Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02638:Or8j3c'

301633

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8j3c

Ensembl Gene

ENSMUSG00000090059

Gene Name

olfactory receptor family 8 subfamily J member 3C

Synonyms

GA_x6K02T2Q125-47892992-47892045, Olfr1062, MOR185-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL02638

Quality Score

Status

Chromosome

Chromosomal Location

86253063-86254018 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 86254021 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000100848 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105213] [ENSMUST00000217481]

AlphaFold

Q7TR71

Predicted Effect

probably null
Transcript: ENSMUST00000105213

SMART Domains

Protein: ENSMUSP00000100848
Gene: ENSMUSG00000090059

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.8e-46	PFAM
Pfam:7tm_1	41	290	2.8e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216166

Predicted Effect

probably benign
Transcript: ENSMUST00000217481

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alkbh3	T	A	2: 93,838,458 (GRCm39)	T38S	probably benign	Het
Btbd8	T	C	5: 107,656,422 (GRCm39)	V895A	possibly damaging	Het
Cdkn2c	A	G	4: 109,522,209 (GRCm39)		probably benign	Het
Clca4b	A	C	3: 144,631,939 (GRCm39)	C189G	probably damaging	Het
Clec4f	T	A	6: 83,629,682 (GRCm39)	N292I	possibly damaging	Het
Dkk3	A	C	7: 111,748,234 (GRCm39)	S123R	probably benign	Het
Dock1	C	T	7: 134,748,209 (GRCm39)	A1557V	probably benign	Het
E130308A19Rik	C	T	4: 59,719,676 (GRCm39)	Q403*	probably null	Het
F5	G	A	1: 164,012,177 (GRCm39)		probably null	Het
Fam98c	T	A	7: 28,852,187 (GRCm39)	D326V	probably damaging	Het
Firrm	G	A	1: 163,786,868 (GRCm39)	Q734*	probably null	Het
Frem2	A	C	3: 53,458,767 (GRCm39)	V2034G	possibly damaging	Het
Galnt2	G	A	8: 124,958,318 (GRCm39)	G18D	probably damaging	Het
Grhl3	T	C	4: 135,284,176 (GRCm39)	E222G	probably benign	Het
Hif3a	A	C	7: 16,778,293 (GRCm39)		probably benign	Het
Ibtk	C	T	9: 85,601,946 (GRCm39)	G755D	probably damaging	Het
Laptm4b	A	G	15: 34,277,630 (GRCm39)	N187S	probably benign	Het
Lrba	A	G	3: 86,232,380 (GRCm39)	T776A	probably damaging	Het
Matcap2	A	T	9: 22,341,775 (GRCm39)	K149*	probably null	Het
Mfhas1	T	A	8: 36,058,104 (GRCm39)	W860R	possibly damaging	Het
Mon2	A	C	10: 122,859,844 (GRCm39)	W811G	probably damaging	Het
Nup42	A	G	5: 24,380,505 (GRCm39)	T167A	probably benign	Het
Or10j2	A	G	1: 173,097,898 (GRCm39)	D52G	probably benign	Het
Or2z2	C	A	11: 58,345,873 (GRCm39)	A301S	probably damaging	Het
Or4k45	T	C	2: 111,395,249 (GRCm39)	D180G	probably damaging	Het
Or5w10	T	C	2: 87,375,093 (GRCm39)	Y265C	probably damaging	Het
Pgap2	T	C	7: 101,886,629 (GRCm39)	L217P	probably damaging	Het
Pik3c2b	T	G	1: 133,005,056 (GRCm39)		probably benign	Het
Ppfia3	T	A	7: 45,006,092 (GRCm39)	D149V	probably damaging	Het
Prkcb	C	T	7: 122,200,063 (GRCm39)		probably benign	Het
Prl	A	G	13: 27,245,562 (GRCm39)	D97G	probably benign	Het
Psma5-ps	T	C	10: 85,149,698 (GRCm39)		noncoding transcript	Het
Rnf112	T	C	11: 61,340,231 (GRCm39)		probably benign	Het
Slc17a8	C	A	10: 89,412,465 (GRCm39)	G323*	probably null	Het
Snx19	T	C	9: 30,343,660 (GRCm39)	F607L	possibly damaging	Het
Suco	A	G	1: 161,655,256 (GRCm39)	S1079P	probably damaging	Het
Taf5	T	C	19: 47,056,649 (GRCm39)	L149P	probably benign	Het
Taf6l	T	C	19: 8,752,630 (GRCm39)	M379V	probably benign	Het
Tcf25	T	C	8: 124,126,031 (GRCm39)	F558L	probably damaging	Het
Tlcd1	T	C	11: 78,070,444 (GRCm39)	V102A	probably benign	Het
Tmc5	G	T	7: 118,226,456 (GRCm39)	A274S	probably benign	Het
Toporsl	C	T	4: 52,611,624 (GRCm39)	H506Y	probably benign	Het
Ubtd1	T	C	19: 42,022,109 (GRCm39)	L127P	possibly damaging	Het
Usp24	A	C	4: 106,295,967 (GRCm39)		probably benign	Het
Usp24	C	A	4: 106,295,969 (GRCm39)		probably benign	Het
Usp43	T	G	11: 67,746,581 (GRCm39)	D1042A	probably benign	Het
Whrn	T	C	4: 63,337,709 (GRCm39)	T48A	possibly damaging	Het
Wnt2b	A	G	3: 104,862,032 (GRCm39)	I102T	probably benign	Het
Zfp763	T	C	17: 33,238,908 (GRCm39)	D79G	probably benign	Het
Zmat4	A	G	8: 24,287,389 (GRCm39)	Y45C	probably damaging	Het

