (GRCm39) T389A probably benign Het
D630003M21Rik T C 2: 158,059,408 (GRCm39) N164S probably benign Het
Eef1akmt2 A T 7: 132,452,318 (GRCm39) probably null Het
Elp3 T C 14: 65,800,760 (GRCm39) T283A probably benign Het
Fads3 C A 19: 10,033,806 (GRCm39) P397Q probably damaging Het
Fam171a1 T C 2: 3,203,612 (GRCm39) V198A possibly damaging Het
Fam171a2 T C 11: 102,330,854 (GRCm39) I208M probably benign Het
Fbxw17 G A 13: 50,577,853 (GRCm39) V119M possibly damaging Het
Gtf2ird1 G A 5: 134,408,832 (GRCm39) T140M probably damaging Het
Hspg2 C T 4: 137,271,823 (GRCm39) probably benign Het
Ing2 G T 8: 48,122,303 (GRCm39) R82S possibly damaging Het
Kat6a A G 8: 23,419,316 (GRCm39) Y693C probably damaging Het
Kcna7 A G 7: 45,059,047 (GRCm39) M445V probably benign Het
Lifr T G 15: 7,216,404 (GRCm39) I793S probably damaging Het
Lrrd1 T A 5: 3,915,770 (GRCm39) M789K probably benign Het
Myom3 T A 4: 135,506,679 (GRCm39) L484Q probably benign Het
Nav2 T A 7: 49,232,623 (GRCm39) M1860K probably damaging Het
Nipbl C T 15: 8,353,131 (GRCm39) probably null Het
Nsun7 T A 5: 66,433,992 (GRCm39) I214K probably damaging Het
Or5k17 T C 16: 58,746,126 (GRCm39) I269M probably benign Het
Or8c20 C T 9: 38,260,421 (GRCm39) S8L probably benign Het
Osm T A 11: 4,189,604 (GRCm39) N129K probably damaging Het
Plce1 C T 19: 38,707,997 (GRCm39) probably benign Het
Plch1 A G 3: 63,660,714 (GRCm39) F302L probably damaging Het
Pld2 T C 11: 70,431,751 (GRCm39) V27A possibly damaging Het
Prex2 A G 1: 11,274,378 (GRCm39) D1350G probably benign Het
Psme4 T A 11: 30,792,083 (GRCm39) V1190D probably damaging Het
Sema3g G T 14: 30,949,823 (GRCm39) R668L probably damaging Het
Sprr2f T A 3: 92,273,204 (GRCm39) M1K probably null Het
Sult6b2 G A 6: 142,747,447 (GRCm39) P101S probably damaging Het
Trem3 G A 17: 48,556,864 (GRCm39) V112I probably benign Het
Ttll9 T A 2: 152,842,117 (GRCm39) F324I possibly damaging Het
Ttn T A 2: 76,557,104 (GRCm39) D29967V probably damaging Het
Ubr4 A G 4: 139,163,516 (GRCm39) K2639E probably damaging Het
Vwce T C 19: 10,641,982 (GRCm39) probably null Het
Zbtb14 T A 17: 69,694,690 (GRCm39) D129E probably benign Het
Zmym6 C T 4: 126,972,295 (GRCm39) Q16* probably null Het
Other mutations in Hspa14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00857:Hspa14 APN 2 3,503,796 (GRCm39) missense probably damaging 1.00
IGL02293:Hspa14 APN 2 3,512,071 (GRCm39) missense probably damaging 1.00
IGL02711:Hspa14 APN 2 3,503,557 (GRCm39) missense probably benign 0.15
R0522:Hspa14 UTSW 2 3,512,086 (GRCm39) missense probably damaging 1.00
R1169:Hspa14 UTSW 2 3,499,161 (GRCm39) missense possibly damaging 0.90
R1426:Hspa14 UTSW 2 3,509,858 (GRCm39) missense probably damaging 1.00
R1471:Hspa14 UTSW 2 3,492,645 (GRCm39) missense probably benign 0.01
R1846:Hspa14 UTSW 2 3,492,697 (GRCm39) missense possibly damaging 0.50
R1971:Hspa14 UTSW 2 3,490,804 (GRCm39) missense possibly damaging 0.51
R2353:Hspa14 UTSW 2 3,512,213 (GRCm39) splice site probably null
R3508:Hspa14 UTSW 2 3,492,045 (GRCm39) missense probably damaging 1.00
R3859:Hspa14 UTSW 2 3,495,616 (GRCm39) nonsense probably null
R4012:Hspa14 UTSW 2 3,513,675 (GRCm39) missense probably damaging 0.99
R4360:Hspa14 UTSW 2 3,503,560 (GRCm39) missense possibly damaging 0.89
R4938:Hspa14 UTSW 2 3,492,646 (GRCm39) missense probably benign 0.01
R5028:Hspa14 UTSW 2 3,499,206 (GRCm39) missense possibly damaging 0.72
R5326:Hspa14 UTSW 2 3,503,560 (GRCm39) missense possibly damaging 0.89
R5542:Hspa14 UTSW 2 3,503,560 (GRCm39) missense possibly damaging 0.89
R5881:Hspa14 UTSW 2 3,499,207 (GRCm39) missense probably benign 0.34
R6046:Hspa14 UTSW 2 3,490,801 (GRCm39) missense possibly damaging 0.91
R6076:Hspa14 UTSW 2 3,512,109 (GRCm39) missense probably benign 0.00
R6112:Hspa14 UTSW 2 3,499,105 (GRCm39) missense probably benign
R6334:Hspa14 UTSW 2 3,490,109 (GRCm39) splice site probably null
R7297:Hspa14 UTSW 2 3,499,179 (GRCm39) missense possibly damaging 0.76
R7424:Hspa14 UTSW 2 3,490,078 (GRCm39) missense possibly damaging 0.95
R7510:Hspa14 UTSW 2 3,499,159 (GRCm39) missense probably benign 0.01
R7692:Hspa14 UTSW 2 3,497,643 (GRCm39) missense probably damaging 1.00
R8394:Hspa14 UTSW 2 3,513,670 (GRCm39) critical splice donor site probably null
R9780:Hspa14 UTSW 2 3,490,741 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16