Other mutations in Or8j3c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02040:Or8j3c	APN	2	86,253,336 (GRCm39)	missense	probably damaging	0.98
IGL02863:Or8j3c	APN	2	86,253,457 (GRCm39)	missense	probably benign	0.44
R0211:Or8j3c	UTSW	2	86,253,451 (GRCm39)	missense	probably damaging	0.96
R0211:Or8j3c	UTSW	2	86,253,451 (GRCm39)	missense	probably damaging	0.96
R1486:Or8j3c	UTSW	2	86,253,825 (GRCm39)	missense	probably damaging	0.99
R2327:Or8j3c	UTSW	2	86,253,165 (GRCm39)	nonsense	probably null
R3695:Or8j3c	UTSW	2	86,253,987 (GRCm39)	missense	probably damaging	0.96
R3981:Or8j3c	UTSW	2	86,253,186 (GRCm39)	missense	probably damaging	1.00
R4156:Or8j3c	UTSW	2	86,253,544 (GRCm39)	missense	possibly damaging	0.67
R4860:Or8j3c	UTSW	2	86,253,301 (GRCm39)	missense	probably damaging	1.00
R4860:Or8j3c	UTSW	2	86,253,301 (GRCm39)	missense	probably damaging	1.00
R5024:Or8j3c	UTSW	2	86,253,805 (GRCm39)	missense	possibly damaging	0.77
R5351:Or8j3c	UTSW	2	86,253,610 (GRCm39)	missense	probably damaging	1.00
R5566:Or8j3c	UTSW	2	86,253,721 (GRCm39)	nonsense	probably null
R5777:Or8j3c	UTSW	2	86,253,669 (GRCm39)	missense	probably benign	0.00
R6628:Or8j3c	UTSW	2	86,253,361 (GRCm39)	missense	probably benign	0.02
R7039:Or8j3c	UTSW	2	86,253,177 (GRCm39)	missense	possibly damaging	0.48
R7159:Or8j3c	UTSW	2	86,253,956 (GRCm39)	splice site	probably null
R7236:Or8j3c	UTSW	2	86,253,533 (GRCm39)	nonsense	probably null
R7251:Or8j3c	UTSW	2	86,253,940 (GRCm39)	missense	probably benign	0.45
R7575:Or8j3c	UTSW	2	86,253,582 (GRCm39)	missense	probably benign
R7840:Or8j3c	UTSW	2	86,253,583 (GRCm39)	missense	probably benign	0.00
R8048:Or8j3c	UTSW	2	86,253,651 (GRCm39)	missense	probably damaging	1.00
R8167:Or8j3c	UTSW	2	86,253,484 (GRCm39)	missense	probably damaging	1.00
R8465:Or8j3c	UTSW	2	86,253,975 (GRCm39)	missense	probably benign	0.03
R8672:Or8j3c	UTSW	2	86,253,976 (GRCm39)	missense	probably benign
R8871:Or8j3c	UTSW	2	86,253,697 (GRCm39)	missense	probably benign
R9244:Or8j3c	UTSW	2	86,253,423 (GRCm39)	missense	probably damaging	0.97
R9513:Or8j3c	UTSW	2	86,253,707 (GRCm39)	missense	probably damaging	1.00
X0065:Or8j3c	UTSW	2	86,253,466 (GRCm39)	missense	probably benign	0.39
Z1176:Or8j3c	UTSW	2	86,253,718 (GRCm39)	missense	probably benign	0.07
Z1177:Or8j3c	UTSW	2	86,253,756 (GRCm39)	missense	probably benign	0.12
Z1177:Or8j3c	UTSW	2	86,253,597 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16